GREMLIN Database
MPRA - Transcriptional repressor MprA
UniProt: P0ACR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10603
Length: 176 (138)
Sequences: 20590 (15066)
Seq/√Len: 1282.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_R116_Q3.1011.00
147_E157_K3.0971.00
106_S114_H2.8511.00
73_Q112_C2.8191.00
102_E116_Q2.6781.00
150_Q154_I2.5171.00
144_S147_E2.4551.00
150_Q153_Q2.2791.00
69_N116_Q2.2091.00
142_A161_R2.2041.00
73_Q76_E2.0081.00
57_L98_R2.0031.00
105_E113_L1.9651.00
65_E125_L1.9361.00
143_L154_I1.9161.00
65_E117_L1.9061.00
147_E150_Q1.8701.00
106_S112_C1.8581.00
32_L156_R1.8081.00
120_K124_F1.7291.00
151_L154_I1.7141.00
96_E103_R1.6581.00
57_L94_E1.6171.00
32_L159_L1.6051.00
147_E153_Q1.6001.00
67_Q80_A1.5771.00
54_N57_L1.5641.00
99_G120_K1.5551.00
92_A115_L1.5311.00
120_K123_E1.5301.00
74_P92_A1.5191.00
124_F127_E1.5131.00
60_A91_I1.4381.00
32_L152_E1.4341.00
65_E122_H1.4271.00
154_I157_K1.4141.00
147_E154_I1.3931.00
63_T80_A1.3721.00
93_D97_K1.3711.00
51_Q131_P1.3601.00
47_M131_P1.3401.00
123_E127_E1.3251.00
93_D110_R1.3001.00
153_Q157_K1.2751.00
60_A88_A1.2731.00
75_S85_R1.2681.00
76_E79_C1.2511.00
75_S79_C1.2121.00
51_Q127_E1.2101.00
35_H159_L1.2051.00
36_M159_L1.1471.00
64_L101_I1.1421.00
45_N49_K1.1381.00
84_S87_N1.1311.00
74_P113_L1.1301.00
103_R113_L1.1281.00
152_E156_R1.1251.00
74_P115_L1.1171.00
86_T89_T1.0871.00
50_A131_P1.0781.00
67_Q72_I1.0381.00
148_K152_E1.0371.00
89_T93_D1.0341.00
100_W124_F1.0301.00
34_M37_Q1.0271.00
83_S87_N1.0221.00
56_T91_I1.0211.00
69_N114_H1.0191.00
36_M155_T1.0091.00
122_H126_R0.9971.00
102_E118_T0.9831.00
146_T150_Q0.9771.00
74_P85_R0.9641.00
37_Q41_L0.9591.00
39_K163_D0.9571.00
74_P88_A0.9521.00
72_I76_E0.9501.00
29_L152_E0.9481.00
145_T149_D0.9461.00
83_S88_A0.9461.00
92_A101_I0.9461.00
131_P134_N0.9401.00
98_R120_K0.9401.00
100_W120_K0.9381.00
43_N135_C0.9311.00
119_E122_H0.9301.00
104_R114_H0.9281.00
96_E102_E0.8961.00
51_Q128_V0.8901.00
132_Q136_L0.8861.00
39_K159_L0.8841.00
47_M138_Q0.8821.00
98_R124_F0.8731.00
117_L121_G0.8711.00
68_E122_H0.8661.00
150_Q157_K0.8661.00
47_M135_C0.8651.00
87_N90_R0.8551.00
72_I80_A0.8531.00
25_Q149_D0.8471.00
45_N55_E0.8461.00
76_E80_A0.8401.00
107_D114_H0.8381.00
65_E129_L0.8361.00
47_M134_N0.8361.00
60_A77_L0.8291.00
52_G98_R0.8151.00
59_M81_L0.8041.00
117_L122_H0.8041.00
109_D112_C0.7921.00
105_E110_R0.7881.00
143_L158_L0.7851.00
78_S85_R0.7831.00
65_E126_R0.7821.00
130_P134_N0.7761.00
67_Q76_E0.7751.00
84_S90_R0.7731.00
134_N137_H0.7721.00
60_A81_L0.7711.00
149_D153_Q0.7701.00
96_E101_I0.7681.00
119_E123_E0.7681.00
93_D96_E0.7671.00
127_E131_P0.7671.00
156_R160_S0.7631.00
34_M38_S0.7571.00
90_R93_D0.7531.00
130_P133_H0.7501.00
157_K161_R0.7471.00
135_C138_Q0.7421.00
32_L35_H0.7371.00
90_R94_E0.7321.00
93_D103_R0.7311.00
68_E72_I0.7291.00
134_N138_Q0.7261.00
106_S109_D0.7211.00
94_E97_K0.7181.00
47_M50_A0.7161.00
146_T149_D0.7101.00
74_P89_T0.7081.00
58_F128_V0.7061.00
64_L117_L0.7021.00
140_W148_K0.6931.00
92_A96_E0.6911.00
94_E98_R0.6891.00
63_T67_Q0.6741.00
63_T81_L0.6711.00
61_L125_L0.6671.00
68_E116_Q0.6661.00
127_E130_P0.6641.00
149_D152_E0.6631.00
36_M158_L0.6591.00
64_L72_I0.6521.00
33_C155_T0.6521.00
154_I158_L0.6511.00
138_Q141_S0.6481.00
44_R47_M0.6481.00
63_T77_L0.6471.00
123_E126_R0.6431.00
33_C36_M0.6331.00
33_C37_Q0.6301.00
88_A92_A0.6291.00
136_L139_L0.6281.00
77_L115_L0.6231.00
133_H137_H0.6171.00
159_L163_D0.6091.00
63_T72_I0.6081.00
42_E46_K0.5901.00
75_S78_S0.5901.00
38_S42_E0.5901.00
57_L91_I0.5811.00
56_T87_N0.5811.00
43_N138_Q0.5761.00
59_M63_T0.5761.00
144_S148_K0.5711.00
58_F132_Q0.5711.00
143_L148_K0.5701.00
95_L100_W0.5701.00
101_I115_L0.5601.00
143_L157_K0.5601.00
41_L45_N0.5491.00
75_S112_C0.5491.00
78_S88_A0.5461.00
99_G102_E0.5401.00
154_I161_R0.5361.00
56_T83_S0.5321.00
73_Q114_H0.5301.00
143_L147_E0.5301.00
78_S81_L0.5291.00
43_N46_K0.5271.00
129_L133_H0.5241.00
77_L88_A0.5191.00
58_F125_L0.5191.00
44_R132_Q0.5181.00
36_M41_L0.5171.00
25_Q28_L0.5171.00
62_I129_L0.5101.00
73_Q106_S0.5091.00
118_T121_G0.5081.00
29_L151_L0.5071.00
41_L55_E0.5071.00
62_I66_S0.5061.00
124_F128_V0.5061.00
144_S157_K0.5061.00
34_M55_E0.5021.00
74_P112_C0.5001.00
120_K127_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbkA 2 0.8523 99.9 0.286 Contact Map
4rguA 4 0.8182 99.9 0.313 Contact Map
3u2rA 4 0.767 99.9 0.314 Contact Map
3zplA 2 0.9091 99.9 0.319 Contact Map
3deuA 2 0.7443 99.9 0.319 Contact Map
3cjnA 2 0.8295 99.9 0.32 Contact Map
3e6mA 2 0.858 99.9 0.323 Contact Map
3boqA 2 0.7727 99.9 0.324 Contact Map
4yifA 2 0.8011 99.9 0.328 Contact Map
2ethA 4 0.8011 99.9 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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