GREMLIN Database
OXYR - Hydrogen peroxide-inducible genes activator
UniProt: P0ACQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10681
Length: 305 (286)
Sequences: 79831 (57868)
Seq/√Len: 3421.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_T74_E3.5361.00
15_H24_S3.3691.00
158_V290_R2.6831.00
96_G141_L2.5241.00
67_Q81_M2.3821.00
231_V238_T2.3231.00
112_M292_R2.2131.00
164_P242_A2.2011.00
162_D267_T2.1821.00
173_H189_E2.1811.00
11_A24_S2.1781.00
159_P162_D2.1541.00
92_P123_Y2.1421.00
20_R23_D2.1201.00
14_E69_R2.1031.00
92_P121_E2.0851.00
159_P267_T2.0521.00
182_P185_D2.0151.00
45_V60_A2.0041.00
8_Y35_Q1.9941.00
10_V65_V1.9891.00
228_R248_E1.9811.00
94_H123_Y1.9601.00
162_D265_R1.9581.00
232_A253_G1.9541.00
112_M288_A1.9341.00
67_Q74_E1.9211.00
192_L236_G1.8981.00
169_I257_L1.8951.00
10_V69_R1.8881.00
11_A14_E1.8851.00
8_Y32_L1.8851.00
71_V75_V1.8811.00
13_A57_F1.8561.00
11_A15_H1.8541.00
10_V14_E1.8471.00
18_F36_I1.8451.00
65_V69_R1.8011.00
166_L242_A1.8001.00
132_L144_V1.7841.00
49_E56_L1.7261.00
232_A248_E1.7161.00
64_L78_L1.7101.00
190_K218_H1.6841.00
178_R185_D1.6541.00
63_L81_M1.6491.00
157_E269_G1.6361.00
113_L285_L1.6341.00
166_L256_Y1.6251.00
135_Q140_K1.6051.00
14_E24_S1.6031.00
9_L65_V1.5781.00
13_A65_V1.5701.00
10_V68_A1.5631.00
8_Y27_V1.5571.00
15_H20_R1.5531.00
156_I274_P1.5271.00
113_L120_L1.5211.00
19_R29_Q1.5111.00
88_T119_K1.5021.00
59_Q62_M1.5001.00
134_A138_S1.4901.00
5_D35_Q1.4821.00
28_S31_T1.4461.00
5_D42_E1.4381.00
46_M49_E1.4301.00
201_R205_M1.4271.00
5_D38_K1.4241.00
158_V272_Y1.4241.00
10_V72_L1.4171.00
17_H20_R1.4171.00
67_Q70_T1.4081.00
11_A25_C1.4001.00
278_L282_Y1.3961.00
286_A290_R1.3921.00
146_L271_V1.3821.00
156_I272_Y1.3741.00
71_V78_L1.3601.00
67_Q77_V1.3531.00
148_L269_G1.3501.00
171_E253_G1.3471.00
90_S119_K1.3351.00
103_P225_E1.3341.00
112_M116_T1.3321.00
137_D154_A1.3261.00
272_Y286_A1.3251.00
270_L286_A1.3091.00
94_H125_H1.3071.00
284_Q287_E1.2961.00
143_C282_Y1.2961.00
163_E243_L1.2731.00
42_E79_K1.2721.00
64_L79_K1.2701.00
135_Q141_L1.2691.00
136_L144_V1.2581.00
3_I75_V1.2571.00
51_T56_L1.2561.00
227_L238_T1.2541.00
169_I237_I1.2531.00
143_C270_L1.2511.00
114_H218_H1.2511.00
189_E237_I1.2461.00
74_E77_V1.2231.00
242_A246_P1.2131.00
208_C213_A1.2121.00
116_T288_A1.2121.00
62_M66_D1.2121.00
37_R41_D1.2021.00
242_A256_Y1.1881.00
66_D70_T1.1881.00
67_Q78_L1.1871.00
248_E253_G1.1871.00
229_N232_A1.1841.00
114_H190_K1.1801.00
171_E255_V1.1751.00
179_E255_V1.1711.00
63_L66_D1.1701.00
9_L48_L1.1681.00
112_M115_Q1.1621.00
174_P189_E1.1601.00
111_P115_Q1.1571.00
192_L227_L1.1441.00
157_E271_V1.1411.00
159_P269_G1.1391.00
127_A131_Q1.1381.00
93_L285_L1.1381.00
27_V31_T1.1311.00
9_L47_L1.1231.00
9_L13_A1.1091.00
246_P250_K1.1081.00
123_Y220_R1.1021.00
33_S37_R1.1011.00
34_G37_R1.0991.00
7_E76_K1.0961.00
34_G38_K1.0931.00
111_P233_A1.0921.00
287_E290_R1.0861.00
113_L288_A1.0861.00
190_K216_D1.0791.00
12_L21_A1.0781.00
18_F55_V1.0751.00
273_R276_S1.0751.00
221_A227_L1.0751.00
