GREMLIN Database
ALLS - HTH-type transcriptional activator AllS
UniProt: P0ACR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13267
Length: 308 (282)
Sequences: 79731 (57877)
Seq/√Len: 3446.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D75_W3.6091.00
16_T25_R3.3341.00
162_D290_T2.6161.00
68_Q82_E2.4541.00
12_A25_R2.4321.00
97_V143_F2.4221.00
163_P268_P2.2301.00
166_S268_P2.1971.00
93_Q125_H2.1951.00
163_P166_S2.1911.00
46_V61_A2.1461.00
232_H239_G2.1441.00
114_W292_R2.1281.00
11_I70_R2.1011.00
9_T36_R2.0941.00
93_Q123_Q2.0301.00
168_Q243_K2.0261.00
11_I15_E2.0221.00
68_Q75_W2.0131.00
166_S266_P2.0001.00
170_R243_K1.9861.00
233_L254_Q1.9691.00
187_T190_Q1.9651.00
12_A16_T1.9561.00
114_W288_L1.9561.00
21_K24_E1.9401.00
95_N125_H1.9371.00
12_A15_E1.9031.00
229_I249_M1.8831.00
14_A58_L1.8691.00
11_I66_L1.8621.00
15_E70_R1.8621.00
9_T33_I1.8391.00
72_W76_L1.8321.00
173_M258_R1.8121.00
66_L70_R1.8121.00
178_P194_F1.7831.00
197_V237_G1.7601.00
170_R257_S1.7521.00
233_L249_M1.7011.00
195_P219_E1.7011.00
161_L270_S1.6911.00
14_A66_L1.6811.00
64_H82_E1.6781.00
50_F57_T1.6691.00
65_L79_M1.6661.00
137_S142_G1.6391.00
16_T21_K1.6101.00
134_V146_A1.6031.00
68_Q71_D1.5691.00
19_F37_I1.5691.00
11_I69_A1.5511.00
160_S275_K1.5501.00
18_S21_K1.5221.00
6_T36_R1.5201.00
162_D273_W1.5191.00
6_T43_N1.5121.00
15_E25_R1.5051.00
136_D140_Y1.4771.00
6_T39_L1.4771.00
183_E190_Q1.4511.00
115_L285_I1.4501.00
273_W286_V1.4461.00
286_V290_T1.4441.00
150_T270_S1.4351.00
89_G121_F1.4321.00
29_T32_T1.4231.00
47_A50_F1.4221.00
9_T28_K1.4161.00
10_F66_L1.4151.00
68_Q78_S1.4141.00
12_A26_L1.4071.00
105_P226_E1.4061.00
148_G272_A1.4041.00
160_S273_W1.4041.00
52_T57_T1.4011.00
20_S30_T1.3981.00
115_L122_T1.3901.00
137_S143_F1.3821.00
206_L210_V1.3801.00
75_W78_S1.3761.00
138_L146_A1.3571.00
72_W79_M1.3491.00
284_D287_T1.3441.00
118_R288_L1.3431.00
95_N127_S1.3421.00
91_E121_F1.3211.00
65_L80_P1.3151.00
11_I73_L1.3141.00
3_D6_T1.3101.00
60_A63_E1.3081.00
67_S71_D1.3041.00
167_V244_S1.2991.00
145_L282_V1.2971.00
271_L286_V1.2931.00
145_L271_L1.2911.00
114_W118_R1.2881.00
194_F238_I1.2851.00
139_L158_T1.2831.00
228_K239_G1.2761.00
4_P76_L1.2751.00
68_Q79_M1.2531.00
230_A233_L1.2471.00
175_A254_Q1.2381.00
175_A256_V1.2341.00
116_N219_E1.2301.00
163_P270_S1.2301.00
28_K32_T1.2261.00
64_H67_S1.2051.00
116_N195_P1.2051.00
243_K257_S1.2051.00
249_M254_Q1.2001.00
35_Y39_L1.1941.00
10_F49_F1.1901.00
43_N80_P1.1841.00
113_A234_A1.1841.00
113_A117_E1.1811.00
243_K247_Q1.1741.00
10_F14_A1.1671.00
173_M238_I1.1641.00
64_H68_Q1.1461.00
161_L272_A1.1391.00
185_P261_P1.1371.00
110_Q234_A1.1201.00
35_Y38_K1.1111.00
71_D78_S1.1101.00
186_L190_Q1.1081.00
63_E67_S1.0941.00
162_D286_V1.0941.00
119_Y284_D1.0901.00
38_K42_E1.0891.00
184_E256_V1.0831.00
7_L69_A1.0821.00
257_S260_I1.0811.00
12_A22_A1.0801.00
288_L292_R1.0781.00
195_P217_Q1.0741.00
19_F56_V1.0671.00
247_Q251_D1.0671.00
125_H221_I1.0661.00
172_V257_S1.0631.00
