GREMLIN Database
YEIE - Uncharacterized HTH-type transcriptional regulator YeiE
UniProt: P0ACR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12105
Length: 293 (281)
Sequences: 79675 (57934)
Seq/√Len: 3456.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_A76_Q3.7861.00
17_S26_M3.4711.00
13_E26_M2.7841.00
156_E287_D2.6441.00
157_P264_T2.5651.00
47_V62_H2.4341.00
12_A71_L2.3851.00
94_Y139_V2.3811.00
164_V239_R2.3051.00
157_P160_E2.2901.00
160_E264_T2.2771.00
12_A16_K2.2701.00
90_A121_E2.2681.00
10_V37_A2.2121.00
13_E17_S2.2021.00
69_R76_Q2.1841.00
171_S186_A2.1001.00
90_A119_P2.0991.00
92_R121_E2.0661.00
164_V253_E2.0371.00
160_E262_M2.0311.00
110_R285_Y2.0311.00
73_L77_A2.0091.00
228_V235_S2.0091.00
15_L59_V2.0031.00
162_E239_R1.9981.00
179_T182_Q1.9361.00
67_Y71_L1.9341.00
10_V34_V1.9121.00
13_E16_K1.9061.00
15_L67_Y1.8961.00
229_R250_T1.8731.00
16_K71_L1.8511.00
22_Q25_V1.8471.00
12_A67_Y1.8461.00
187_P215_A1.8231.00
155_S266_W1.7881.00
69_R72_A1.7791.00
189_I233_G1.7581.00
167_A254_V1.7471.00
17_S22_Q1.7331.00
19_S22_Q1.6771.00
51_D58_V1.6751.00
133_A138_R1.6551.00
156_E269_H1.6141.00
154_I271_R1.5821.00
7_Q44_Q1.5701.00
269_H283_L1.5691.00
101_N222_E1.5641.00
7_Q40_D1.5611.00
53_V58_V1.5541.00
12_A70_A1.5511.00
114_D285_Y1.5371.00
7_Q37_A1.5161.00
76_Q79_E1.5111.00
133_A139_V1.5061.00
154_I269_H1.5041.00
30_S33_A1.5011.00
16_K26_M1.4981.00
13_E27_L1.4911.00
283_L287_D1.4861.00
20_T38_L1.4731.00
68_P72_A1.4571.00
146_G266_W1.4511.00
92_R123_S1.4501.00
144_I268_I1.4461.00
175_R182_Q1.4441.00
132_Q136_D1.4331.00
48_Q51_D1.4141.00
111_Y118_L1.4101.00
275_L279_L1.4101.00
161_D240_R1.4001.00
69_R79_E1.3971.00
111_Y282_F1.3901.00
157_P266_W1.3901.00
134_V142_G1.3731.00
267_R283_L1.3691.00
29_L33_A1.3601.00
5_L77_A1.3581.00
281_R284_D1.3511.00
21_T31_Q1.3491.00
198_R202_D1.3481.00
224_I235_S1.3381.00
226_H229_R1.3361.00
11_F67_Y1.3311.00
169_P252_S1.3271.00
141_I267_R1.3251.00
110_R114_D1.3231.00
4_T7_Q1.3191.00
12_A74_L1.3131.00
109_A230_H1.3071.00
36_A40_D1.3031.00
61_E64_R1.2951.00
135_L152_E1.2871.00
186_A234_I1.2761.00
112_R215_A1.2751.00
10_V29_L1.2601.00
177_P257_P1.2521.00
141_I279_L1.2521.00
112_R187_P1.2521.00
109_A113_H1.2441.00
125_G133_A1.2431.00
167_A234_I1.2411.00
239_R253_E1.2361.00
88_N117_Q1.2341.00
172_P186_A1.2251.00
106_A230_H1.2221.00
155_S268_I1.2141.00
72_A79_E1.2071.00
253_E256_V1.2061.00
169_P250_T1.2031.00
11_F15_L1.2011.00
8_L70_A1.1951.00
65_L69_R1.1831.00
36_A39_T1.1701.00
65_L68_P1.1701.00
226_H230_H1.1681.00
11_F50_F1.1631.00
239_R243_E1.1611.00
156_E283_L1.1561.00
64_R68_P1.1551.00
123_S133_A1.1451.00
13_E23_A1.1451.00
73_L76_Q1.1451.00
115_Y281_R1.1411.00
178_V182_Q1.1371.00
187_P213_E1.1321.00
37_A40_D1.1271.00
176_G252_S1.0931.00
20_T57_L1.0921.00
121_E217_E1.0911.00
39_T43_G1.0851.00
162_E262_M1.0761.00
190_L214_M1.0751.00
135_L150_S1.0741.00
166_F253_E1.0621.00
168_A231_G1.0611.00
91_I282_F1.0581.00
285_Y288_P1.0451.00
280_R284_D1.0441.00
62_H65_L1.0431.00
