YEGW - ECOLI - GREMLIN Contacts

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YEGW - Uncharacterized HTH-type transcriptional regulator YegW

UniProt:	P0ACM5	Sequences: MEQAHTQLIAQLNERILAADNTPLYIKFAETVKNAVRSGVLEHGNILPGERDLSQLTGVSRITVRKAMQALEEEGVVTRSRGYGTQINNIFEYSLKEARGFSQQVVLRGKKPDTLWVNKRVVKCPEEVAQQLAVEAGSDVFLLKRIRYVDEEAVSIEESWVPAHLIHDVDAIGISLYDYFRSQHIYPQRTRSRVSARMPDAEFQSHIQLDSKIPVLVIKQVALDQQQRPIEYSISHCRSDLYVFVCEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14066
Length:	248 (197)
Sequences:	22871 (17556)
Seq/√Len:	1250.8

ECOLI - YEGW PHNF YIDP YIHL FRLR MNGR NANR EXUR PDHR YIEP FADR YJJM LLDR MCBR DGOR GLCC UXUR
BACSU - YURK YVOA YMFC YYDK TRER GMUR YBGA YCBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_E	45_N	4.117	1.00
35_A	40_V	3.873	1.00
33_K	74_E	3.381	1.00
35_A	56_L	3.186	1.00
29_A	70_A	3.176	1.00
78_T	88_N	2.825	1.00
28_F	59_V	2.672	1.00
50_E	61_R	2.651	1.00
133_A	192_S	2.605	1.00
80_S	83_Y	2.516	1.00
46_I	86_Q	2.446	1.00
31_T	35_A	2.417	1.00
195_S	198_M	2.347	1.00
118_N	200_D	2.295	1.00
29_A	74_E	2.245	1.00
125_P	128_V	2.233	1.00
34_N	38_S	2.177	1.00
79_R	85_T	2.176	1.00
28_F	57_T	2.150	1.00
22_T	30_E	2.050	1.00
199_P	215_V	1.945	1.00
83_Y	86_Q	1.904	1.00
31_T	57_T	1.866	1.00
66_K	69_Q	1.787	1.00
29_A	33_K	1.784	1.00
72_E	79_R	1.779	1.00
33_K	37_R	1.725	1.00
128_V	150_D	1.722	1.00
72_E	77_V	1.683	1.00
35_A	41_L	1.655	1.00
52_D	56_L	1.647	1.00
24_L	27_K	1.644	1.00
200_D	203_F	1.642	1.00
111_K	115_L	1.625	1.00
104_Q	152_E	1.608	1.00
33_K	76_V	1.591	1.00
27_K	31_T	1.584	1.00
68_M	77_V	1.578	1.00
53_L	64_V	1.563	1.00
51_R	55_Q	1.556	1.00
77_V	85_T	1.553	1.00
31_T	34_N	1.541	1.00
122_V	196_A	1.528	1.00
147_R	155_S	1.475	1.00
50_E	65_R	1.473	1.00
142_L	158_E	1.439	1.00
200_D	204_Q	1.410	1.00
124_C	129_A	1.408	1.00
49_G	52_D	1.406	1.00
113_D	148_Y	1.387	1.00
78_T	86_Q	1.378	1.00
52_D	55_Q	1.378	1.00
41_L	87_I	1.378	1.00
25_Y	70_A	1.367	1.00
36_V	87_I	1.357	1.00
43_H	89_N	1.353	1.00
80_S	86_Q	1.337	1.00
128_V	160_W	1.315	1.00
143_L	159_S	1.296	1.00
198_M	214_P	1.296	1.00
183_Q	209_L	1.286	1.00
198_M	202_E	1.254	1.00
144_K	147_R	1.247	1.00
69_Q	79_R	1.242	1.00
115_L	148_Y	1.240	1.00
129_A	192_S	1.233	1.00
69_Q	72_E	1.224	1.00
70_A	73_E	1.218	1.00
178_D	182_S	1.216	1.00
124_C	128_V	1.214	1.00
46_I	84_G	1.208	1.00
59_V	64_V	1.205	1.00
26_I	30_E	1.199	1.00
80_S	84_G	1.198	1.00
69_Q	73_E	1.191	1.00
35_A	39_G	1.152	1.00
110_K	208_Q	1.148	1.00
37_R	76_V	1.140	1.00
185_I	189_R	1.138	1.00
22_T	27_K	1.120	1.00
144_K	158_E	1.103	1.00
156_I	160_W	1.093	1.00
201_A	205_S	1.079	1.00
26_I	70_A	1.076	1.00
35_A	57_T	1.073	1.00
22_T	26_I	1.072	1.00
