GREMLIN Database
CRA - Catabolite repressor/activator
UniProt: P0ACP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10338
Length: 334 (321)
Sequences: 37197 (26686)
Seq/√Len: 1489.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_Q203_T3.3091.00
179_A240_Q3.1271.00
9_L44_E3.0801.00
263_K266_S3.0021.00
120_A304_V2.5931.00
170_L271_A2.5921.00
198_E202_R2.5701.00
179_A269_A2.4691.00
275_D290_A2.4251.00
157_T307_S2.3641.00
168_E207_D2.2561.00
32_D36_E2.2281.00
40_A44_E2.2101.00
86_Q89_Q2.1891.00
226_A259_R2.1751.00
36_E40_A2.1351.00
86_Q302_E2.1161.00
230_E260_R2.1081.00
172_E204_A2.0421.00
168_E203_T2.0391.00
168_E204_A2.0391.00
299_R302_E2.0231.00
165_D169_M2.0161.00
175_R208_D2.0041.00
230_E256_V2.0001.00
87_A301_L1.9511.00
20_V38_V1.9441.00
35_V39_M1.8941.00
166_D273_F1.8741.00
164_Q199_Q1.8671.00
24_K29_R1.8601.00
82_Y297_A1.8591.00
167_A171_A1.8571.00
86_Q298_E1.8561.00
4_D14_R1.8521.00
21_I42_V1.8411.00
174_L241_A1.8361.00
172_E176_K1.8231.00
234_E260_R1.8031.00
225_A252_G1.7711.00
257_T268_L1.7631.00
306_A311_P1.7621.00
290_A324_N1.7601.00
167_A243_F1.7581.00
171_A201_F1.7431.00
85_R294_R1.7351.00
9_L41_V1.7251.00
172_E208_D1.7101.00
168_E172_E1.6931.00
10_A41_V1.6831.00
226_A256_V1.6691.00
229_F253_V1.6651.00
183_L239_P1.6571.00
65_G118_V1.6571.00
299_R319_T1.6531.00
173_E177_F1.6471.00
262_G267_D1.6421.00
285_P329_G1.6371.00
292_R295_D1.6271.00
244_T253_V1.6231.00
184_Y245_T1.6201.00
82_Y294_R1.6191.00
86_Q90_R1.6071.00
169_M323_R1.6001.00
256_V260_R1.5731.00
147_L300_V1.5431.00
263_K267_D1.5421.00
258_L283_Q1.5391.00
165_D168_E1.5171.00
39_M43_R1.5141.00
199_Q203_T1.5121.00
173_E176_K1.5101.00
90_R305_L1.5021.00
181_T238_M1.4901.00
256_V259_R1.4631.00
295_D299_R1.4611.00
175_R204_A1.4531.00
173_E327_R1.4511.00
162_A165_D1.4481.00
275_D328_R1.4271.00
20_V42_V1.4271.00
6_I41_V1.4261.00
39_M42_V1.4251.00
305_L309_D1.4021.00
62_R119_D1.3991.00
202_R206_K1.3971.00
196_L199_Q1.3941.00
295_D298_E1.3851.00
86_Q301_L1.3671.00
204_A207_D1.3561.00
226_A255_D1.3521.00
181_T213_H1.3521.00
181_T240_Q1.3481.00
166_D323_R1.3441.00
230_E259_R1.3291.00
219_S224_A1.3271.00
183_L232_W1.3241.00
257_T262_G1.3231.00
25_A29_R1.3171.00
9_L45_H1.3131.00
226_A230_E1.3091.00
171_A175_R1.3081.00
229_F242_L1.2981.00
171_A204_A1.2921.00
167_A200_G1.2791.00
32_D35_V1.2731.00
171_A200_G1.2711.00
62_R92_Y1.2641.00
4_D8_R1.2611.00
229_F257_T1.2451.00
64_I87_A1.2431.00
302_E306_A1.2421.00
164_Q168_E1.2401.00
5_E8_R1.2401.00
230_E234_E1.2341.00
37_K41_V1.2271.00
122_I300_V1.2271.00
41_V44_E1.2271.00
