GREMLIN Database
GNTR - HTH-type transcriptional regulator GntR
UniProt: P0ACP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12630
Length: 331 (321)
Sequences: 36279 (26190)
Seq/√Len: 1461.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_F203_Q3.4231.00
180_H241_D3.2871.00
14_R46_E3.1541.00
264_K267_D3.1211.00
171_M272_A2.6491.00
198_Q202_E2.6191.00
122_G305_L2.6001.00
180_H270_A2.5691.00
276_G291_L2.5181.00
169_R207_D2.3771.00
34_V38_G2.2691.00
227_I260_R2.2591.00
88_V91_A2.2361.00
42_A46_E2.2321.00
38_G42_A2.2031.00
158_I308_R2.2031.00
88_V303_E2.1601.00
231_R261_L2.1331.00
300_I303_E2.0941.00
169_R203_Q2.0721.00
176_I208_A2.0421.00
169_R204_A2.0371.00
173_T204_A2.0371.00
166_E170_Q2.0271.00
231_R257_E2.0081.00
25_F40_I1.9661.00
89_T302_A1.9591.00
165_F199_K1.9161.00
37_R41_A1.9141.00
173_T177_A1.8911.00
168_A172_T1.8911.00
26_L44_L1.8881.00
167_A274_F1.8861.00
84_G298_G1.8831.00
88_V299_S1.8701.00
9_Q19_K1.8411.00
307_A312_E1.8371.00
175_I242_G1.8331.00
226_G253_G1.8261.00
235_R261_L1.8221.00
258_C269_M1.8161.00
168_A244_F1.8051.00
172_T201_Y1.7931.00
291_L324_T1.7811.00
87_S295_E1.7701.00
173_T208_A1.7461.00
169_R173_T1.7121.00
15_V43_A1.6971.00
227_I257_E1.6861.00
14_R43_A1.6841.00
184_A240_L1.6521.00
263_L268_D1.6471.00
230_I254_A1.6471.00
67_G120_I1.6431.00
170_Q323_F1.6401.00
293_P296_R1.6391.00
185_Y246_T1.6381.00
174_A178_R1.6351.00
84_G295_E1.6261.00
300_I319_L1.6221.00
245_C254_A1.6181.00
264_K268_D1.5861.00
182_H239_Q1.5771.00
257_E261_L1.5531.00
41_A45_D1.5311.00
148_L301_G1.5281.00
166_E169_R1.5181.00
88_V92_H1.5101.00
199_K203_Q1.5081.00
296_R300_I1.5011.00
176_I204_A1.4911.00
174_A177_A1.4861.00
163_D166_E1.4821.00
25_F44_L1.4661.00
259_Q284_E1.4591.00
257_E260_R1.4481.00
41_A44_L1.4371.00
217_V232_Q1.4331.00
11_V43_A1.4321.00
92_H306_L1.4251.00
196_I199_K1.4191.00
272_A288_A1.4141.00
64_R121_D1.4111.00
276_G328_G1.4071.00
202_E206_L1.4041.00
296_R299_S1.4021.00
88_V302_A1.3761.00
220_S225_S1.3751.00
174_A327_P1.3461.00
172_T176_I1.3431.00
258_C263_L1.3391.00
227_I231_R1.3311.00
167_A323_F1.3211.00
230_I243_V1.3201.00
204_A207_D1.3191.00
306_L310_R1.3161.00
231_R260_R1.3141.00
227_I256_F1.3131.00
182_H241_D1.3101.00
184_A233_A1.3081.00
136_K140_V1.2921.00
9_Q13_D1.2901.00
182_H213_Y1.2881.00
172_T200_G1.2871.00
172_T204_A1.2871.00
10_D13_D1.2831.00
168_A200_G1.2831.00
14_R47_L1.2811.00
303_E307_A1.2771.00
66_I89_T1.2771.00
180_H242_G1.2761.00
64_R94_Y1.2751.00
34_V37_R1.2701.00
231_R235_R1.2511.00
33_S36_L1.2501.00
67_G115_M1.2491.00
230_I258_C1.2461.00
