GREMLIN Database
DDG - Protein Ddg
UniProt: P0ACV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12901
Length: 306 (279)
Sequences: 4319 (3101)
Seq/√Len: 185.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_A274_K3.9261.00
111_E251_R3.8971.00
109_D251_R3.6851.00
111_E253_F3.2961.00
244_K251_R3.0141.00
60_R79_I2.8301.00
60_R76_E2.7751.00
81_E285_E2.7631.00
212_P217_E2.7251.00
71_S74_E2.7221.00
115_N256_P2.6891.00
46_A84_R2.6821.00
212_P270_A2.6491.00
113_L117_K2.5871.00
70_H74_E2.5521.00
274_K277_E2.4901.00
63_L75_R2.4601.00
69_Q281_M2.3661.00
64_E75_R2.2711.00
221_T273_N2.2491.00
41_G87_G2.2001.00
117_K121_M2.1851.00
112_G115_N2.1731.00
188_A193_E2.1251.00
33_P36_V2.1231.00
65_L216_V2.0951.00
150_M193_E2.0871.00
114_D118_R2.0681.00
255_T275_I2.0641.00
70_H78_M2.0561.00
115_N118_R2.0511.00
58_I292_R1.9831.00
214_F277_E1.9751.00
238_T255_T1.9231.00
242_V251_R1.9081.00
242_V283_A1.9071.00
61_K64_E1.8771.00
155_P178_G1.8461.00
42_T84_R1.8101.00
64_E72_A1.8031.00
163_W167_R1.8011.00
124_R235_A1.7881.00
210_F217_E1.7841.00
67_F70_H1.7761.00
266_N270_A1.7571.00
238_T257_E1.7541.00
211_A270_A1.7341.00
109_D249_G1.7161.00
264_D267_Q1.7091.00
92_E243_R1.7071.00
59_A79_I1.7021.00
209_S269_A1.6491.00
211_A273_N1.6341.00
131_V276_I1.6171.00
49_R56_E1.5431.00
275_I278_K1.5421.00
119_A237_L1.5101.00
242_V253_F1.4971.00
115_N237_L1.4941.00
118_R122_Q1.4741.00
186_V190_K1.4721.00
74_E77_K1.4411.00
77_K81_E1.4371.00
237_L254_I1.4291.00
150_M188_A1.4111.00
271_Y275_I1.4051.00
185_I195_V1.3971.00
255_T278_K1.3961.00
59_A82_N1.3811.00
60_R64_E1.3751.00
216_V297_R1.3741.00
245_A249_G1.3571.00
27_W31_Q1.3561.00
60_R75_R1.3541.00
99_W103_R1.3351.00
42_T88_M1.3321.00
175_A184_G1.3261.00
277_E281_M1.3171.00
263_T268_A1.3061.00
154_R157_N1.3001.00
74_E78_M1.2911.00
103_R107_W1.2901.00
57_S61_K1.2871.00
49_R80_A1.2831.00
41_G45_G1.2801.00
166_T170_M1.2791.00
37_L91_V1.2721.00
124_R233_G1.2641.00
70_H75_R1.2641.00
47_M51_F1.2631.00
240_T279_E1.2631.00
66_C294_F1.2521.00
35_P39_F1.2491.00
118_R121_M1.2411.00
212_P274_K1.2321.00
210_F220_A1.2271.00
127_M234_A1.2131.00
214_F281_M1.2121.00
276_I280_I1.2111.00
128_V239_V1.2081.00
240_T255_T1.1971.00
271_Y274_K1.1941.00
39_F43_R1.1901.00
105_R145_L1.1861.00
210_F298_P1.1801.00
53_K56_E1.1771.00
187_G191_K1.1731.00
101_D105_R1.1701.00
126_V194_A1.1681.00
226_Y269_A1.1621.00
126_V235_A1.1581.00
238_T258_M1.1491.00
162_E166_T1.1391.00
244_K249_G1.1291.00
78_M285_E1.1271.00
253_F282_R1.1261.00
153_Y176_M1.1171.00
49_R79_I1.1171.00
150_M177_I1.1131.00
229_S236_M1.1121.00
245_A248_S1.1101.00
175_A193_E1.1091.00
152_T185_I1.1051.00
56_E60_R1.1051.00
109_D244_K1.1051.00
243_R286_Q1.0921.00
265_E268_A1.0841.00
117_K120_Q1.0691.00
244_K247_Y1.0641.00
202_D296_T1.0611.00
184_G187_G1.0561.00
238_T275_I1.0561.00
43_R47_M1.0511.00
34_Y38_C1.0491.00
128_V194_A1.0431.00
240_T275_I1.0401.00
39_F42_T1.0381.00
129_V272_M1.0381.00
152_T197_F1.0361.00
217_E298_P1.0341.00
