GREMLIN Database
LLDR - Putative L-lactate dehydrogenase operon regulatory protein
UniProt: P0ACL7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11962
Length: 258 (202)
Sequences: 22250 (16236)
Seq/√Len: 1142.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_Q207_F3.5961.00
114_W215_R3.2941.00
210_D213_G2.9131.00
136_L200_Q2.7641.00
19_L24_N2.7301.00
26_E29_M2.7001.00
19_L40_Q2.3771.00
107_A111_S2.3351.00
127_K153_A2.2561.00
34_E45_R2.2231.00
100_D161_I2.1691.00
13_A54_K2.0841.00
106_Y223_S2.0771.00
62_L72_R1.9961.00
118_M211_A1.9921.00
12_V43_V1.9761.00
17_R58_E1.9551.00
103_E115_H1.9401.00
125_K207_F1.8471.00
124_D159_H1.8291.00
12_V41_L1.7871.00
205_A213_G1.7791.00
156_E164_L1.7731.00
153_A156_E1.7531.00
63_S69_T1.7411.00
121_T124_D1.7131.00
15_R19_L1.6851.00
110_A219_M1.6841.00
132_F203_I1.6611.00
198_Q224_F1.6361.00
139_D142_I1.6331.00
114_W211_A1.6321.00
104_A166_T1.6291.00
213_G217_A1.5891.00
111_S114_W1.5621.00
215_R219_M1.5591.00
110_A215_R1.5501.00
18_A22_E1.5311.00
201_A217_A1.5001.00
6_R14_D1.4951.00
113_A214_A1.4541.00
151_H199_H1.4211.00
64_R67_G1.4181.00
152_L168_R1.4131.00
106_Y219_M1.4131.00
155_A167_M1.4051.00
165_Q169_G1.4031.00
162_V173_V1.4031.00
129_Q203_I1.4011.00
204_D208_A1.3911.00
124_D157_A1.3851.00
13_A58_E1.3831.00
131_C146_A1.3671.00
134_A146_A1.3521.00
136_L196_T1.3481.00
208_A213_G1.3371.00
106_Y226_H1.3351.00
200_Q204_D1.3151.00
120_A125_K1.3051.00
211_A215_R1.3011.00
35_R39_M1.2991.00
100_D162_V1.2851.00
129_Q133_E1.2801.00
130_L134_A1.2231.00
134_A149_R1.2141.00
99_F230_K1.2101.00
36_Q40_Q1.2071.00
37_L48_L1.1921.00
132_F200_Q1.1881.00
216_K220_A1.1811.00
30_K70_F1.1761.00
11_E15_R1.1691.00
131_C153_A1.1691.00
64_R70_F1.1661.00
106_Y110_A1.1651.00
99_F226_H1.1551.00
198_Q221_H1.1541.00
152_L156_E1.1481.00
132_F135_T1.1341.00
33_A36_Q1.1341.00
149_R153_A1.1341.00
15_R18_A1.1321.00
120_A209_G1.1291.00
219_M223_S1.1281.00
120_A157_A1.1251.00
120_A124_D1.1221.00
114_W212_D1.1191.00
15_R41_L1.1181.00
110_A114_W1.1151.00
154_I206_I1.1151.00
56_V63_S1.1101.00
105_R109_E1.1091.00
19_L41_L1.1081.00
213_G216_K1.1031.00
112_T155_A1.0981.00
113_A218_M1.0961.00
113_A117_A1.0861.00
100_D160_N1.0841.00
125_K209_G1.0811.00
226_H230_K1.0751.00
125_K203_I1.0651.00
131_C149_R1.0631.00
204_D207_F1.0621.00
142_I145_Q1.0611.00
132_F136_L1.0501.00
153_A157_A1.0461.00
203_I207_F1.0411.00
146_A149_R1.0241.00
103_E160_N1.0231.00
25_L71_I1.0191.00
147_D151_H1.0181.00
166_T169_G1.0181.00
127_K156_E1.0181.00
56_V61_L1.0111.00
151_H221_H0.9911.00
129_Q200_Q0.9891.00
6_R11_E0.9851.00
115_H119_R0.9771.00
50_E53_A0.9771.00
117_A211_A0.9771.00
127_K130_L0.9731.00
133_E136_L0.9731.00
62_L70_F0.9691.00
111_S215_R0.9681.00
150_F203_I0.9671.00
19_L25_L0.9651.00
205_A210_D0.9611.00
94_D97_Y0.9601.00
201_A220_A0.9421.00
127_K131_C0.9311.00
109_E151_H0.9281.00
126_E130_L0.9271.00
201_A213_G0.9191.00
199_H221_H0.9191.00
52_L69_T0.9171.00
34_E49_R0.9151.00
9_S54_K0.9111.00
20_I71_I0.9021.00
202_V218_M0.9021.00
145_Q149_R0.9011.00
197_E201_A0.8991.00
61_L69_T0.8951.00
158_S164_L0.8941.00
117_A206_I0.8931.00
30_K68_G0.8901.00
164_L168_R0.8891.00
54_K57_S0.8841.00
64_R68_G0.8831.00
119_R159_H0.8781.00
131_C134_A0.8751.00
111_S115_H0.8711.00
13_A17_R0.8631.00
201_A204_D0.8591.00
212_D216_K0.8521.00
134_A137_S0.8491.00
104_A162_V0.8481.00
17_R60_V0.8471.00
