GREMLIN Database
PURR - HTH-type transcriptional repressor PurR
UniProt: P0ACP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10800
Length: 341 (325)
Sequences: 36683 (26666)
Seq/√Len: 1479.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_H241_T3.4851.00
163_F202_K3.4251.00
10_R42_E3.1881.00
264_R267_Q3.0871.00
169_A272_I2.6541.00
118_G305_L2.5871.00
276_N291_H2.5831.00
155_T308_R2.5711.00
178_H270_S2.4961.00
197_L201_M2.4561.00
167_Y206_E2.3511.00
227_Y260_E2.2461.00
84_N87_Q2.2081.00
38_A42_E2.2061.00
34_N38_A2.1881.00
30_E34_N2.1781.00
84_N303_N2.1741.00
300_T303_N2.0821.00
167_Y202_K2.0521.00
258_A269_V2.0491.00
80_A298_G2.0321.00
174_I207_A2.0211.00
231_Q261_M2.0041.00
166_G170_G1.9991.00
85_C302_F1.9971.00
226_G253_G1.9921.00
176_R331_V1.9871.00
171_R175_E1.9691.00
165_G274_Y1.9661.00
167_Y203_A1.9541.00
235_S261_M1.9421.00
33_R37_W1.9161.00
164_E168_M1.8971.00
307_D312_K1.8951.00
21_V36_V1.8941.00
171_R203_A1.8451.00
22_I40_I1.8431.00
163_F198_A1.8321.00
231_Q257_A1.8011.00
83_K295_D1.7861.00
166_G244_F1.7851.00
291_H324_R1.7411.00
5_K15_T1.7401.00
173_L242_A1.7341.00
263_L268_D1.7141.00
84_N299_E1.7121.00
167_Y171_R1.7071.00
227_Y257_A1.6851.00
180_E212_P1.6811.00
171_R207_A1.6561.00
63_G116_V1.6411.00
170_G200_F1.6381.00
293_P296_S1.6261.00
11_A39_A1.6041.00
230_M254_A1.6001.00
80_A295_D1.5941.00
168_M323_P1.5941.00
264_R268_D1.5811.00
21_V40_I1.5501.00
230_M243_V1.5401.00
183_V246_G1.5391.00
276_N328_R1.5311.00
182_G240_P1.5291.00
286_A329_R1.5261.00
10_R39_A1.5141.00
145_M301_A1.5011.00
300_T319_I1.4981.00
198_A202_K1.4921.00
160_D164_E1.4911.00
245_C254_A1.4871.00
7_V39_A1.4851.00
37_W41_K1.4711.00
180_E239_R1.4711.00
84_N88_K1.4661.00
172_Y176_R1.4561.00
174_I203_A1.4521.00
170_G174_I1.4491.00
257_A261_M1.4411.00
164_E167_Y1.4391.00
84_N302_F1.4341.00
259_D284_T1.4261.00
37_W40_I1.4141.00
88_K306_L1.3971.00
170_G199_G1.3911.00
217_V232_Q1.3901.00
296_S300_T1.3901.00
165_G323_P1.3901.00
231_Q260_E1.3881.00
195_G198_A1.3761.00
166_G199_G1.3721.00
272_I288_T1.3711.00
296_S299_E1.3571.00
172_Y175_E1.3551.00
201_M205_E1.3491.00
178_H242_A1.3471.00
7_V11_A1.3441.00
257_A260_E1.3421.00
258_A263_L1.3381.00
62_I85_C1.3161.00
63_G111_M1.3151.00
182_G233_I1.3141.00
60_K117_D1.3071.00
170_G203_A1.3071.00
172_Y331_V1.3051.00
227_Y256_C1.3001.00
212_P215_W1.2981.00
303_N307_D1.2961.00
172_Y327_E1.2941.00
199_G203_A1.2851.00
227_Y231_Q1.2691.00
132_A136_E1.2681.00
180_E241_T1.2601.00
60_K90_Y1.2581.00
64_L81_V1.2451.00
29_A32_T1.2401.00
171_R206_E1.2361.00
6_D9_K1.2311.00
230_M258_A1.2311.00
95_G111_M1.2211.00
