GREMLIN Database
FABR - HTH-type transcriptional repressor FabR
UniProt: P0ACU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11394
Length: 215 (183)
Sequences: 43680 (34779)
Seq/√Len: 2570.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R36_E4.1421.00
21_S40_E4.0521.00
35_R45_P3.9701.00
53_R57_E2.9521.00
24_S32_L2.4921.00
13_R65_E2.4551.00
26_E40_E2.2771.00
23_L32_L2.1961.00
38_A48_F2.1751.00
89_R184_V2.1011.00
11_T14_S2.0741.00
54_D57_E2.0511.00
44_A47_S2.0491.00
83_K86_S2.0291.00
13_R17_E1.9541.00
93_S180_E1.9391.00
136_A151_E1.9351.00
19_A24_S1.8261.00
136_A140_E1.8041.00
20_F65_E1.8011.00
23_L40_E1.7581.00
14_S18_A1.7531.00
93_S184_V1.7021.00
35_R39_R1.6851.00
87_V141_L1.6761.00
34_L45_P1.6611.00
23_L36_E1.6531.00
18_A40_E1.6451.00
61_T64_D1.6421.00
12_R61_T1.6101.00
34_L49_Y1.6011.00
142_E145_M1.5531.00
36_E39_R1.5461.00
16_V61_T1.5351.00
23_L27_R1.5201.00
21_S26_E1.4921.00
17_E65_E1.4671.00
10_K14_S1.4601.00
64_D123_A1.4461.00
24_S29_F1.4461.00
34_L48_F1.4451.00
33_S36_E1.4271.00
18_A21_S1.4081.00
20_F62_M1.4061.00
156_A160_I1.3911.00
52_F61_T1.3841.00
32_L37_V1.3661.00
19_A58_L1.3621.00
75_R134_E1.3491.00
28_S32_L1.3401.00
28_S31_S1.3331.00
57_E61_T1.3321.00
140_E150_T1.3221.00
36_E40_E1.3011.00
16_V62_M1.2901.00
10_K13_R1.2821.00
175_Q178_Q1.2771.00
47_S50_R1.2531.00
138_Y142_E1.2331.00
60_L64_D1.2181.00
65_E69_M1.2111.00
86_S90_T1.2081.00
43_I47_S1.2071.00
132_I151_E1.1901.00
18_A41_A1.1801.00
27_R31_S1.1791.00
20_F66_S1.1761.00
64_D68_L1.1591.00
89_R93_S1.1561.00
56_D117_S1.1521.00
29_F59_G1.1521.00
17_E21_S1.1441.00
49_Y54_D1.1411.00
132_I155_E1.1251.00
47_S51_H1.1251.00
48_F58_L1.1241.00
8_K50_R1.1241.00
85_G89_R1.1211.00
37_V58_L1.1141.00
159_T163_S1.1031.00
184_V188_R1.1001.00
137_D141_L1.0961.00
89_R188_R1.0931.00
180_E184_V1.0921.00
97_E180_E1.0921.00
18_A23_L1.0891.00
149_F152_A1.0891.00
129_Q133_A1.0741.00
19_A62_M1.0521.00
148_A153_Q1.0491.00
16_V52_F1.0441.00
181_E184_V1.0431.00
12_R51_H1.0421.00
98_F102_N1.0391.00
11_T51_H1.0351.00
185_L188_R1.0331.00
83_K144_H1.0331.00
46_T50_R1.0291.00
68_L72_Q1.0271.00
104_N107_R1.0151.00
134_E137_D1.0151.00
27_R32_L1.0131.00
44_A50_R1.0121.00
90_T93_S1.0001.00
45_P49_Y0.9941.00
104_N108_L0.9931.00
126_R130_H0.9901.00
85_G188_R0.9861.00
73_L94_T0.9861.00
9_E13_R0.9831.00
132_I136_A0.9771.00
133_A137_D0.9731.00
29_F55_V0.9721.00
57_E60_L0.9701.00
177_R180_E0.9621.00
72_Q76_Q0.9611.00
93_S97_E0.9561.00
27_R40_E0.9561.00
16_V20_F0.9551.00
65_E68_L0.9551.00
75_R79_Q0.9521.00
45_P50_R0.9371.00
73_L76_Q0.9291.00
86_S89_R0.9271.00
178_Q181_E0.9101.00
61_T65_E0.9051.00
87_V138_Y0.9041.00
137_D140_E0.9011.00
7_Q11_T0.8991.00
15_L48_F0.8981.00
60_L123_A0.8961.00
106_F109_L0.8941.00
56_D60_L0.8901.00
20_F25_A0.8891.00
8_K11_T0.8871.00
176_R180_E0.8821.00
152_A185_L0.8741.00
14_S41_A0.8741.00
123_A126_R0.8701.00
122_A126_R0.8671.00
186_Q190_I0.8661.00
21_S104_N0.8561.00
136_A150_T0.8551.00
56_D119_A0.8551.00
150_T154_A0.8541.00