31_S34_T1.2261.00
216_Y231_K1.2261.00
65_G113_L1.2251.00
200_G204_A1.2171.00
169_M172_E1.2141.00
19_Y24_K1.2101.00
6_I10_A1.2091.00
41_V45_H1.2001.00
97_A109_C1.1991.00
97_A113_L1.1961.00
135_Q139_N1.1941.00
179_A241_A1.1931.00
83_L301_L1.1861.00
254_M270_I1.1791.00
172_E207_D1.1771.00
111_E136_R1.1751.00
87_A94_L1.1711.00
294_R298_E1.1561.00
34_T37_K1.1471.00
6_I45_H1.1451.00
201_F205_W1.1441.00
231_K235_T1.1401.00
63_S93_Q1.1401.00
164_Q196_L1.1341.00
20_V30_V1.1291.00
66_L83_L1.1261.00
204_A208_D1.1191.00
271_A287_L1.1161.00
180_E240_Q1.1121.00
223_E227_Q1.1111.00
184_Y198_E1.1101.00
164_Q200_G1.1041.00
90_R302_E1.0981.00
83_L122_I1.0971.00
228_L231_K1.0961.00
252_G256_V1.0891.00
84_E88_R1.0881.00
185_L253_V1.0861.00
36_E39_M1.0851.00
63_S95_L1.0801.00
303_I319_T1.0781.00
203_T207_D1.0781.00
221_E224_A1.0771.00
175_R210_R1.0681.00
177_F327_R1.0681.00
242_L253_V1.0681.00
66_L94_L1.0661.00
299_R303_I1.0591.00
182_V205_W1.0581.00
170_L243_F1.0551.00
202_R212_V1.0541.00
297_A301_L1.0521.00
40_A43_R1.0521.00
50_N56_L1.0421.00
247_F288_A1.0391.00
199_Q202_R1.0381.00
107_M111_E1.0271.00
181_T237_P1.0261.00
23_G35_V1.0251.00
52_V55_G1.0251.00
201_F243_F1.0101.00
88_R105_N1.0101.00
181_T211_E1.0101.00
92_Y305_L1.0071.00
176_K208_D1.0021.00
227_Q231_K0.9981.00
298_E302_E0.9961.00
195_F199_Q0.9961.00
236_H239_P0.9951.00
42_V45_H0.9861.00
247_F272_T0.9831.00
90_R309_D0.9811.00
244_T250_L0.9791.00
244_T249_L0.9781.00
222_R255_D0.9701.00
224_A227_Q0.9691.00
165_D322_K0.9691.00
157_T303_I0.9641.00
177_F269_A0.9621.00
299_R321_I0.9601.00
290_A326_Y0.9571.00
304_V308_L0.9571.00
105_N108_R0.9541.00
225_A229_F0.9501.00
180_E210_R0.9471.00
182_V241_A0.9431.00
89_Q298_E0.9411.00
192_S196_L0.9391.00
254_M264_L0.9311.00
229_F233_L0.9291.00
216_Y228_L0.9231.00
10_A17_A0.9201.00
122_I304_V0.9201.00
111_E115_Q0.9161.00
80_A84_E0.9071.00
81_N85_R0.9051.00
324_N327_R0.9011.00
292_R324_N0.8981.00
170_L289_V0.8971.00
187_A220_Y0.8961.00
171_A205_W0.8951.00
23_G39_M0.8941.00
158_S318_L0.8931.00
53_A56_L0.8851.00
50_N53_A0.8831.00
162_A320_R0.8821.00
161_G292_R0.8791.00
242_L268_L0.8791.00
189_P217_A0.8781.00
205_W212_V0.8741.00
85_R298_E0.8721.00
175_R180_E0.8681.00
83_L297_A0.8681.00
64_I122_I0.8671.00
254_M282_L0.8661.00
190_E195_F0.8621.00
205_W210_R0.8591.00
262_G268_L0.8581.00
227_Q230_E0.8521.00
102_Q105_N0.8471.00
49_P54_A0.8461.00
165_D323_R0.8391.00
224_A228_L0.8391.00
75_S293_H0.8391.00
303_I306_A0.8371.00
247_F275_D0.8361.00
292_R321_I0.8361.00
20_V39_M0.8351.00
159_V303_I0.8331.00
120_A308_L0.8301.00