85_C92_L1.2201.00
255_L271_L1.2161.00
39_A43_L1.2151.00
306_L310_V1.2111.00
30_E33_R1.2101.00
20_H25_T1.2091.00
220_D225_S1.2081.00
184_I254_A1.2041.00
237_P240_P1.1991.00
5_K9_K1.1961.00
203_A206_E1.1921.00
10_R43_L1.1901.00
253_G257_A1.1831.00
120_L301_A1.1811.00
7_V43_L1.1781.00
81_V120_L1.1771.00
179_R241_T1.1691.00
109_S133_M1.1671.00
248_D289_T1.1611.00
270_S331_V1.1551.00
81_V302_F1.1551.00
163_F195_G1.1531.00
95_G107_Y1.1511.00
168_M171_R1.1491.00
200_F204_M1.1481.00
4_I18_V1.1451.00
232_Q236_Q1.1381.00
163_F167_Y1.1371.00
231_Q235_S1.1321.00
35_A39_A1.1201.00
224_E228_R1.1071.00
64_L92_L1.1051.00
243_V254_A1.1021.00
39_A42_E1.0991.00
4_I15_T1.0941.00
48_S54_L1.0871.00
226_G230_M1.0841.00
181_I204_M1.0831.00
202_K206_E1.0791.00
248_D273_G1.0781.00
163_F199_G1.0731.00
174_I209_I1.0711.00
295_D299_E1.0701.00
32_T35_A1.0671.00
82_E86_F1.0641.00
169_A244_F1.0591.00
88_K303_N1.0561.00
175_E207_A1.0511.00
176_R327_E1.0491.00
228_R232_Q1.0461.00
204_M209_I1.0441.00
298_G302_F1.0411.00
183_V197_L1.0401.00
176_R270_S1.0391.00
48_S51_A1.0341.00
200_F244_F1.0321.00
38_A41_K1.0301.00
21_V28_V1.0261.00
304_M319_I1.0261.00
300_T304_M1.0081.00
180_E238_H1.0061.00
105_R109_S0.9991.00
255_L265_V0.9981.00
293_P321_V0.9941.00
61_S91_T0.9901.00
222_E225_S0.9901.00
245_C251_A0.9841.00
186_G221_F0.9811.00
24_K33_R0.9791.00
217_V229_A0.9771.00
40_I43_L0.9721.00
34_N37_W0.9721.00
83_K299_E0.9711.00
203_A207_A0.9661.00
88_K310_V0.9651.00
273_G289_T0.9641.00
50_V53_S0.9631.00
181_I242_A0.9581.00
219_G250_M0.9531.00
61_S93_I0.9461.00
103_K106_A0.9441.00
245_C250_M0.9411.00
86_F103_K0.9401.00
51_A54_L0.9381.00
64_L78_I0.9341.00
188_L218_Q0.9311.00
169_A290_I0.9311.00
299_E303_N0.9291.00
159_I293_P0.9271.00
198_A201_M0.9261.00
189_E194_A0.9251.00
255_L283_F0.9241.00
305_L309_I0.9221.00
300_T321_V0.9211.00
230_M234_L0.9201.00
87_Q299_E0.9191.00
172_Y288_T0.9161.00
229_A232_Q0.9101.00
194_A198_A0.9071.00
225_S228_R0.9061.00
90_Y306_L0.9051.00
81_V298_G0.9051.00
160_D320_E0.9021.00
47_P52_R0.8971.00
109_S113_Q0.8951.00
120_L305_L0.8891.00
11_A18_V0.8831.00
170_G204_M0.8831.00
223_P256_C0.8821.00
248_D276_N0.8811.00
258_A271_L0.8701.00
59_T117_D0.8681.00
248_D251_A0.8651.00
157_A304_M0.8591.00
180_E215_W0.8561.00
234_L257_A0.8561.00
79_E83_K0.8531.00
275_D292_Q0.8531.00
324_R327_E0.8511.00
62_I120_L0.8501.00
291_H326_I0.8491.00
159_I292_Q0.8441.00
327_E331_V0.8401.00
164_E322_H0.8401.00
182_G243_V0.8391.00
155_T317_Q0.8371.00
191_N195_G0.8341.00
263_L269_V0.8311.00
228_R231_Q0.8291.00
259_D286_A0.8261.00
164_E323_P0.8251.00
159_I323_P0.8221.00
