GREMLIN Database
ZNTR - HTH-type transcriptional regulator ZntR
UniProt: P0ACS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11969
Length: 141 (116)
Sequences: 12994 (8994)
Seq/√Len: 835.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_E104_Q3.9311.00
41_T44_D3.3531.00
90_L108_Q3.0521.00
97_I101_Q2.8781.00
20_Y24_Q2.8061.00
87_Q111_N2.5291.00
16_D23_K2.4461.00
89_R92_E2.1951.00
15_P19_R2.0601.00
33_T39_L1.9961.00
90_L94_E1.9211.00
83_K87_Q1.8861.00
5_G9_K1.8131.00
7_L45_L1.7311.00
55_R61_L1.6971.00
7_L48_L1.6341.00
60_S63_S1.6331.00
24_Q65_R1.6261.00
90_L104_Q1.6221.00
52_R55_R1.5911.00
101_Q104_Q1.5581.00
96_R99_E1.5501.00
2_Y39_L1.5301.00
87_Q115_C1.4551.00
83_K115_C1.4541.00
47_R72_I1.4461.00
94_E108_Q1.4441.00
104_Q108_Q1.4331.00
97_I100_L1.4271.00
86_V111_N1.4201.00
95_A99_E1.4071.00
92_E96_R1.3811.00
47_R68_L1.3731.00
90_L111_N1.3591.00
94_E97_I1.3201.00
6_E9_K1.3041.00
4_I19_R1.3031.00
3_R6_E1.2811.00
3_R39_L1.2581.00
96_R100_L1.2441.00
26_M51_I1.2141.00
81_E84_G1.1991.00
98_A101_Q1.1951.00
10_M45_L1.1701.00
11_A48_L1.1661.00
31_V41_T1.1401.00
7_L44_D1.1381.00
97_I104_Q1.1011.00
14_T17_T1.0981.00
63_S89_R1.0831.00
6_E10_M1.0761.00
22_E28_E1.0661.00
56_Q99_E1.0651.00
109_R113_A1.0461.00
65_R69_S1.0401.00
51_I64_I1.0391.00
100_L104_Q1.0391.00
18_I40_Y1.0301.00
63_S66_E1.0281.00
93_V97_I1.0121.00
52_R56_Q1.0071.00
21_Y48_L0.9811.00
98_A102_S0.9711.00
91_Q95_A0.9641.00
3_R37_F0.9631.00
31_V39_L0.9551.00
17_T20_Y0.9391.00
95_A98_A0.9351.00
18_I48_L0.9311.00
11_A45_L0.9271.00
73_D77_H0.9171.00
94_E98_A0.9161.00
24_Q62_E0.9071.00
2_Y10_M0.9051.00
58_G96_R0.9011.00
8_A15_P0.8941.00
5_G15_P0.8921.00
84_G88_E0.8861.00
93_V100_L0.8801.00
45_L49_K0.8791.00
30_E44_D0.8691.00
91_Q94_E0.8451.00
27_M51_I0.8341.00
20_Y61_L0.8331.00
87_Q90_L0.8321.00
62_E65_R0.8271.00
4_I8_A0.8181.00
92_E95_A0.7981.00
22_E27_M0.7851.00
85_I88_E0.7791.00
30_E40_Y0.7781.00
113_A116_G0.7781.00
87_Q91_Q0.7761.00
99_E102_S0.7751.00
27_M44_D0.7741.00
22_E40_Y0.7721.00
42_E46_Q0.7691.00
2_Y42_E0.7641.00
83_K111_N0.7611.00
8_A18_I0.7541.00
113_A117_T0.7521.00
63_S88_E0.7451.00
59_F67_L0.7411.00
50_F54_A0.7401.00
89_R96_R0.7371.00
13_V48_L0.7351.00
33_T37_F0.7311.00
10_M49_K0.7201.00
11_A18_I0.7171.00
35_G39_L0.7151.00
25_Q28_E0.7121.00
88_E91_Q0.7011.00
31_V44_D0.6871.00
113_A118_A0.6851.00
57_L103_M0.6831.00
13_V52_R0.6811.00
10_M42_E0.6771.00
110_L114_C0.6711.00
13_V17_T0.6651.00
86_V107_L0.6631.00
47_R69_S0.6601.00
32_R38_R0.6581.00
85_I89_R0.6571.00
78_T81_E0.6551.00
103_M106_S0.6481.00
49_K53_H0.6441.00
83_K118_A0.6411.00
7_L11_A0.6401.00
88_E92_E0.6361.00
18_I22_E0.6301.00
110_L113_A0.6291.00
30_E41_T0.6251.00
101_Q105_R0.6241.00
105_R109_R0.6221.00
43_S46_Q0.6151.00
48_L55_R0.6131.00
111_N115_C0.6081.00
84_G87_Q0.6001.00
20_Y23_K0.5981.00
22_E30_E0.5981.00
93_V104_Q0.5901.00
59_F89_R0.5871.00
82_S85_I0.5831.00
96_R103_M0.5811.00
32_R35_G0.5811.00
55_R64_I0.5751.00
102_S105_R0.5751.00
112_D115_C0.5701.00
66_E69_S0.5651.00
54_A59_F0.5621.00
46_Q49_K0.5591.00
78_T82_S0.5571.00
93_V103_M0.5561.00
82_S86_V0.5521.00
7_L27_M0.5511.00
24_Q61_L0.5441.00
77_H81_E0.5411.00
14_T20_Y0.5411.00
93_V107_L0.5381.00
86_V90_L0.5361.00
11_A27_M0.5351.00
108_Q112_D0.5331.00
44_D47_R0.5291.00
4_I15_P0.5281.00
49_K52_R0.5231.00
102_S106_S0.5191.00
11_A21_Y0.5141.00
80_Q84_G0.5141.00
33_T36_G0.5141.00
80_Q118_A0.5101.00
5_G37_F0.5091.00
105_R108_Q0.5081.00
99_E103_M0.5051.00
112_D116_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q06A 2 0.9007 100 0.225 Contact Map
3gp4A 4 0.9362 100 0.237 Contact Map
3gpvA 2 0.8227 100 0.252 Contact Map
3hh0A 4 0.9433 99.9 0.255 Contact Map
2dg6A 2 0.9078 99.9 0.256 Contact Map
4ua1A 2 0.8865 99.9 0.261 Contact Map
2zhgA 2 0.8511 99.9 0.265 Contact Map
3qaoA 2 0.9362 99.9 0.269 Contact Map
1r8dA 2 0.766 99.9 0.294 Contact Map
2vz4A 2 0.7092 99.9 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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