66_L80_A0.8271.00
163_D197_R0.8271.00
233_L256_V0.8241.00
186_G198_E0.8241.00
183_L242_L0.8221.00
257_T270_I0.8171.00
79_I147_L0.8151.00
203_T206_K0.8131.00
218_N249_L0.8091.00
161_G323_R0.8081.00
161_G291_Q0.8061.00
157_T317_G0.8041.00
160_V318_L0.8031.00
85_R89_Q0.8031.00
83_L94_L0.7971.00
51_A54_A0.7961.00
33_K36_E0.7951.00
275_D326_Y0.7951.00
160_V320_R0.7911.00
16_T19_Y0.7891.00
12_V38_V0.7871.00
173_E325_L0.7871.00
63_S116_R0.7851.00
238_M262_G0.7821.00
280_D284_C0.7811.00
185_L244_T0.7791.00
301_L305_L0.7741.00
272_T288_A0.7731.00
229_F256_V0.7691.00
80_A96_I0.7681.00
82_Y298_E0.7661.00
174_L271_A0.7661.00
78_R294_R0.7651.00
184_Y243_F0.7641.00
196_L200_G0.7641.00
82_Y86_Q0.7601.00
108_R111_E0.7601.00
162_A322_K0.7571.00
210_R213_H0.7521.00
233_L260_R0.7521.00
61_T119_D0.7521.00
15_T19_Y0.7521.00
150_A318_L0.7501.00
33_K37_K0.7481.00
81_N84_E0.7471.00
229_F232_W0.7451.00
114_L140_D0.7441.00
136_R139_N0.7431.00
19_Y25_A0.7421.00
275_D279_L0.7321.00
169_M289_V0.7311.00
274_G291_Q0.7311.00
19_Y29_R0.7301.00
48_H115_Q0.7231.00
214_F235_T0.7231.00
60_R119_D0.7221.00
69_P76_Y0.7211.00
250_L272_T0.7151.00
168_E200_G0.7151.00
173_E287_L0.7141.00
105_N109_C0.7121.00
240_Q269_A0.7121.00
95_L118_V0.7121.00
255_D258_L0.7101.00
65_G121_I0.7031.00
104_D108_R0.7031.00
306_A310_E0.7021.00
201_F212_V0.7001.00
235_T238_M0.6981.00
257_T264_L0.6911.00
251_Q282_L0.6901.00
122_I147_L0.6881.00
64_I301_L0.6871.00
231_K234_E0.6871.00
84_E94_L0.6841.00
67_V109_C0.6841.00
137_W144_I0.6821.00
214_F217_A0.6811.00
255_D285_P0.6771.00
100_E105_N0.6771.00
282_L285_P0.6761.00
255_D259_R0.6761.00
36_E43_R0.6741.00
17_A42_V0.6711.00
310_E313_K0.6711.00
135_Q138_A0.6711.00
175_R205_W0.6701.00
243_F271_A0.6701.00
20_V35_V0.6691.00
84_E98_C0.6661.00
247_F250_L0.6651.00
138_A156_F0.6651.00
198_E215_L0.6621.00
184_Y201_F0.6611.00
225_A228_L0.6601.00
218_N224_A0.6591.00
120_A145_V0.6581.00
285_P328_R0.6551.00
133_F136_R0.6551.00
182_V240_Q0.6551.00
95_L116_R0.6541.00
4_D57_R0.6531.00
146_A151_L0.6521.00
12_V34_T0.6481.00
60_R309_D0.6471.00
169_M173_E0.6461.00
48_H111_E0.6451.00
107_M133_F0.6441.00
235_T239_P0.6431.00
144_I156_F0.6421.00
145_V307_S0.6391.00
138_A144_I0.6361.00
114_L142_F0.6351.00
110_I121_I0.6331.00
148_D193_V0.6331.00
194_S220_Y0.6311.00
229_F252_G0.6291.00
120_A300_V0.6231.00
6_I17_A0.6221.00
78_R293_H0.6201.00
37_K40_A0.6191.00
246_S274_G0.6191.00
255_D283_Q0.6191.00
220_Y245_T0.6171.00
222_R278_L0.6151.00
254_M258_L0.6131.00
82_Y293_H0.6121.00
81_N294_R0.6091.00
146_A156_F0.6091.00
148_D163_D0.6071.00
