GREMLIN Database
ENVR - Probable acrEF/envCD operon repressor
UniProt: P0ACT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11741
Length: 220 (188)
Sequences: 45576 (36169)
Seq/√Len: 2637.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_N45_R3.9931.00
27_H36_D3.9571.00
22_A40_A3.5431.00
53_E57_Q2.7271.00
24_F32_T2.4171.00
54_N57_Q2.2471.00
38_A48_I2.1471.00
141_R160_D2.0971.00
23_Q40_A2.0411.00
26_Q40_A2.0041.00
13_R61_E1.9711.00
14_Q65_Q1.9641.00
23_Q36_D1.9411.00
23_Q32_T1.9261.00
23_Q27_H1.9011.00
12_T15_E1.8801.00
84_D87_Q1.8701.00
19_T40_A1.8431.00
15_E19_T1.8421.00
88_Q146_A1.8401.00
141_R145_Q1.8321.00
35_N39_D1.8221.00
21_I65_Q1.7141.00
19_T22_A1.6691.00
145_Q159_L1.6411.00
44_T47_A1.6291.00
145_Q149_Q1.6231.00
14_Q18_E1.5791.00
20_A24_F1.5761.00
17_I61_E1.5421.00
34_L49_Y1.5291.00
61_E64_L1.5251.00
21_I66_Q1.5241.00
22_A26_Q1.5161.00
161_V192_A1.5051.00
13_R51_H1.5041.00
145_Q148_Q1.5031.00
34_L45_R1.5021.00
36_D39_D1.4831.00
33_T36_D1.4761.00
36_D40_A1.4541.00
90_R191_P1.4291.00
32_T37_I1.4261.00
74_Q139_T1.4191.00
147_C153_V1.3651.00
165_I169_A1.3621.00
146_A150_Q1.3561.00
65_Q68_S1.3441.00
28_G32_T1.3391.00
21_I62_M1.3391.00
94_I190_A1.3361.00
60_N64_L1.3351.00
52_F61_E1.3281.00
20_A58_L1.3251.00
18_E65_Q1.3041.00
11_K15_E1.2841.00
86_F198_L1.2691.00
34_L48_I1.2481.00
47_A50_W1.2471.00
94_I191_P1.2411.00
27_H31_K1.2311.00
148_Q155_N1.2201.00
90_R94_I1.2191.00
64_L128_V1.2151.00
87_Q91_E1.2151.00
19_T23_Q1.1971.00
94_I187_Y1.1791.00
196_N200_M1.1751.00
137_P164_I1.1721.00
195_D199_R1.1681.00
24_F29_V1.1681.00
45_R49_Y1.1641.00
86_F90_R1.1611.00
72_L95_V1.1571.00
44_T50_W1.1541.00
158_D161_V1.1451.00
147_C152_C1.1341.00
57_Q61_E1.1301.00
116_K120_N1.1131.00
90_R194_V1.1081.00
43_V47_A1.1021.00
56_T60_N1.1011.00
12_T51_H1.0961.00
120_N123_M1.0941.00
11_K14_Q1.0931.00
18_E22_A1.0791.00
46_G50_W1.0791.00
19_T41_A1.0771.00
185_D188_K1.0771.00
28_G31_K1.0761.00
137_P141_R1.0701.00
20_A62_M1.0651.00
17_I62_M1.0651.00
88_Q143_V1.0631.00
168_G172_G1.0551.00
76_H95_V1.0511.00
37_I58_L1.0491.00
91_E94_I1.0461.00
139_T142_E1.0431.00
161_V188_K1.0421.00
29_V59_F1.0351.00
57_Q60_N1.0311.00
60_N128_V1.0181.00
83_H91_E1.0181.00
21_I25_A1.0171.00
64_L67_P1.0121.00
48_I58_L1.0071.00
107_Q110_L1.0061.00
47_A51_H1.0041.00
27_H40_A0.9991.00
56_T122_E0.9971.00
9_A50_W0.9911.00
82_E88_Q0.9881.00
143_V147_C0.9871.00
17_I52_F0.9771.00
134_G138_Q0.9701.00
61_E65_Q0.9681.00
84_D152_C0.9581.00
90_R195_D0.9571.00
177_W180_N0.9561.00
142_E146_A0.9511.00
22_A105_R0.9421.00
72_L75_E0.9401.00
30_S116_K0.9361.00
94_I98_Q0.9321.00
148_Q159_L0.9281.00
115_H119_F0.9271.00
128_V131_E0.9261.00
67_P71_E0.9241.00
154_A157_L0.9211.00
10_L14_Q0.9181.00
49_Y54_N0.9141.00
141_R159_L0.9081.00
138_Q142_E0.9061.00
87_Q90_R0.9031.00
191_P195_D0.9011.00
70_R135_F0.8941.00
85_P150_Q0.8891.00
7_A11_K0.8851.00
194_V198_L0.8811.00
192_A195_D0.8801.00
160_D164_I0.8731.00
95_V98_Q0.8701.00
141_R163_M0.8581.00
71_E75_E0.8581.00
8_E11_K0.8551.00
12_T43_V0.8511.00
187_Y191_P0.8481.00
94_I194_V0.8461.00
