GREMLIN Database
YEGW - Uncharacterized HTH-type transcriptional regulator YegW
UniProt: P0ACM5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14066
Length: 248 (197)
Sequences: 22871 (17556)
Seq/√Len: 1250.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E45_N4.1171.00
35_A40_V3.8731.00
33_K74_E3.3811.00
35_A56_L3.1861.00
29_A70_A3.1761.00
78_T88_N2.8251.00
28_F59_V2.6721.00
50_E61_R2.6511.00
133_A192_S2.6051.00
80_S83_Y2.5161.00
46_I86_Q2.4461.00
31_T35_A2.4171.00
195_S198_M2.3471.00
118_N200_D2.2951.00
29_A74_E2.2451.00
125_P128_V2.2331.00
34_N38_S2.1771.00
79_R85_T2.1761.00
28_F57_T2.1501.00
22_T30_E2.0501.00
199_P215_V1.9451.00
83_Y86_Q1.9041.00
31_T57_T1.8661.00
66_K69_Q1.7871.00
29_A33_K1.7841.00
72_E79_R1.7791.00
33_K37_R1.7251.00
128_V150_D1.7221.00
72_E77_V1.6831.00
35_A41_L1.6551.00
52_D56_L1.6471.00
24_L27_K1.6441.00
200_D203_F1.6421.00
111_K115_L1.6251.00
104_Q152_E1.6081.00
33_K76_V1.5911.00
27_K31_T1.5841.00
68_M77_V1.5781.00
53_L64_V1.5631.00
51_R55_Q1.5561.00
77_V85_T1.5531.00
31_T34_N1.5411.00
122_V196_A1.5281.00
147_R155_S1.4751.00
50_E65_R1.4731.00
142_L158_E1.4391.00
200_D204_Q1.4101.00
124_C129_A1.4081.00
49_G52_D1.4061.00
113_D148_Y1.3871.00
78_T86_Q1.3781.00
52_D55_Q1.3781.00
41_L87_I1.3781.00
25_Y70_A1.3671.00
36_V87_I1.3571.00
43_H89_N1.3531.00
80_S86_Q1.3371.00
128_V160_W1.3151.00
143_L159_S1.2961.00
198_M214_P1.2961.00
183_Q209_L1.2861.00
198_M202_E1.2541.00
144_K147_R1.2471.00
69_Q79_R1.2421.00
115_L148_Y1.2401.00
129_A192_S1.2331.00
69_Q72_E1.2241.00
70_A73_E1.2181.00
178_D182_S1.2161.00
124_C128_V1.2141.00
46_I84_G1.2081.00
59_V64_V1.2051.00
26_I30_E1.1991.00
80_S84_G1.1981.00
69_Q73_E1.1911.00
35_A39_G1.1521.00
110_K208_Q1.1481.00
37_R76_V1.1401.00
185_I189_R1.1381.00
22_T27_K1.1201.00
144_K158_E1.1031.00
156_I160_W1.0931.00
201_A205_S1.0791.00
26_I70_A1.0761.00
35_A57_T1.0731.00
22_T26_I1.0721.00
24_L63_T1.0671.00
143_L147_R1.0601.00
23_P26_I1.0581.00
156_I203_F1.0581.00
131_Q144_K1.0551.00
70_A74_E1.0551.00
196_A200_D1.0531.00
68_M85_T1.0391.00
121_V139_D1.0331.00
135_E138_S1.0251.00
60_S63_T1.0201.00
124_C194_V1.0181.00
122_V142_L1.0141.00
108_R157_E1.0121.00
188_Q192_S1.0091.00
189_R193_R1.0021.00
140_V144_K0.9961.00
107_L123_K0.9901.00
190_T198_M0.9891.00
120_R142_L0.9871.00
82_G85_T0.9811.00
110_K114_T0.9631.00
44_G78_T0.9621.00
41_L45_N0.9511.00
155_S159_S0.9501.00
25_Y29_A0.9501.00
30_E33_K0.9481.00
121_V163_A0.9471.00
118_N196_A0.9461.00
204_Q208_Q0.9451.00
142_L184_H0.9341.00
130_Q134_V0.9231.00
66_K70_A0.9081.00
114_T200_D0.8981.00
210_D213_I0.8911.00
117_V121_V0.8901.00
109_G113_D0.8891.00
133_A188_Q0.8841.00
153_A164_H0.8831.00
32_V53_L0.8821.00
114_T204_Q0.8811.00
136_A140_V0.8771.00
131_Q135_E0.8771.00
30_E34_N0.8741.00
118_N142_L0.8621.00
144_K148_Y0.8521.00
131_Q134_V0.8501.00
145_R191_R0.8491.00
107_L119_K0.8441.00
44_G89_N0.8441.00
104_Q108_R0.8441.00
126_E130_Q0.8371.00
144_K202_E0.8331.00
110_K204_Q0.8301.00
25_Y66_K0.8281.00
196_A216_L0.8201.00
139_D163_A0.8171.00
129_A134_V0.8161.00
28_F64_V0.8131.00
197_R203_F0.8111.00
128_V131_Q0.8061.00
129_A188_Q0.8031.00
176_L179_Y0.8021.00
115_L118_N0.8001.00
50_E79_R0.7841.00
138_S164_H0.7841.00
189_R192_S0.7821.00
146_I158_E0.7821.00
137_G140_V0.7811.00