24_R29_P1.2391.00
255_A271_I1.2301.00
200_G204_A1.2291.00
165_F169_R1.2251.00
39_K43_A1.2251.00
11_V15_V1.2131.00
89_T96_T1.2071.00
124_I301_G1.2031.00
170_Q173_T1.2011.00
99_A115_M1.2001.00
43_A46_E1.1991.00
43_A47_L1.1961.00
8_L19_K1.1921.00
173_T207_D1.1901.00
181_R241_D1.1861.00
99_A111_R1.1841.00
165_F196_I1.1811.00
85_I124_I1.1791.00
85_I302_A1.1721.00
68_V85_I1.1651.00
232_Q236_E1.1601.00
36_L39_K1.1571.00
113_E137_M1.1531.00
224_S228_E1.1491.00
11_V47_L1.1361.00
295_E299_S1.1331.00
186_L254_A1.1291.00
201_Y205_M1.1271.00
237_Y240_L1.1101.00
253_G257_E1.1081.00
42_A45_D1.0971.00
183_I205_M1.0901.00
203_Q207_D1.0841.00
165_F200_G1.0821.00
92_H303_E1.0801.00
65_A95_Q1.0771.00
171_M244_F1.0761.00
68_V96_T1.0761.00
178_R327_P1.0701.00
205_M210_L1.0661.00
243_V254_A1.0651.00
86_E90_D1.0621.00
38_G41_A1.0601.00
300_I304_R1.0591.00
204_A208_A1.0581.00
248_D289_S1.0581.00
25_F32_V1.0551.00
185_Y198_Q1.0551.00
298_G302_A1.0541.00
8_L22_V1.0531.00
222_S225_S1.0521.00
92_H310_R1.0511.00
65_A97_M1.0481.00
90_D107_M1.0411.00
109_Q113_E1.0401.00
229_L232_Q1.0381.00
182_H238_P1.0261.00
28_N37_R1.0251.00
199_K202_E1.0241.00
176_I210_L1.0231.00
248_D273_G1.0211.00
174_A288_A1.0211.00
226_G230_I1.0171.00
177_A208_A1.0141.00
201_Y244_F1.0131.00
209_G212_P1.0121.00
299_S303_E1.0071.00
282_V285_P1.0001.00
245_C251_A0.9991.00
245_C250_L0.9941.00
44_L47_L0.9931.00
225_S228_E0.9901.00
52_N58_L0.9891.00
228_E232_Q0.9851.00
54_A57_I0.9851.00
107_M110_E0.9801.00
304_R319_L0.9721.00
195_I199_K0.9691.00
305_L309_I0.9691.00
166_E322_G0.9681.00
300_I321_L0.9611.00
94_Y306_L0.9611.00
283_M286_R0.9601.00
91_A299_S0.9511.00
15_V22_V0.9491.00
188_A221_S0.9461.00
223_Y256_F0.9371.00
113_E117_S0.9321.00
178_R270_A0.9301.00
183_I242_G0.9271.00
255_A283_M0.9251.00
230_I234_R0.9241.00
171_M290_V0.9241.00
205_M212_P0.9221.00
255_A265_V0.9201.00
52_N55_P0.9161.00
217_V229_L0.9161.00
202_E212_P0.9121.00
87_S299_S0.9091.00
176_I181_R0.9061.00
259_Q286_R0.8981.00
172_T205_M0.8981.00
124_I305_L0.8971.00
324_T327_P0.8951.00
181_R210_L0.8941.00
293_P321_L0.8811.00
66_I124_I0.8801.00
83_R87_S0.8791.00
68_V82_L0.8751.00
162_F293_P0.8731.00
159_A318_M0.8731.00
28_N41_A0.8721.00
55_P58_L0.8711.00
190_L218_E0.8681.00
85_I298_G0.8661.00
166_E323_F0.8581.00
234_R257_E0.8521.00
184_A243_V0.8511.00
51_P56_D0.8501.00
82_L86_E0.8471.00
163_D322_G0.8471.00
243_V269_M0.8471.00
160_V304_R0.8441.00
258_C271_I0.8401.00
163_D320_D0.8351.00
132_P136_K0.8311.00
219_Q250_L0.8301.00
263_L269_M0.8291.00
248_D276_G0.8271.00
25_F41_A0.8261.00
162_F323_F0.8211.00