143_V146_A0.8431.00
23_Q26_Q0.8431.00
188_K192_A0.8411.00
38_A45_R0.8381.00
15_E41_A0.8381.00
39_D45_R0.8371.00
137_P160_D0.8321.00
91_E95_V0.8281.00
131_E135_F0.8261.00
90_R198_L0.8251.00
76_H91_E0.8221.00
45_R50_W0.8201.00
148_Q157_L0.8181.00
16_L48_I0.8161.00
56_T120_N0.8081.00
142_E145_Q0.7981.00
182_A185_D0.7971.00
135_F139_T0.7931.00
70_R74_Q0.7881.00
99_Y103_I0.7861.00
17_I65_Q0.7841.00
16_L41_A0.7811.00
83_H87_Q0.7811.00
148_Q153_V0.7751.00
9_A12_T0.7711.00
15_E18_E0.7651.00
176_N179_M0.7461.00
103_I106_Q0.7431.00
148_Q151_G0.7431.00
85_P147_C0.7421.00
104_P108_A0.7371.00
148_Q156_N0.7281.00
128_V132_K0.7271.00
157_L162_V0.7231.00
192_A196_N0.7221.00
82_E87_Q0.7221.00
159_L163_M0.7181.00
27_H32_T0.7161.00
138_Q141_R0.7131.00
190_A193_L0.7091.00
130_R134_G0.7091.00
34_L55_K0.7071.00
146_A149_Q0.7071.00
12_T47_A0.7021.00
168_G171_S0.6991.00
17_I21_I0.6911.00
190_A194_V0.6861.00
41_A44_T0.6831.00
116_K119_F0.6791.00
26_Q36_D0.6771.00
71_E74_Q0.6751.00
187_Y190_A0.6751.00
70_R139_T0.6701.00
18_E21_I0.6671.00
144_L159_L0.6641.00
25_A105_R0.6641.00
64_L132_K0.6631.00
189_Q193_L0.6611.00
106_Q109_L0.6601.00
29_V55_K0.6581.00
8_E12_T0.6551.00
7_A10_L0.6511.00
165_I168_G0.6511.00
154_A199_R0.6461.00
135_F138_Q0.6441.00
34_L38_A0.6431.00
98_Q190_A0.6421.00
90_R93_L0.6381.00
122_E125_A0.6371.00
98_Q187_Y0.6361.00
144_L166_I0.6361.00
161_V164_I0.6351.00
93_L166_I0.6281.00
120_N124_L0.6231.00
186_L189_Q0.6231.00
68_S71_E0.6221.00
161_V165_I0.6221.00
35_N49_Y0.6221.00
64_L131_E0.6201.00
176_N180_N0.6191.00
158_D192_A0.6141.00
184_Y187_Y0.6121.00
169_A193_L0.6111.00
120_N125_A0.6101.00
101_A186_L0.6061.00
130_R133_M0.6051.00
29_V32_T0.6031.00
16_L51_H0.5981.00
144_L148_Q0.5901.00
82_E91_E0.5821.00
9_A51_H0.5811.00
197_V200_M0.5781.00
195_D198_L0.5781.00
84_D88_Q0.5731.00
30_S119_F0.5701.00
121_D124_L0.5691.00
168_G176_N0.5691.00
68_S72_L0.5691.00
175_Q179_M0.5681.00
186_L190_A0.5671.00
98_Q102_K0.5661.00
29_V56_T0.5641.00
158_D162_V0.5601.00
184_Y188_K0.5531.00
133_M137_P0.5491.00
99_Y102_K0.5491.00
35_N44_T0.5481.00
139_T143_V0.5451.00
12_T44_T0.5421.00
45_R48_I0.5391.00
189_Q192_A0.5361.00
132_K136_N0.5351.00
72_L99_Y0.5301.00
24_F59_F0.5301.00
191_P194_V0.5291.00
7_A12_T0.5151.00
144_L147_C0.5141.00
93_L96_G0.5121.00
98_Q186_L0.5121.00
38_A43_V0.5101.00
13_R52_F0.5091.00
155_N158_D0.5081.00
10_L13_R0.5071.00
75_E95_V0.5071.00
98_Q101_A0.5071.00
145_Q160_D0.5061.00
183_G187_Y0.5061.00
171_S175_Q0.5061.00
12_T16_L0.5051.00
86_F152_C0.5041.00
166_I197_V0.5041.00
21_I68_S0.5041.00
37_I41_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xdnA 2 0.9227 100 0.214 Contact Map
2wuiA 2 0.8909 100 0.244 Contact Map
2w53A 2 0.9045 100 0.247 Contact Map
3lhqA 2 0.9455 100 0.248 Contact Map
2ibdA 2 0.8682 100 0.258 Contact Map
4udsA 2 0.8455 100 0.26 Contact Map
2gfnA 2 0.8682 100 0.263 Contact Map
4cgrA 2 0.8682 100 0.265 Contact Map
3bhqA 2 0.8773 100 0.27 Contact Map
3g1oA 2 0.8636 100 0.273 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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