GREMLIN Database
YIHL - Uncharacterized HTH-type transcriptional regulator YihL
UniProt: P0ACM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11838
Length: 236 (195)
Sequences: 22604 (18104)
Seq/√Len: 1296.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_W23_I4.1401.00
25_T28_G4.0371.00
16_D57_E3.4771.00
18_W39_L3.3211.00
12_K53_N3.2881.00
61_F71_T2.9861.00
183_K186_R2.6761.00
11_A42_I2.6331.00
14_K18_W2.5831.00
62_R68_W2.5691.00
33_E44_R2.5501.00
63_K66_K2.4111.00
11_A40_L2.2951.00
29_K69_F2.2501.00
12_K57_E2.2161.00
17_R21_D2.1381.00
123_T180_L2.1111.00
102_E188_P2.0581.00
12_K16_D2.0161.00
66_K69_F1.9901.00
110_P113_L1.9561.00
55_E62_R1.9561.00
5_Q13_E1.9501.00
49_Q52_L1.9191.00
14_K40_L1.9101.00
130_G173_K1.9091.00
109_I113_L1.8461.00
188_P191_I1.7701.00
16_D20_K1.7661.00
16_D59_K1.6911.00
7_T10_N1.6551.00
18_W24_T1.6451.00
34_R38_E1.6441.00
52_L62_R1.6271.00
35_E39_L1.6271.00
14_K17_R1.5991.00
10_N14_K1.5951.00
51_L60_I1.5841.00
32_S35_E1.5601.00
188_P192_S1.5551.00
36_L47_L1.5541.00
113_L145_Y1.5541.00
97_S133_A1.5411.00
55_E60_I1.5381.00
95_E99_G1.5321.00
60_I68_W1.5321.00
127_R143_E1.5171.00
129_T143_E1.4671.00
8_V53_N1.4441.00
42_I47_L1.4371.00
18_W22_G1.4361.00
33_E48_R1.4181.00
186_R190_D1.3951.00
26_P72_Q1.3811.00
24_T70_V1.3771.00
63_K69_F1.3681.00
149_E152_P1.3371.00
61_F69_F1.3331.00
19_L70_V1.3321.00
35_E38_E1.3221.00
52_L56_A1.3101.00
6_S9_E1.3061.00
109_I116_L1.2901.00
99_G133_A1.2651.00
53_N56_A1.2601.00
178_K186_R1.2441.00
52_L55_E1.2401.00
5_Q10_N1.2381.00
88_A157_Q1.2351.00
120_T123_T1.2311.00
173_K177_V1.2251.00
135_E138_K1.2161.00
189_G193_K1.2141.00
20_K59_K1.2101.00
63_K67_G1.1941.00
113_L117_I1.1921.00
141_Y191_I1.1911.00
148_P152_P1.1801.00
162_S166_V1.1781.00
176_V180_L1.1671.00
7_T46_T1.1471.00
51_L68_W1.1451.00
53_N57_E1.1381.00
117_I180_L1.1241.00
184_P188_P1.0941.00
93_G97_S1.0711.00
170_C197_G1.0631.00
198_S201_M1.0521.00
9_E13_E1.0321.00
29_K67_G1.0291.00
24_T28_G1.0241.00
94_R98_W1.0211.00
145_Y149_E1.0151.00
18_W40_L1.0071.00
13_E16_D0.9971.00
9_E53_N0.9931.00
104_N107_S0.9891.00
143_E147_N0.9831.00
109_I114_A0.9801.00
187_M197_G0.9731.00
49_Q53_N0.9711.00
192_S196_G0.9691.00
108_D113_L0.9551.00
15_L36_L0.9451.00
149_E153_G0.9421.00
27_G61_F0.9401.00
85_F88_A0.9221.00
8_V12_K0.9091.00
43_K46_T0.9091.00
128_I132_G0.9081.00
98_W102_E0.9071.00
107_S113_L0.8961.00
147_N150_V0.8931.00
65_R68_W0.8891.00
99_G103_K0.8881.00
177_V181_I0.8841.00
128_I145_Y0.8791.00
164_S168_E0.8771.00
174_E190_D0.8761.00
138_K141_Y0.8761.00
29_K32_S0.8671.00
108_D124_E0.8661.00
5_Q9_E0.8661.00
132_G142_H0.8581.00
181_I186_R0.8201.00
163_F166_V0.8131.00
127_R130_G0.8101.00
103_K155_I0.8101.00
51_L55_E0.8091.00
185_V191_I0.8051.00
26_P71_T0.8011.00
129_T190_D0.8001.00
141_Y145_Y0.7881.00
94_R196_G0.7881.00
37_G47_L0.7871.00
177_V180_L0.7861.00
146_I176_V0.7851.00
33_E62_R0.7841.00
124_E128_I0.7811.00
109_I112_T0.7811.00
99_G102_E0.7781.00
106_T109_I0.7731.00
87_R90_I0.7731.00
119_V123_T0.7721.00
125_L142_H0.7661.00
150_V179_K0.7621.00
8_V49_Q0.7591.00
84_S88_A0.7571.00
125_L145_Y0.7491.00
162_S167_W0.7491.00
98_W101_T0.7451.00
123_T127_R0.7451.00
15_L24_T0.7401.00
112_T116_L0.7391.00
