GREMLIN Database
UIDR - HTH-type transcriptional regulator UidR
UniProt: P0ACT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12667
Length: 196 (180)
Sequences: 44052 (35494)
Seq/√Len: 2645.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_N36_A3.9701.00
35_K45_P3.9451.00
22_E40_S3.5851.00
53_I57_A2.7151.00
24_F32_A2.4011.00
54_S57_A2.2461.00
134_A153_A2.0971.00
38_C48_L2.0471.00
23_I40_S2.0321.00
23_I32_A1.9911.00
12_T15_R1.9731.00
19_A40_S1.9601.00
26_E40_S1.9501.00
23_I36_A1.9481.00
13_R61_A1.9171.00
14_T65_Q1.9131.00
23_I27_N1.8821.00
134_A138_R1.8571.00
15_R19_A1.8361.00
35_K39_K1.7541.00
19_A22_E1.7521.00
138_R152_T1.6821.00
14_T18_N1.6701.00
44_S47_T1.5981.00
34_M49_Y1.5981.00
21_R66_D1.5831.00
21_R65_Q1.5831.00
17_L61_A1.5811.00
138_R142_Q1.5681.00
20_A24_F1.5561.00
34_M45_P1.5511.00
13_R51_H1.4951.00
92_V182_A1.4931.00
138_R141_Q1.4891.00
36_A40_S1.4861.00
61_A64_L1.4781.00
83_F86_Y1.4501.00
33_S36_A1.4461.00
22_E26_E1.4451.00
36_A39_K1.4411.00
88_V186_R1.4181.00
28_G31_S1.4081.00
60_Q64_L1.3991.00
75_R132_F1.3901.00
65_Q69_R1.3851.00
82_H85_D1.3691.00
141_Q148_P1.3641.00
158_L162_L1.3531.00
32_A37_I1.3481.00
139_D143_K1.3461.00
28_G32_A1.3411.00
21_R62_I1.3321.00
60_Q121_M1.3311.00
11_P15_R1.3211.00
34_M48_L1.3151.00
64_L121_M1.3031.00
20_A58_L1.2741.00
140_A145_E1.2731.00
27_N31_S1.2631.00
18_N65_Q1.2461.00
177_R180_S1.2361.00
45_P49_Y1.2291.00
19_A23_I1.2211.00
47_T50_H1.2191.00
52_F61_A1.2181.00
107_E111_E1.2031.00
86_Y139_D1.2011.00
182_A186_R1.1911.00
140_A146_I1.1891.00
24_F29_F1.1831.00
48_L58_L1.1541.00
11_P14_T1.1501.00
44_S50_H1.1491.00
130_T157_R1.1221.00
130_T134_A1.1211.00
47_T51_H1.1181.00
43_I47_T1.1051.00
12_T51_H1.0871.00
141_Q150_I1.0861.00
46_G50_H1.0851.00
56_E60_Q1.0791.00
151_N154_M1.0751.00
132_F135_Q1.0741.00
136_R140_A1.0741.00
21_R25_S1.0681.00
57_A61_A1.0621.00
92_V186_R1.0531.00
17_L62_I1.0511.00
147_S150_I1.0501.00
56_E115_N1.0481.00
88_V92_V1.0481.00
57_A60_Q1.0431.00
9_A50_H1.0431.00
18_N22_E1.0401.00
107_E110_A1.0381.00
89_E92_V1.0351.00
17_L52_F1.0321.00
183_Q186_R1.0181.00
37_I58_L1.0151.00
121_M124_N1.0091.00
29_F59_I1.0081.00
110_A114_R1.0021.00
134_A152_T1.0011.00
19_A41_C0.9931.00
64_L68_E0.9921.00
38_C45_P0.9901.00
27_N40_S0.9861.00
93_S96_H0.9541.00
71_L128_T0.9501.00
83_F87_M0.9441.00
85_D89_E0.9351.00
20_A62_I0.9341.00
12_T43_I0.9311.00
75_R79_E0.9231.00
73_R76_E0.9151.00
49_Y54_S0.9141.00
141_Q152_T0.9131.00
56_E117_Q0.8991.00
135_Q139_D0.8981.00
106_V110_A0.8931.00
161_D165_G0.8911.00
82_H86_Y0.8861.00
45_P50_H0.8851.00
10_Q14_T0.8841.00
65_Q68_E0.8771.00
61_A65_Q0.8751.00
102_R107_E0.8731.00
72_A76_E0.8661.00
66_D69_R0.8651.00
71_L75_R0.8611.00
30_H111_E0.8591.00
39_K45_P0.8521.00
8_E11_P0.8491.00
120_A124_N0.8461.00
23_I26_E0.8381.00
141_Q144_G0.8381.00
85_D88_V0.8371.00
64_L125_K0.8311.00
141_Q146_I0.8291.00
131_E135_Q0.8241.00
121_M125_K0.8231.00
124_N128_T0.8191.00
94_L98_A0.8191.00