201_Q291_H1.0321.00
122_Q235_A1.0221.00
283_A286_Q1.0141.00
278_K281_M1.0131.00
23_L27_W1.0030.99
38_C88_M0.9980.99
63_L79_I0.9950.99
53_K57_S0.9940.99
35_P38_C0.9930.99
59_A290_I0.9850.99
255_T279_E0.9750.99
219_V293_R0.9720.99
56_E83_F0.9710.99
115_N119_A0.9610.99
260_G263_T0.9480.99
67_F75_R0.9480.99
23_L164_V0.9450.99
140_G151_A0.9440.99
199_P225_T0.9390.99
66_C214_F0.9340.99
279_E282_R0.9270.99
156_H165_Q0.9260.99
61_K65_L0.9250.99
274_K278_K0.9240.99
86_L290_I0.9220.99
233_G262_P0.9210.99
46_A80_A0.9190.99
85_S88_M0.9170.99
183_R186_V0.9160.99
50_P76_E0.9150.99
115_N257_E0.9130.99
36_V39_F0.8980.99
125_G234_A0.8970.99
209_S266_N0.8970.99
119_A122_Q0.8930.99
230_R268_A0.8930.99
265_E269_A0.8820.99
37_L95_M0.8780.99
209_S223_N0.8750.99
123_N192_G0.8730.99
27_W30_V0.8680.98
32_L36_V0.8650.98
50_P80_A0.8600.98
82_N290_I0.8580.98
85_S285_E0.8550.98
110_V113_L0.8530.98
33_P39_F0.8480.98
131_V199_P0.8480.98
289_W293_R0.8440.98
235_A257_E0.8390.98
261_Y268_A0.8380.98
210_F296_T0.8370.98
63_L70_H0.8350.98
120_Q192_G0.8320.98
201_Q289_W0.8230.98
55_R291_H0.8220.98
118_R256_P0.8220.98
256_P259_E0.8200.98
133_F286_Q0.8190.98
137_E169_R0.8080.98
209_S270_A0.8080.98
201_Q288_L0.8060.97
102_S106_K0.8020.97
203_Y222_T0.8020.97
150_M175_A0.7990.97
129_V199_P0.7990.97
275_I279_E0.7970.97
62_N280_I0.7950.97
225_T272_M0.7940.97
107_W249_G0.7930.97
38_C42_T0.7910.97
82_N86_L0.7830.97
202_D210_F0.7810.97
49_R76_E0.7760.97
212_P215_A0.7680.97
175_A188_A0.7660.97
55_R58_I0.7640.97
103_R106_K0.7640.97
219_V294_F0.7640.97
255_T282_R0.7630.97
230_R265_E0.7610.96
287_Y294_F0.7540.96
19_T23_L0.7520.96
56_E79_I0.7510.96
243_R250_Y0.7510.96
136_L198_A0.7480.96
119_A235_A0.7440.96
100_P103_R0.7430.96
26_L94_G0.7420.96
43_R46_A0.7400.96
112_G256_P0.7380.96
133_F279_E0.7380.96
201_Q293_R0.7360.96
85_S243_R0.7280.95
211_A269_A0.7260.95
110_V142_V0.7250.95
102_S105_R0.7220.95
81_E84_R0.7220.95
186_V231_L0.7210.95
188_A191_K0.7210.95
135_S287_Y0.7160.95
49_R60_R0.7130.95
65_L294_F0.7090.95
208_S220_A0.7090.95
189_L195_V0.7050.95
63_L78_M0.7050.95
220_A296_T0.7020.94
184_G188_A0.7020.94
268_A271_Y0.7000.94
58_I62_N0.6930.94
205_R296_T0.6930.94
159_Q163_W0.6930.94
52_L55_R0.6920.94
226_Y230_R0.6920.94
62_N214_F0.6910.94
181_N184_G0.6910.94
291_H295_K0.6890.94
61_K216_V0.6890.94
148_P193_E0.6840.94
183_R227_V0.6830.94
49_R83_F0.6830.94
114_D117_K0.6810.94
32_L35_P0.6770.93
185_I228_L0.6760.93
87_G90_L0.6760.93
210_F297_R0.6740.93
177_I188_A0.6680.93
28_L31_Q0.6640.93
143_M149_M0.6640.93
170_M176_M0.6620.93
31_Q36_V0.6610.93
225_T236_M0.6590.92
188_A195_V0.6580.92
58_I291_H0.6570.92
156_H162_E0.6570.92
139_G196_W0.6560.92
244_K248_S0.6530.92
258_M261_Y0.6530.92
136_L196_W0.6510.92
269_A273_N0.6490.92
45_G84_R0.6470.92
131_V272_M0.6470.92
133_F283_A0.6460.92
30_V98_F0.6450.92
125_G189_L0.6450.92
119_A126_V0.6450.92
227_V231_L0.6440.92
86_L288_L0.6440.92
45_G49_R0.6430.91
137_E196_W0.6420.91
72_A76_E0.6380.91
46_A50_P0.6380.91