156_D318_S0.8191.00
81_V92_L0.8161.00
128_E132_A0.8151.00
118_G309_I0.8131.00
155_T304_M0.8121.00
24_K37_W0.8121.00
252_M283_F0.8101.00
174_I179_R0.8091.00
239_R263_L0.8051.00
241_T270_S0.8051.00
73_Y294_K0.8021.00
31_E34_N0.8011.00
172_Y325_L0.7981.00
80_A299_E0.7961.00
76_E295_D0.7951.00
201_M211_V0.7941.00
17_T20_H0.7931.00
215_W236_Q0.7931.00
21_V37_W0.7921.00
197_L216_I0.7921.00
293_P324_R0.7921.00
183_V244_F0.7911.00
202_K205_E0.7871.00
276_N326_I0.7851.00
67_T74_F0.7821.00
161_N196_R0.7811.00
160_D322_H0.7801.00
225_S229_A0.7741.00
63_G119_L0.7671.00
276_N280_A0.7661.00
243_V269_V0.7651.00
179_R209_I0.7611.00
288_T331_V0.7601.00
31_E35_A0.7591.00
173_L272_I0.7561.00
134_L142_M0.7561.00
230_M233_I0.7541.00
58_H117_D0.7531.00
133_M136_E0.7521.00
158_V320_E0.7521.00
49_A52_R0.7481.00
46_S113_Q0.7471.00
83_K87_Q0.7461.00
78_I82_E0.7461.00
219_G225_S0.7451.00
236_Q240_P0.7451.00
304_M307_D0.7441.00
61_S114_K0.7431.00
204_M211_V0.7421.00
302_F306_L0.7411.00
217_V233_I0.7381.00
100_N103_K0.7371.00
184_I245_C0.7361.00
195_G199_G0.7351.00
77_I145_M0.7331.00
236_Q239_R0.7331.00
20_H27_F0.7291.00
230_M257_A0.7251.00
112_A140_I0.7221.00
106_A109_S0.7211.00
20_H26_R0.7211.00
230_M253_G0.7201.00
13_V36_V0.7201.00
78_I94_L0.7171.00
103_K107_Y0.7171.00
80_A84_N0.7161.00
168_M290_I0.7131.00
118_G143_V0.7131.00
288_T325_L0.7101.00
234_L261_M0.7101.00
79_E82_E0.7011.00
112_A138_R0.7001.00
185_P197_L0.7001.00
244_F272_I0.6971.00
167_Y199_G0.6951.00
58_H310_V0.6951.00
62_I302_F0.6951.00
34_N41_K0.6921.00
256_C259_D0.6891.00
144_V149_E0.6851.00
16_T20_H0.6841.00
132_A135_E0.6831.00
82_E92_L0.6831.00
232_Q235_S0.6821.00
158_V318_S0.6821.00
102_E106_A0.6791.00
146_D161_N0.6781.00
226_G229_A0.6761.00
181_I200_F0.6761.00
174_I204_M0.6731.00
65_L107_Y0.6731.00
148_G318_S0.6721.00
98_W103_K0.6701.00
135_E154_F0.6681.00
307_D311_N0.6661.00
82_E96_N0.6661.00
251_A273_G0.6611.00
295_D298_G0.6591.00
258_A261_M0.6581.00
108_L119_L0.6581.00
120_L145_M0.6571.00
5_K55_K0.6561.00
247_G275_D0.6551.00
97_A104_Q0.6541.00
193_G221_F0.6541.00
143_V157_A0.6501.00
307_D317_Q0.6491.00
18_V21_V0.6481.00
93_I116_V0.6471.00
258_A265_V0.6461.00
27_F32_T0.6421.00
211_V216_I0.6421.00
280_A289_T0.6391.00
71_A249_I0.6391.00
41_K44_H0.6331.00
146_D192_T0.6321.00
186_G193_G0.6311.00
252_M277_V0.6291.00
256_C286_A0.6291.00
181_I241_T0.6281.00
46_S109_S0.6271.00
118_G301_A0.6251.00
173_L244_F0.6241.00
77_I294_K0.6221.00
129_P132_A0.6171.00
161_N195_G0.6161.00
221_F246_G0.6151.00
169_A242_A0.6141.00
80_A294_K0.6141.00
217_V236_Q0.6131.00
90_Y309_I0.6121.00
