GREMLIN Database
GLCC - Glc operon transcriptional activator
UniProt: P0ACL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12998
Length: 254 (205)
Sequences: 23214 (17135)
Seq/√Len: 1196.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_T210_L3.7811.00
110_R218_Q3.3501.00
213_L216_V2.9281.00
132_L203_A2.8261.00
19_L24_V2.7241.00
26_K29_Q2.6781.00
19_L40_K2.4151.00
103_L107_E2.3781.00
123_V156_A2.2711.00
34_E45_R2.2291.00
96_D164_Q2.1911.00
102_A226_R2.1011.00
13_A54_V2.0641.00
62_E72_A2.0521.00
17_E58_R1.9941.00
114_T214_P1.9901.00
12_V43_F1.9671.00
99_D111_L1.9491.00
121_F210_L1.8491.00
159_Q167_V1.8171.00
120_D162_H1.8141.00
208_A216_V1.8111.00
63_T69_S1.7951.00
12_V41_L1.7911.00
156_A159_Q1.7321.00
15_S19_L1.7251.00
142_S145_E1.7191.00
117_T120_D1.7091.00
106_G222_R1.7061.00
128_Y206_Y1.6691.00
110_R214_P1.6471.00
201_Q227_T1.6381.00
100_V169_T1.6021.00
216_V220_A1.5881.00
106_G218_Q1.5871.00
107_E110_R1.5861.00
218_Q222_R1.5671.00
18_R22_D1.5641.00
154_H202_H1.5111.00
204_R220_A1.5051.00
155_L171_Q1.4371.00
130_K149_L1.4351.00
64_A67_R1.4321.00
120_D160_A1.4261.00
168_F172_S1.4251.00
158_C170_L1.4101.00
207_N211_Q1.4081.00
13_A58_R1.4071.00
165_V176_L1.4041.00
102_A222_R1.4041.00
127_C149_L1.4021.00
109_A217_A1.3901.00
125_T206_Y1.3861.00
132_L199_D1.3821.00
211_Q216_V1.3451.00
102_A229_K1.3401.00
214_P218_Q1.3181.00
96_D165_V1.3181.00
35_R39_E1.2861.00
203_A207_N1.2831.00
126_R130_K1.2781.00
130_K152_A1.2781.00
116_G121_F1.2591.00
128_Y203_A1.2511.00
36_R40_K1.2371.00
125_T129_E1.2281.00
127_C156_A1.2081.00
219_R223_D1.2051.00
95_Y233_H1.1941.00
30_P70_R1.1911.00
102_A106_G1.1831.00
11_V15_S1.1811.00
201_Q224_H1.1811.00
37_L48_L1.1791.00
64_A70_R1.1781.00
155_L159_Q1.1601.00
95_Y229_K1.1571.00
15_S18_R1.1551.00
106_G110_R1.1541.00
56_R63_T1.1531.00
19_L41_L1.1511.00
15_S41_L1.1501.00
152_A156_A1.1421.00
216_V219_R1.1401.00
116_G212_R1.1381.00
157_I209_V1.1361.00
101_R105_E1.1291.00
222_R226_R1.1211.00
116_G160_A1.1111.00
25_L71_V1.1101.00
110_R215_H1.1051.00
109_A113_A1.1041.00
109_A221_A1.1011.00
96_D163_N1.0931.00
121_F206_Y1.0891.00
207_N210_L1.0831.00
128_Y131_M1.0771.00
150_D154_H1.0761.00
108_S158_C1.0741.00
116_G120_D1.0631.00
145_E148_Q1.0561.00
99_D163_N1.0551.00
156_A160_A1.0501.00
206_Y210_L1.0461.00
125_T203_A1.0401.00
128_Y132_L1.0381.00
129_E132_L1.0341.00
123_V126_R1.0271.00
229_K233_H1.0261.00
121_F212_R1.0251.00
123_V159_Q1.0231.00
149_L152_A1.0221.00
169_T172_S1.0151.00
62_E70_R1.0111.00
127_C152_A0.9981.00
50_E53_T0.9981.00
56_R61_I0.9941.00
154_H224_H0.9861.00
111_L115_L0.9811.00
113_A214_P0.9791.00
208_A213_L0.9771.00
19_L25_L0.9731.00
107_E218_Q0.9681.00
20_I71_V0.9631.00
153_F206_Y0.9611.00
204_R223_D0.9561.00
202_H224_H0.9491.00
64_A68_D0.9471.00
113_A209_V0.9351.00
52_L69_S0.9301.00
161_S167_V0.9301.00
204_R216_V0.9291.00
105_E154_H0.9271.00
34_E49_R0.9271.00
148_Q152_A0.9231.00
200_R204_R0.9211.00
215_H219_R0.9121.00
121_F125_T0.9101.00
205_I221_A0.9101.00
122_V126_R0.9071.00
204_R207_N0.9011.00
123_V127_C0.9011.00
9_C54_V0.8991.00
54_V57_G0.8971.00
93_T165_V0.8951.00
30_P68_D0.8921.00
115_L162_H0.8871.00
116_G209_V0.8781.00
61_I69_S0.8781.00
167_V171_Q0.8741.00
150_D202_H0.8731.00
107_E111_L0.8731.00
13_A17_E0.8671.00
127_C130_K0.8661.00
101_R225_V0.8651.00
67_R70_R0.8621.00
100_V165_V0.8591.00
38_C48_L0.8541.00
32_P36_R0.8491.00