304_R307_A0.8211.00
164_N197_K0.8191.00
228_E231_R0.8191.00
7_V10_D0.8091.00
81_V148_L0.8081.00
273_G289_S0.8051.00
35_A38_G0.8051.00
239_Q263_L0.8021.00
291_L326_S0.8021.00
77_V294_R0.8021.00
122_G309_I0.7991.00
210_L213_Y0.7991.00
293_P324_T0.7971.00
63_S121_D0.7951.00
80_E295_E0.7941.00
161_G320_D0.7941.00
203_Q206_L0.7921.00
162_F292_T0.7881.00
85_I96_T0.7881.00
187_G198_Q0.7851.00
302_A306_L0.7851.00
225_S229_L0.7841.00
137_M140_V0.7781.00
17_V40_I0.7761.00
276_G326_S0.7671.00
87_S91_A0.7651.00
104_K107_M0.7611.00
53_R56_D0.7611.00
84_G299_S0.7601.00
161_G318_M0.7591.00
65_A118_W0.7561.00
186_L245_C0.7561.00
196_I200_G0.7541.00
21_T24_R0.7531.00
84_G88_V0.7531.00
182_H215_V0.7521.00
175_I272_A0.7501.00
230_I233_A0.7491.00
35_A39_K0.7481.00
82_L98_L0.7481.00
185_Y244_F0.7481.00
230_I257_E0.7431.00
71_P78_F0.7431.00
191_D195_I0.7411.00
20_M24_R0.7381.00
241_D270_A0.7301.00
252_V283_M0.7281.00
50_I117_S0.7261.00
234_R261_L0.7251.00
110_E113_E0.7211.00
62_T121_D0.7211.00
170_Q290_V0.7211.00
275_H292_T0.7201.00
66_I302_A0.7191.00
215_V236_E0.7181.00
193_R196_I0.7171.00
158_I317_K0.7171.00
256_F259_Q0.7171.00
248_D251_A0.7171.00
67_G123_L0.7141.00
24_R30_E0.7131.00
116_L141_A0.7131.00
174_A325_L0.7081.00
83_R86_E0.7071.00
102_G107_M0.7061.00
86_E96_T0.7061.00
217_V233_A0.7061.00
251_A273_G0.7051.00
281_Q286_R0.7001.00
151_S318_M0.6991.00
244_F272_A0.6991.00
97_M120_I0.6981.00
24_R31_Q0.6971.00
276_G280_G0.6951.00
256_F286_R0.6931.00
107_M111_R0.6931.00
258_C265_V0.6911.00
198_Q216_M0.6891.00
307_A311_G0.6831.00
147_E152_K0.6821.00
219_Q225_S0.6811.00
226_G229_L0.6801.00
232_Q235_R0.6791.00
158_I304_R0.6781.00
139_E145_V0.6721.00
136_K139_E0.6721.00
169_R200_G0.6721.00
236_E239_Q0.6691.00
138_I145_V0.6681.00
106_E110_E0.6681.00
176_I205_M0.6671.00
25_F37_R0.6631.00
69_L111_R0.6621.00
38_G45_D0.6611.00
86_E100_H0.6601.00
183_I241_D0.6551.00
124_I148_L0.6541.00
147_E157_D0.6541.00
247_N275_H0.6511.00
170_Q174_A0.6501.00
62_T310_R0.6491.00
236_E240_L0.6461.00
122_G146_V0.6461.00
217_V236_E0.6451.00
139_E156_L0.6441.00
182_H212_P0.6421.00
50_I113_E0.6411.00
210_L214_S0.6411.00
286_R328_G0.6371.00
9_Q59_S0.6301.00
112_L123_L0.6291.00
256_F260_R0.6271.00
146_V305_L0.6251.00
146_V308_R0.6211.00
83_R295_E0.6201.00
75_N249_D0.6191.00
31_Q36_L0.6181.00
282_V286_R0.6161.00
122_G301_G0.6151.00
221_S246_T0.6141.00
11_V22_V0.6141.00
17_V36_L0.6141.00
39_K42_A0.6141.00
116_L143_I0.6131.00
45_D48_G0.6121.00
212_P216_M0.6111.00
175_I244_F0.6071.00
149_M164_N0.6071.00
97_M118_W0.6071.00
230_I253_G0.6071.00