174_L243_F0.6051.00
92_Y308_L0.6041.00
187_A194_S0.6021.00
145_V304_V0.6001.00
17_A20_V0.6001.00
168_E171_A0.6001.00
223_E226_A0.5991.00
64_I120_A0.5991.00
19_Y30_V0.5971.00
121_I142_F0.5961.00
257_T260_R0.5951.00
163_D196_L0.5951.00
138_A155_H0.5951.00
64_I92_Y0.5951.00
182_V201_F0.5951.00
216_Y235_T0.5951.00
243_F273_F0.5931.00
29_R34_T0.5921.00
61_T93_Q0.5911.00
246_S249_L0.5881.00
279_L288_A0.5881.00
43_R46_N0.5871.00
251_Q276_N0.5871.00
145_V159_V0.5831.00
251_Q278_L0.5821.00
92_Y119_D0.5821.00
79_I293_H0.5811.00
170_L241_A0.5801.00
48_H52_V0.5801.00
216_Y232_W0.5771.00
73_N248_A0.5761.00
132_P135_Q0.5731.00
222_R252_G0.5731.00
258_L263_K0.5711.00
145_V300_V0.5691.00
228_L232_W0.5661.00
294_R297_A0.5661.00
303_I307_S0.5651.00
64_I308_L0.5641.00
307_S310_E0.5641.00
24_K30_V0.5611.00
279_L286_V0.5601.00
173_E271_A0.5581.00
103_P107_M0.5581.00
75_S79_I0.5571.00
136_R140_D0.5551.00
97_A112_H0.5541.00
150_A158_S0.5541.00
146_A158_S0.5521.00
87_A92_Y0.5511.00
181_T214_F0.5501.00
289_V323_R0.5501.00
280_D285_P0.5481.00
296_V321_I0.5471.00
113_L118_V0.5461.00
306_A317_G0.5461.00
287_L325_L0.5451.00
181_T236_H0.5441.00
145_V303_I0.5421.00
181_T239_P0.5411.00
54_A58_A0.5381.00
194_S245_T0.5381.00
226_A252_G0.5371.00
76_Y124_S0.5371.00
159_V299_R0.5351.00
247_F276_N0.5351.00
273_F291_Q0.5341.00
74_T248_A0.5281.00
111_E114_L0.5281.00
226_A229_F0.5281.00
163_D193_V0.5261.00
87_A305_L0.5241.00
253_V257_T0.5241.00
262_G265_P0.5231.00
299_R306_A0.5231.00
10_A20_V0.5211.00
5_E9_L0.5211.00
214_F218_N0.5211.00
30_V35_V0.5201.00
63_S119_D0.5191.00
143_P308_L0.5191.00
244_T272_T0.5191.00
23_G29_R0.5181.00
15_T24_K0.5181.00
161_G166_D0.5181.00
12_V17_A0.5171.00
185_L228_L0.5171.00
107_M136_R0.5141.00
118_V121_I0.5141.00
220_Y249_L0.5131.00
320_R323_R0.5121.00
78_R277_E0.5111.00
65_G97_A0.5101.00
112_H115_Q0.5101.00
171_A208_D0.5091.00
233_L257_T0.5091.00
55_G58_A0.5081.00
198_E212_V0.5051.00
239_P242_L0.5031.00
264_L267_D0.5031.00
86_Q305_L0.5021.00
17_A38_V0.5021.00
160_V163_D0.5011.00
83_L87_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.9701 100 0.058 Contact Map
3dbiA 2 0.8204 100 0.059 Contact Map
1qpzA 2 0.985 100 0.064 Contact Map
4o5aA 2 0.8024 100 0.068 Contact Map
2o20A 2 0.8174 100 0.068 Contact Map
3bilA 2 0.7665 100 0.07 Contact Map
3kjxA 2 0.985 100 0.076 Contact Map
3e3mA 2 0.7964 100 0.078 Contact Map
3ctpA 2 0.7904 100 0.08 Contact Map
1jyeA 2 0.8054 100 0.081 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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