GREMLIN Database
RBSR - Ribose operon repressor
UniProt: P0ACQ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10819
Length: 330 (322)
Sequences: 36441 (26362)
Seq/√Len: 1469.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_H240_Q3.4681.00
162_L201_A3.4021.00
10_L42_E3.1871.00
263_Q266_Q3.0811.00
168_A271_I2.6751.00
118_G304_L2.6281.00
177_H269_A2.6231.00
196_L200_R2.5831.00
275_D290_H2.5821.00
166_D205_R2.3891.00
226_F259_Q2.2741.00
155_D307_R2.2661.00
84_S87_E2.2391.00
30_E34_A2.2191.00
38_A42_E2.2111.00
34_A38_A2.1841.00
84_S302_D2.1741.00
230_R260_A2.1201.00
299_L302_D2.0811.00
166_D201_A2.0691.00
173_I206_A2.0551.00
170_Q202_A2.0461.00
166_D202_A2.0361.00
85_C301_I1.9921.00
163_L167_L1.9911.00
21_V36_V1.9831.00
164_G273_Y1.9821.00
230_R256_A1.9811.00
80_G297_G1.9471.00
165_G169_T1.9441.00
225_G252_G1.9251.00
33_T37_E1.9251.00
22_I40_I1.9221.00
162_L197_E1.9081.00
170_Q174_D1.8831.00
172_L241_A1.8691.00
5_K15_T1.8421.00
84_S298_E1.8411.00
165_G243_F1.8321.00
306_H311_P1.8061.00
257_L268_I1.8051.00
234_S260_A1.7901.00
169_T199_Y1.7781.00
83_R294_D1.7581.00
170_Q206_A1.7581.00
290_H323_I1.7541.00
11_A39_A1.7231.00
166_D170_Q1.7001.00
229_M253_V1.6801.00
179_R211_P1.6801.00
226_F256_A1.6731.00
63_G116_V1.6651.00
181_A239_P1.6561.00
10_L39_A1.6471.00
244_T253_V1.6421.00
182_C245_G1.6341.00
80_G294_D1.6321.00
292_P295_E1.6311.00
299_L318_L1.6181.00
167_L322_P1.6161.00
262_L267_D1.6101.00
171_Y175_K1.5821.00
275_D327_R1.5591.00
145_M300_A1.5531.00
263_Q267_D1.5451.00
37_E41_K1.5391.00
256_A260_A1.5351.00
163_L166_D1.5321.00
197_E201_A1.5131.00
258_Y283_T1.5041.00
84_S88_R1.5031.00
21_V40_I1.5021.00
216_V231_Q1.4861.00
179_R238_R1.4821.00
160_N163_L1.4801.00
173_I202_A1.4781.00
295_E299_L1.4751.00
171_Y174_D1.4491.00
7_V39_A1.4411.00
256_A259_Q1.4291.00
271_I287_T1.4231.00
88_R305_I1.4191.00
194_L197_E1.4151.00
37_E40_I1.4151.00
200_R204_K1.3901.00
60_H117_D1.3851.00
295_E298_E1.3831.00
84_S301_I1.3831.00
164_G322_P1.3701.00
169_T173_I1.3691.00
169_T198_G1.3511.00
165_G198_G1.3431.00
257_L262_L1.3421.00
230_R259_Q1.3341.00
171_Y326_E1.3311.00
229_M242_V1.3301.00
202_A205_R1.3301.00
226_F255_Q1.3181.00
177_H241_A1.3081.00
179_R240_Q1.3031.00
226_F230_R1.2971.00
181_A232_L1.2911.00
7_V11_A1.2891.00
169_T202_A1.2871.00
305_I309_T1.2821.00
5_K9_R1.2821.00
10_L43_L1.2771.00
302_D306_H1.2681.00
229_M257_L1.2641.00
20_H25_D1.2631.00
29_S32_I1.2561.00
60_H90_Y1.2541.00
30_E33_T1.2491.00
198_G202_A1.2491.00
63_G111_L1.2431.00
6_D9_R1.2401.00
230_R234_S1.2321.00
62_I85_C1.2261.00
