GREMLIN Database
TDCA - HTH-type transcriptional regulator TdcA
UniProt: P0ACQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10989
Length: 312 (286)
Sequences: 79376 (57344)
Seq/√Len: 3390.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_S80_E3.5831.00
21_S30_E3.3821.00
166_E295_K2.7141.00
102_G147_L2.5071.00
73_R87_E2.4141.00
237_V244_T2.2981.00
17_E30_E2.2351.00
118_K297_Y2.2341.00
181_R195_E2.2211.00
167_P170_E2.2041.00
170_E272_Q2.2021.00
172_E248_C2.2021.00
98_E129_S2.1621.00
26_S29_K2.1071.00
98_E127_Q2.1041.00
167_P272_Q2.1001.00
20_R75_E2.0761.00
188_T191_S2.0301.00
51_V66_A2.0261.00
14_V41_I2.0171.00
16_Q71_L1.9941.00
170_E270_V1.9911.00
238_L258_Q1.9821.00
100_S129_S1.9741.00
234_Y253_P1.9671.00
118_K293_L1.9651.00
73_R80_E1.9581.00
16_Q75_E1.9301.00
198_V242_F1.9081.00
17_E20_R1.9081.00
177_A262_I1.8901.00
77_I81_M1.8781.00
16_Q20_R1.8771.00
14_V38_V1.8741.00
17_E21_S1.8691.00
19_I63_L1.8621.00
174_V248_C1.8361.00
71_L75_E1.8111.00
24_I42_I1.8021.00
138_F150_A1.7531.00
55_V62_T1.7371.00
238_L253_P1.7241.00
70_L84_M1.7071.00
196_Q224_I1.7071.00
69_L87_E1.6631.00
174_V261_T1.6611.00
165_V274_A1.6521.00
141_A146_R1.6381.00
119_F290_L1.6141.00
19_I71_L1.5951.00
20_R30_E1.5881.00
15_F71_L1.5701.00
16_Q74_S1.5681.00
21_S26_S1.5581.00
164_H279_K1.5521.00
14_V33_L1.5311.00
94_E125_K1.5121.00
140_P144_D1.5111.00
25_G35_Q1.4971.00
119_F126_A1.4971.00
11_H41_I1.4851.00
65_P68_Q1.4771.00
11_H48_Y1.4741.00
166_E277_W1.4571.00
52_E55_V1.4391.00
34_T37_A1.4381.00
8_K11_H1.4301.00
23_S26_S1.4261.00
73_R76_S1.4241.00
11_H44_D1.4221.00
207_Y211_L1.4161.00
16_Q78_T1.4121.00
17_E31_L1.4101.00
291_V295_K1.4101.00
283_I287_A1.3841.00
164_H277_W1.3791.00
152_G276_V1.3771.00
73_R83_N1.3761.00
179_K258_Q1.3691.00
154_L274_A1.3691.00
186_T191_S1.3671.00
77_I84_M1.3561.00
277_W291_V1.3541.00
109_F231_V1.3521.00
96_V125_K1.3491.00
9_T81_M1.3361.00
118_K122_V1.3351.00
275_A291_V1.3251.00
100_S131_Y1.3171.00
289_V292_E1.3111.00
171_S249_D1.2951.00
149_F287_A1.2921.00
143_R162_D1.2891.00
142_I150_A1.2881.00
141_A147_L1.2871.00
57_K62_T1.2831.00
195_E243_L1.2711.00
177_A243_L1.2671.00
70_L85_V1.2641.00
149_F275_A1.2561.00
120_K224_I1.2561.00
233_I244_T1.2541.00
80_E83_N1.2501.00
122_V293_L1.2351.00
72_S76_S1.2191.00
235_N238_L1.2091.00
179_K260_I1.2061.00
248_C261_T1.2061.00
68_Q72_S1.2011.00
248_C252_S1.1961.00
73_R84_M1.1921.00
43_N47_D1.1841.00
69_L72_S1.1831.00
120_K196_Q1.1731.00
182_T195_E1.1711.00
167_P274_A1.1691.00
117_N121_E1.1631.00
15_F54_V1.1631.00
214_L219_I1.1571.00
165_V276_V1.1491.00
118_K121_E1.1481.00
252_S255_G1.1461.00
253_P258_Q1.1441.00
33_L37_A1.1391.00
48_Y85_V1.1341.00
15_F19_I1.1271.00
40_K43_N1.1211.00
15_F53_L1.1171.00
198_V233_I1.1161.00
117_N239_N1.1111.00
40_K44_D1.1101.00
99_V290_L1.1071.00
129_S226_K1.1011.00
292_E295_K1.0841.00
39_S43_N1.0831.00
123_F289_V1.0801.00
24_I61_V1.0781.00
76_S83_N1.0771.00
119_F293_L1.0761.00
293_L297_Y1.0721.00
196_Q222_E1.0681.00
227_T233_I1.0681.00
278_S281_Y1.0651.00
