GREMLIN Database
HTRB - Lipid A biosynthesis lauroyl acyltransferase
UniProt: P0ACV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10464
Length: 306 (280)
Sequences: 4319 (3103)
Seq/√Len: 185.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_A275_K3.9611.00
111_I251_Q3.9201.00
109_E251_Q3.5241.00
111_I253_I3.3261.00
244_K251_Q3.0121.00
60_H76_R2.8481.00
60_H79_V2.8121.00
81_K286_E2.8071.00
212_P217_E2.7571.00
71_S74_E2.7521.00
212_P271_A2.7421.00
46_K84_E2.7291.00
115_H256_P2.7261.00
113_M117_R2.6801.00
70_M74_E2.5471.00
63_L75_R2.5191.00
275_K278_E2.4631.00
69_E282_M2.3141.00
112_G115_H2.2891.00
221_T274_N2.2811.00
64_E75_R2.2711.00
41_G87_G2.2461.00
117_R121_A2.2171.00
150_I193_E2.1531.00
267_E271_A2.1391.00
33_P36_V2.1301.00
188_A193_E2.1261.00
70_M78_M2.1091.00
255_L276_V2.0581.00
65_L216_V2.0491.00
115_H118_D2.0361.00
58_I293_R2.0331.00
214_F278_E2.0151.00
114_E118_D1.9771.00
242_R284_A1.9011.00
238_P255_L1.8991.00
242_R251_Q1.8931.00
61_R64_E1.8771.00
155_P178_D1.8641.00
109_E249_G1.8621.00
238_P257_P1.8521.00
64_E72_E1.8291.00
163_W167_W1.8101.00
42_C84_E1.7591.00
67_F70_M1.7551.00
265_D268_T1.7331.00
124_R235_C1.7321.00
210_F217_E1.7321.00
92_E243_R1.7241.00
211_V271_A1.7101.00
59_V79_V1.6801.00
211_V274_N1.6381.00
131_I277_V1.6331.00
209_V270_A1.6281.00
49_L56_A1.5841.00
119_V237_V1.5481.00
276_V279_K1.5351.00
242_R253_I1.4661.00
74_E77_K1.4631.00
185_M195_V1.4491.00
115_H237_V1.4331.00
150_I188_A1.4311.00
186_I190_K1.4291.00
77_K81_K1.4281.00
118_D122_Q1.4221.00
255_L279_K1.4011.00
216_V298_R1.3971.00
59_V82_N1.3831.00
237_V254_M1.3811.00
60_H64_E1.3621.00
245_P249_G1.3591.00
272_W276_V1.3521.00
70_M75_R1.3321.00
42_C88_M1.3211.00
41_G45_G1.2981.00
60_H75_R1.2961.00
175_S184_G1.2931.00
74_E78_M1.2921.00
124_R233_G1.2851.00
99_W103_R1.2841.00
47_L51_F1.2831.00
57_K61_R1.2691.00
212_P275_K1.2671.00
27_W31_Q1.2621.00
278_E282_M1.2601.00
37_I91_M1.2591.00
103_R107_W1.2531.00
166_T170_L1.2531.00
66_C295_F1.2521.00
35_P39_R1.2511.00
240_V280_C1.2491.00
238_P258_E1.2421.00
154_R157_D1.2391.00
127_L234_A1.2311.00
128_L239_F1.2281.00
210_F220_A1.2121.00
272_W275_K1.2111.00
214_F282_M1.2001.00
244_K249_G1.1951.00
266_A270_A1.1881.00
277_V281_I1.1811.00
210_F299_P1.1801.00
49_L80_V1.1791.00
187_K191_K1.1791.00
101_D105_A1.1761.00
118_D121_A1.1561.00
226_W270_A1.1541.00
53_K56_A1.1541.00
240_V255_L1.1541.00
126_I194_V1.1481.00
162_D166_T1.1431.00
260_S265_D1.1411.00
261_P264_D1.1411.00
150_I177_L1.1371.00
153_Y176_M1.1361.00
109_E244_K1.1301.00
126_I235_C1.1291.00
105_A145_M1.1291.00
175_S193_E1.1271.00
78_M286_E1.1211.00
56_A60_H1.1211.00
39_R43_G1.1191.00
243_R287_Q1.1091.00
115_H119_V1.1071.00
229_A236_L1.1051.00
202_D297_T1.1031.00
49_L79_V1.0951.00
34_Y38_Y1.0851.00
152_V185_M1.0831.00
279_K282_M1.0731.00
209_V267_E1.0731.00
184_G187_K1.0681.00
152_V197_Y1.0651.00
117_R120_Q1.0431.00
43_G47_L1.0421.00
201_H292_H1.0411.00
240_V276_V1.0301.00
128_L194_V1.0301.00
217_E299_P1.0271.00
238_P276_V1.0261.00
