GREMLIN Database
ACRR - HTH-type transcriptional regulator AcrR
UniProt: P0ACS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12116
Length: 215 (189)
Sequences: 44375 (35287)
Seq/√Len: 2566.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_G45_R4.0201.00
27_Q36_E3.9611.00
22_R40_A3.4701.00
53_K57_D2.6841.00
24_F32_T2.4411.00
54_D57_D2.2171.00
38_A48_I2.1161.00
142_E161_R2.1131.00
23_L40_A2.0301.00
13_R61_E1.9781.00
142_E146_K1.9601.00
26_Q40_A1.9571.00
23_L32_T1.9501.00
23_L36_E1.9311.00
14_Q65_L1.9261.00
19_V40_A1.9221.00
12_T15_H1.8961.00
88_V147_H1.8941.00
23_L27_Q1.8661.00
84_D87_S1.8451.00
35_G39_K1.8421.00
15_H19_V1.8111.00
19_V22_R1.7461.00
146_K150_E1.7381.00
146_K160_T1.7031.00
44_T47_A1.6801.00
21_L65_L1.6251.00
14_Q18_D1.6021.00
17_L61_E1.5671.00
146_K149_I1.5631.00
20_A24_F1.5541.00
34_L49_Y1.5301.00
61_E64_E1.5121.00
34_L45_R1.5091.00
36_E40_A1.5061.00
33_S36_E1.4981.00
22_R26_Q1.4971.00
162_R193_D1.4841.00
21_L66_S1.4651.00
36_E39_K1.4641.00
75_L140_R1.4531.00
13_R51_H1.4501.00
65_L69_N1.4361.00
32_T37_I1.4231.00
60_S64_E1.4191.00
90_R192_R1.4131.00
147_H151_A1.4061.00
166_I170_Y1.3691.00
11_E15_H1.3611.00
64_E129_A1.3261.00
34_L48_I1.3121.00
20_A58_L1.3051.00
21_L62_I1.3021.00
28_G32_T1.2991.00
52_F61_E1.2721.00
149_I156_A1.2601.00
18_D65_L1.2591.00
148_C154_L1.2561.00
47_A50_W1.2551.00
94_I192_R1.2541.00
27_Q31_S1.2391.00
94_I191_A1.2351.00
90_R94_I1.2321.00
73_L95_H1.2241.00
138_Y165_I1.2111.00
19_V23_L1.2091.00
159_M162_R1.1791.00
24_F29_V1.1691.00
87_S91_E1.1661.00
44_T50_W1.1651.00
43_V47_A1.1631.00
60_S129_A1.1631.00
88_V144_T1.1561.00
28_G31_S1.1491.00
148_C153_M1.1461.00
48_I58_L1.1411.00
94_I188_K1.1401.00
45_R49_Y1.1401.00
86_L199_L1.1381.00
86_L90_R1.1241.00
196_A200_E1.1241.00
91_E94_I1.1191.00
138_Y142_E1.1061.00
11_E14_Q1.0961.00
12_T51_H1.0941.00
57_D61_E1.0771.00
46_G50_W1.0751.00
29_V59_F1.0621.00
56_S125_V1.0611.00
56_S60_S1.0601.00
144_T148_C1.0591.00
140_R143_Q1.0571.00
47_A51_H1.0541.00
57_D60_S1.0491.00
162_R189_K1.0461.00
56_S123_M1.0411.00
178_W181_A1.0411.00
90_R195_V1.0331.00
17_L52_F1.0301.00
18_D22_R1.0301.00
19_V41_A1.0241.00
27_Q40_A1.0241.00
17_L62_I1.0231.00
20_A62_I1.0201.00
37_I58_L1.0181.00
64_E68_S1.0091.00
186_D189_K1.0071.00
110_M113_I1.0041.00
21_L25_S1.0041.00
83_G91_E1.0041.00
169_G173_G0.9951.00
73_L76_E0.9921.00
77_Y95_H0.9891.00
9_A50_W0.9741.00
49_Y54_D0.9741.00
129_A132_N0.9641.00
71_G136_E0.9571.00
85_P151_A0.9501.00
142_E160_T0.9451.00
61_E65_L0.9411.00
113_I116_K0.9351.00
149_I157_D0.9261.00
135_L139_D0.9261.00
84_D153_M0.9241.00
90_R196_A0.9211.00
87_S90_R0.9201.00
91_E95_H0.9151.00
10_Q14_Q0.9111.00
143_Q147_H0.9101.00
65_L68_S0.9091.00
138_Y161_R0.9051.00
132_N136_E0.9031.00
95_H98_E0.9011.00
38_A45_R0.8981.00
110_M114_F0.8891.00
103_E106_R0.8891.00
195_V199_L0.8881.00
144_T147_H0.8871.00
149_I152_K0.8801.00
149_I160_T0.8801.00
99_S103_E0.8801.00
12_T43_V0.8741.00
142_E164_A0.8691.00
7_Q11_E0.8681.00
82_P88_V0.8631.00
161_R165_I0.8601.00
139_D143_Q0.8561.00
45_R50_W0.8531.00
94_I98_E0.8501.00
128_Q132_N0.8491.00