66_L70_A1.0361.00
75_E79_E1.0351.00
35_S39_T1.0331.00
100_G124_V1.0311.00
244_D248_A1.0281.00
66_L80_I1.0261.00
111_Y285_Y1.0121.00
284_D287_D1.0081.00
72_A75_E1.0061.00
111_Y115_Y1.0001.00
107_V286_C1.0001.00
110_R113_H0.9971.00
14_V23_A0.9931.00
6_R9_E0.9931.00
243_E247_Q0.9911.00
23_A34_V0.9881.00
189_I224_I0.9871.00
199_E202_D0.9841.00
40_D43_G0.9791.00
14_V20_T0.9781.00
109_A232_L0.9731.00
18_G58_V0.9731.00
9_E78_V0.9701.00
166_F242_I0.9691.00
199_E203_Y0.9681.00
225_K229_R0.9671.00
59_V63_G0.9591.00
11_F49_L0.9561.00
15_L50_F0.9531.00
22_Q26_M0.9521.00
154_I157_P0.9491.00
277_N281_R0.9491.00
204_L208_H0.9411.00
11_F41_L0.9381.00
276_S279_L0.9351.00
218_L224_I0.9321.00
165_V234_I0.9291.00
114_D288_P0.9241.00
6_R37_A0.9221.00
29_L34_V0.9151.00
107_V285_Y0.9081.00
10_V27_L0.9061.00
133_A136_D0.9061.00
17_S23_A0.9041.00
146_G264_T0.9041.00
167_A171_S0.9031.00
9_E13_E0.9011.00
112_R232_L0.9001.00
171_S174_A0.8961.00
89_G278_A0.8951.00
15_L18_G0.8931.00
97_S220_N0.8921.00
21_T25_V0.8921.00
9_E12_A0.8891.00
68_P71_L0.8881.00
18_G56_R0.8881.00
64_R67_Y0.8841.00
173_L186_A0.8811.00
53_V56_R0.8791.00
11_F59_V0.8731.00
218_L227_A0.8721.00
16_K67_Y0.8691.00
131_M135_L0.8671.00
14_V50_F0.8651.00
170_T231_G0.8641.00
174_A252_S0.8571.00
50_F57_L0.8551.00
66_L81_E0.8461.00
69_R73_L0.8421.00
205_L210_P0.8411.00
229_R248_A0.8411.00
227_A232_L0.8411.00
70_A73_L0.8411.00
187_P214_M0.8381.00
123_S139_V0.8371.00
93_I141_I0.8341.00
14_V34_V0.8291.00
275_L280_R0.8281.00
270_H273_K0.8281.00
94_Y142_G0.8271.00
31_Q35_S0.8251.00
71_L75_E0.8241.00
139_V142_G0.8211.00
14_V38_L0.8191.00
27_L34_V0.8161.00
94_Y144_I0.8151.00
220_N223_A0.8141.00
281_R285_Y0.8131.00
204_L207_S0.8071.00
137_F270_H0.8001.00
182_Q185_A0.7981.00
162_E260_R0.7981.00
181_E184_A0.7961.00
200_I204_L0.7931.00
119_P213_E0.7881.00
172_P176_G0.7861.00
118_L278_A0.7821.00
101_N226_H0.7811.00
95_A100_G0.7801.00
179_T257_P0.7761.00
167_A172_P0.7751.00
5_L74_L0.7741.00
20_T34_V0.7741.00
44_Q81_E0.7711.00
192_E217_E0.7691.00
7_Q10_V0.7681.00
111_Y281_R0.7671.00
153_I268_I0.7661.00
168_A171_S0.7651.00
170_T174_A0.7641.00
11_F63_G0.7631.00
246_L249_G0.7631.00
9_E74_L0.7621.00
61_E65_L0.7611.00
203_Y207_S0.7571.00
59_V64_R0.7561.00
168_A232_L0.7561.00
11_F66_L0.7541.00
106_A109_A0.7531.00
167_A252_S0.7521.00
184_A210_P0.7501.00
39_T48_Q0.7481.00
51_D60_N0.7451.00
166_F237_L0.7451.00
201_V205_L0.7421.00
89_G118_L0.7411.00
87_D115_Y0.7361.00
135_L153_I0.7361.00
15_L64_R0.7341.00
18_G64_R0.7331.00
140_D279_L0.7291.00
188_W212_F0.7271.00
141_I282_F0.7251.00
15_L63_G0.7221.00
177_P255_A0.7221.00
165_V236_C0.7211.00
200_I203_Y0.7161.00
92_R140_D0.7141.00
162_E255_A0.7131.00
6_R40_D0.7051.00
25_V28_A0.7031.00
166_F235_S0.7021.00
78_V81_E0.7011.00
202_D206_L0.7001.00
33_A37_A0.6981.00
73_L80_I0.6961.00
62_H66_L0.6951.00
273_K276_S0.6941.00
74_L78_V0.6911.00
191_R224_I0.6891.00
284_D288_P0.6881.00
114_D281_R0.6881.00
188_W234_I0.6821.00
45_L66_L0.6751.00