288_T327_E0.6121.00
35_A38_A0.6121.00
7_V18_V0.6111.00
256_C260_E0.6101.00
21_V33_R0.6091.00
73_Y77_I0.6081.00
285_P330_S0.6041.00
167_Y170_G0.6031.00
201_M213_E0.6031.00
221_F250_M0.6011.00
286_A328_R0.6001.00
272_I331_V0.5991.00
180_E240_P0.5981.00
20_H28_V0.5981.00
297_L321_V0.5951.00
308_R311_N0.5931.00
62_I90_Y0.5931.00
245_C273_G0.5931.00
18_V40_I0.5911.00
155_T316_P0.5881.00
79_E295_D0.5871.00
144_V154_F0.5871.00
240_P263_L0.5861.00
182_G215_W0.5861.00
135_E142_M0.5851.00
85_C306_L0.5841.00
183_V200_F0.5841.00
90_Y117_D0.5821.00
143_V305_L0.5811.00
116_V119_L0.5811.00
244_F274_Y0.5791.00
280_A287_L0.5771.00
168_M172_Y0.5761.00
18_V36_V0.5751.00
76_E294_K0.5751.00
176_R241_T0.5741.00
93_I114_K0.5741.00
135_E153_D0.5741.00
142_M154_F0.5721.00
143_V308_R0.5711.00
130_L133_M0.5681.00
11_A21_V0.5681.00
274_Y292_Q0.5681.00
159_I165_G0.5681.00
71_A74_F0.5671.00
223_P279_N0.5661.00
211_V214_S0.5651.00
247_G250_M0.5641.00
111_M116_V0.5641.00
79_E98_W0.5601.00
223_P253_G0.5601.00
234_L258_A0.5591.00
143_V304_M0.5591.00
224_E227_Y0.5581.00
143_V301_A0.5561.00
25_T28_V0.5521.00
229_A233_I0.5481.00
62_I118_G0.5471.00
105_R130_L0.5451.00
259_D264_R0.5451.00
276_N281_R0.5441.00
225_S250_M0.5441.00
252_M279_N0.5431.00
72_A249_I0.5421.00
62_I309_I0.5411.00
227_Y253_G0.5401.00
13_V18_V0.5381.00
255_L259_D0.5381.00
219_G226_G0.5361.00
46_S50_V0.5341.00
185_P218_Q0.5341.00
13_V32_T0.5331.00
180_E210_K0.5281.00
196_R292_Q0.5241.00
197_L218_Q0.5241.00
281_R286_A0.5241.00
260_E284_T0.5241.00
220_D250_M0.5231.00
157_A300_T0.5221.00
84_N306_L0.5221.00
53_S56_V0.5221.00
304_M308_R0.5211.00
311_N314_E0.5201.00
180_E237_P0.5191.00
283_F286_A0.5191.00
44_H47_P0.5191.00
99_N147_W0.5181.00
193_G246_G0.5171.00
277_V289_T0.5161.00
28_V33_R0.5161.00
308_R312_K0.5141.00
172_Y272_I0.5131.00
256_C284_T0.5121.00
16_T25_T0.5111.00
68_S79_E0.5111.00
24_K27_F0.5071.00
200_F211_V0.5071.00
170_G207_A0.5061.00
159_I274_Y0.5061.00
265_V268_D0.5051.00
254_A258_A0.5041.00
101_L105_R0.5031.00
201_M216_I0.5031.00
227_Y230_M0.5031.00
97_A107_Y0.5031.00
59_T90_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qpzA 2 0.9883 100 0.059 Contact Map
3dbiA 2 0.8094 100 0.06 Contact Map
2hsgA 1 0.9589 100 0.065 Contact Map
2o20A 2 0.8065 100 0.073 Contact Map
4o5aA 2 0.7889 100 0.076 Contact Map
3bilA 2 0.7507 100 0.079 Contact Map
3ctpA 2 0.7771 100 0.081 Contact Map
3kjxA 2 0.9707 100 0.082 Contact Map
3e3mA 2 0.7859 100 0.085 Contact Map
3h5oA 2 0.7918 100 0.087 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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