5_E8_R1.0611.00
230_A234_A1.0551.00
72_W75_W1.0551.00
114_W117_E1.0541.00
36_R39_L1.0511.00
139_L156_A1.0501.00
287_T290_T1.0491.00
10_F48_L1.0401.00
229_I233_L1.0371.00
34_S38_K1.0371.00
111_L289_F1.0351.00
283_E287_T1.0291.00
127_S137_S1.0291.00
206_L209_R1.0291.00
274_R277_G1.0231.00
115_L288_L1.0161.00
80_P84_Q1.0131.00
168_Q266_P1.0111.00
248_S252_N1.0081.00
174_A235_G1.0051.00
13_V22_A1.0021.00
288_L291_Q1.0011.00
74_S78_S1.0011.00
188_E262_T0.9961.00
197_V228_K0.9781.00
222_V228_K0.9781.00
94_V285_I0.9771.00
207_T210_V0.9751.00
13_V19_F0.9731.00
39_L42_E0.9701.00
115_L119_Y0.9581.00
65_L69_A0.9571.00
8_R77_E0.9511.00
77_E80_P0.9501.00
28_K33_I0.9471.00
172_V246_C0.9471.00
58_L62_G0.9451.00
9_T26_L0.9431.00
279_G282_V0.9421.00
22_A33_I0.9411.00
198_N218_K0.9411.00
14_A49_F0.9381.00
10_F40_L0.9201.00
21_K25_R0.9181.00
10_F58_L0.9181.00
71_D74_S0.9161.00
137_S140_Y0.9121.00
100_N224_D0.9081.00
64_H86_V0.9081.00
171_F238_I0.9021.00
222_V231_A0.9001.00
118_R291_Q0.8961.00
5_E36_R0.8951.00
76_L80_P0.8931.00
77_E81_S0.8901.00
17_G57_T0.8841.00
173_M179_L0.8781.00
49_F56_V0.8751.00
67_S70_R0.8751.00
143_F146_A0.8691.00
46_V83_L0.8651.00
150_T268_P0.8631.00
111_L288_L0.8611.00
180_A256_V0.8611.00
61_A64_H0.8601.00
97_V148_G0.8601.00
209_R214_L0.8601.00
208_K212_W0.8581.00
160_S163_P0.8571.00
20_S24_E0.8541.00
113_A236_V0.8541.00
97_V134_V0.8491.00
246_C249_M0.8371.00
135_W139_L0.8331.00
111_L292_R0.8291.00
61_A86_V0.8291.00
179_L194_F0.8281.00
14_A62_G0.8261.00
78_S82_E0.8251.00
92_R281_A0.8241.00
26_L33_I0.8231.00
127_S143_F0.8231.00
123_Q217_Q0.8211.00
195_P218_K0.8201.00
207_T211_A0.8201.00
52_T55_S0.8201.00
75_W79_M0.8201.00
96_I145_L0.8191.00
30_T34_S0.8181.00
122_T281_A0.8171.00
15_E66_L0.8141.00
116_N236_V0.8131.00
61_A83_L0.8121.00
17_G55_S0.8101.00
8_R12_A0.8091.00
76_L79_M0.8091.00
97_V146_A0.8071.00
16_T22_A0.8051.00
159_F272_A0.8031.00
233_L252_N0.8001.00
280_K284_D0.8001.00
10_F65_L0.7981.00
14_A17_G0.7951.00
249_M252_N0.7921.00
190_Q193_R0.7881.00
17_G63_E0.7861.00
13_V49_F0.7801.00
174_A236_V0.7791.00
176_D180_A0.7761.00
38_K47_A0.7761.00
178_P195_P0.7741.00
189_A192_R0.7741.00
287_T291_Q0.7711.00
4_P73_L0.7681.00
70_R74_S0.7671.00
19_F33_I0.7671.00
172_V239_G0.7661.00
79_M83_L0.7661.00
6_T9_T0.7641.00
187_T261_P0.7641.00
208_K211_A0.7611.00
144_S282_V0.7591.00
231_A236_V0.7561.00
13_V33_I0.7541.00
69_A72_W0.7511.00
63_E66_L0.7501.00
98_I104_N0.7481.00
168_Q264_R0.7481.00
139_L159_F0.7461.00
172_V241_L0.7451.00
133_G136_D0.7441.00
50_F59_T0.7421.00
168_Q259_V0.7411.00
145_L285_I0.7341.00
92_R122_T0.7341.00
13_V37_I0.7321.00
284_D288_L0.7271.00
246_C250_I0.7261.00
141_E274_R0.7191.00
173_M256_V0.7181.00
8_R11_I0.7181.00
118_R284_D0.7171.00
250_I253_Q0.7161.00
192_R214_L0.7151.00
224_D227_T0.7121.00
115_L284_D0.7111.00
60_A64_H0.7101.00
176_D235_G0.7081.00
242_P245_L0.7071.00
158_T275_K0.6991.00
90_V119_Y0.6981.00
196_A216_G0.6981.00
172_V250_I0.6951.00
114_W291_Q0.6921.00