162_L166_D1.2241.00
211_P214_Y1.2231.00
95_C111_L1.2231.00
120_L300_A1.2181.00
254_Y270_V1.2181.00
35_K39_A1.2141.00
231_Q235_H1.2101.00
167_L170_Q1.2031.00
219_D224_G1.2001.00
95_C107_N1.1991.00
64_M81_V1.1951.00
39_A43_L1.1921.00
178_T240_Q1.1911.00
81_V301_I1.1901.00
85_C92_L1.1881.00
39_A42_E1.1861.00
7_V43_L1.1671.00
162_L194_L1.1541.00
170_Q205_R1.1531.00
4_M15_T1.1521.00
32_I35_K1.1441.00
252_G256_A1.1401.00
294_D298_E1.1391.00
247_D288_T1.1381.00
81_V120_L1.1371.00
199_Y203_M1.1271.00
183_I253_V1.1201.00
4_M18_V1.1161.00
223_N227_D1.1121.00
175_K326_E1.1061.00
168_A243_F1.0961.00
180_I203_M1.0941.00
38_A41_K1.0901.00
297_G301_I1.0871.00
162_L198_G1.0861.00
182_C196_L1.0861.00
242_V253_V1.0841.00
201_A205_R1.0811.00
247_D272_G1.0721.00
21_V28_V1.0701.00
88_R302_D1.0691.00
82_E86_F1.0651.00
61_T91_S1.0571.00
34_A37_E1.0531.00
221_E224_G1.0531.00
299_L303_V1.0521.00
64_M92_L1.0511.00
86_F103_R1.0481.00
228_A231_Q1.0431.00
61_T93_V1.0411.00
48_S54_L1.0321.00
202_A206_A1.0311.00
88_R309_T1.0261.00
24_K33_T1.0231.00
179_R237_L1.0201.00
203_M208_L1.0151.00
244_T249_M1.0121.00
173_I208_L1.0111.00
40_I43_L1.0091.00
174_D206_A1.0081.00
50_L53_S1.0061.00
132_E136_R1.0041.00
171_Y287_T1.0041.00
298_E302_D1.0031.00
227_D231_Q1.0021.00
199_Y243_F0.9991.00
244_T250_A0.9951.00
225_G229_M0.9871.00
197_E200_R0.9821.00
236_P239_P0.9821.00
105_N109_E0.9801.00
216_V228_A0.9761.00
304_L308_I0.9751.00
303_V318_L0.9701.00
163_L321_T0.9681.00
222_F255_Q0.9681.00
299_L320_L0.9671.00
48_S51_A0.9631.00
11_A18_V0.9631.00
224_G227_D0.9601.00
90_Y305_I0.9591.00
187_L217_T0.9501.00
87_E298_E0.9491.00
103_R106_R0.9471.00
168_A289_I0.9421.00
229_M233_L0.9391.00
254_Y282_M0.9391.00
193_R197_E0.9381.00
180_I241_A0.9351.00
120_L304_L0.9271.00
159_D292_P0.9251.00
190_T194_L0.9241.00
175_K269_A0.9231.00
109_E113_Q0.9171.00
83_R298_E0.9151.00
323_I326_E0.9101.00
62_I120_L0.8931.00
247_D275_D0.8931.00
254_Y264_V0.8931.00
169_T203_M0.8921.00
79_R83_R0.8861.00
173_I178_T0.8801.00
47_P52_R0.8741.00
51_A54_L0.8741.00
188_D193_R0.8731.00
185_G220_F0.8681.00
163_L322_P0.8661.00
24_K37_E0.8631.00
64_M78_V0.8621.00
157_I303_V0.8521.00
81_V297_G0.8511.00
292_P320_L0.8501.00
156_L317_R0.8501.00
227_D230_R0.8481.00
181_A242_V0.8421.00
179_R214_Y0.8421.00
160_N319_Q0.8421.00
160_N321_T0.8411.00
200_R210_I0.8391.00
262_L268_I0.8371.00
161_S195_R0.8361.00
257_L270_V0.8361.00
21_V37_E0.8281.00
159_D322_P0.8271.00
78_V82_E0.8271.00
242_V268_I0.8241.00
258_Y285_P0.8221.00
17_T20_H0.8211.00
233_L256_A0.8201.00