13_V82_K1.0631.00
18_V27_A1.0621.00
12_L74_S1.0601.00
10_Q13_V1.0581.00
17_E27_A1.0581.00
261_T264_V1.0531.00
176_V261_T1.0511.00
288_S292_E1.0491.00
77_I80_E1.0451.00
187_T191_S1.0391.00
69_L73_R1.0381.00
178_S240_A1.0341.00
41_I44_D1.0331.00
115_M294_A1.0271.00
114_G239_N1.0231.00
143_R160_L1.0231.00
166_E291_V1.0201.00
234_Y238_L1.0181.00
63_L67_G1.0131.00
235_N239_N1.0061.00
85_V89_S0.9991.00
176_V251_T0.9901.00
175_L243_L0.9871.00
177_A181_R0.9871.00
19_I54_V0.9751.00
172_E270_V0.9741.00
33_L38_V0.9731.00
208_S211_L0.9721.00
102_G138_F0.9721.00
82_K86_N0.9691.00
82_K85_V0.9671.00
199_L223_N0.9671.00
7_P48_Y0.9601.00
14_V31_L0.9591.00
122_V296_E0.9551.00
79_R83_N0.9551.00
119_F123_F0.9511.00
189_L266_E0.9491.00
18_V24_I0.9451.00
15_F63_L0.9411.00
181_R184_T0.9381.00
70_L74_S0.9361.00
293_L296_E0.9351.00
131_Y141_A0.9261.00
227_T236_L0.9181.00
141_A144_D0.9181.00
115_M293_L0.9141.00
54_V61_V0.9121.00
284_K287_A0.9081.00
15_F45_I0.9071.00
156_A160_L0.9031.00
44_D47_D0.9021.00
27_A38_V0.8971.00
127_Q222_E0.8951.00
51_V88_I0.8931.00
19_I67_G0.8851.00
147_L150_A0.8831.00
162_D279_K0.8791.00
26_S30_E0.8771.00
181_R196_Q0.8711.00
72_S75_E0.8701.00
191_S194_N0.8631.00
126_A286_A0.8511.00
102_G152_G0.8511.00
177_A182_T0.8511.00
154_L272_Q0.8511.00
22_G62_T0.8461.00
176_V244_T0.8451.00
105_S229_S0.8441.00
163_L276_V0.8441.00
196_Q223_N0.8431.00
183_C195_E0.8421.00
76_S79_R0.8411.00
101_F149_F0.8411.00
181_R185_G0.8391.00
25_G29_K0.8371.00
57_K60_G0.8341.00
210_L214_L0.8321.00
139_L143_R0.8321.00
292_E296_E0.8311.00
254_F257_N0.8281.00
131_Y147_L0.8231.00
164_H167_P0.8171.00
10_Q41_I0.8161.00
185_G196_Q0.8121.00
102_G150_A0.8091.00
31_L38_V0.8091.00
208_S212_T0.8011.00
22_G68_Q0.8001.00
9_T78_T0.7991.00
283_I288_S0.7931.00
19_I22_G0.7891.00
15_F70_L0.7881.00
213_T217_N0.7871.00
66_A88_I0.7871.00
190_E193_K0.7861.00
43_N52_E0.7841.00
97_V286_A0.7831.00
117_N241_D0.7811.00
178_S241_D0.7781.00
20_R71_L0.7771.00
18_V54_V0.7761.00
80_E84_M0.7721.00
149_F290_L0.7661.00
35_Q39_S0.7651.00
18_V42_I0.7651.00
188_T265_E0.7631.00
172_E263_P0.7601.00
285_K289_V0.7561.00
21_S27_A0.7551.00
81_M84_M0.7531.00
81_M85_V0.7521.00
137_S140_P0.7521.00
95_A123_F0.7511.00
69_L91_M0.7501.00
115_M297_Y0.7461.00
172_E268_L0.7431.00
180_S184_T0.7421.00
83_N87_E0.7421.00
120_K241_D0.7411.00
97_V126_A0.7401.00
236_L241_D0.7381.00
122_V289_V0.7361.00
118_K296_E0.7361.00
22_G60_G0.7351.00
66_A69_L0.7331.00
184_T260_I0.7321.00
11_H14_V0.7291.00
253_P256_S0.7271.00
66_A91_M0.7251.00
89_S92_S0.7251.00
176_V246_I0.7241.00
7_P85_V0.7241.00
177_A183_C0.7231.00
63_L68_Q0.7221.00
143_R163_L0.7211.00
62_T68_Q0.7171.00
84_M88_I0.7171.00
24_I38_V0.7141.00
177_A260_I0.7141.00
207_Y226_K0.7141.00
103_F108_G0.7121.00
213_T216_R0.7121.00
100_S147_L0.7101.00
247_P250_M0.7081.00
13_V17_E0.7051.00
74_S77_I0.7041.00
119_F289_V0.7031.00
55_V64_T0.7031.00
193_K219_I0.7021.00
55_V60_G0.6981.00
37_A41_I0.6901.00
238_L256_S0.6891.00
190_E217_N0.6891.00
75_E79_R0.6881.00
210_L213_T0.6881.00
