GREMLIN Database
ALLR - HTH-type transcriptional repressor AllR
UniProt: P0ACN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13616
Length: 271 (247)
Sequences: 12885 (9388)
Seq/√Len: 597.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_L27_G3.3101.00
112_L253_L3.0991.00
120_A156_A2.8731.00
105_F257_T2.8401.00
25_E67_A2.8251.00
198_Q202_L2.6091.00
32_Q84_G2.5691.00
158_K195_D2.3981.00
170_M193_L2.3931.00
103_G131_G2.3911.00
28_I69_F2.3591.00
158_K210_E2.3141.00
126_E148_R2.2361.00
115_E241_R2.1421.00
34_L70_V2.0941.00
73_D76_L2.0871.00
105_F260_D2.0821.00
29_A67_A2.0711.00
207_D217_C2.0041.00
107_R133_L1.9941.00
164_L168_E1.9701.00
122_R151_L1.9421.00
163_P223_Y1.9221.00
208_K216_N1.8881.00
220_S254_V1.8721.00
105_F264_A1.8181.00
216_N239_S1.8151.00
108_R260_D1.7891.00
220_S258_A1.7861.00
32_Q67_A1.7761.00
71_Y80_H1.7321.00
102_A261_I1.7271.00
110_M117_V1.6981.00
251_G255_R1.6941.00
188_D191_T1.6831.00
189_M193_L1.6801.00
30_I46_I1.6791.00
108_R112_L1.6761.00
33_Y50_L1.6601.00
33_Y41_S1.6511.00
61_L70_V1.6471.00
33_Y46_I1.6051.00
237_G242_L1.6011.00
220_S255_R1.5971.00
209_E239_S1.5921.00
235_I250_Q1.5851.00
61_L79_W1.5721.00
33_Y49_N1.5411.00
165_A168_E1.5311.00
41_S49_N1.5241.00
204_Y251_G1.5231.00
246_R249_S1.5221.00
209_E214_G1.5201.00
40_S80_H1.5161.00
195_D198_Q1.5041.00
42_S45_D1.4911.00
105_F108_R1.4891.00
169_L193_L1.4821.00
46_I57_T1.4611.00
113_S253_L1.4501.00
134_E140_R1.4441.00
52_L57_T1.4361.00
199_A205_T1.4291.00
182_T185_T1.4291.00
40_S78_W1.4271.00
253_L256_D1.4271.00
84_G87_N1.4251.00
127_A160_L1.4151.00
170_M189_M1.4131.00
34_L40_S1.4001.00
99_L131_G1.3991.00
223_Y262_S1.3971.00
127_A151_L1.3811.00
109_L253_L1.3751.00
110_M133_L1.3631.00
34_L41_S1.3621.00
32_Q69_F1.3551.00
65_Q70_V1.3511.00
106_M119_V1.3141.00
102_A119_V1.3071.00
73_D80_H1.3041.00
28_I67_A1.3031.00
65_Q72_Q1.2771.00
258_A262_S1.2661.00
125_N175_Q1.2601.00
109_L257_T1.2581.00
53_P56_T1.2571.00
166_E193_L1.2431.00
153_A185_T1.2381.00
37_S49_N1.2291.00
58_F62_K1.2281.00
37_S41_S1.2251.00
46_I61_L1.2191.00
166_E170_M1.2141.00
256_D260_D1.2141.00
174_L189_M1.2091.00
163_P221_A1.2081.00
103_G107_R1.2061.00
47_S57_T1.1911.00
186_L195_D1.1771.00
196_L199_A1.1741.00
223_Y229_V1.1651.00
43_V58_F1.1631.00
255_R259_R1.1571.00
120_A127_A1.1571.00
162_Y199_A1.1471.00
113_S250_Q1.1421.00
153_A181_F1.1391.00
220_S251_G1.1341.00
119_V231_A1.1171.00
25_E66_A1.1101.00
163_P229_V1.0981.00
122_R125_N1.0961.00
44_S48_L1.0871.00
184_T209_E1.0861.00
123_N148_R1.0851.00
107_R111_L1.0851.00
169_L200_R1.0841.00
121_I231_A1.0731.00
42_S78_W1.0721.00
85_V92_Y1.0711.00
122_R164_L1.0691.00
106_M117_V1.0661.00
224_D228_S1.0641.00
