CRA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CRA - Catabolite repressor/activator

UniProt:	P0ACP1	Sequences: MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVHFLYANSYEREAAAQLFEKWLETHPMPQALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10338
Length:	334 (321)
Sequences:	37197 (26686)
Seq/√Len:	1489.5

ECOLI - CRA GALR LACI GALS IDNR CYTR MALI GNTR PURR ASCG RBSR YCJW EBGR TRER TORT ALSB YTFQ RBSB XYLF ARAF YPHF LSRB DGAL XYLR
BACSU - CCPA KDGR RBSR DEGA NTDR EXUR YKVZ MSMR GANR YVDE ARAR CCPB RBSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_Q	203_T	3.309	1.00
179_A	240_Q	3.127	1.00
9_L	44_E	3.080	1.00
263_K	266_S	3.002	1.00
120_A	304_V	2.593	1.00
170_L	271_A	2.592	1.00
198_E	202_R	2.570	1.00
179_A	269_A	2.469	1.00
275_D	290_A	2.425	1.00
157_T	307_S	2.364	1.00
168_E	207_D	2.256	1.00
32_D	36_E	2.228	1.00
40_A	44_E	2.210	1.00
86_Q	89_Q	2.189	1.00
226_A	259_R	2.175	1.00
36_E	40_A	2.135	1.00
86_Q	302_E	2.116	1.00
230_E	260_R	2.108	1.00
172_E	204_A	2.042	1.00
168_E	203_T	2.039	1.00
168_E	204_A	2.039	1.00
299_R	302_E	2.023	1.00
165_D	169_M	2.016	1.00
175_R	208_D	2.004	1.00
230_E	256_V	2.000	1.00
87_A	301_L	1.951	1.00
20_V	38_V	1.944	1.00
35_V	39_M	1.894	1.00
166_D	273_F	1.874	1.00
164_Q	199_Q	1.867	1.00
24_K	29_R	1.860	1.00
82_Y	297_A	1.859	1.00
167_A	171_A	1.857	1.00
86_Q	298_E	1.856	1.00
4_D	14_R	1.852	1.00
21_I	42_V	1.841	1.00
174_L	241_A	1.836	1.00
172_E	176_K	1.823	1.00
234_E	260_R	1.803	1.00
225_A	252_G	1.771	1.00
257_T	268_L	1.763	1.00
306_A	311_P	1.762	1.00
290_A	324_N	1.760	1.00
167_A	243_F	1.758	1.00
171_A	201_F	1.743	1.00
85_R	294_R	1.735	1.00
9_L	41_V	1.725	1.00
172_E	208_D	1.710	1.00
168_E	172_E	1.693	1.00
10_A	41_V	1.683	1.00
226_A	256_V	1.669	1.00
229_F	253_V	1.665	1.00
183_L	239_P	1.657	1.00
65_G	118_V	1.657	1.00
299_R	319_T	1.653	1.00
173_E	177_F	1.647	1.00
262_G	267_D	1.642	1.00
285_P	329_G	1.637	1.00
292_R	295_D	1.627	1.00
244_T	253_V	1.623	1.00
184_Y	245_T	1.620	1.00
82_Y	294_R	1.619	1.00
86_Q	90_R	1.607	1.00
169_M	323_R	1.600	1.00
256_V	260_R	1.573	1.00
147_L	300_V	1.543	1.00
263_K	267_D	1.542	1.00
258_L	283_Q	1.539	1.00
165_D	168_E	1.517	1.00
39_M	43_R	1.514	1.00
199_Q	203_T	1.512	1.00
173_E	176_K	1.510	1.00
90_R	305_L	1.502	1.00
181_T	238_M	1.490	1.00
256_V	259_R	1.463	1.00
295_D	299_R	1.461	1.00
175_R	204_A	1.453	1.00
173_E	327_R	1.451	1.00
162_A	165_D	1.448	1.00
275_D	328_R	1.427	1.00