149_V155_S0.7771.00
46_I49_G0.7741.00
175_S178_D0.7701.00
132_L144_K0.7631.00
68_M72_E0.7571.00
113_D151_E0.7561.00
129_A133_A0.7561.00
35_A38_S0.7461.00
118_N197_R0.7461.00
127_E131_Q0.7381.00
185_I188_Q0.7361.00
57_T64_V0.7351.00
126_E194_V0.7301.00
135_E144_K0.7301.00
124_C148_Y0.7281.00
162_P165_L0.7271.00
47_L77_V0.7241.00
106_V109_G0.7231.00
149_V154_V0.7181.00
203_F206_H0.7171.00
20_D27_K0.7161.00
199_P204_Q0.7141.00
123_K139_D0.7141.00
43_H88_N0.7011.00
32_V41_L0.7001.00
186_Y202_E0.7001.00
116_W146_I0.6981.00
118_N144_K0.6971.00
197_R215_V0.6861.00
197_R200_D0.6851.00
176_L180_F0.6841.00
129_A194_V0.6781.00
209_L213_I0.6781.00
63_T67_A0.6721.00
132_L135_E0.6711.00
124_C191_R0.6691.00
54_S57_T0.6691.00
199_P209_L0.6681.00
105_V149_V0.6671.00
48_P56_L0.6601.00
28_F31_T0.6581.00
163_A167_H0.6551.00
31_T56_L0.6541.00
106_V111_K0.6541.00
133_A185_I0.6531.00
115_L200_D0.6531.00
179_Y183_Q0.6531.00
29_A67_A0.6511.00
55_Q58_G0.6501.00
209_L215_V0.6491.00
202_E205_S0.6461.00
110_K211_S0.6451.00
205_S209_L0.6431.00
53_L68_M0.6401.00
41_L47_L0.6391.00
179_Y182_S0.6361.00
131_Q147_R0.6351.00
198_M201_A0.6341.00
54_S64_V0.6331.00
141_F188_Q0.6321.00
199_P213_I0.6271.00
51_R54_S0.6241.00
110_K150_D0.6221.00
108_R112_P0.6211.00
181_R186_Y0.6201.00
72_E85_T0.6201.00
135_E140_V0.6181.00
119_K123_K0.6131.00
128_V148_Y0.6131.00
54_S61_R0.6111.00
187_P202_E0.6111.00
103_Q106_V0.6101.00
124_C140_V0.6071.00
53_L57_T0.6061.00
46_I83_Y0.6021.00
117_V203_F0.5961.00
202_E206_H0.5951.00
68_M79_R0.5931.00
177_Y180_F0.5911.00
193_R198_M0.5911.00
143_L162_P0.5891.00
211_S215_V0.5851.00
181_R185_I0.5841.00
104_Q151_E0.5811.00
199_P212_K0.5791.00
111_K154_V0.5781.00
103_Q107_L0.5781.00
134_V140_V0.5771.00
115_L146_I0.5711.00
177_Y181_R0.5701.00
164_H167_H0.5691.00
117_V146_I0.5671.00
166_I169_V0.5651.00
104_Q109_G0.5651.00
127_E130_Q0.5641.00
64_V77_V0.5641.00
34_N37_R0.5611.00
197_R201_A0.5601.00
106_V210_D0.5591.00
201_A204_Q0.5581.00
109_G112_P0.5581.00
118_N122_V0.5561.00
190_T195_S0.5561.00
119_K141_F0.5561.00
62_I66_K0.5551.00
148_Y151_E0.5541.00
204_Q212_K0.5541.00
171_A179_Y0.5521.00
191_R194_V0.5501.00
21_N27_K0.5491.00
159_S162_P0.5471.00
139_D166_I0.5461.00
186_Y189_R0.5431.00
47_L68_M0.5431.00
157_E160_W0.5421.00
114_T118_N0.5401.00
143_L155_S0.5391.00
104_Q153_A0.5391.00
54_S62_I0.5361.00
28_F67_A0.5351.00
114_T117_V0.5341.00
126_E129_A0.5341.00
49_G64_V0.5301.00
170_D173_G0.5261.00
143_L169_V0.5231.00
96_K99_R0.5231.00
183_Q206_H0.5211.00
186_Y198_M0.5181.00
124_C134_V0.5161.00
104_Q107_L0.5161.00
141_F145_R0.5151.00
170_D180_F0.5141.00
139_D162_P0.5101.00
63_T66_K0.5101.00
50_E85_T0.5091.00
101_F105_V0.5071.00
71_L77_V0.5061.00
93_Y96_K0.5051.00
41_L48_P0.5041.00
81_R84_G0.5001.00
139_D143_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ra5A 2 0.5806 100 0.218 Contact Map
4u0wA 2 0.9516 100 0.223 Contact Map
3f8mA 2 0.8992 100 0.234 Contact Map
3edpA 2 0.875 100 0.251 Contact Map
3eetA 2 0.9113 100 0.264 Contact Map
3bwgA 2 0.8952 100 0.269 Contact Map
1hw1A 2 0.8105 100 0.458 Contact Map
3sxyA 2 0.75 100 0.459 Contact Map
4p96A 2 0.8589 100 0.466 Contact Map
3c7jA 4 0.879 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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