GREMLIN Database
SOXR - Redox-sensitive transcriptional activator SoxR
UniProt: P0ACS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10957
Length: 154 (125)
Sequences: 8328 (5954)
Seq/√Len: 532.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_D113_R4.4291.00
50_K53_V3.6461.00
99_R117_D3.3791.00
106_I110_V3.1321.00
30_F34_K3.0191.00
96_S120_I2.6681.00
26_S33_S2.4321.00
98_W101_E2.0481.00
25_V29_H1.9711.00
99_R113_R1.8971.00
103_D117_D1.7811.00
95_S120_I1.7701.00
110_V113_R1.7491.00
61_K64_Q1.7261.00
15_G19_K1.7121.00
42_N48_R1.6891.00
64_Q70_L1.6551.00
34_K74_G1.6321.00
99_R120_I1.6221.00
14_P29_H1.6141.00
113_R117_D1.5771.00
105_R108_T1.5241.00
17_V54_L1.5011.00
56_Y82_E1.4941.00
12_L48_R1.4811.00
106_I109_L1.4761.00
13_T48_R1.4661.00
69_P72_T1.4361.00
104_R108_T1.4351.00
99_R103_D1.4351.00
13_T16_E1.4271.00
17_V57_V1.4201.00
72_T98_W1.4171.00
24_A27_A1.4011.00
106_I113_R1.3671.00
17_V53_V1.3541.00
92_K96_S1.3421.00
101_E105_R1.3171.00
16_E19_K1.3171.00
103_D106_I1.3091.00
107_H110_V1.2261.00
96_S123_G1.2201.00
92_K123_G1.2131.00
65_R108_T1.2121.00
100_E104_R1.2031.00
74_G78_G1.1961.00
56_Y77_F1.1671.00
36_L60_I1.1651.00
27_A30_F1.1301.00
71_A74_G1.1161.00
90_E93_Q1.1161.00
102_L109_L1.1101.00
31_Y57_V1.0881.00
105_R109_L1.0851.00
34_K71_A1.0761.00
39_S42_N1.0721.00
44_G48_R1.0671.00
16_E20_R1.0591.00
40_I50_K1.0511.00
107_H111_A1.0441.00
95_S116_L1.0371.00
101_E104_R1.0351.00
60_I73_I1.0341.00
20_R54_L1.0241.00
102_L113_R1.0221.00
97_Q100_E1.0181.00
72_T75_E1.0141.00
28_L49_Y0.9971.00
18_A25_V0.9951.00
13_T46_Q0.9681.00
28_L57_V0.9641.00
12_L51_R0.9531.00
67_G105_R0.9351.00
109_L113_R0.9281.00
122_C130_C0.9181.00
110_V114_D0.9071.00
15_G25_V0.8941.00
42_N45_N0.8921.00
96_S100_E0.8911.00
102_L106_I0.8901.00
72_T97_Q0.8881.00
103_D107_H0.8791.00
102_L116_L0.8771.00
104_R107_H0.8761.00
37_I60_I0.8701.00
12_L20_R0.8641.00
21_S57_V0.8571.00
32_E37_I0.8521.00
68_I76_A0.8451.00
62_I108_T0.8451.00
32_E49_Y0.8441.00
93_Q97_Q0.8421.00
32_E38_T0.8351.00
100_E103_D0.8351.00
72_T101_E0.8151.00
21_S54_L0.7991.00
14_P18_A0.7961.00
61_K65_R0.7961.00
68_I98_W0.7951.00
30_F70_L0.7891.00
18_A28_L0.7811.00
92_K120_I0.7771.00
39_S53_V0.7771.00
20_R58_A0.7731.00
68_I72_T0.7711.00
108_T111_A0.7681.00
59_I63_A0.7611.00
88_A91_W0.7591.00
52_D55_R0.7571.00
98_W105_R0.7531.00
129_D133_R0.7521.00
87_S90_E0.7511.00
111_A114_D0.7501.00
20_R51_R0.7441.00
30_F33_S0.7411.00
21_S28_L0.7391.00
128_S131_P0.7291.00
38_T53_V0.7261.00
23_V61_K0.7221.00
112_L115_E0.7171.00
40_I48_R0.7171.00
99_R102_L0.7131.00
63_A68_I0.7111.00
99_R116_L0.7101.00
51_R55_R0.7001.00
124_C127_R0.6911.00
102_L112_L0.6901.00
15_G46_Q0.6851.00
24_A30_F0.6721.00
32_E41_R0.6671.00
53_V56_Y0.6651.00
64_Q73_I0.6631.00
23_V27_A0.6541.00
21_S25_V0.6501.00
58_A61_K0.6481.00
57_V64_Q0.6471.00
129_D132_L0.6421.00
17_V21_S0.6331.00
83_G86_L0.6251.00
26_S30_F0.6241.00
24_A33_S0.6231.00
55_R58_A0.6201.00
34_K70_L0.6171.00
40_I53_V0.6171.00
37_I53_V0.6131.00
119_C122_C0.6111.00
96_S99_R0.6091.00
28_L32_E0.6061.00
130_C134_N0.6061.00
32_E47_R0.6051.00
66_I112_L0.5951.00
35_G38_T0.5941.00
133_R136_G0.5880.99
127_R130_C0.5780.99
21_S31_Y0.5710.99
134_N137_D0.5700.99
51_R58_A0.5670.99
56_Y78_G0.5650.99
114_D118_G0.5640.99
38_T82_E0.5550.99
64_Q69_P0.5500.99
127_R131_P0.5500.99
117_D121_G0.5500.99
75_E78_G0.5490.99
12_L54_L0.5480.99
93_Q96_S0.5470.99
54_L58_A0.5470.99
17_V37_I0.5450.99
21_S61_K0.5430.99
23_V73_I0.5420.99
103_D110_V0.5380.99
89_K93_Q0.5350.99
64_Q98_W0.5320.99
75_E90_E0.5310.99
15_G18_A0.5290.99
18_A24_A0.5290.99
39_S49_Y0.5280.99
114_D117_D0.5270.99
75_E94_L0.5260.99
23_V57_V0.5250.99
125_L129_D0.5220.99
118_G121_G0.5210.99
121_G124_C0.5200.99
43_S48_R0.5200.99
128_S134_N0.5100.99
130_C133_R0.5060.98
65_R105_R0.5040.98
133_R137_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zhgA 2 0.7857 100 0.192 Contact Map
1q06A 2 0.8117 100 0.276 Contact Map
3hh0A 4 0.8571 100 0.286 Contact Map
2dg6A 2 0.8636 99.9 0.289 Contact Map
3gp4A 4 0.8442 99.9 0.3 Contact Map
3gpvA 2 0.7403 99.9 0.301 Contact Map
3qaoA 2 0.8766 99.9 0.309 Contact Map
4ua1A 2 0.7922 99.9 0.312 Contact Map
2vz4A 2 0.6429 99.9 0.335 Contact Map
1r8dA 2 0.7013 99.9 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.