24_L	63_T	1.067	1.00
143_L	147_R	1.060	1.00
23_P	26_I	1.058	1.00
156_I	203_F	1.058	1.00
131_Q	144_K	1.055	1.00
70_A	74_E	1.055	1.00
196_A	200_D	1.053	1.00
68_M	85_T	1.039	1.00
121_V	139_D	1.033	1.00
135_E	138_S	1.025	1.00
60_S	63_T	1.020	1.00
124_C	194_V	1.018	1.00
122_V	142_L	1.014	1.00
108_R	157_E	1.012	1.00
188_Q	192_S	1.009	1.00
189_R	193_R	1.002	1.00
140_V	144_K	0.996	1.00
107_L	123_K	0.990	1.00
190_T	198_M	0.989	1.00
120_R	142_L	0.987	1.00
82_G	85_T	0.981	1.00
110_K	114_T	0.963	1.00
44_G	78_T	0.962	1.00
41_L	45_N	0.951	1.00
155_S	159_S	0.950	1.00
25_Y	29_A	0.950	1.00
30_E	33_K	0.948	1.00
121_V	163_A	0.947	1.00
118_N	196_A	0.946	1.00
204_Q	208_Q	0.945	1.00
142_L	184_H	0.934	1.00
130_Q	134_V	0.923	1.00
66_K	70_A	0.908	1.00
114_T	200_D	0.898	1.00
210_D	213_I	0.891	1.00
117_V	121_V	0.890	1.00
109_G	113_D	0.889	1.00
133_A	188_Q	0.884	1.00
153_A	164_H	0.883	1.00
32_V	53_L	0.882	1.00
114_T	204_Q	0.881	1.00
136_A	140_V	0.877	1.00
131_Q	135_E	0.877	1.00
30_E	34_N	0.874	1.00
118_N	142_L	0.862	1.00
144_K	148_Y	0.852	1.00
131_Q	134_V	0.850	1.00
145_R	191_R	0.849	1.00
107_L	119_K	0.844	1.00
44_G	89_N	0.844	1.00
104_Q	108_R	0.844	1.00
126_E	130_Q	0.837	1.00
144_K	202_E	0.833	1.00
110_K	204_Q	0.830	1.00
25_Y	66_K	0.828	1.00
196_A	216_L	0.820	1.00
139_D	163_A	0.817	1.00
129_A	134_V	0.816	1.00
28_F	64_V	0.813	1.00
197_R	203_F	0.811	1.00
128_V	131_Q	0.806	1.00
129_A	188_Q	0.803	1.00
176_L	179_Y	0.802	1.00
115_L	118_N	0.800	1.00
50_E	79_R	0.784	1.00
138_S	164_H	0.784	1.00
189_R	192_S	0.782	1.00
146_I	158_E	0.782	1.00
137_G	140_V	0.781	1.00
149_V	155_S	0.777	1.00
46_I	49_G	0.774	1.00
175_S	178_D	0.770	1.00
132_L	144_K	0.763	1.00
68_M	72_E	0.757	1.00
113_D	151_E	0.756	1.00
129_A	133_A	0.756	1.00
35_A	38_S	0.746	1.00
118_N	197_R	0.746	1.00
127_E	131_Q	0.738	1.00
185_I	188_Q	0.736	1.00
57_T	64_V	0.735	1.00
126_E	194_V	0.730	1.00
135_E	144_K	0.730	1.00
124_C	148_Y	0.728	1.00
162_P	165_L	0.727	1.00
47_L	77_V	0.724	1.00
106_V	109_G	0.723	1.00
149_V	154_V	0.718	1.00
203_F	206_H	0.717	1.00
20_D	27_K	0.716	1.00
199_P	204_Q	0.714	1.00
123_K	139_D	0.714	1.00
43_H	88_N	0.701	1.00
32_V	41_L	0.700	1.00
186_Y	202_E	0.700	1.00
116_W	146_I	0.698	1.00
118_N	144_K	0.697	1.00
197_R	215_V	0.686	1.00
197_R	200_D	0.685	1.00
176_L	180_F	0.684	1.00
129_A	194_V	0.678	1.00
209_L	213_I	0.678	1.00
63_T	67_A	0.672	1.00
132_L	135_E	0.671	1.00
124_C	191_R	0.669	1.00
54_S	57_T	0.669	1.00
199_P	209_L	0.668	1.00
105_V	149_V	0.667	1.00
48_P	56_L	0.660	1.00
28_F	31_T	0.658	1.00
163_A	167_H	0.655	1.00
31_T	56_L	0.654	1.00
106_V	111_K	0.654	1.00
133_A	185_I	0.653	1.00
115_L	200_D	0.653	1.00
179_Y	183_Q	0.653	1.00