119_V222_I1.0641.00
173_I189_M1.0571.00
21_A63_V1.0571.00
35_E38_G1.0561.00
113_S235_I1.0541.00
166_E197_E1.0541.00
166_E169_L1.0531.00
233_I261_I1.0371.00
156_A232_A1.0371.00
25_E63_V1.0231.00
152_H185_T1.0191.00
45_D48_L1.0191.00
154_S157_G1.0131.00
43_V47_S1.0051.00
260_D264_A1.0051.00
252_E256_D0.9981.00
69_F88_V0.9821.00
22_Q26_R0.9821.00
170_M174_L0.9771.00
112_L256_D0.9761.00
98_V231_A0.9711.00
199_A202_L0.9531.00
259_R263_T0.9491.00
108_R257_T0.9481.00
44_S54_L0.9481.00
183_P213_V0.9481.00
168_E171_S0.9381.00
120_A129_L0.9341.00
180_Q187_V0.9331.00
31_L85_V0.9301.00
181_F185_T0.9231.00
194_K197_E0.9211.00
155_G217_C0.9151.00
197_E201_E0.9151.00
40_S73_D0.9141.00
103_G133_L0.9111.00
128_V148_R0.9111.00
243_T246_R0.9091.00
106_M131_G0.8971.00
194_K198_Q0.8971.00
221_A229_V0.8961.00
30_I50_L0.8941.00
36_K49_N0.8911.00
20_G66_A0.8881.00
159_A163_P0.8881.00
248_V252_E0.8831.00
218_I251_G0.8771.00
26_R56_T0.8771.00
161_L192_L0.8751.00
171_S175_Q0.8691.00
55_S58_F0.8651.00
159_A229_V0.8651.00
118_N236_S0.8631.00
117_V235_I0.8581.00
219_A234_S0.8571.00
45_D49_N0.8501.00
101_V264_A0.8421.00
208_K239_S0.8411.00
181_F211_H0.8411.00
156_A234_S0.8411.00
99_L103_G0.8401.00
106_M233_I0.8371.00
191_T195_D0.8371.00
209_E213_V0.8361.00
191_T194_K0.8321.00
159_A199_A0.8311.00
193_L197_E0.8281.00
169_L196_L0.8261.00
43_V61_L0.8141.00
65_Q79_W0.8131.00
202_L251_G0.8091.00
195_D202_L0.8091.00
195_D199_A0.8041.00
115_E137_S0.8001.00
30_I60_L0.7951.00
168_E172_I0.7941.00
254_V258_A0.7931.00
217_C236_S0.7911.00
50_L57_T0.7891.00
34_L39_G0.7881.00
224_D230_V0.7861.00
118_N143_A0.7851.00
247_F252_E0.7851.00
81_I85_V0.7831.00
238_P241_R0.7801.00
198_Q201_E0.7771.00
105_F261_I0.7751.00
123_N128_V0.7741.00
31_L69_F0.7741.00
160_L232_A0.7741.00
169_L172_I0.7701.00
34_L37_S0.7661.00
155_G219_A0.7621.00
217_C234_S0.7601.00
137_S241_R0.7601.00
257_T260_D0.7551.00
20_G25_E0.7441.00
247_F251_G0.7411.00
122_R168_E0.7401.00
186_L191_T0.7401.00
98_V102_A0.7361.00
23_A27_G0.7361.00
118_N132_Q0.7361.00
186_L192_L0.7341.00
85_V89_G0.7301.00
30_I57_T0.7301.00
153_A211_H0.7281.00
72_Q77_G0.7231.00
85_V88_V0.7161.00
172_I176_T0.7161.00
162_Y196_L0.7071.00
43_V54_L0.7051.00
97_D100_S0.7051.00
52_L56_T0.7051.00
106_M133_L0.7021.00
166_E200_R0.6991.00
252_E255_R0.6931.00
249_S253_L0.6931.00
41_S46_I0.6911.00
223_Y230_V0.6881.00
158_K199_A0.6861.00
62_K65_Q0.6851.00
206_V247_F0.6781.00
24_L60_L0.6771.00
71_Y82_G0.6771.00
249_S252_E0.6771.00
257_T261_I0.6741.00
47_S50_L0.6731.00
208_K244_E0.6731.00
122_R160_L0.6701.00
43_V57_T0.6681.00
72_Q76_L0.6681.00
125_N172_I0.6641.00
169_L197_E0.6631.00
43_V79_W0.6601.00
218_I247_F0.6571.00