39_K45_R0.8471.00
77_Y91_E0.8461.00
192_R196_A0.8451.00
149_I154_L0.8441.00
193_D196_A0.8421.00
75_L79_A0.8401.00
72_E76_E0.8401.00
90_R199_L0.8331.00
143_Q146_K0.8321.00
8_E11_E0.8281.00
189_K193_D0.8261.00
177_N180_F0.8221.00
147_H150_E0.8211.00
71_G75_L0.8171.00
68_S72_E0.8151.00
188_K192_R0.8131.00
23_L26_Q0.8061.00
177_N181_A0.8031.00
85_P148_C0.7961.00
136_E140_R0.7941.00
15_H41_A0.7901.00
16_I41_A0.7891.00
16_I48_I0.7841.00
29_V55_K0.7781.00
66_S69_N0.7741.00
9_A12_T0.7691.00
107_R110_M0.7591.00
129_A133_L0.7551.00
17_L65_L0.7541.00
191_A194_Y0.7521.00
15_H18_D0.7491.00
83_G87_S0.7461.00
94_I195_V0.7441.00
162_R166_I0.7391.00
111_E115_H0.7311.00
139_D142_E0.7301.00
191_A195_V0.7291.00
127_Q131_R0.7261.00
111_E114_F0.7251.00
71_G140_R0.7221.00
116_K119_F0.7111.00
160_T164_A0.7111.00
27_Q32_T0.7101.00
155_P158_L0.7051.00
131_R135_L0.7041.00
82_P87_S0.7011.00
41_A44_T0.7011.00
69_N72_E0.7001.00
193_D197_I0.6981.00
124_A128_Q0.6941.00
136_E139_D0.6931.00
169_G172_S0.6921.00
34_L38_A0.6831.00
158_L163_A0.6831.00
98_E188_K0.6801.00
166_I169_G0.6741.00
30_S119_F0.6711.00
124_A127_Q0.6701.00
72_E75_L0.6701.00
17_L21_L0.6611.00
149_I158_L0.6591.00
8_E12_T0.6551.00
155_P200_E0.6541.00
26_Q36_E0.6521.00
35_G49_Y0.6431.00
170_Y194_Y0.6411.00
93_L167_M0.6391.00
145_L160_T0.6381.00
188_K191_A0.6371.00
18_D21_L0.6361.00
78_Q140_R0.6321.00
101_V187_L0.6321.00
159_M193_D0.6311.00
22_R105_R0.6291.00
98_E102_T0.6241.00
185_F188_K0.6211.00
162_R165_I0.6201.00
145_L149_I0.6191.00
12_T47_A0.6191.00
64_E132_N0.6161.00
34_L55_K0.6141.00
145_L167_M0.6131.00
29_V32_T0.6131.00
122_E125_V0.6121.00
190_E194_Y0.6051.00
64_E133_L0.6021.00
98_E191_A0.6021.00
29_V56_S0.5961.00
7_Q10_Q0.5881.00
16_I51_H0.5851.00
172_S176_E0.5811.00
90_R93_L0.5811.00
131_R134_C0.5791.00
187_L191_A0.5781.00
68_S133_L0.5751.00
76_E95_H0.5701.00
45_R48_I0.5701.00
24_F59_F0.5671.00
82_P91_E0.5561.00
187_L190_E0.5561.00
185_F189_K0.5551.00
98_E187_L0.5541.00
50_W53_K0.5541.00
21_L69_N0.5531.00
192_R195_V0.5531.00
85_P153_M0.5531.00
149_I155_P0.5521.00
9_A51_H0.5521.00
160_T163_A0.5511.00
110_M115_H0.5421.00
128_Q131_R0.5381.00
84_D88_V0.5381.00
146_K161_R0.5331.00
41_A45_R0.5281.00
73_L99_S0.5281.00
20_A37_I0.5241.00
95_H99_S0.5231.00
38_A43_V0.5231.00
159_M163_A0.5211.00
81_F91_E0.5211.00
140_R144_T0.5191.00
134_C138_Y0.5151.00
167_M198_L0.5141.00
88_V148_C0.5121.00
16_I43_V0.5121.00
12_T50_W0.5121.00
12_T44_T0.5121.00
43_V51_H0.5111.00
156_A159_M0.5101.00
196_A199_L0.5091.00
67_E133_L0.5061.00
133_L136_E0.5041.00
93_L96_V0.5011.00
7_Q12_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xdnA 2 0.9581 100 0.176 Contact Map
3lhqA 2 0.9814 100 0.203 Contact Map
2w53A 2 0.9349 100 0.207 Contact Map
2wuiA 2 0.9256 100 0.215 Contact Map
4udsA 2 0.8744 100 0.22 Contact Map
3vibA 2 0.9442 100 0.221 Contact Map
2ibdA 2 0.893 100 0.232 Contact Map
2gfnA 2 0.8977 100 0.235 Contact Map
3npiA 2 0.9349 100 0.245 Contact Map
4cgrA 2 0.893 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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