117_F284_Q1.0731.00
70_T77_V1.0721.00
168_A256_Y1.0691.00
102_G126_E1.0631.00
6_L68_A1.0501.00
11_A21_A1.0501.00
71_V74_E1.0491.00
127_A135_Q1.0441.00
288_A292_R1.0421.00
57_F61_G1.0411.00
283_E287_E1.0411.00
35_Q38_K1.0251.00
109_I289_I1.0231.00
170_Y234_G1.0211.00
180_C260_I1.0211.00
4_R7_E1.0091.00
63_L67_Q1.0081.00
181_V185_D1.0031.00
108_H233_A1.0011.00
228_R232_A1.0011.00
256_Y259_C0.9981.00
158_V286_A0.9951.00
168_A245_V0.9921.00
8_Y25_C0.9891.00
137_D152_S0.9881.00
167_L237_I0.9821.00
79_K83_S0.9811.00
229_N233_A0.9811.00
76_K80_E0.9771.00
27_V32_L0.9691.00
13_A48_L0.9671.00
76_K79_K0.9641.00
116_T291_A0.9591.00
96_G132_L0.9581.00
127_A132_L0.9541.00
193_M217_T0.9501.00
64_L68_A0.9491.00
164_P265_R0.9471.00
12_L18_F0.9461.00
169_I173_H0.9411.00
113_L117_F0.9351.00
73_R77_V0.9351.00
9_L57_F0.9321.00
135_Q138_S0.9261.00
288_A291_A0.9201.00
173_H190_K0.9191.00
279_R282_Y0.9111.00
125_H135_Q0.9111.00
221_A230_M0.9111.00
249_R252_D0.9091.00
109_I288_A0.9081.00
48_L55_V0.9051.00
173_H176_A0.9021.00
202_D205_M0.9021.00
9_L39_L0.8991.00
21_A32_L0.8981.00
154_A274_P0.8981.00
121_E216_D0.8971.00
13_A61_G0.8971.00
45_V82_A0.8961.00
141_L144_V0.8831.00
38_K41_D0.8791.00
183_M261_K0.8741.00
63_L85_Q0.8721.00
96_G146_L0.8661.00
177_N190_K0.8651.00
66_D69_R0.8641.00
20_R24_S0.8581.00
190_K217_T0.8561.00
174_P179_E0.8561.00
120_L281_R0.8551.00
245_V248_E0.8551.00
155_F271_V0.8541.00
99_P223_S0.8531.00
169_I174_P0.8491.00
185_D188_G0.8431.00
19_R23_D0.8421.00
16_R56_L0.8411.00
287_E291_A0.8411.00
51_T54_K0.8401.00
95_I143_C0.8381.00
148_L267_T0.8371.00
168_A238_T0.8351.00
133_L137_D0.8291.00
70_T73_R0.8191.00
25_C32_L0.8181.00
12_L36_I0.8081.00
60_A85_Q0.8071.00
204_A208_C0.8061.00
125_H141_L0.8031.00
175_W189_E0.8001.00
156_I159_P0.7981.00
60_A82_A0.7941.00
9_L64_L0.7921.00
16_R62_M0.7881.00
96_G144_V0.7871.00
91_G281_R0.7861.00
89_M117_F0.7851.00
37_R46_M0.7821.00
278_L283_E0.7781.00
13_A16_R0.7771.00
12_L48_L0.7731.00
111_P235_S0.7731.00
184_A187_A0.7701.00
29_Q33_S0.7671.00
14_E65_V0.7661.00
202_D206_G0.7651.00
91_G120_L0.7651.00
170_Y235_S0.7611.00
131_Q134_A0.7571.00
74_E78_L0.7571.00
75_V78_L0.7551.00
4_R35_Q0.7501.00
172_D176_A0.7481.00
15_H21_A0.7461.00
230_M235_S0.7451.00
3_I72_L0.7451.00
164_P258_P0.7451.00
143_C285_L0.7451.00
16_R54_K0.7411.00
201_R220_R0.7391.00
112_M291_A0.7391.00
207_F211_A0.7391.00
137_D155_F0.7381.00
280_S284_Q0.7361.00
116_T284_Q0.7331.00
164_P263_E0.7321.00
248_E251_R0.7321.00
57_F62_M0.7311.00
60_A63_L0.7291.00
109_I292_R0.7261.00
56_L62_M0.7251.00
77_V81_M0.7241.00
114_H235_S0.7241.00
168_A240_L0.7221.00
75_V79_K0.7211.00
5_D8_Y0.7201.00
31_T35_Q0.7201.00
94_H141_L0.7141.00
145_I289_I0.7101.00
184_A211_A0.7091.00
68_A71_V0.7081.00
173_H177_N0.7061.00
83_S86_G0.7041.00
7_E11_A0.7031.00
169_I255_V0.7031.00
113_L284_Q0.7001.00
18_F32_L0.6991.00
78_L82_A0.6991.00
97_L102_G0.6981.00
182_P260_I0.6961.00
180_C258_P0.6951.00
12_L32_L0.6931.00
241_P244_A0.6921.00
49_E58_T0.6881.00
187_A213_A0.6881.00
232_A251_R0.6851.00