61_A65_L0.6891.00
105_P230_A0.6871.00
95_N144_S0.6831.00
84_Q87_N0.6821.00
68_Q72_W0.6811.00
50_F55_S0.6801.00
187_T262_T0.6751.00
200_E221_I0.6731.00
58_L63_E0.6711.00
5_E39_L0.6711.00
196_A238_I0.6681.00
185_P259_V0.6671.00
65_L83_L0.6651.00
95_N143_F0.6601.00
57_T63_E0.6551.00
133_G137_S0.6541.00
32_T36_R0.6531.00
171_F240_F0.6511.00
8_R73_L0.6501.00
24_E27_C0.6501.00
110_Q113_A0.6491.00
179_L184_E0.6481.00
78_S81_S0.6411.00
199_I228_K0.6391.00
280_K283_E0.6381.00
10_F62_G0.6381.00
123_Q221_I0.6361.00
250_I257_S0.6331.00
41_E51_R0.6331.00
248_S251_D0.6271.00
37_I41_E0.6271.00
209_R212_W0.6271.00
108_V111_L0.6251.00
220_I231_A0.6231.00
173_M180_A0.6231.00
104_N131_Y0.6221.00
149_V267_S0.6211.00
110_Q114_W0.6201.00
41_E46_V0.6191.00
74_S77_E0.6151.00
94_V281_A0.6121.00
145_L286_V0.6071.00
44_T65_L0.6051.00
171_F191_L0.6041.00
13_V18_S0.5971.00
5_E9_T0.5971.00
3_D39_L0.5951.00
69_A73_L0.5951.00
206_L212_W0.5921.00
273_W283_E0.5901.00
94_V145_L0.5891.00
22_A26_L0.5881.00
81_S85_Q0.5861.00
73_L77_E0.5851.00
98_I108_V0.5851.00
222_V227_T0.5841.00
44_T83_L0.5821.00
14_A63_E0.5811.00
46_V50_F0.5771.00
64_H83_L0.5761.00
193_R217_Q0.5761.00
176_D256_V0.5741.00
173_M178_P0.5731.00
138_L272_A0.5731.00
285_I289_F0.5721.00
200_E223_P0.5711.00
164_L271_L0.5701.00
138_L159_F0.5701.00
175_A253_Q0.5701.00
91_E123_Q0.5681.00
102_L107_A0.5661.00
19_F30_T0.5661.00
167_V267_S0.5601.00
171_F196_A0.5591.00
119_Y122_T0.5591.00
31_A35_Y0.5571.00
44_T47_A0.5571.00
49_F58_L0.5561.00
178_P181_N0.5561.00
150_T161_L0.5551.00
32_T35_Y0.5541.00
29_T35_Y0.5501.00
228_K232_H0.5491.00
19_F55_S0.5441.00
169_W240_F0.5431.00
241_L246_C0.5411.00
82_E85_Q0.5411.00
28_K36_R0.5401.00
92_R121_F0.5381.00
107_A111_L0.5381.00
97_V127_S0.5361.00
225_M242_P0.5361.00
58_L66_L0.5331.00
165_G269_L0.5321.00
282_V286_V0.5311.00
139_L142_G0.5291.00
179_L183_E0.5291.00
231_A237_G0.5291.00
17_G56_V0.5251.00
85_Q90_V0.5251.00
136_D142_G0.5251.00
109_A113_A0.5251.00
81_S84_Q0.5251.00
9_T37_I0.5241.00
183_E186_L0.5241.00
19_F51_R0.5201.00
98_I126_I0.5191.00
105_P224_D0.5181.00
160_S276_F0.5161.00
110_Q230_A0.5161.00
47_A61_A0.5161.00
147_I289_F0.5141.00
113_A116_N0.5131.00
67_S82_E0.5101.00
112_L124_F0.5091.00
134_V141_E0.5091.00
31_A34_S0.5091.00
79_M82_E0.5091.00
99_N102_L0.5081.00
178_P183_E0.5071.00
281_A284_D0.5071.00
9_T22_A0.5071.00
86_V90_V0.5071.00
254_Q257_S0.5021.00
3_D8_R0.5021.00
167_V242_P0.5011.00
11_I77_E0.5001.00
68_Q83_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9416 100 0.102 Contact Map
3fzvA 4 0.9221 100 0.11 Contact Map
2esnA 3 0.9416 100 0.113 Contact Map
1ixcA 4 0.9351 100 0.115 Contact Map
1uthA 2 0.7208 100 0.12 Contact Map
2h98A 2 0.6721 100 0.129 Contact Map
1al3A 1 0.7078 100 0.131 Contact Map
2h9bA 2 0.6753 100 0.132 Contact Map
4x6gA 4 0.9675 100 0.134 Contact Map
3szpA 3 0.9253 100 0.14 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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