GREMLIN Database
CYTR - HTH-type transcriptional repressor CytR
UniProt: P0ACN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10200
Length: 341 (326)
Sequences: 35863 (26031)
Seq/√Len: 1441.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_L208_Q3.3721.00
184_H247_T3.3171.00
18_K50_E3.1261.00
270_K273_E3.0611.00
175_A278_I2.6471.00
126_G311_L2.5921.00
203_L207_V2.5651.00
282_N297_A2.5381.00
184_H276_S2.5201.00
162_P314_Q2.3371.00
173_F212_R2.3221.00
233_S266_R2.2511.00
38_Q42_N2.2071.00
46_K50_E2.2041.00
92_T95_N2.1851.00
42_N46_K2.1611.00
92_T309_L2.1481.00
237_Q267_Q2.1061.00
180_Y213_C2.0711.00
306_E309_L2.0711.00
177_N209_A2.0421.00
173_F208_Q2.0411.00
182_Q337_T2.0291.00
173_F209_A2.0241.00
170_T174_D1.9961.00
29_A44_V1.9801.00
237_Q263_Q1.9771.00
93_A308_M1.9701.00
172_A176_V1.9171.00
169_L204_Q1.9071.00
171_A280_F1.8981.00
88_G304_G1.8921.00
41_R45_E1.8911.00
30_L48_A1.8881.00
232_G259_G1.8801.00
177_N181_E1.8711.00
179_L248_A1.8591.00
13_K23_T1.8291.00
92_T305_R1.8101.00
172_A250_F1.8031.00
313_D318_Q1.7921.00
264_A275_L1.7901.00
241_D267_Q1.7731.00
297_A330_E1.7721.00
176_V206_Y1.7601.00
91_V301_Y1.7381.00
177_N213_C1.7101.00
19_A47_A1.7091.00
18_K47_A1.6801.00
233_S263_Q1.6801.00
173_F177_N1.6731.00
306_E325_R1.6671.00
299_P302_E1.6531.00
71_L124_I1.6511.00
88_G301_Y1.6351.00
236_M260_A1.6331.00
188_G246_P1.6291.00
189_C252_H1.6271.00
292_P335_G1.6201.00
174_D329_C1.6091.00
251_C260_A1.5991.00
269_L274_D1.5991.00
186_R218_D1.5891.00
270_K274_D1.5631.00
263_Q267_Q1.5451.00
265_K290_D1.5421.00
92_T96_H1.5311.00
152_A307_A1.5221.00
282_N334_R1.5201.00
45_E49_R1.5121.00
186_R245_P1.5081.00
170_T173_F1.5061.00
29_A48_A1.5001.00
167_D170_T1.4931.00
178_Y182_Q1.4871.00
223_A238_Q1.4871.00
204_Q208_Q1.4821.00
180_Y209_A1.4661.00
302_E306_E1.4651.00
263_Q266_R1.4551.00
178_Y181_E1.4431.00
278_I294_T1.4361.00
96_H312_L1.4241.00
45_E48_A1.4161.00
15_V47_A1.4061.00
201_Y204_Q1.4031.00
207_V211_R1.4001.00
68_R125_D1.3991.00
171_A329_C1.3951.00
302_E305_R1.3941.00
178_Y333_I1.3901.00
92_T308_M1.3631.00
176_V205_G1.3541.00
176_V180_Y1.3511.00
264_A269_L1.3231.00
237_Q266_R1.3141.00
186_R247_T1.3121.00
209_A212_R1.3061.00
233_S262_S1.3021.00
172_A205_G1.2991.00
13_K17_L1.2911.00
178_Y337_T1.2881.00
188_G239_L1.2851.00
18_K51_V1.2851.00
184_H248_A1.2831.00
312_L316_Q1.2811.00
236_M249_V1.2801.00
176_V209_A1.2791.00
233_S237_Q1.2691.00
218_D221_Y1.2681.00
15_V19_A1.2641.00
14_D17_L1.2611.00
37_S40_T1.2521.00
309_L313_D1.2511.00
68_R98_Y1.2511.00
237_Q241_D1.2471.00
28_R33_P1.2431.00
70_I93_A1.2431.00
38_Q41_R1.2421.00