20_V	42_V	1.427	1.00
6_I	41_V	1.426	1.00
39_M	42_V	1.425	1.00
305_L	309_D	1.402	1.00
62_R	119_D	1.399	1.00
202_R	206_K	1.397	1.00
196_L	199_Q	1.394	1.00
295_D	298_E	1.385	1.00
86_Q	301_L	1.367	1.00
204_A	207_D	1.356	1.00
226_A	255_D	1.352	1.00
181_T	213_H	1.352	1.00
181_T	240_Q	1.348	1.00
166_D	323_R	1.344	1.00
230_E	259_R	1.329	1.00
219_S	224_A	1.327	1.00
183_L	232_W	1.324	1.00
257_T	262_G	1.323	1.00
25_A	29_R	1.317	1.00
9_L	45_H	1.313	1.00
226_A	230_E	1.309	1.00
171_A	175_R	1.308	1.00
229_F	242_L	1.298	1.00
171_A	204_A	1.292	1.00
167_A	200_G	1.279	1.00
32_D	35_V	1.273	1.00
171_A	200_G	1.271	1.00
62_R	92_Y	1.264	1.00
4_D	8_R	1.261	1.00
229_F	257_T	1.245	1.00
64_I	87_A	1.243	1.00
302_E	306_A	1.242	1.00
164_Q	168_E	1.240	1.00
5_E	8_R	1.240	1.00
230_E	234_E	1.234	1.00
37_K	41_V	1.227	1.00
122_I	300_V	1.227	1.00
41_V	44_E	1.227	1.00
31_S	34_T	1.226	1.00
216_Y	231_K	1.226	1.00
65_G	113_L	1.225	1.00
200_G	204_A	1.217	1.00
169_M	172_E	1.214	1.00
19_Y	24_K	1.210	1.00
6_I	10_A	1.209	1.00
41_V	45_H	1.200	1.00
97_A	109_C	1.199	1.00
97_A	113_L	1.196	1.00
135_Q	139_N	1.194	1.00
179_A	241_A	1.193	1.00
83_L	301_L	1.186	1.00
254_M	270_I	1.179	1.00
172_E	207_D	1.177	1.00
111_E	136_R	1.175	1.00
87_A	94_L	1.171	1.00
294_R	298_E	1.156	1.00
34_T	37_K	1.147	1.00
6_I	45_H	1.145	1.00
201_F	205_W	1.144	1.00
231_K	235_T	1.140	1.00
63_S	93_Q	1.140	1.00
164_Q	196_L	1.134	1.00
20_V	30_V	1.129	1.00
66_L	83_L	1.126	1.00
204_A	208_D	1.119	1.00
271_A	287_L	1.116	1.00
180_E	240_Q	1.112	1.00
223_E	227_Q	1.111	1.00
184_Y	198_E	1.110	1.00
164_Q	200_G	1.104	1.00
90_R	302_E	1.098	1.00
83_L	122_I	1.097	1.00
228_L	231_K	1.096	1.00
252_G	256_V	1.089	1.00
84_E	88_R	1.088	1.00
185_L	253_V	1.086	1.00
36_E	39_M	1.085	1.00
63_S	95_L	1.080	1.00
303_I	319_T	1.078	1.00
203_T	207_D	1.078	1.00
221_E	224_A	1.077	1.00
175_R	210_R	1.068	1.00
177_F	327_R	1.068	1.00
242_L	253_V	1.068	1.00
66_L	94_L	1.066	1.00
299_R	303_I	1.059	1.00
182_V	205_W	1.058	1.00
170_L	243_F	1.055	1.00
202_R	212_V	1.054	1.00
297_A	301_L	1.052	1.00
40_A	43_R	1.052	1.00
50_N	56_L	1.042	1.00
247_F	288_A	1.039	1.00
199_Q	202_R	1.038	1.00
107_M	111_E	1.027	1.00
181_T	237_P	1.026	1.00
23_G	35_V	1.025	1.00
52_V	55_G	1.025	1.00
201_F	243_F	1.010	1.00
88_R	105_N	1.010	1.00
181_T	211_E	1.010	1.00
92_Y	305_L	1.007	1.00
176_K	208_D	1.002	1.00
227_Q	231_K	0.998	1.00
298_E	302_E	0.996	1.00
195_F	199_Q	0.996	1.00
