GREMLIN Database
PDHR - Pyruvate dehydrogenase complex repressor
UniProt: P0ACL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11088
Length: 254 (206)
Sequences: 23353 (17030)
Seq/√Len: 1186.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_R210_M3.8621.00
113_Y218_R3.3261.00
213_K216_E2.9331.00
135_E203_T2.8721.00
29_R32_E2.7581.00
22_L27_T2.7211.00
22_L43_Q2.3891.00
106_A110_I2.3201.00
37_E48_R2.2511.00
99_D164_V2.2301.00
126_R156_A2.1971.00
105_H226_A2.1091.00
16_E57_R2.0921.00
65_L75_Q2.0331.00
20_E61_K1.9991.00
117_L214_P1.9581.00
15_I46_V1.9471.00
102_E114_Y1.9121.00
124_K210_M1.8331.00
123_D162_H1.8111.00
208_A216_E1.7951.00
15_I44_F1.7881.00
120_T123_D1.7761.00
159_E167_L1.7611.00
66_R72_T1.7381.00
156_A159_E1.7191.00
142_D145_A1.7051.00
131_H206_F1.6761.00
18_Q22_L1.6491.00
109_G222_H1.6461.00
201_H227_F1.6191.00
113_Y214_P1.6061.00
216_E220_A1.5881.00
154_Q202_R1.5781.00
9_P17_Q1.5711.00
103_T169_L1.5691.00
21_F25_E1.5561.00
109_G218_R1.5531.00
218_R222_H1.5471.00
110_I113_Y1.5171.00
204_R220_A1.4721.00
67_R70_G1.4681.00
207_E211_A1.4431.00
158_T170_L1.4371.00
155_I171_R1.4191.00
130_L149_A1.4141.00
133_A149_A1.4111.00
112_A217_A1.4051.00
123_D160_A1.4011.00
16_E61_K1.3961.00
168_H172_C1.3911.00
128_R206_F1.3891.00
165_V176_M1.3831.00
105_H222_H1.3811.00
211_A216_E1.3611.00
135_E199_S1.3521.00
38_R42_K1.3441.00
105_H229_E1.3441.00
203_T207_E1.3241.00
99_D165_V1.3121.00
128_R132_H1.2741.00
214_P218_R1.2721.00
133_A152_Q1.2661.00
39_E43_Q1.2591.00
119_S124_K1.2521.00
131_H203_T1.2381.00
129_E133_A1.2351.00
219_E223_R1.2041.00
201_H224_H1.1981.00
33_K73_F1.1961.00
40_L51_L1.1951.00
105_H109_G1.1931.00
98_Y233_L1.1891.00
18_Q21_F1.1871.00
14_V18_Q1.1851.00
130_L156_A1.1841.00
67_R73_F1.1691.00
22_L44_F1.1611.00
216_E219_E1.1561.00
18_Q44_F1.1531.00
104_R108_E1.1501.00
113_Y215_E1.1421.00
98_Y229_E1.1361.00
155_I159_E1.1291.00
119_S160_A1.1271.00
152_Q156_A1.1201.00
112_A116_A1.1191.00
222_H226_A1.1181.00
119_S212_G1.1131.00
124_K206_F1.1121.00
119_S123_D1.1101.00
145_A148_N1.1081.00
157_V209_I1.1071.00
150_V154_Q1.1061.00
109_G113_Y1.1021.00
59_E66_R1.0991.00
207_E210_M1.0981.00
28_L74_V1.0881.00
112_A221_S1.0871.00
99_D163_N1.0841.00
206_F210_M1.0601.00
131_H134_I1.0571.00
126_R159_E1.0501.00
102_E163_N1.0411.00
128_R203_T1.0391.00
131_H135_E1.0381.00
111_A158_T1.0321.00
130_L152_Q1.0291.00
132_H135_E1.0241.00
156_A160_A1.0241.00
154_Q224_H1.0201.00
59_E64_L1.0191.00
229_E233_L1.0151.00
124_K212_G1.0141.00
202_R224_H1.0141.00
126_R129_E0.9901.00
149_A152_Q0.9901.00
161_A167_L0.9851.00
65_L73_F0.9841.00
116_A214_P0.9821.00
53_E56_Q0.9791.00
169_L172_C0.9671.00
204_R223_R0.9651.00
200_S204_R0.9641.00
208_A213_K0.9631.00
108_E154_Q0.9631.00
37_E52_R0.9621.00
110_I218_R0.9571.00
9_P14_V0.9551.00
22_L28_L0.9501.00
204_R216_E0.9461.00
114_Y118_R0.9441.00
148_N152_Q0.9381.00
153_Y206_F0.9351.00
125_E129_E0.9271.00
55_I72_T0.9261.00
116_A209_I0.9201.00
23_I74_V0.9171.00
64_L72_T0.9171.00
205_I221_S0.9141.00
12_S57_R0.9061.00
126_R130_L0.9051.00
36_P39_E0.8971.00
124_K128_R0.8971.00
67_R71_G0.8971.00
204_R207_E0.8941.00
104_R225_L0.8831.00
130_L133_A0.8811.00
96_S165_V0.8801.00
33_K71_G0.8801.00
103_T165_V0.8751.00
41_A51_L0.8751.00
95_E99_D0.8751.00
215_E219_E0.8721.00
70_G73_F0.8661.00
57_R60_A0.8621.00
135_E139_Q0.8581.00
150_V202_R0.8541.00
215_E218_R0.8521.00
118_R162_H0.8501.00
20_E63_L0.8491.00