253_I283_M1.0251.00
23_I27_W1.0231.00
38_Y88_M1.0231.00
129_V273_M1.0151.00
263_L269_T1.0131.00
39_R42_C1.0120.99
53_K57_K1.0040.99
264_D269_T0.9940.99
219_A294_R0.9920.99
56_A83_F0.9860.99
284_A287_Q0.9830.99
59_V291_L0.9760.99
230_R269_T0.9760.99
115_H257_P0.9620.99
122_Q235_C0.9620.99
183_K186_I0.9560.99
35_P38_Y0.9510.99
67_F75_R0.9500.99
280_C283_M0.9480.99
264_D268_T0.9350.99
63_L79_V0.9330.99
140_A151_G0.9330.99
119_V122_Q0.9270.99
85_S88_M0.9230.99
260_S264_D0.9200.99
66_C214_F0.9190.99
46_K80_V0.9170.99
86_V291_L0.9150.99
255_L280_C0.9130.99
156_N165_Q0.9130.99
275_K279_K0.9120.99
50_R76_R0.9110.99
199_P225_T0.9050.99
36_V39_R0.8990.99
181_D184_G0.8970.99
125_G234_A0.8900.99
37_I95_M0.8880.99
82_N291_L0.8870.99
120_Q192_G0.8830.99
33_P39_R0.8810.99
23_I164_L0.8810.99
32_L36_V0.8690.98
61_R65_L0.8660.98
27_W30_V0.8640.98
290_W294_R0.8640.98
110_V113_M0.8630.98
63_L70_M0.8610.98
107_W249_G0.8570.98
131_I199_P0.8530.98
201_H290_W0.8400.98
210_F297_T0.8330.98
85_S286_E0.8320.98
133_F287_Q0.8310.98
201_H289_M0.8300.98
50_R80_V0.8240.98
82_N86_V0.8210.98
150_I175_S0.8150.98
268_T272_W0.8090.98
26_L94_G0.8090.98
118_D256_P0.8090.98
203_Y222_T0.8080.98
209_V223_T0.8050.97
55_R292_H0.8040.97
276_V280_C0.8000.97
202_D210_F0.7950.97
137_E169_R0.7930.97
129_V199_P0.7900.97
119_V235_C0.7900.97
38_Y42_C0.7870.97
62_N281_I0.7860.97
235_C257_P0.7860.97
49_L76_R0.7850.97
219_A295_F0.7830.97
212_P215_A0.7800.97
105_A146_Q0.7750.97
110_V142_Q0.7710.97
117_R146_Q0.7680.97
123_K192_G0.7670.97
209_V271_A0.7670.97
230_R266_A0.7660.97
102_R106_R0.7660.97
225_T273_M0.7630.97
288_Y295_F0.7540.96
136_L198_A0.7530.96
268_T271_A0.7430.96
201_H294_R0.7390.96
55_R58_I0.7380.96
56_A79_V0.7360.96
211_V270_A0.7330.96
133_F280_C0.7310.96
255_L283_M0.7250.95
230_R260_S0.7230.95
269_T272_W0.7230.95
85_S243_R0.7220.95
49_L60_H0.7180.95
58_I62_N0.7180.95
52_M55_R0.7160.95
262_P269_T0.7160.95
243_R250_Y0.7150.95
19_T23_I0.7130.95
183_K227_M0.7130.95
135_T288_Y0.7120.95
184_G188_A0.7100.95
65_L295_F0.7060.95
205_P297_T0.7050.95
256_P259_C0.7050.95
186_I231_M0.7040.95
230_R264_D0.7020.94
102_R105_A0.7020.94
43_G46_K0.6990.94
208_S220_A0.6990.94
210_F298_R0.6880.94
100_P103_R0.6850.94
30_V98_F0.6850.94
139_G196_W0.6850.94
112_G256_P0.6840.94
61_R216_V0.6830.94
292_H296_K0.6810.94
45_G84_E0.6800.93
76_R79_V0.6800.93
189_L195_V0.6790.93
31_Q36_V0.6780.93
69_E75_R0.6780.93
45_G49_L0.6740.93
261_P269_T0.6740.93
175_S188_A0.6720.93
81_K84_E0.6720.93
113_M146_Q0.6710.93
62_N214_F0.6700.93
220_A297_T0.6690.93
270_A274_N0.6690.93
159_P163_W0.6670.93
125_G189_L0.6670.93
114_E117_R0.6660.93
133_F284_A0.6640.93
103_R106_R0.6630.93
20_W24_G0.6630.93
49_L83_F0.6620.93
226_W269_T0.6590.92
86_V289_M0.6590.92
32_L35_P0.6570.92
185_M228_L0.6570.92
260_S263_L0.6530.92
58_I292_H0.6530.92
87_G90_L0.6510.92
136_L196_W0.6510.92
88_M243_R0.6450.92
188_A195_V0.6440.92
137_E196_W0.6420.91
63_L78_M0.6420.91
148_P193_E0.6390.91
142_Q146_Q0.6380.91