114_A118_A0.7371.00
13_E17_R0.7341.00
11_A47_L0.7321.00
126_Y176_V0.7321.00
186_R189_G0.7311.00
142_H145_Y0.7311.00
123_T149_E0.7291.00
190_D193_K0.7281.00
165_A169_K0.7231.00
163_F167_W0.7231.00
126_Y130_G0.7221.00
127_R131_W0.7181.00
91_E103_K0.7171.00
98_W188_P0.7161.00
115_P118_A0.7161.00
30_L60_I0.7141.00
27_G72_Q0.7121.00
97_S101_T0.7111.00
85_F89_A0.7091.00
18_W21_D0.7071.00
166_V170_C0.7061.00
14_K39_L0.7051.00
104_N127_R0.7041.00
125_L128_I0.7021.00
11_A14_K0.7021.00
102_E184_P0.7011.00
147_N172_Q0.6961.00
197_G201_M0.6941.00
185_V189_G0.6921.00
133_A136_G0.6911.00
38_E41_G0.6901.00
36_L40_L0.6871.00
36_L51_L0.6831.00
94_R192_S0.6821.00
86_Q90_I0.6811.00
40_L47_L0.6791.00
113_L116_L0.6781.00
112_T115_P0.6751.00
114_A119_V0.6741.00
90_I93_G0.6661.00
127_R145_Y0.6651.00
161_H164_S0.6651.00
24_T30_L0.6641.00
83_A91_E0.6621.00
191_I194_Y0.6611.00
31_P39_L0.6551.00
98_W192_S0.6501.00
189_G192_S0.6491.00
23_I39_L0.6471.00
107_S127_R0.6471.00
109_I117_I0.6451.00
175_T191_I0.6431.00
117_I122_S0.6421.00
34_R37_G0.6411.00
138_K142_H0.6391.00
190_D194_Y0.6341.00
89_A134_L0.6331.00
111_E121_P0.6251.00
100_F104_N0.6251.00
95_E159_E0.6241.00
186_R201_M0.6201.00
185_V188_P0.6191.00
143_E191_I0.6191.00
97_S104_N0.6181.00
128_I131_W0.6101.00
107_S110_P0.6021.00
90_I96_P0.6001.00
155_I158_L0.5981.00
110_P117_I0.5961.00
17_R20_K0.5941.00
116_L122_S0.5921.00
12_K50_A0.5921.00
173_K176_V0.5861.00
100_F151_A0.5861.00
151_A167_W0.5851.00
92_Q97_S0.5841.00
11_A15_L0.5821.00
187_M191_I0.5801.00
191_I195_L0.5781.00
85_F90_I0.5761.00
46_T49_Q0.5741.00
37_G40_L0.5731.00
29_K66_K0.5721.00
92_Q96_P0.5711.00
24_T31_P0.5711.00
123_T176_V0.5681.00
46_T50_A0.5671.00
129_T141_Y0.5671.00
102_E127_R0.5661.00
111_E115_P0.5641.00
84_S87_R0.5641.00
187_M201_M0.5611.00
45_M49_Q0.5601.00
88_A92_Q0.5581.00
32_S65_R0.5571.00
111_E114_A0.5561.00
47_L60_I0.5551.00
106_T184_P0.5531.00
193_K197_G0.5521.00
175_T190_D0.5511.00
131_W138_K0.5501.00
51_L62_R0.5411.00
123_T173_K0.5411.00
101_T106_T0.5401.00
162_S165_A0.5401.00
187_M200_G0.5391.00
126_Y129_T0.5381.00
109_I119_V0.5351.00
117_I123_T0.5341.00
37_G44_R0.5341.00
103_K107_S0.5331.00
101_T104_N0.5321.00
187_M192_S0.5301.00
55_E68_W0.5291.00
97_S136_G0.5271.00
125_L149_E0.5261.00
118_A122_S0.5241.00
87_R91_E0.5241.00
37_G45_M0.5211.00
100_F103_K0.5201.00
160_N164_S0.5191.00
156_E159_E0.5191.00
107_S184_P0.5191.00
91_E107_S0.5171.00
101_T131_W0.5171.00
33_E68_W0.5161.00
9_E12_K0.5161.00
101_T191_I0.5151.00
109_I125_L0.5091.00
83_A87_R0.5081.00
144_T148_P0.5061.00
102_E185_V0.5061.00
103_K156_E0.5061.00
119_V125_L0.5051.00
172_Q194_Y0.5051.00
145_Y148_P0.5021.00
174_E186_R0.5011.00
108_D112_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9958 100 0.093 Contact Map
3edpA 2 0.9322 100 0.128 Contact Map
2ra5A 2 0.6102 100 0.129 Contact Map
3f8mA 2 0.9534 100 0.13 Contact Map
3eetA 2 0.9619 100 0.151 Contact Map
3bwgA 2 0.9576 100 0.156 Contact Map
3f8lA 2 0.678 100 0.424 Contact Map
1hw1A 2 0.8178 99.9 0.469 Contact Map
4p96A 2 0.8941 99.9 0.485 Contact Map
2di3A 2 0.8305 99.9 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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