29_A	67_A	0.651	1.00
55_Q	58_G	0.650	1.00
209_L	215_V	0.649	1.00
202_E	205_S	0.646	1.00
110_K	211_S	0.645	1.00
205_S	209_L	0.643	1.00
53_L	68_M	0.640	1.00
41_L	47_L	0.639	1.00
179_Y	182_S	0.636	1.00
131_Q	147_R	0.635	1.00
198_M	201_A	0.634	1.00
54_S	64_V	0.633	1.00
141_F	188_Q	0.632	1.00
199_P	213_I	0.627	1.00
51_R	54_S	0.624	1.00
110_K	150_D	0.622	1.00
108_R	112_P	0.621	1.00
181_R	186_Y	0.620	1.00
72_E	85_T	0.620	1.00
135_E	140_V	0.618	1.00
119_K	123_K	0.613	1.00
128_V	148_Y	0.613	1.00
54_S	61_R	0.611	1.00
187_P	202_E	0.611	1.00
103_Q	106_V	0.610	1.00
124_C	140_V	0.607	1.00
53_L	57_T	0.606	1.00
46_I	83_Y	0.602	1.00
117_V	203_F	0.596	1.00
202_E	206_H	0.595	1.00
68_M	79_R	0.593	1.00
177_Y	180_F	0.591	1.00
193_R	198_M	0.591	1.00
143_L	162_P	0.589	1.00
211_S	215_V	0.585	1.00
181_R	185_I	0.584	1.00
104_Q	151_E	0.581	1.00
199_P	212_K	0.579	1.00
111_K	154_V	0.578	1.00
103_Q	107_L	0.578	1.00
134_V	140_V	0.577	1.00
115_L	146_I	0.571	1.00
177_Y	181_R	0.570	1.00
164_H	167_H	0.569	1.00
117_V	146_I	0.567	1.00
166_I	169_V	0.565	1.00
104_Q	109_G	0.565	1.00
127_E	130_Q	0.564	1.00
64_V	77_V	0.564	1.00
34_N	37_R	0.561	1.00
197_R	201_A	0.560	1.00
106_V	210_D	0.559	1.00
201_A	204_Q	0.558	1.00
109_G	112_P	0.558	1.00
118_N	122_V	0.556	1.00
190_T	195_S	0.556	1.00
119_K	141_F	0.556	1.00
62_I	66_K	0.555	1.00
148_Y	151_E	0.554	1.00
204_Q	212_K	0.554	1.00
171_A	179_Y	0.552	1.00
191_R	194_V	0.550	1.00
21_N	27_K	0.549	1.00
159_S	162_P	0.547	1.00
139_D	166_I	0.546	1.00
186_Y	189_R	0.543	1.00
47_L	68_M	0.543	1.00
157_E	160_W	0.542	1.00
114_T	118_N	0.540	1.00
143_L	155_S	0.539	1.00
104_Q	153_A	0.539	1.00
54_S	62_I	0.536	1.00
28_F	67_A	0.535	1.00
114_T	117_V	0.534	1.00
126_E	129_A	0.534	1.00
49_G	64_V	0.530	1.00
170_D	173_G	0.526	1.00
143_L	169_V	0.523	1.00
96_K	99_R	0.523	1.00
183_Q	206_H	0.521	1.00
186_Y	198_M	0.518	1.00
124_C	134_V	0.516	1.00
104_Q	107_L	0.516	1.00
141_F	145_R	0.515	1.00
170_D	180_F	0.514	1.00
139_D	162_P	0.510	1.00
63_T	66_K	0.510	1.00
50_E	85_T	0.509	1.00
101_F	105_V	0.507	1.00
71_L	77_V	0.506	1.00
93_Y	96_K	0.505	1.00
41_L	48_P	0.504	1.00
81_R	84_G	0.500	1.00
139_D	143_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ra5A	2	0.5806	100	0.218	Contact Map
4u0wA	2	0.9516	100	0.223	Contact Map
3f8mA	2	0.8992	100	0.234	Contact Map
3edpA	2	0.875	100	0.251	Contact Map
3eetA	2	0.9113	100	0.264	Contact Map
3bwgA	2	0.8952	100	0.269	Contact Map
1hw1A	2	0.8105	100	0.458	Contact Map
3sxyA	2	0.75	100	0.459	Contact Map
4p96A	2	0.8589	100	0.466	Contact Map
3c7jA	4	0.879	100	0.466	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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