112_G254_I0.6380.91
278_K282_R0.6370.91
116_L120_Q0.6350.91
76_E79_I0.6340.91
66_C216_V0.6330.91
240_T282_R0.6320.91
208_S211_A0.6310.91
32_L40_L0.6290.91
46_A49_R0.6290.91
127_M232_S0.6280.91
155_P162_E0.6220.90
85_S286_Q0.6200.90
88_M243_R0.6180.90
203_Y220_A0.6170.90
34_Y95_M0.6170.90
153_Y178_G0.6140.90
238_T279_E0.6130.89
131_V240_T0.6090.89
241_M252_L0.6080.89
214_F280_I0.6070.89
199_P272_M0.6070.89
110_V252_L0.6060.89
88_M92_E0.6040.89
20_W24_G0.6040.89
68_P75_R0.6040.89
242_V282_R0.6010.89
28_L32_L0.6010.89
202_D220_A0.5990.88
30_V33_P0.5990.88
216_V296_T0.5930.88
21_F24_G0.5930.88
57_S60_R0.5900.88
19_T160_L0.5890.88
116_L128_V0.5880.87
89_A130_G0.5870.87
68_P74_E0.5840.87
50_P53_K0.5830.87
154_R289_W0.5820.87
86_L89_A0.5800.87
65_L214_F0.5790.87
48_A83_F0.5780.87
229_S235_A0.5780.87
124_R259_E0.5780.87
153_Y162_E0.5740.86
116_L126_V0.5740.86
222_T225_T0.5730.86
239_V254_I0.5720.86
82_N288_L0.5720.86
87_G91_V0.5700.86
127_M197_F0.5700.86
58_I61_K0.5700.86
236_M268_A0.5690.86
43_R51_F0.5690.86
130_G196_W0.5690.86
152_T224_G0.5680.86
137_E151_A0.5670.85
135_S201_Q0.5670.85
33_P37_L0.5670.85
134_M241_M0.5660.85
73_E77_K0.5660.85
110_V254_I0.5650.85
44_I81_E0.5650.85
213_F280_I0.5640.85
177_I184_G0.5630.85
157_N179_R0.5600.85
75_R78_M0.5600.85
42_T46_A0.5600.85
101_D141_R0.5590.85
62_N169_R0.5570.84
163_W166_T0.5560.84
257_E271_Y0.5540.84
130_G139_G0.5520.84
223_N227_V0.5510.84
111_E244_K0.5510.84
101_D145_L0.5490.84
154_R203_Y0.5490.84
204_G220_A0.5480.84
116_L143_M0.5470.83
267_Q271_Y0.5470.83
34_Y92_E0.5460.83
113_L116_L0.5460.83
195_V228_L0.5460.83
83_F86_L0.5430.83
80_A84_R0.5420.83
125_G195_V0.5420.83
88_M247_Y0.5390.83
221_T293_R0.5390.83
151_A176_M0.5380.82
45_G50_P0.5380.82
54_R58_I0.5370.82
170_M175_A0.5370.82
207_G231_L0.5330.82
189_L234_A0.5330.82
125_G235_A0.5320.82
139_G198_A0.5320.82
129_V225_T0.5310.82
295_K298_P0.5300.81
95_M103_R0.5300.81
189_L228_L0.5290.81
40_L43_R0.5290.81
267_Q270_A0.5290.81
258_M271_Y0.5280.81
19_T164_V0.5270.81
52_L83_F0.5270.81
238_T276_I0.5260.81
140_G176_M0.5250.81
202_D295_K0.5220.80
259_E263_T0.5220.80
216_V294_F0.5210.80
20_W23_L0.5190.80
175_A191_K0.5180.80
152_T162_E0.5170.80
212_P221_T0.5170.80
189_L232_S0.5160.80
83_F290_I0.5150.80
69_Q75_R0.5150.80
162_E241_M0.5110.79
226_Y294_F0.5080.79
108_F252_L0.5080.79
211_A221_T0.5070.79
63_L66_C0.5070.79
62_N66_C0.5060.78
126_V237_L0.5060.78
86_L136_L0.5030.78
24_G28_L0.5030.78
203_Y224_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.915 97.7 0.884 Contact Map
2lpmA 1 0.3987 23.5 0.957 Contact Map
4nutA 1 0.3627 14.5 0.961 Contact Map
4nicA 2 0.3725 9.9 0.964 Contact Map
3n0rA 1 0.719 9.9 0.964 Contact Map
4gr2A 2 0.1961 9.4 0.964 Contact Map
5by3A 1 0.366 9.2 0.964 Contact Map
3a10A 1 0.3791 9 0.964 Contact Map
2pw6A 2 0.5654 8.4 0.965 Contact Map
3eodA 1 0.366 7.9 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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