73_F293_K0.8181.00
290_H325_M0.8161.00
158_Q319_Q0.8151.00
100_D103_R0.8151.00
272_G288_T0.8151.00
275_D325_M0.8121.00
31_A34_A0.8111.00
77_L145_M0.8091.00
303_V306_H0.8091.00
131_R134_M0.8071.00
218_G249_M0.8041.00
59_T117_D0.8031.00
159_D291_Q0.7991.00
20_H26_R0.7981.00
184_T196_L0.7981.00
274_D291_Q0.7971.00
76_E294_D0.7941.00
118_G308_I0.7921.00
83_R87_E0.7901.00
172_L271_I0.7881.00
80_G298_E0.7881.00
214_Y235_H0.7851.00
210_I213_G0.7841.00
178_T208_L0.7831.00
183_I244_T0.7831.00
13_V36_V0.7821.00
81_V92_L0.7821.00
67_T74_Y0.7821.00
224_G228_A0.7821.00
292_P323_I0.7761.00
247_D250_A0.7761.00
49_A52_R0.7731.00
201_A204_K0.7721.00
251_V282_M0.7701.00
238_R262_L0.7691.00
16_S20_H0.7641.00
203_M210_I0.7641.00
158_Q317_R0.7641.00
182_C243_F0.7621.00
301_I305_I0.7611.00
31_A35_K0.7571.00
80_G84_S0.7521.00
196_L215_E0.7441.00
61_T114_K0.7431.00
229_M256_A0.7371.00
106_R109_E0.7361.00
194_L198_G0.7351.00
112_M138_P0.7341.00
229_M232_L0.7341.00
155_D303_V0.7341.00
63_G119_L0.7271.00
58_Q117_D0.7231.00
216_V232_L0.7231.00
240_Q269_A0.7221.00
62_I301_I0.7221.00
167_L289_I0.7211.00
46_A113_Q0.7191.00
78_V94_L0.7181.00
98_E103_R0.7171.00
243_F271_I0.7171.00
233_L260_A0.7131.00
155_D316_Q0.7101.00
82_E92_L0.7081.00
58_Q309_T0.7081.00
275_D279_A0.7061.00
255_Q258_Y0.7061.00
171_Y324_L0.7011.00
102_Q106_R0.7011.00
93_V116_V0.7011.00
79_R82_E0.7001.00
216_V235_H0.7001.00
257_L264_V0.6991.00
235_H238_R0.6931.00
231_Q234_S0.6931.00
144_M149_P0.6921.00
144_M154_S0.6921.00
166_D198_G0.6921.00
250_A272_G0.6791.00
21_V33_T0.6791.00
148_A317_R0.6781.00
285_P327_R0.6761.00
279_A282_M0.6761.00
65_L107_N0.6751.00
120_L145_M0.6751.00
229_M252_G0.6751.00
225_G228_A0.6701.00
34_A41_K0.6701.00
180_I240_Q0.6691.00
255_Q285_P0.6691.00
118_G143_V0.6671.00
306_H310_Q0.6641.00
82_E96_N0.6631.00
173_I203_M0.6621.00
146_D191_P0.6601.00
103_R107_N0.6571.00
310_Q313_L0.6551.00
5_K55_K0.6501.00
246_N274_D0.6491.00
235_H239_P0.6491.00
192_A220_F0.6481.00
278_L282_M0.6471.00
182_C199_Y0.6431.00
146_D161_S0.6401.00
112_M140_V0.6401.00
167_L171_Y0.6371.00
132_E135_Q0.6351.00
80_G293_K0.6331.00
142_T154_S0.6321.00
18_V21_V0.6291.00
90_Y117_D0.6271.00
41_K44_N0.6261.00
172_L243_F0.6261.00
18_V40_I0.6241.00
118_G300_A0.6241.00
46_A109_E0.6231.00
35_K38_A0.6201.00
133_I136_R0.6201.00
71_N248_A0.6201.00
220_F245_G0.6201.00
294_D297_G0.6181.00
218_G224_G0.6181.00
7_V18_V0.6171.00
143_V157_I0.6171.00
20_H27_F0.6161.00
27_F32_I0.6151.00
180_I199_Y0.6111.00
131_R136_R0.6101.00
76_E293_K0.6091.00
255_Q259_Q0.6071.00
251_V276_I0.6071.00