135_Q138_R0.8191.00
127_M131_E0.8151.00
154_M184_G0.8131.00
153_A157_R0.8131.00
134_A156_S0.8081.00
136_R139_D0.8071.00
130_T153_A0.8061.00
15_R41_C0.8041.00
180_S184_G0.8001.00
103_A106_V0.7971.00
83_F143_K0.7961.00
169_D172_A0.7911.00
73_R93_S0.7901.00
139_D142_Q0.7821.00
87_M92_V0.7801.00
106_V109_M0.7791.00
68_E72_A0.7791.00
84_V88_V0.7771.00
88_V91_I0.7761.00
103_A111_E0.7751.00
154_M180_S0.7741.00
15_R18_N0.7711.00
150_I155_T0.7701.00
128_T132_F0.7641.00
152_T156_S0.7591.00
178_E182_A0.7581.00
91_I94_L0.7541.00
82_H145_E0.7521.00
179_A182_A0.7521.00
161_D164_Y0.7481.00
84_V87_M0.7471.00
92_V96_H0.7421.00
71_L132_F0.7411.00
27_N32_A0.7381.00
34_M55_K0.7381.00
69_R72_A0.7341.00
16_I48_L0.7331.00
34_M38_C0.7231.00
9_A12_T0.7221.00
8_E12_T0.7191.00
72_A75_R0.7181.00
97_E101_Q0.7161.00
137_M152_T0.7151.00
102_R105_V0.7101.00
16_I41_C0.7021.00
184_G188_M0.6991.00
116_P120_A0.6931.00
17_L21_R0.6921.00
22_E103_A0.6901.00
77_P80_G0.6891.00
29_F55_K0.6861.00
86_Y136_R0.6861.00
154_M158_L0.6841.00
119_A123_K0.6821.00
111_E114_R0.6791.00
178_E181_F0.6791.00
128_T131_E0.6771.00
89_E93_S0.6731.00
154_M183_Q0.6721.00
93_S97_E0.6681.00
131_E134_A0.6651.00
35_K49_Y0.6591.00
116_P119_A0.6581.00
76_E80_G0.6571.00
182_A185_L0.6521.00
17_L65_Q0.6491.00
180_S183_Q0.6471.00
184_G187_A0.6461.00
25_S103_A0.6431.00
96_H182_A0.6401.00
18_N21_R0.6391.00
30_H114_R0.6381.00
77_P93_S0.6341.00
26_E36_A0.6341.00
41_C44_S0.6311.00
154_M157_R0.6291.00
96_H178_E0.6261.00
29_F32_A0.6231.00
103_A107_E0.6161.00
158_L161_D0.6131.00
24_F59_I0.6121.00
105_V108_I0.6091.00
101_Q104_L0.6091.00
181_F185_L0.6031.00
38_C43_I0.5991.00
151_N155_T0.5951.00
12_T47_T0.5951.00
94_L97_E0.5931.00
137_M159_L0.5931.00
137_M141_Q0.5861.00
87_M139_D0.5861.00
123_K126_H0.5711.00
183_Q187_A0.5701.00
81_I85_D0.5651.00
78_I132_F0.5651.00
81_I89_E0.5641.00
154_M187_A0.5581.00
29_F56_E0.5561.00
16_I51_H0.5551.00
77_P89_E0.5551.00
126_H130_T0.5521.00
60_Q117_Q0.5511.00
179_A183_Q0.5501.00
81_I86_Y0.5481.00
164_Y168_A0.5471.00
86_Y89_E0.5451.00
170_I173_E0.5411.00
10_Q13_R0.5391.00
124_N127_M0.5361.00
83_F88_V0.5361.00
155_T158_L0.5351.00
90_S94_L0.5341.00
35_K44_S0.5331.00
165_G168_A0.5321.00
125_K128_T0.5321.00
45_P48_L0.5301.00
64_L124_N0.5271.00
117_Q120_A0.5261.00
111_E115_N0.5261.00
9_A51_H0.5251.00
92_V183_Q0.5251.00
148_P151_N0.5231.00
41_C45_P0.5151.00
16_I43_I0.5151.00
123_K127_M0.5141.00
68_E125_K0.5021.00
120_A123_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xdnA 2 0.9796 100 0.203 Contact Map
4udsA 2 0.9337 100 0.204 Contact Map
3g1oA 2 0.9592 100 0.212 Contact Map
4cgrA 2 0.9592 100 0.214 Contact Map
3crjA 2 0.949 100 0.217 Contact Map
2raeA 2 0.9694 100 0.223 Contact Map
2ibdA 2 0.9643 100 0.224 Contact Map
3dcfA 2 0.9235 100 0.225 Contact Map
4jykA 2 0.9745 100 0.226 Contact Map
3npiA 2 0.9592 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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