205_G209_A1.2411.00
236_M264_A1.2281.00
140_I144_R1.2211.00
103_G115_F1.2201.00
12_M23_T1.2171.00
47_A50_E1.2161.00
243_P246_P1.2111.00
226_D231_A1.2101.00
43_R47_A1.2061.00
169_L173_F1.2051.00
103_G119_I1.2021.00
128_L307_A1.1981.00
174_D177_N1.1921.00
276_S337_T1.1851.00
238_Q242_L1.1831.00
71_L119_I1.1821.00
93_A100_V1.1791.00
261_L277_I1.1761.00
47_A51_V1.1701.00
89_I308_M1.1621.00
89_I128_L1.1611.00
169_L201_Y1.1601.00
185_K247_T1.1561.00
72_V89_I1.1551.00
177_N212_R1.1511.00
15_V51_V1.1451.00
40_T43_R1.1321.00
206_Y210_L1.1261.00
230_E234_K1.1241.00
301_Y305_R1.1161.00
46_K49_R1.1081.00
96_H309_L1.1021.00
259_G263_Q1.0941.00
72_V100_V1.0931.00
69_T99_L1.0871.00
187_I210_L1.0811.00
190_I260_A1.0771.00
254_D295_T1.0731.00
304_G308_M1.0711.00
249_V260_A1.0691.00
169_L205_G1.0661.00
306_E310_L1.0651.00
90_E94_A1.0651.00
12_M26_V1.0641.00
310_L325_R1.0631.00
209_A213_C1.0601.00
189_C203_L1.0601.00
42_N45_E1.0591.00
208_Q212_R1.0581.00
175_A250_F1.0581.00
29_A36_V1.0571.00
235_A238_Q1.0501.00
254_D279_G1.0481.00
117_D141_E1.0451.00
56_Q62_V1.0421.00
228_T231_A1.0351.00
180_Y215_I1.0341.00
94_A111_Q1.0251.00
69_T101_L1.0241.00
181_E213_C1.0211.00
113_K117_D1.0211.00
182_Q333_I1.0191.00
32_N41_R1.0141.00
186_R244_Q1.0041.00
204_Q207_V1.0021.00
210_L215_I0.9971.00
251_C256_M0.9961.00
58_M61_N0.9961.00
232_G236_M0.9931.00
48_A51_V0.9901.00
251_C257_A0.9901.00
182_Q276_S0.9881.00
194_E224_R0.9871.00
223_A235_A0.9811.00
311_L315_M0.9811.00
305_R309_L0.9751.00
306_E327_M0.9731.00
111_Q114_T0.9721.00
96_H316_Q0.9701.00
98_Y312_L0.9661.00
19_A26_V0.9641.00
170_T328_D0.9641.00
234_K238_Q0.9591.00
297_A332_I0.9561.00
206_Y250_F0.9541.00
200_H204_Q0.9501.00
231_A234_K0.9401.00
261_L289_C0.9361.00
175_A296_I0.9331.00
197_P201_Y0.9271.00
229_F262_S0.9221.00
187_I248_A0.9201.00
95_N305_R0.9191.00
117_D121_T0.9141.00
236_M240_L0.9121.00
178_Y294_T0.9111.00
87_R91_V0.9061.00
91_V305_R0.8981.00
59_G62_V0.8971.00
176_V210_L0.8961.00
128_L311_L0.8951.00
56_Q59_G0.8951.00
163_T324_S0.8921.00
166_I299_P0.8881.00
167_D326_L0.8861.00
180_Y185_K0.8841.00
330_E333_I0.8801.00
299_P327_M0.8801.00
70_I128_L0.8801.00
186_R221_Y0.8771.00
261_L271_V0.8751.00
89_I304_G0.8661.00
299_P330_E0.8661.00
32_N45_E0.8661.00
192_G227_F0.8641.00
55_P60_R0.8631.00
72_V86_I0.8591.00
234_K237_Q0.8501.00
207_V217_V0.8491.00
254_D282_N0.8461.00
195_E200_H0.8421.00
249_V275_L0.8421.00
188_G249_V0.8411.00
164_V310_L0.8391.00
221_Y242_L0.8381.00
29_A45_E0.8351.00
170_T329_C0.8311.00
264_A277_I0.8291.00
279_G295_T0.8291.00
240_L263_Q0.8291.00
86_I90_E0.8281.00
333_I337_T0.8271.00