166_F246_L0.6741.00
58_V64_R0.6731.00
246_L253_E0.6721.00
277_N280_R0.6721.00
180_L258_L0.6711.00
152_E271_R0.6701.00
145_E263_R0.6691.00
170_T173_L0.6661.00
201_V204_L0.6661.00
238_S241_V0.6621.00
119_P217_E0.6571.00
124_V219_G0.6571.00
104_L107_V0.6561.00
192_E219_G0.6561.00
51_D56_R0.6561.00
242_I246_L0.6481.00
92_R139_V0.6431.00
167_A173_L0.6431.00
203_Y206_L0.6331.00
218_L223_A0.6331.00
134_V153_I0.6301.00
47_V51_D0.6291.00
216_M227_A0.6251.00
77_A80_I0.6201.00
135_L138_R0.6201.00
141_I283_L0.6201.00
169_P249_G0.6181.00
278_A281_R0.6161.00
105_P109_A0.6161.00
6_R10_V0.6141.00
197_T201_V0.6121.00
45_L48_Q0.6091.00
115_Y118_L0.6081.00
172_P175_R0.6071.00
89_G117_Q0.6061.00
91_I141_I0.6041.00
80_I84_F0.5991.00
14_V19_S0.5991.00
146_G155_S0.5991.00
23_A27_L0.5971.00
42_E52_R0.5971.00
109_A112_R0.5931.00
20_T31_Q0.5931.00
282_F286_C0.5911.00
103_I107_V0.5911.00
244_D247_Q0.5881.00
198_R217_E0.5861.00
106_A110_R0.5861.00
250_T253_E0.5851.00
94_Y123_S0.5851.00
95_A122_L0.5831.00
163_L236_C0.5821.00
75_E78_V0.5781.00
165_V183_L0.5771.00
205_L212_F0.5761.00
83_L86_E0.5751.00
40_D44_Q0.5751.00
171_S234_I0.5741.00
18_G57_L0.5741.00
199_E204_L0.5731.00
88_N119_P0.5731.00
158_W267_R0.5721.00
269_H275_L0.5721.00
48_Q62_H0.5721.00
181_E208_H0.5681.00
95_A104_L0.5681.00
171_S187_P0.5681.00
94_Y125_G0.5671.00
134_V268_I0.5651.00
173_L178_V0.5651.00
97_S126_N0.5641.00
280_R283_L0.5601.00
50_F59_V0.5591.00
185_A213_E0.5591.00
8_L66_L0.5551.00
197_T200_I0.5531.00
33_A36_A0.5531.00
106_A226_H0.5521.00
110_R288_P0.5521.00
269_H280_R0.5521.00
222_E226_H0.5511.00
12_A78_V0.5511.00
202_D205_L0.5481.00
279_L283_L0.5481.00
119_P215_A0.5471.00
161_D263_R0.5451.00
99_I103_I0.5451.00
179_T258_L0.5441.00
4_T40_D0.5421.00
77_A81_E0.5411.00
191_R221_S0.5411.00
29_L37_A0.5391.00
38_L42_E0.5391.00
70_A74_L0.5371.00
198_R204_L0.5341.00
170_T252_S0.5341.00
181_E210_P0.5331.00
101_N220_N0.5321.00
69_R80_I0.5311.00
224_I228_V0.5301.00
167_A174_A0.5291.00
69_R83_L0.5281.00
113_H232_L0.5281.00
32_S35_S0.5271.00
165_V188_W0.5271.00
94_Y133_A0.5251.00
161_D238_S0.5221.00
15_L71_L0.5191.00
184_A211_K0.5181.00
221_S238_S0.5171.00
65_L83_L0.5141.00
143_F286_C0.5141.00
76_Q80_I0.5131.00
237_L242_I0.5121.00
119_P214_M0.5121.00
32_S36_A0.5111.00
247_Q250_T0.5101.00
34_V37_A0.5101.00
59_V67_Y0.5061.00
97_S124_V0.5061.00
10_V38_L0.5051.00
20_T52_R0.5021.00
242_I253_E0.5011.00
96_S99_I0.5011.00
166_F251_L0.5011.00
275_L278_A0.5001.00
134_V270_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9932 100 0.08 Contact Map
1uthA 2 0.7509 100 0.09 Contact Map
3fxqA 3 0.9863 100 0.102 Contact Map
3fzvA 4 0.9693 100 0.105 Contact Map
1ixcA 4 0.9795 100 0.113 Contact Map
2h98A 2 0.6928 100 0.113 Contact Map
1al3A 1 0.7099 100 0.116 Contact Map
2h9bA 2 0.6928 100 0.119 Contact Map
4x6gA 4 0.9932 100 0.121 Contact Map
3hhgA 3 0.9863 100 0.13 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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