236_H	239_P	0.995	1.00
42_V	45_H	0.986	1.00
247_F	272_T	0.983	1.00
90_R	309_D	0.981	1.00
244_T	250_L	0.979	1.00
244_T	249_L	0.978	1.00
222_R	255_D	0.970	1.00
224_A	227_Q	0.969	1.00
165_D	322_K	0.969	1.00
157_T	303_I	0.964	1.00
177_F	269_A	0.962	1.00
299_R	321_I	0.960	1.00
290_A	326_Y	0.957	1.00
304_V	308_L	0.957	1.00
105_N	108_R	0.954	1.00
225_A	229_F	0.950	1.00
180_E	210_R	0.947	1.00
182_V	241_A	0.943	1.00
89_Q	298_E	0.941	1.00
192_S	196_L	0.939	1.00
254_M	264_L	0.931	1.00
229_F	233_L	0.929	1.00
216_Y	228_L	0.923	1.00
10_A	17_A	0.920	1.00
122_I	304_V	0.920	1.00
111_E	115_Q	0.916	1.00
80_A	84_E	0.907	1.00
81_N	85_R	0.905	1.00
324_N	327_R	0.901	1.00
292_R	324_N	0.898	1.00
170_L	289_V	0.897	1.00
187_A	220_Y	0.896	1.00
171_A	205_W	0.895	1.00
23_G	39_M	0.894	1.00
158_S	318_L	0.893	1.00
53_A	56_L	0.885	1.00
50_N	53_A	0.883	1.00
162_A	320_R	0.882	1.00
161_G	292_R	0.879	1.00
242_L	268_L	0.879	1.00
189_P	217_A	0.878	1.00
205_W	212_V	0.874	1.00
85_R	298_E	0.872	1.00
175_R	180_E	0.868	1.00
83_L	297_A	0.868	1.00
64_I	122_I	0.867	1.00
254_M	282_L	0.866	1.00
190_E	195_F	0.862	1.00
205_W	210_R	0.859	1.00
262_G	268_L	0.858	1.00
227_Q	230_E	0.852	1.00
102_Q	105_N	0.847	1.00
49_P	54_A	0.846	1.00
165_D	323_R	0.839	1.00
224_A	228_L	0.839	1.00
75_S	293_H	0.839	1.00
303_I	306_A	0.837	1.00
247_F	275_D	0.836	1.00
292_R	321_I	0.836	1.00
20_V	39_M	0.835	1.00
159_V	303_I	0.833	1.00
120_A	308_L	0.830	1.00
66_L	80_A	0.827	1.00
163_D	197_R	0.827	1.00
233_L	256_V	0.824	1.00
186_G	198_E	0.824	1.00
183_L	242_L	0.822	1.00
257_T	270_I	0.817	1.00
79_I	147_L	0.815	1.00
203_T	206_K	0.813	1.00
218_N	249_L	0.809	1.00
161_G	323_R	0.808	1.00
161_G	291_Q	0.806	1.00
157_T	317_G	0.804	1.00
160_V	318_L	0.803	1.00
85_R	89_Q	0.803	1.00
83_L	94_L	0.797	1.00
51_A	54_A	0.796	1.00
33_K	36_E	0.795	1.00
275_D	326_Y	0.795	1.00
160_V	320_R	0.791	1.00
16_T	19_Y	0.789	1.00
12_V	38_V	0.787	1.00
173_E	325_L	0.787	1.00
63_S	116_R	0.785	1.00
238_M	262_G	0.782	1.00
280_D	284_C	0.781	1.00
185_L	244_T	0.779	1.00
301_L	305_L	0.774	1.00
272_T	288_A	0.773	1.00
229_F	256_V	0.769	1.00
80_A	96_I	0.768	1.00
82_Y	298_E	0.766	1.00
174_L	271_A	0.766	1.00
78_R	294_R	0.765	1.00
184_Y	243_F	0.764	1.00
196_L	200_G	0.764	1.00
82_Y	86_Q	0.760	1.00
108_R	111_E	0.760	1.00
162_A	322_K	0.757	1.00
210_R	213_H	0.752	1.00
233_L	260_R	0.752	1.00
61_T	119_D	0.752	1.00
15_T	19_Y	0.752	1.00
150_A	318_L	0.750	1.00