120_A206_I0.8461.00
116_A157_A0.8451.00
38_A48_L0.8451.00
17_R21_D0.8451.00
105_R222_L0.8341.00
96_D100_D0.8311.00
196_T200_Q0.8311.00
122_P126_E0.8281.00
97_Y162_V0.8191.00
67_G70_F0.8191.00
212_D215_R0.8171.00
133_E137_S0.8151.00
129_Q204_D0.8121.00
53_A56_V0.8031.00
96_D159_H0.8031.00
125_K129_Q0.8021.00
147_D199_H0.8011.00
117_A209_G0.8011.00
201_A205_A0.8001.00
44_S47_S0.7971.00
115_H118_M0.7971.00
116_A120_A0.7951.00
36_Q39_M0.7941.00
122_P209_G0.7931.00
52_L61_L0.7901.00
202_V217_A0.7771.00
53_A63_S0.7731.00
7_R10_D0.7731.00
133_E200_Q0.7711.00
128_I153_A0.7701.00
117_A214_A0.7691.00
124_D127_K0.7661.00
126_E207_F0.7631.00
8_L47_S0.7601.00
205_A217_A0.7551.00
8_L11_E0.7541.00
10_D54_K0.7531.00
114_W118_M0.7501.00
162_V165_Q0.7491.00
223_S227_T0.7441.00
217_A220_A0.7421.00
135_T143_A0.7401.00
103_E226_H0.7361.00
162_V166_T0.7351.00
193_S197_E0.7321.00
152_L171_F0.7271.00
102_L225_V0.7251.00
37_L52_L0.7241.00
128_I203_I0.7211.00
202_V214_A0.7201.00
104_A163_L0.7191.00
30_K33_A0.7171.00
115_H160_N0.7111.00
216_K219_M0.7091.00
103_E119_R0.7081.00
9_S13_A0.7061.00
126_E129_Q0.7001.00
148_V175_Q0.6941.00
54_K58_E0.6851.00
142_I146_A0.6821.00
223_S226_H0.6821.00
43_V48_L0.6811.00
104_A112_T0.6781.00
127_K149_R0.6751.00
148_V171_F0.6691.00
149_R152_L0.6661.00
220_A224_F0.6651.00
134_A142_I0.6601.00
224_F228_T0.6601.00
124_D153_A0.6591.00
152_L164_L0.6561.00
24_N40_Q0.6541.00
47_S51_A0.6491.00
202_V221_H0.6391.00
132_F196_T0.6341.00
103_E111_S0.6341.00
198_Q201_A0.6301.00
19_L23_K0.6231.00
113_A211_A0.6211.00
130_L133_E0.6191.00
107_A163_L0.6191.00
125_K206_I0.6191.00
25_L29_M0.6191.00
27_A73_W0.6131.00
104_A108_I0.6101.00
116_A154_I0.6071.00
112_T158_S0.6041.00
227_T230_K0.6021.00
97_Y161_I0.6011.00
143_A195_L0.6011.00
116_A158_S0.5991.00
112_T163_L0.5991.00
9_S50_E0.5991.00
106_Y222_L0.5981.00
124_D156_E0.5951.00
31_L61_L0.5801.00
97_Y100_D0.5761.00
165_Q173_V0.5761.00
128_I157_A0.5721.00
41_L48_L0.5701.00
66_G69_T0.5701.00
6_R10_D0.5671.00
109_E199_H0.5631.00
114_W219_M0.5601.00
113_A154_I0.5571.00
107_A110_A0.5571.00
110_A211_A0.5531.00
110_A218_M0.5511.00
108_I167_M0.5501.00
35_R38_A0.5491.00
135_T196_T0.5491.00
122_P207_F0.5461.00
70_F73_W0.5421.00
227_T231_R0.5371.00
111_S163_L0.5371.00
197_E200_Q0.5351.00
28_G73_W0.5341.00
21_D60_V0.5331.00
202_V205_A0.5321.00
109_E222_L0.5321.00
103_E106_Y0.5311.00
128_I132_F0.5281.00
72_R176_S0.5271.00
129_Q132_F0.5261.00
19_L22_E0.5251.00
115_H158_S0.5201.00
123_G127_K0.5191.00
148_V152_L0.5181.00
96_D99_F0.5171.00
191_V194_Q0.5171.00
220_A223_S0.5131.00
65_R68_G0.5131.00
95_P99_F0.5111.00
198_Q220_A0.5111.00
39_M42_G0.5101.00
95_P230_K0.5101.00
96_D161_I0.5091.00
117_A218_M0.5091.00
155_A171_F0.5081.00
16_V37_L0.5081.00
165_Q168_R0.5071.00
53_A57_S0.5071.00
110_A113_A0.5031.00
191_V228_T0.5031.00
25_L31_L0.5011.00
10_D14_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p96A 2 0.9302 100 0.218 Contact Map
3sxyA 2 0.7674 100 0.241 Contact Map
3c7jA 4 0.8411 100 0.243 Contact Map
2di3A 2 0.8721 100 0.243 Contact Map
2hs5A 1 0.7868 100 0.245 Contact Map
3ihuA 1 0.7752 100 0.254 Contact Map
1hw1A 2 0.876 100 0.254 Contact Map
4p9fA 1 0.8023 100 0.256 Contact Map
3ic7A 2 0.4302 99.9 0.572 Contact Map
3by6A 2 0.469 99.8 0.573 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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