215_H218_Q0.8491.00
92_R162_H0.8451.00
17_E60_I0.8441.00
120_D123_V0.8431.00
17_E21_I0.8401.00
53_T56_R0.8351.00
125_T207_N0.8331.00
92_R96_D0.8321.00
130_K133_A0.8261.00
124_I156_A0.8251.00
113_A212_R0.8251.00
36_R39_E0.8241.00
113_A217_A0.8171.00
133_A137_N0.8151.00
199_D203_A0.8121.00
112_A116_G0.8111.00
112_A160_A0.8101.00
204_R208_A0.8061.00
10_E54_V0.8041.00
129_E133_A0.8041.00
44_S47_A0.8021.00
118_Q122_V0.7981.00
134_A145_E0.7911.00
52_L61_I0.7871.00
8_I11_V0.7851.00
205_I220_A0.7841.00
118_Q212_R0.7821.00
196_K200_R0.7771.00
124_I206_Y0.7741.00
155_L174_T0.7701.00
208_A220_A0.7661.00
165_V169_T0.7651.00
37_L52_L0.7651.00
131_M146_H0.7621.00
53_T63_T0.7611.00
99_D229_K0.7611.00
110_R114_T0.7581.00
111_L114_T0.7531.00
165_V168_F0.7531.00
111_L163_N0.7521.00
226_R230_K0.7501.00
43_F48_L0.7441.00
7_P10_E0.7441.00
129_E203_A0.7431.00
130_K145_E0.7411.00
8_I47_A0.7241.00
220_A223_D0.7241.00
100_V166_L0.7221.00
205_I217_A0.7181.00
134_A149_L0.7161.00
122_V210_L0.7141.00
99_D115_L0.7121.00
98_L228_V0.7091.00
219_R222_R0.7001.00
32_P35_R0.6981.00
151_H178_F0.6941.00
121_F209_V0.6921.00
123_V152_A0.6921.00
145_E149_L0.6881.00
122_V125_T0.6851.00
9_C13_A0.6771.00
24_V40_K0.6741.00
226_R229_K0.6721.00
155_L167_V0.6691.00
54_V58_R0.6691.00
223_D227_T0.6681.00
100_V108_S0.6611.00
99_D107_E0.6601.00
126_R129_E0.6601.00
151_H174_T0.6581.00
128_Y199_D0.6561.00
120_D156_A0.6551.00
25_L29_Q0.6541.00
201_Q204_R0.6521.00
227_T231_N0.6491.00
93_T164_Q0.6481.00
205_I224_H0.6441.00
132_L136_E0.6401.00
47_A51_G0.6391.00
66_G69_S0.6381.00
152_A155_L0.6341.00
120_D159_Q0.6331.00
130_K134_A0.6321.00
75_N93_T0.6251.00
109_A214_P0.6241.00
103_L166_L0.6131.00
102_A225_V0.6111.00
108_S161_S0.6101.00
19_L23_G0.6071.00
108_S166_L0.6021.00
100_V104_L0.6011.00
112_A161_S0.5961.00
35_R38_C0.5921.00
27_V73_R0.5901.00
106_G221_A0.5891.00
106_G214_P0.5851.00
137_N142_S0.5821.00
105_E202_H0.5821.00
230_K234_D0.5811.00
119_A123_V0.5791.00
41_L48_L0.5741.00
146_H198_I0.5711.00
168_F176_L0.5711.00
112_A157_I0.5701.00
110_R222_R0.5691.00
103_L106_G0.5681.00
230_K233_H0.5631.00
92_R164_Q0.5611.00
131_M199_D0.5611.00
124_I160_A0.5571.00
16_I37_L0.5561.00
28_G73_R0.5551.00
72_A179_N0.5511.00
194_Q197_Q0.5501.00
31_L61_I0.5481.00
105_E225_V0.5461.00
95_Y99_D0.5421.00
104_L170_L0.5411.00
109_A157_I0.5381.00
53_T57_G0.5281.00
124_I128_Y0.5281.00
19_L22_D0.5271.00
99_D102_A0.5271.00
205_I208_A0.5261.00
70_R73_R0.5241.00
118_Q210_L0.5221.00
113_A218_Q0.5221.00
93_T176_L0.5201.00
107_E166_L0.5201.00
168_F171_Q0.5191.00
134_A142_S0.5181.00
193_Q196_K0.5181.00
151_H155_L0.5151.00
164_Q167_V0.5151.00
9_C50_E0.5141.00
223_D226_R0.5141.00
200_R203_A0.5131.00
137_N145_E0.5111.00
158_C174_T0.5111.00
100_V103_L0.5101.00
221_A225_V0.5071.00
227_T230_K0.5071.00
92_R95_Y0.5071.00
21_I60_I0.5061.00
39_E42_G0.5061.00
25_L31_L0.5061.00
201_Q223_D0.5051.00
124_I127_C0.5031.00
111_L161_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p96A 2 0.9567 100 0.186 Contact Map
3c7jA 4 0.8583 100 0.201 Contact Map
2hs5A 1 0.815 100 0.202 Contact Map
4p9fA 1 0.8307 100 0.202 Contact Map
2di3A 2 0.8937 100 0.203 Contact Map
3ihuA 1 0.8031 100 0.206 Contact Map
3sxyA 2 0.7874 100 0.212 Contact Map
1hw1A 2 0.874 100 0.234 Contact Map
3ic7A 2 0.437 99.9 0.55 Contact Map
3by6A 2 0.4724 99.9 0.551 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.