33_K	37_K	0.748	1.00
81_N	84_E	0.747	1.00
229_F	232_W	0.745	1.00
114_L	140_D	0.744	1.00
136_R	139_N	0.743	1.00
19_Y	25_A	0.742	1.00
275_D	279_L	0.732	1.00
169_M	289_V	0.731	1.00
274_G	291_Q	0.731	1.00
19_Y	29_R	0.730	1.00
48_H	115_Q	0.723	1.00
214_F	235_T	0.723	1.00
60_R	119_D	0.722	1.00
69_P	76_Y	0.721	1.00
250_L	272_T	0.715	1.00
168_E	200_G	0.715	1.00
173_E	287_L	0.714	1.00
105_N	109_C	0.712	1.00
240_Q	269_A	0.712	1.00
95_L	118_V	0.712	1.00
255_D	258_L	0.710	1.00
65_G	121_I	0.703	1.00
104_D	108_R	0.703	1.00
306_A	310_E	0.702	1.00
201_F	212_V	0.700	1.00
235_T	238_M	0.698	1.00
257_T	264_L	0.691	1.00
251_Q	282_L	0.690	1.00
122_I	147_L	0.688	1.00
64_I	301_L	0.687	1.00
231_K	234_E	0.687	1.00
84_E	94_L	0.684	1.00
67_V	109_C	0.684	1.00
137_W	144_I	0.682	1.00
214_F	217_A	0.681	1.00
255_D	285_P	0.677	1.00
100_E	105_N	0.677	1.00
282_L	285_P	0.676	1.00
255_D	259_R	0.676	1.00
36_E	43_R	0.674	1.00
17_A	42_V	0.671	1.00
310_E	313_K	0.671	1.00
135_Q	138_A	0.671	1.00
175_R	205_W	0.670	1.00
243_F	271_A	0.670	1.00
20_V	35_V	0.669	1.00
84_E	98_C	0.666	1.00
247_F	250_L	0.665	1.00
138_A	156_F	0.665	1.00
198_E	215_L	0.662	1.00
184_Y	201_F	0.661	1.00
225_A	228_L	0.660	1.00
218_N	224_A	0.659	1.00
120_A	145_V	0.658	1.00
285_P	328_R	0.655	1.00
133_F	136_R	0.655	1.00
182_V	240_Q	0.655	1.00
95_L	116_R	0.654	1.00
4_D	57_R	0.653	1.00
146_A	151_L	0.652	1.00
12_V	34_T	0.648	1.00
60_R	309_D	0.647	1.00
169_M	173_E	0.646	1.00
48_H	111_E	0.645	1.00
107_M	133_F	0.644	1.00
235_T	239_P	0.643	1.00
144_I	156_F	0.642	1.00
145_V	307_S	0.639	1.00
138_A	144_I	0.636	1.00
114_L	142_F	0.635	1.00
110_I	121_I	0.633	1.00
148_D	193_V	0.633	1.00
194_S	220_Y	0.631	1.00
229_F	252_G	0.629	1.00
120_A	300_V	0.623	1.00
6_I	17_A	0.622	1.00
78_R	293_H	0.620	1.00
37_K	40_A	0.619	1.00
246_S	274_G	0.619	1.00
255_D	283_Q	0.619	1.00
220_Y	245_T	0.617	1.00
222_R	278_L	0.615	1.00
254_M	258_L	0.613	1.00
82_Y	293_H	0.612	1.00
81_N	294_R	0.609	1.00
146_A	156_F	0.609	1.00
148_D	163_D	0.607	1.00
174_L	243_F	0.605	1.00
92_Y	308_L	0.604	1.00
187_A	194_S	0.602	1.00
145_V	304_V	0.600	1.00
17_A	20_V	0.600	1.00
168_E	171_A	0.600	1.00
223_E	226_A	0.599	1.00
64_I	120_A	0.599	1.00
19_Y	30_V	0.597	1.00
121_I	142_F	0.596	1.00
257_T	260_R	0.595	1.00
163_D	196_L	0.595	1.00
138_A	155_H	0.595	1.00
64_I	92_Y	0.595	1.00
182_V	201_F	0.595	1.00
216_Y	235_T	0.595	1.00
243_F	273_F	0.593	1.00
29_R	34_T	0.592	1.00