110_I114_Y0.8441.00
167_L171_R0.8411.00
128_R207_E0.8391.00
16_E20_E0.8391.00
39_E42_K0.8371.00
95_E162_H0.8351.00
123_D126_R0.8311.00
137_A145_A0.8261.00
127_I156_A0.8261.00
199_S203_T0.8261.00
136_L140_S0.8221.00
133_A136_L0.8201.00
47_S50_S0.8191.00
119_S209_I0.8171.00
116_A212_G0.8151.00
40_L55_I0.8011.00
20_E24_L0.8001.00
121_D212_G0.7991.00
56_Q59_E0.7981.00
132_H136_L0.7971.00
11_L14_V0.7961.00
116_A217_A0.7961.00
55_I64_L0.7941.00
121_D125_E0.7931.00
127_I206_F0.7911.00
205_I220_A0.7911.00
134_I146_E0.7891.00
204_R208_A0.7801.00
196_P200_S0.7781.00
115_A160_A0.7771.00
13_D57_R0.7731.00
46_V51_L0.7701.00
132_H203_T0.7671.00
208_A220_A0.7641.00
165_V169_L0.7631.00
11_L50_S0.7611.00
226_A230_E0.7461.00
113_Y117_L0.7451.00
102_E229_E0.7451.00
155_I174_E0.7441.00
12_S16_E0.7421.00
10_K13_D0.7401.00
115_A119_S0.7391.00
114_Y117_L0.7391.00
165_V168_H0.7291.00
102_E118_R0.7261.00
126_R152_Q0.7231.00
101_L228_I0.7191.00
103_T166_L0.7181.00
114_Y163_N0.7161.00
220_A223_R0.7121.00
56_Q66_R0.7101.00
27_T43_Q0.7091.00
133_A145_A0.7041.00
219_E222_H0.7031.00
151_L178_A0.6971.00
124_K209_I0.6961.00
145_A149_A0.6961.00
125_E210_M0.6931.00
205_I217_A0.6881.00
125_E128_R0.6811.00
103_T111_A0.6791.00
129_E132_H0.6711.00
137_A149_A0.6631.00
226_A229_E0.6631.00
131_H199_S0.6621.00
123_D159_E0.6601.00
223_R227_F0.6591.00
227_F231_I0.6561.00
155_I167_L0.6541.00
205_I224_H0.6541.00
57_R61_K0.6491.00
105_H225_L0.6421.00
9_P13_D0.6411.00
96_S164_V0.6371.00
133_A137_A0.6341.00
69_G72_T0.6281.00
50_S54_A0.6271.00
78_L96_S0.6241.00
112_A214_P0.6201.00
28_L32_E0.6191.00
111_A161_A0.6151.00
123_D156_A0.6131.00
102_E110_I0.6131.00
151_L174_E0.6131.00
201_H204_R0.6111.00
103_T107_L0.6031.00
106_A166_L0.6021.00
115_A161_A0.6011.00
146_E198_V0.5961.00
115_A157_V0.5891.00
22_L26_G0.5871.00
108_E202_R0.5861.00
137_A142_D0.5851.00
152_Q155_I0.5831.00
109_G214_P0.5821.00
38_R41_A0.5781.00
230_E234_D0.5761.00
136_L139_Q0.5751.00
134_I199_S0.5711.00
109_G221_S0.5701.00
12_S53_E0.5661.00
30_P76_S0.5661.00
44_F51_L0.5611.00
106_A109_G0.5591.00
34_L64_L0.5581.00
107_L170_L0.5571.00
127_I160_A0.5541.00
122_E126_R0.5541.00
95_E164_V0.5531.00
111_A166_L0.5511.00
73_F76_S0.5471.00
94_P98_Y0.5431.00
31_G76_S0.5431.00
56_Q60_A0.5421.00
230_E233_L0.5411.00
194_M197_L0.5391.00
121_D124_K0.5361.00
168_H176_M0.5351.00
223_R226_A0.5311.00
121_D210_M0.5281.00
113_Y222_H0.5281.00
28_L34_L0.5271.00
137_A141_G0.5251.00
19_L40_L0.5251.00
112_A157_V0.5241.00
158_T174_E0.5221.00
95_E98_Y0.5211.00
75_Q179_Q0.5201.00
42_K45_D0.5191.00
108_E225_L0.5171.00
217_A221_S0.5171.00
127_I131_H0.5161.00
200_S203_T0.5141.00
205_I208_A0.5131.00
194_M231_I0.5131.00
24_L63_L0.5121.00
135_E200_S0.5101.00
168_H171_R0.5091.00
110_I166_L0.5081.00
193_E196_P0.5071.00
221_S225_L0.5051.00
28_L43_Q0.5051.00
227_F230_E0.5041.00
114_Y161_A0.5031.00
22_L25_E0.5021.00
139_Q196_P0.5011.00
116_A218_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sxyA 2 0.7874 100 0.195 Contact Map
4p96A 2 0.9449 100 0.2 Contact Map
3c7jA 4 0.8701 100 0.201 Contact Map
2hs5A 1 0.815 100 0.205 Contact Map
2di3A 2 0.8937 100 0.207 Contact Map
3ihuA 1 0.8031 100 0.213 Contact Map
4p9fA 1 0.8307 100 0.215 Contact Map
1hw1A 2 0.874 100 0.244 Contact Map
4r1hA 2 0.4488 99.9 0.551 Contact Map
3ic7A 2 0.437 99.9 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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