265_K292_P0.8241.00
166_I329_C0.8241.00
165_H326_L0.8221.00
185_K215_I0.8211.00
162_P310_L0.8191.00
310_L313_D0.8181.00
269_L275_L0.8161.00
126_G315_M0.8161.00
11_T14_D0.8111.00
282_N332_I0.8081.00
85_I152_A0.8081.00
168_N202_R0.8061.00
225_G256_M0.8031.00
81_F300_R0.8021.00
167_D328_D0.7961.00
166_I298_Q0.7941.00
203_L222_I0.7931.00
191_A203_L0.7901.00
39_A42_N0.7901.00
162_P323_G0.7891.00
179_L278_I0.7881.00
190_I251_C0.7851.00
178_Y331_L0.7841.00
136_F140_I0.7831.00
258_L289_C0.7811.00
245_P269_L0.7811.00
208_Q211_R0.7801.00
25_T28_R0.7751.00
21_V44_V0.7741.00
91_V95_N0.7721.00
84_E301_Y0.7711.00
57_P60_R0.7711.00
308_M312_L0.7711.00
67_S125_D0.7711.00
88_G305_R0.7691.00
75_P82_F0.7641.00
294_T337_T0.7591.00
120_I145_N0.7591.00
108_Q111_Q0.7591.00
189_C250_F0.7591.00
89_I100_V0.7581.00
231_A235_A0.7581.00
165_H324_S0.7581.00
39_A43_R0.7561.00
88_G92_T0.7561.00
24_A28_R0.7541.00
281_D298_Q0.7531.00
236_M239_L0.7521.00
236_M263_Q0.7491.00
201_Y205_G0.7451.00
254_D257_A0.7451.00
70_I308_M0.7441.00
210_L217_V0.7421.00
28_R34_D0.7371.00
69_T122_K0.7371.00
114_T117_D0.7351.00
66_E125_D0.7341.00
141_E144_R0.7301.00
174_D296_I0.7291.00
71_L127_M0.7271.00
262_S265_K0.7271.00
223_A239_L0.7241.00
86_I102_I0.7181.00
106_A111_Q0.7171.00
54_L121_T0.7151.00
142_E149_M0.7141.00
240_L267_Q0.7131.00
155_F324_S0.7091.00
28_R35_K0.7081.00
111_Q115_F0.7041.00
87_R90_E0.7031.00
257_A279_G0.7021.00
101_L124_I0.7011.00
217_V220_Q0.6891.00
282_N286_T0.6881.00
238_Q241_D0.6881.00
90_E100_V0.6881.00
250_F278_I0.6871.00
173_F205_G0.6841.00
151_M156_A0.6831.00
294_T331_L0.6821.00
223_A242_L0.6781.00
66_E316_Q0.6771.00
264_A271_V0.6751.00
247_T276_S0.6721.00
262_S292_P0.6691.00
313_D317_G0.6691.00
42_N49_R0.6661.00
90_E104_D0.6651.00
187_I247_T0.6651.00
180_Y210_L0.6601.00
151_M161_L0.6591.00
143_Q160_E0.6571.00
29_A41_R0.6551.00
262_S266_R0.6551.00
128_L152_A0.6551.00
232_G235_A0.6541.00
242_L245_P0.6501.00
317_G320_V0.6471.00
126_G150_V0.6461.00
199_C227_F0.6451.00
143_Q149_M0.6431.00
225_G231_A0.6421.00
179_L250_F0.6401.00
153_N168_N0.6381.00
149_M161_L0.6351.00
236_M259_G0.6341.00
253_S281_D0.6311.00
242_L246_P0.6301.00
73_I115_F0.6261.00
153_N198_L0.6261.00
110_Q114_T0.6231.00
113_K138_A0.6221.00
15_V26_V0.6221.00
79_D255_V0.6201.00
174_D178_Y0.6181.00
35_K40_T0.6171.00
88_G300_R0.6171.00
126_G307_A0.6171.00
227_F252_H0.6161.00
26_V29_A0.6161.00
87_R301_Y0.6121.00
49_R52_G0.6121.00
54_L117_D0.6121.00
120_I147_P0.6111.00
189_C206_Y0.6101.00
116_I127_M0.6091.00
13_K63_K0.6091.00
101_L122_K0.6071.00
187_I206_Y0.6071.00
43_R46_K0.6051.00
192_G199_C0.6041.00