61_T	93_Q	0.591	1.00
246_S	249_L	0.588	1.00
279_L	288_A	0.588	1.00
43_R	46_N	0.587	1.00
251_Q	276_N	0.587	1.00
145_V	159_V	0.583	1.00
251_Q	278_L	0.582	1.00
92_Y	119_D	0.582	1.00
79_I	293_H	0.581	1.00
170_L	241_A	0.580	1.00
48_H	52_V	0.580	1.00
216_Y	232_W	0.577	1.00
73_N	248_A	0.576	1.00
132_P	135_Q	0.573	1.00
222_R	252_G	0.573	1.00
258_L	263_K	0.571	1.00
145_V	300_V	0.569	1.00
228_L	232_W	0.566	1.00
294_R	297_A	0.566	1.00
303_I	307_S	0.565	1.00
64_I	308_L	0.564	1.00
307_S	310_E	0.564	1.00
24_K	30_V	0.561	1.00
279_L	286_V	0.560	1.00
173_E	271_A	0.558	1.00
103_P	107_M	0.558	1.00
75_S	79_I	0.557	1.00
136_R	140_D	0.555	1.00
97_A	112_H	0.554	1.00
150_A	158_S	0.554	1.00
146_A	158_S	0.552	1.00
87_A	92_Y	0.551	1.00
181_T	214_F	0.550	1.00
289_V	323_R	0.550	1.00
280_D	285_P	0.548	1.00
296_V	321_I	0.547	1.00
113_L	118_V	0.546	1.00
306_A	317_G	0.546	1.00
287_L	325_L	0.545	1.00
181_T	236_H	0.544	1.00
145_V	303_I	0.542	1.00
181_T	239_P	0.541	1.00
54_A	58_A	0.538	1.00
194_S	245_T	0.538	1.00
226_A	252_G	0.537	1.00
76_Y	124_S	0.537	1.00
159_V	299_R	0.535	1.00
247_F	276_N	0.535	1.00
273_F	291_Q	0.534	1.00
74_T	248_A	0.528	1.00
111_E	114_L	0.528	1.00
226_A	229_F	0.528	1.00
163_D	193_V	0.526	1.00
87_A	305_L	0.524	1.00
253_V	257_T	0.524	1.00
262_G	265_P	0.523	1.00
299_R	306_A	0.523	1.00
10_A	20_V	0.521	1.00
5_E	9_L	0.521	1.00
214_F	218_N	0.521	1.00
30_V	35_V	0.520	1.00
63_S	119_D	0.519	1.00
143_P	308_L	0.519	1.00
244_T	272_T	0.519	1.00
23_G	29_R	0.518	1.00
15_T	24_K	0.518	1.00
161_G	166_D	0.518	1.00
12_V	17_A	0.517	1.00
185_L	228_L	0.517	1.00
107_M	136_R	0.514	1.00
118_V	121_I	0.514	1.00
220_Y	249_L	0.513	1.00
320_R	323_R	0.512	1.00
78_R	277_E	0.511	1.00
65_G	97_A	0.510	1.00
112_H	115_Q	0.510	1.00
171_A	208_D	0.509	1.00
233_L	257_T	0.509	1.00
55_G	58_A	0.508	1.00
198_E	212_V	0.505	1.00
239_P	242_L	0.503	1.00
264_L	267_D	0.503	1.00
86_Q	305_L	0.502	1.00
17_A	38_V	0.502	1.00
160_V	163_D	0.501	1.00
83_L	87_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hsgA	1	0.9701	100	0.058	Contact Map
3dbiA	2	0.8204	100	0.059	Contact Map
1qpzA	2	0.985	100	0.064	Contact Map
4o5aA	2	0.8024	100	0.068	Contact Map
2o20A	2	0.8174	100	0.068	Contact Map
3bilA	2	0.7665	100	0.07	Contact Map
3kjxA	2	0.985	100	0.076	Contact Map
3e3mA	2	0.7964	100	0.078	Contact Map
3ctpA	2	0.7904	100	0.08	Contact Map
1jyeA	2	0.8054	100	0.081	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.