24_L28_I0.6561.00
259_R262_S0.6561.00
154_S217_C0.6521.00
256_D259_R0.6501.00
233_I258_A0.6491.00
108_R111_L0.6481.00
62_K66_A0.6481.00
89_G92_Y0.6481.00
111_L136_K0.6441.00
110_M135_C0.6441.00
164_L169_L0.6421.00
161_L196_L0.6401.00
71_Y83_L0.6301.00
35_E88_V0.6281.00
109_L113_S0.6271.00
160_L164_L0.6251.00
197_E200_R0.6241.00
246_R250_Q0.6241.00
118_N217_C0.6211.00
121_I130_I0.6201.00
32_Q87_N0.6201.00
26_R52_L0.6191.00
169_L173_I0.6161.00
109_L235_I0.6151.00
260_D263_T0.6151.00
182_T186_L0.6101.00
255_R258_A0.6071.00
23_A60_L0.6071.00
107_R131_G0.6051.00
161_L169_L0.6051.00
187_V191_T0.6021.00
38_G49_N0.6021.00
45_D78_W0.6011.00
152_H178_L0.5971.00
101_V104_P0.5971.00
72_Q79_W0.5961.00
220_S262_S0.5951.00
132_Q145_L0.5931.00
109_L117_V0.5921.00
120_A154_S0.5901.00
208_K247_F0.5891.00
115_E237_G0.5881.00
34_L38_G0.5851.00
233_I257_T0.5811.00
129_L143_A0.5801.00
69_F84_G0.5791.00
209_E216_N0.5771.00
117_V133_L0.5731.00
42_S54_L0.5701.00
253_L257_T0.5701.00
184_T213_V0.5681.00
129_L156_A0.5661.00
32_Q88_V0.5651.00
190_P193_L0.5621.00
159_A219_A0.5621.00
127_A156_A0.5621.00
159_A221_A0.5611.00
160_L231_A0.5601.00
47_S54_L0.5601.00
139_V240_S0.5591.00
150_P153_A0.5581.00
144_P147_S0.5581.00
102_A106_M0.5570.99
68_D84_G0.5560.99
203_G223_Y0.5550.99
104_P264_A0.5550.99
73_D78_W0.5490.99
127_A154_S0.5480.99
114_G136_K0.5470.99
24_L63_V0.5470.99
220_S233_I0.5460.99
62_K72_Q0.5440.99
29_A32_Q0.5430.99
40_S76_L0.5420.99
21_A60_L0.5420.99
158_K207_D0.5410.99
26_R60_L0.5410.99
233_I254_V0.5400.99
190_P194_K0.5390.99
184_T208_K0.5390.99
29_A33_Y0.5390.99
134_E144_P0.5380.99
156_A217_C0.5360.99
27_G60_L0.5350.99
132_Q143_A0.5320.99
35_E81_I0.5320.99
115_E235_I0.5310.99
204_Y255_R0.5310.99
180_Q183_P0.5290.99
86_F93_I0.5290.99
250_Q253_L0.5280.99
173_I177_G0.5270.99
127_A149_L0.5260.99
159_A205_T0.5250.99
222_I231_A0.5250.99
192_L196_L0.5250.99
20_G63_V0.5240.99
223_Y231_A0.5220.99
74_S77_G0.5210.99
115_E246_R0.5170.99
125_N176_T0.5170.99
116_T132_Q0.5130.99
22_Q63_V0.5120.99
131_G145_L0.5090.99
130_I145_L0.5070.99
129_L149_L0.5060.99
129_L154_S0.5050.99
178_L189_M0.5010.99
118_N234_S0.5000.99
28_I63_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ia2A 4 0.9188 100 0.11 Contact Map
3mq0A 2 0.9262 100 0.111 Contact Map
2g7uA 6 0.9262 100 0.12 Contact Map
3r4kA 2 0.9262 100 0.124 Contact Map
1mkmA 4 0.9114 100 0.129 Contact Map
2xrnA 3 0.8893 100 0.148 Contact Map
2o0yA 4 0.941 100 0.17 Contact Map
1ysqA 1 0.6421 100 0.421 Contact Map
1tf1A 1 0.679 100 0.423 Contact Map
1yspA 1 0.6052 100 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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