307_A317_K0.6051.00
185_Y201_Y0.6041.00
84_G294_R0.6041.00
252_V279_I0.6011.00
258_C261_L0.5991.00
22_V25_F0.5981.00
169_R172_T0.5961.00
134_T137_M0.5961.00
146_V160_V0.5951.00
183_I201_Y0.5941.00
80_E294_R0.5891.00
94_Y309_I0.5881.00
201_Y212_P0.5881.00
247_N250_L0.5881.00
255_A259_Q0.5851.00
133_R136_K0.5841.00
164_N196_I0.5821.00
288_A325_L0.5811.00
109_Q134_T0.5801.00
223_Y279_I0.5801.00
24_R32_V0.5781.00
295_E298_G0.5781.00
252_V277_H0.5741.00
280_G289_S0.5741.00
81_V294_R0.5721.00
281_Q285_P0.5711.00
256_F284_E0.5701.00
224_S227_I0.5701.00
259_Q264_K0.5701.00
22_V44_L0.5691.00
145_V157_D0.5681.00
308_R311_G0.5671.00
66_I122_G0.5671.00
66_I309_I0.5621.00
146_V304_R0.5611.00
244_F274_F0.5611.00
94_Y121_D0.5601.00
223_Y253_G0.5581.00
174_A272_A0.5561.00
66_I94_Y0.5551.00
77_V81_V0.5541.00
63_S95_Q0.5541.00
274_F292_T0.5531.00
280_G287_L0.5501.00
171_M242_G0.5481.00
101_Y108_E0.5471.00
229_L233_A0.5451.00
105_P109_Q0.5441.00
99_A114_S0.5431.00
32_V37_R0.5431.00
123_L143_I0.5421.00
160_V300_I0.5401.00
149_M194_T0.5391.00
146_V301_G0.5381.00
245_C273_G0.5371.00
184_A215_V0.5371.00
209_G213_Y0.5351.00
221_S250_L0.5351.00
151_S159_A0.5351.00
304_R308_R0.5331.00
22_V40_I0.5331.00
182_H240_L0.5321.00
28_N31_Q0.5311.00
115_M120_I0.5311.00
50_I54_A0.5311.00
265_V268_D0.5301.00
89_T94_Y0.5301.00
234_R258_C0.5281.00
297_M321_L0.5271.00
263_L266_P0.5271.00
227_I253_G0.5261.00
208_A211_V0.5251.00
83_R102_G0.5251.00
300_I307_A0.5231.00
65_A121_D0.5201.00
56_D60_N0.5201.00
29_P32_V0.5191.00
17_V22_V0.5191.00
76_Q249_D0.5171.00
113_E116_L0.5171.00
120_I123_L0.5161.00
240_L243_V0.5141.00
147_E159_A0.5141.00
162_F274_F0.5131.00
78_F126_T0.5121.00
254_A258_C0.5121.00
88_V306_L0.5121.00
137_M141_A0.5111.00
227_I230_I0.5111.00
15_V40_I0.5101.00
15_V25_F0.5101.00
162_F167_A0.5091.00
89_T306_L0.5081.00
182_H237_Y0.5061.00
215_V218_E0.5051.00
219_Q226_G0.5051.00
320_D323_F0.5031.00
202_E216_M0.5031.00
248_D277_H0.5021.00
85_I89_T0.5021.00
20_M29_P0.5021.00
168_A201_Y0.5021.00
256_F281_Q0.5001.00
63_S94_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o20A 2 0.8218 100 0.051 Contact Map
2hsgA 1 0.9789 100 0.063 Contact Map
3kjxA 2 0.994 100 0.069 Contact Map
3bilA 2 0.7613 100 0.071 Contact Map
3h5oA 2 0.8066 100 0.071 Contact Map
3dbiA 2 0.8157 100 0.072 Contact Map
3e3mA 2 0.7946 100 0.074 Contact Map
1qpzA 2 0.9849 100 0.075 Contact Map
4o5aA 2 0.7976 100 0.076 Contact Map
3jvdA 2 0.7795 100 0.085 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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