262_S290_D0.6041.00
21_V40_T0.6031.00
26_V48_A0.6031.00
188_G221_Y0.6001.00
261_L265_K0.5961.00
140_I143_Q0.5931.00
258_L283_I0.5931.00
150_V314_Q0.5931.00
191_A224_R0.5911.00
168_N201_Y0.5911.00
84_E300_R0.5891.00
253_S256_M0.5881.00
207_V222_I0.5881.00
98_Y125_D0.5881.00
85_I300_R0.5881.00
173_F176_V0.5871.00
203_L224_R0.5861.00
206_Y217_V0.5851.00
301_Y304_G0.5841.00
313_D323_G0.5831.00
98_Y315_M0.5831.00
292_P334_R0.5821.00
278_I337_T0.5811.00
250_F280_F0.5811.00
251_C279_G0.5811.00
264_A267_Q0.5801.00
150_V311_L0.5761.00
207_V219_P0.5761.00
28_R36_V0.5741.00
280_F298_Q0.5731.00
138_A141_E0.5731.00
81_F85_I0.5711.00
286_T293_L0.5711.00
70_I98_Y0.5711.00
70_I126_G0.5691.00
175_A248_A0.5691.00
265_K270_K0.5681.00
229_F259_G0.5681.00
137_D140_I0.5681.00
127_M147_P0.5671.00
296_I329_C0.5651.00
150_V164_V0.5651.00
229_F285_L0.5621.00
70_I315_M0.5611.00
67_S99_L0.5591.00
227_F256_M0.5591.00
286_T295_T0.5581.00
26_V44_V0.5571.00
54_L58_M0.5541.00
186_R246_P0.5541.00
258_L285_L0.5541.00
150_V310_L0.5531.00
265_K291_P0.5501.00
285_L289_C0.5491.00
217_V222_I0.5491.00
155_F163_T0.5461.00
310_L314_Q0.5451.00
287_Q292_P0.5451.00
230_E233_S0.5431.00
186_R216_M0.5431.00
233_S259_G0.5431.00
93_A312_L0.5431.00
19_A29_A0.5411.00
32_N35_K0.5411.00
117_D120_I0.5401.00
178_Y278_I0.5381.00
36_V41_R0.5341.00
150_V307_A0.5341.00
303_I327_M0.5311.00
151_M163_T0.5271.00
199_C252_H0.5261.00
286_T289_C0.5251.00
164_V306_E0.5231.00
21_V26_V0.5231.00
119_I124_I0.5221.00
143_Q161_L0.5211.00
314_Q317_G0.5211.00
82_F130_L0.5201.00
186_R243_P0.5191.00
306_E313_D0.5161.00
240_L264_A0.5161.00
289_C292_P0.5161.00
118_L121_T0.5151.00
60_R64_R0.5131.00
203_L217_V0.5131.00
246_P249_V0.5131.00
103_G118_L0.5121.00
19_A44_V0.5121.00
87_R106_A0.5101.00
105_C112_E0.5101.00
246_P269_L0.5091.00
33_P36_V0.5091.00
233_S236_M0.5091.00
269_L272_P0.5081.00
80_P255_V0.5071.00
294_T333_I0.5061.00
109_N113_K0.5061.00
235_A239_L0.5051.00
191_A222_I0.5051.00
24_A33_P0.5041.00
254_D283_I0.5041.00
314_Q320_V0.5021.00
61_N64_R0.5011.00
84_E284_D0.5001.00
166_I280_F0.5001.00
260_A264_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qpzA 2 0.9736 100 0.081 Contact Map
3dbiA 2 0.8094 100 0.086 Contact Map
2hsgA 1 0.9589 100 0.088 Contact Map
4o5aA 2 0.7889 100 0.089 Contact Map
3bilA 2 0.7507 100 0.09 Contact Map
2o20A 2 0.8065 100 0.091 Contact Map
3e3mA 2 0.7859 100 0.098 Contact Map
3kjxA 2 0.9765 100 0.099 Contact Map
3ctpA 2 0.7801 100 0.106 Contact Map
3jvdA 2 0.7654 100 0.108 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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