108_L119_L0.6061.00
77_L293_K0.6051.00
257_L260_A0.6041.00
254_Y258_Y0.6041.00
143_V304_L0.6011.00
93_V114_K0.6011.00
79_R294_D0.6001.00
109_E133_I0.6001.00
13_V32_I0.5991.00
181_A214_Y0.5981.00
246_N249_M0.5951.00
73_F77_L0.5921.00
243_F273_Y0.5921.00
306_H316_Q0.5921.00
62_I90_Y0.5901.00
168_A241_A0.5891.00
185_G192_A0.5891.00
119_L140_V0.5871.00
143_V307_R0.5871.00
166_D169_T0.5871.00
199_Y210_I0.5871.00
20_H28_V0.5861.00
18_V36_V0.5821.00
25_D28_V0.5821.00
62_I118_G0.5791.00
220_F249_M0.5781.00
161_S194_L0.5771.00
280_S285_P0.5771.00
200_R215_E0.5761.00
258_Y284_P0.5751.00
273_Y291_Q0.5751.00
196_L217_T0.5741.00
90_Y308_I0.5711.00
101_E105_N0.5691.00
200_R212_D0.5671.00
255_Q283_T0.5661.00
223_N226_F0.5661.00
46_A50_L0.5621.00
222_F252_G0.5621.00
62_I308_I0.5591.00
287_T324_L0.5591.00
239_P262_L0.5581.00
307_R310_Q0.5551.00
13_V18_V0.5541.00
258_Y263_Q0.5511.00
251_V278_L0.5501.00
148_A156_L0.5491.00
171_Y271_I0.5491.00
97_T104_M0.5471.00
233_L257_L0.5451.00
282_M285_P0.5451.00
11_A21_V0.5451.00
143_V300_A0.5431.00
262_L265_P0.5431.00
279_A288_T0.5391.00
244_T272_G0.5391.00
111_L116_V0.5391.00
85_C90_Y0.5391.00
143_V303_V0.5381.00
228_A232_L0.5371.00
279_A286_L0.5371.00
72_P248_A0.5371.00
303_V307_R0.5361.00
296_L320_L0.5351.00
157_I299_L0.5351.00
226_F252_G0.5351.00
247_D276_I0.5341.00
253_V257_L0.5341.00
192_A245_G0.5341.00
59_T91_S0.5321.00
16_S25_D0.5311.00
184_T217_T0.5291.00
85_C305_I0.5291.00
264_V267_D0.5281.00
179_R239_P0.5281.00
299_L306_H0.5251.00
144_M156_L0.5251.00
159_D164_G0.5241.00
189_K192_A0.5211.00
195_R291_Q0.5201.00
95_C110_T0.5191.00
287_T326_E0.5181.00
159_D273_Y0.5181.00
179_R236_P0.5171.00
109_E112_M0.5161.00
11_A36_V0.5161.00
292_P296_L0.5141.00
179_R209_N0.5131.00
52_R56_L0.5121.00
116_V119_L0.5121.00
84_S305_I0.5111.00
74_Y122_L0.5101.00
28_V33_T0.5091.00
59_T90_Y0.5071.00
239_P242_V0.5071.00
222_F278_L0.5071.00
196_L210_I0.5071.00
24_K27_F0.5061.00
79_R98_E0.5061.00
210_I215_E0.5061.00
241_A269_A0.5041.00
255_Q280_S0.5041.00
161_S191_P0.5041.00
226_F229_M0.5001.00
76_E277_E0.5001.00
99_G147_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8273 100 0.044 Contact Map
2hsgA 1 0.9879 100 0.048 Contact Map
2o20A 2 0.8303 100 0.053 Contact Map
1qpzA 2 0.997 100 0.055 Contact Map
4o5aA 2 0.8061 100 0.066 Contact Map
3bilA 2 0.7667 100 0.067 Contact Map
3kjxA 2 0.997 100 0.068 Contact Map
3ctpA 2 0.797 100 0.069 Contact Map
3e3mA 2 0.803 100 0.071 Contact Map
1jyeA 2 0.8091 100 0.075 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.