72_E76_R0.6360.91
225_T236_L0.6350.91
131_I273_M0.6340.91
156_N162_D0.6340.91
203_Y220_A0.6320.91
226_W230_R0.6310.91
28_L31_Q0.6300.91
116_I120_Q0.6280.90
177_L188_A0.6270.90
34_Y95_M0.6270.90
123_K126_I0.6260.90
32_L40_L0.6230.90
246_D249_G0.6230.90
240_V283_M0.6220.90
202_D220_A0.6200.90
238_P280_C0.6200.90
257_P272_W0.6200.90
116_I128_L0.6170.90
127_L232_S0.6160.90
279_K283_M0.6130.89
188_A191_K0.6110.89
46_K50_R0.6090.89
43_G51_F0.6080.89
260_S272_W0.6070.89
110_V252_L0.6070.89
208_S211_V0.6050.89
85_S287_Q0.6050.89
66_C216_V0.6030.89
130_G139_G0.6020.89
214_F281_I0.6010.88
226_W261_P0.5990.88
229_A235_C0.5970.88
155_P162_D0.5970.88
227_M231_M0.5930.88
50_R53_K0.5910.88
88_M92_E0.5900.88
154_R203_Y0.5890.87
130_G196_W0.5870.87
116_I126_I0.5870.87
68_P75_R0.5840.87
131_I240_V0.5840.87
82_N289_M0.5840.87
48_A83_F0.5820.87
86_V89_G0.5800.87
127_L197_Y0.5790.87
28_L32_L0.5780.87
20_W23_I0.5770.86
177_L184_G0.5760.86
21_L24_G0.5760.86
199_P273_M0.5750.86
242_R283_M0.5740.86
135_T201_H0.5740.86
153_Y178_D0.5730.86
87_G91_M0.5730.86
89_G130_G0.5690.86
65_L214_F0.5690.86
153_Y162_D0.5690.86
151_G176_M0.5690.86
19_T160_L0.5670.85
216_V297_T0.5670.85
101_D141_R0.5670.85
96_A196_W0.5660.85
154_R290_W0.5660.85
72_E75_R0.5660.85
46_K49_L0.5620.85
57_K60_H0.5620.85
58_I61_R0.5620.85
42_C46_K0.5620.85
119_V126_I0.5620.85
211_V267_E0.5600.85
221_T294_R0.5590.85
170_L176_M0.5590.85
213_L281_I0.5590.85
83_F86_V0.5580.85
137_E151_G0.5580.85
125_G195_V0.5570.84
62_N169_R0.5570.84
143_F149_G0.5550.84
170_L175_S0.5540.84
33_P37_I0.5530.84
222_T225_T0.5530.84
34_Y92_E0.5530.84
116_I143_F0.5510.84
45_G87_G0.5490.84
73_Q77_K0.5480.83
134_L241_P0.5460.83
52_M83_F0.5460.83
80_V84_E0.5420.83
152_V224_G0.5400.83
129_V225_T0.5390.82
163_W166_T0.5390.82
45_G50_R0.5390.82
75_R78_M0.5370.82
189_L234_A0.5350.82
113_M116_I0.5340.82
101_D145_M0.5330.82
122_Q259_C0.5330.82
30_V33_P0.5310.82
68_P74_E0.5310.82
241_P252_L0.5290.81
223_T227_M0.5280.81
125_G235_C0.5280.81
44_L81_K0.5250.81
152_V162_D0.5240.81
239_F254_M0.5230.81
54_R57_K0.5220.80
204_G220_A0.5220.80
195_V228_L0.5210.80
40_L43_G0.5190.80
189_L232_S0.5180.80
110_V254_M0.5170.80
112_G254_M0.5170.80
124_R259_C0.5160.80
19_T163_W0.5150.80
202_D296_K0.5120.79
197_Y224_G0.5110.79
216_V295_F0.5100.79
244_K247_G0.5090.79
119_V123_K0.5070.79
139_G198_A0.5050.78
88_M246_D0.5050.78
75_R79_V0.5040.78
140_A202_D0.5040.78
59_V63_L0.5030.78
38_Y41_G0.5020.78
214_F273_M0.5010.78
24_G28_L0.5010.78
63_L66_C0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.9281 97.8 0.883 Contact Map
4nicA 2 0.3627 15 0.961 Contact Map
2e7pA 3 0.3725 13.6 0.961 Contact Map
2lpmA 1 0.3856 12.7 0.962 Contact Map
3cnbA 1 0.3824 12.3 0.962 Contact Map
4gr6A 2 0.1667 11.1 0.963 Contact Map
3grcA 3 0.3856 10 0.964 Contact Map
1xhfA 2 0.3791 9.6 0.964 Contact Map
3nhmA 2 0.3758 9.1 0.964 Contact Map
3n0rA 1 0.7059 9 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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