18_V38_V0.6881.00
188_T266_E0.6821.00
209_E213_T0.6791.00
178_S181_R0.6781.00
151_I294_A0.6771.00
66_A70_L0.6771.00
212_T216_R0.6761.00
281_Y284_K0.6751.00
148_D287_A0.6691.00
46_E51_V0.6661.00
194_N222_E0.6631.00
100_S148_D0.6631.00
145_G278_S0.6611.00
200_P233_I0.6611.00
229_S232_T0.6611.00
212_T215_Q0.6591.00
65_P69_L0.6581.00
79_R82_K0.6571.00
254_F261_T0.6571.00
211_L215_Q0.6561.00
68_Q71_L0.6551.00
225_V236_L0.6531.00
83_N86_N0.6521.00
289_V293_L0.6511.00
103_F112_M0.6511.00
74_S78_T0.6411.00
201_Q226_K0.6411.00
197_W221_I0.6401.00
46_E56_R0.6391.00
24_I60_G0.6371.00
180_S260_I0.6371.00
127_Q226_K0.6371.00
99_V286_A0.6351.00
70_L88_I0.6301.00
29_K32_G0.6291.00
180_S240_A0.6291.00
179_K257_N0.6251.00
176_V254_F0.6251.00
175_L192_L0.6251.00
73_R77_I0.6231.00
10_Q44_D0.6201.00
42_I46_E0.6201.00
180_S183_C0.6191.00
251_T254_F0.6181.00
13_V16_Q0.6151.00
108_G135_L0.6141.00
197_W243_L0.6131.00
27_A31_L0.6131.00
96_V127_Q0.6121.00
18_V23_S0.6091.00
109_F235_N0.6051.00
285_K288_S0.6001.00
169_F273_Y0.5981.00
142_I276_V0.5981.00
175_L245_V0.5971.00
208_S213_T0.5951.00
112_M115_M0.5931.00
211_L214_L0.5911.00
69_L88_I0.5891.00
290_L294_A0.5881.00
137_S141_A0.5871.00
206_Y210_L0.5871.00
86_N90_G0.5861.00
149_F291_V0.5861.00
99_V149_F0.5841.00
201_Q228_D0.5831.00
236_L242_F0.5781.00
175_L197_W0.5781.00
233_I237_V0.5771.00
214_L221_I0.5751.00
63_L71_L0.5741.00
114_G118_K0.5731.00
164_H280_N0.5731.00
36_P40_K0.5711.00
142_I163_L0.5701.00
49_F70_L0.5681.00
277_W288_S0.5661.00
13_V78_T0.5661.00
171_S271_A0.5651.00
227_T232_T0.5641.00
49_F88_I0.5631.00
183_C186_T0.5631.00
182_T185_G0.5621.00
54_V63_L0.5621.00
206_Y209_E0.5601.00
153_T271_A0.5591.00
183_C187_T0.5581.00
114_G117_N0.5581.00
177_A184_T0.5581.00
116_I128_V0.5581.00
182_T186_T0.5541.00
173_F245_V0.5541.00
34_T40_K0.5541.00
51_V55_V0.5501.00
37_A40_K0.5501.00
10_Q14_V0.5481.00
138_F145_G0.5431.00
181_R243_L0.5401.00
72_S87_E0.5371.00
123_F126_A0.5321.00
207_Y210_L0.5311.00
209_E212_T0.5311.00
102_G131_Y0.5291.00
107_I111_F0.5261.00
78_T82_K0.5261.00
230_V247_P0.5261.00
246_I251_T0.5251.00
202_T226_K0.5231.00
15_F67_G0.5211.00
14_V42_I0.5211.00
42_I54_V0.5201.00
49_F52_E0.5201.00
78_T81_M0.5191.00
73_R88_I0.5181.00
74_S81_M0.5161.00
97_V125_K0.5161.00
168_L275_A0.5161.00
52_E66_A0.5121.00
140_P146_R0.5121.00
33_L41_I0.5091.00
151_I275_A0.5071.00
14_V27_A0.5061.00
109_F229_S0.5041.00
287_A291_V0.5031.00
24_I56_R0.5031.00
176_V259_F0.5021.00
24_I35_Q0.5011.00
154_L165_V0.5011.00
86_N89_S0.5011.00
19_I68_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9423 100 0.113 Contact Map
2esnA 3 0.9487 100 0.117 Contact Map
1uthA 2 0.7212 100 0.119 Contact Map
1al3A 1 0.7051 100 0.133 Contact Map
1ixcA 4 0.9295 100 0.134 Contact Map
3fzvA 4 0.9167 100 0.138 Contact Map
2h98A 2 0.6731 100 0.14 Contact Map
4x6gA 4 0.9744 100 0.143 Contact Map
2h9bA 2 0.6763 100 0.148 Contact Map
3szpA 3 0.9199 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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