94_T97_E0.8361.00
71_R75_R0.8151.00
143_N146_P0.8121.00
7_Q10_K0.8031.00
64_D126_R0.7901.00
105_A108_L0.7791.00
69_M72_Q0.7781.00
90_T94_T0.7751.00
14_S17_E0.7731.00
77_A94_T0.7711.00
118_A122_A0.7671.00
71_R130_H0.7641.00
38_A45_P0.7631.00
39_R45_P0.7621.00
25_A104_N0.7591.00
97_E101_N0.7561.00
177_R181_E0.7531.00
29_F32_L0.7501.00
84_G142_E0.7481.00
185_L189_M0.7481.00
11_T43_I0.7401.00
151_E155_E0.7391.00
15_L41_A0.7371.00
72_Q75_R0.7351.00
121_R125_A0.7291.00
138_Y141_L0.7291.00
125_A129_Q0.7211.00
149_F153_Q0.7191.00
35_R49_Y0.7141.00
11_T47_S0.7091.00
146_P149_F0.7061.00
66_S69_M0.7051.00
15_L51_H0.7001.00
24_S59_G0.6901.00
179_L182_R0.6851.00
134_E138_Y0.6821.00
143_N150_T0.6801.00
77_A90_T0.6781.00
168_A171_V0.6761.00
133_A136_A0.6731.00
29_F56_D0.6721.00
84_G144_H0.6691.00
130_H133_A0.6641.00
82_A90_T0.6641.00
152_A181_E0.6631.00
112_E115_G0.6611.00
118_A121_R0.6531.00
92_V157_M0.6511.00
78_R134_E0.6461.00
82_A86_S0.6461.00
37_V41_A0.6451.00
81_I86_S0.6441.00
100_G176_R0.6431.00
139_L142_E0.6431.00
116_T120_F0.6401.00
159_T162_F0.6401.00
20_F69_M0.6381.00
11_T44_A0.6311.00
167_E170_D0.6281.00
136_A154_A0.6231.00
182_R185_L0.6211.00
180_E183_L0.6141.00
183_L186_Q0.6071.00
123_A127_E0.6061.00
140_E151_E0.6021.00
178_Q182_R0.6001.00
23_L26_E0.5991.00
156_A159_T0.5981.00
181_E185_L0.5961.00
95_F131_F0.5951.00
139_L150_T0.5941.00
81_I87_V0.5911.00
111_R115_G0.5911.00
125_A128_I0.5881.00
16_V65_E0.5831.00
30_A112_E0.5811.00
83_K87_V0.5781.00
97_E176_R0.5761.00
81_I90_T0.5751.00
184_V189_M0.5751.00
182_R186_Q0.5751.00
35_R44_A0.5741.00
50_R53_R0.5731.00
17_E20_F0.5721.00
163_S166_A0.5721.00
119_A123_A0.5711.00
116_T119_A0.5711.00
24_S28_S0.5681.00
139_L157_M0.5641.00
157_M190_I0.5621.00
48_F53_R0.5621.00
107_R111_R0.5611.00
80_R90_T0.5611.00
23_L33_S0.5611.00
15_L43_I0.5561.00
167_E171_V0.5561.00
34_L38_A0.5561.00
128_I132_I0.5561.00
38_A41_A0.5551.00
95_F162_F0.5521.00
102_N105_A0.5521.00
159_T167_E0.5491.00
64_D127_E0.5481.00
41_A44_A0.5471.00
143_N149_F0.5471.00
71_R134_E0.5451.00
122_A125_A0.5431.00
89_R92_V0.5421.00
77_A81_I0.5401.00
87_V142_E0.5371.00
162_F167_E0.5371.00
30_A115_G0.5341.00
41_A45_P0.5321.00
176_R179_L0.5271.00
75_R137_D0.5251.00
129_Q132_I0.5231.00
60_L119_A0.5231.00
183_L187_L0.5211.00
152_A156_A0.5211.00
38_A43_I0.5181.00
8_K12_R0.5131.00
45_P48_F0.5091.00
38_A44_A0.5081.00
160_I186_Q0.5061.00
150_T153_Q0.5061.00
74_M78_R0.5051.00
9_E12_R0.5031.00
76_Q94_T0.5031.00
43_I50_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f0cA 2 0.8558 100 0.27 Contact Map
2rasA 2 0.9256 100 0.27 Contact Map
3lsjA 2 0.9209 100 0.271 Contact Map
2np5A 3 0.8558 100 0.28 Contact Map
3s5rA 2 0.8744 100 0.285 Contact Map
3on2A 1 0.8837 100 0.286 Contact Map
2hytA 2 0.893 100 0.287 Contact Map
3anpC 2 0.9209 100 0.287 Contact Map
4jykA 2 0.893 100 0.288 Contact Map
1vi0A 2 0.8605 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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