170_Y173_H0.6801.00
169_I175_W0.6771.00
223_S226_T0.6761.00
18_F54_K0.6761.00
191_L215_E0.6761.00
249_R256_Y0.6741.00
49_E54_K0.6741.00
60_A64_L0.6731.00
188_G216_D0.6731.00
40_E45_V0.6721.00
206_G210_E0.6721.00
176_A255_V0.6701.00
94_H142_D0.6671.00
69_R73_R0.6661.00
97_L106_L0.6651.00
142_D282_Y0.6641.00
73_R76_K0.6601.00
276_S279_R0.6581.00
207_F210_E0.6581.00
194_L227_L0.6571.00
168_A249_R0.6571.00
62_M65_V0.6521.00
219_F230_M0.6501.00
59_Q63_L0.6501.00
195_E220_R0.6491.00
68_A72_L0.6481.00
77_V80_E0.6431.00
93_L281_R0.6411.00
121_E220_R0.6411.00
172_D175_W0.6381.00
40_E50_R0.6361.00
206_G209_F0.6361.00
205_M209_F0.6361.00
284_Q288_A0.6341.00
245_V249_R0.6331.00
36_I40_E0.6321.00
191_L237_I0.6321.00
21_A25_C0.6301.00
139_G273_R0.6291.00
64_L82_A0.6291.00
136_L271_V0.6281.00
171_E252_D0.6271.00
203_Q207_F0.6231.00
172_D255_V0.6231.00
23_D26_H0.6191.00
126_E222_T0.6171.00
167_L186_L0.6161.00
7_E10_V0.6121.00
172_D234_G0.6101.00
90_S121_E0.6081.00
12_L17_H0.6071.00
161_F268_I0.6061.00
208_C215_E0.6011.00
67_Q71_V0.5991.00
63_L82_A0.5971.00
103_P229_N0.5971.00
143_C286_A0.5941.00
93_L143_C0.5941.00
280_S283_E0.5941.00
156_I275_G0.5941.00
30_P34_G0.5921.00
126_E223_S0.5911.00
136_L155_F0.5901.00
230_M236_G0.5861.00
195_E222_T0.5851.00
80_E84_Q0.5851.00
106_L109_I0.5851.00
4_R38_K0.5851.00
57_F65_V0.5851.00
285_L289_I0.5831.00
227_L231_V0.5821.00
175_W178_R0.5811.00
167_L191_L0.5791.00
204_A207_F0.5791.00
163_E266_R0.5741.00
110_I122_M0.5731.00
167_L239_L0.5721.00
175_W181_V0.5711.00
205_M208_C0.5681.00
174_P178_R0.5671.00
43_L82_A0.5671.00
131_Q135_Q0.5641.00
31_T34_G0.5641.00
165_M239_L0.5631.00
108_H112_M0.5631.00
182_P261_K0.5581.00
132_L139_G0.5581.00
196_D220_R0.5571.00
147_A266_R0.5571.00
28_S34_G0.5561.00
221_A226_T0.5561.00
4_R8_Y0.5541.00
48_L57_F0.5521.00
43_L64_L0.5511.00
45_V49_E0.5481.00
43_L46_M0.5451.00
180_C185_D0.5441.00
108_H111_P0.5441.00
272_Y283_E0.5431.00
7_E72_L0.5411.00
36_I48_L0.5371.00
101_V105_L0.5351.00
72_L75_V0.5341.00
240_L245_V0.5311.00
91_G119_K0.5311.00
66_D81_M0.5301.00
200_L204_A0.5281.00
68_A75_V0.5241.00
8_Y36_I0.5241.00
72_L76_K0.5221.00
145_I270_L0.5221.00
91_G117_F0.5221.00
173_H237_I0.5211.00
202_D207_F0.5191.00
67_Q82_A0.5161.00
117_F120_L0.5131.00
282_Y286_A0.5111.00
96_G125_H0.5111.00
224_L241_P0.5081.00
46_M60_A0.5061.00
18_F50_R0.5061.00
160_L270_L0.5061.00
134_A140_K0.5031.00
8_Y21_A0.5031.00
148_L157_E0.5021.00
96_G127_A0.5011.00
9_L61_G0.5011.00
168_A254_V0.5011.00
18_F29_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7443 100 0.09 Contact Map
2esnA 3 0.9607 100 0.091 Contact Map
4x6gA 4 0.9934 100 0.094 Contact Map
1ixcA 4 0.9574 100 0.095 Contact Map
3fxqA 3 0.9574 100 0.096 Contact Map
3fzvA 4 0.941 100 0.096 Contact Map
1al3A 1 0.718 100 0.098 Contact Map
2h98A 2 0.6951 100 0.102 Contact Map
2h9bA 2 0.6984 100 0.112 Contact Map
3szpA 3 0.9508 100 0.114 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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