GREMLIN Database
EXUR - Exu regulon transcriptional regulator
UniProt: P0ACL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12739
Length: 258 (202)
Sequences: 22471 (16475)
Seq/√Len: 1159.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_M203_I3.5821.00
110_E211_K3.2351.00
206_D209_A2.8511.00
27_L30_D2.7501.00
132_R196_D2.7011.00
20_R25_V2.6471.00
20_R41_E2.3461.00
103_L107_N2.2461.00
35_E46_R2.1911.00
96_E157_S2.1571.00
123_K149_Q2.1261.00
14_A55_M2.0651.00
102_Q219_E2.0341.00
18_K59_E1.9611.00
63_E73_V1.9191.00
13_L44_V1.9011.00
114_T207_P1.8971.00
99_Q111_F1.8441.00
120_D155_Q1.8101.00
121_I203_I1.7971.00
201_A209_A1.7641.00
64_V70_I1.7591.00
117_T120_D1.7191.00
135_Q138_R1.7171.00
152_L160_A1.7011.00
13_L42_K1.6981.00
149_Q152_L1.6641.00
16_D20_R1.6301.00
106_S215_W1.5981.00
194_D220_N1.5811.00
128_Q199_L1.5801.00
100_A162_I1.5571.00
110_E207_P1.5421.00
19_E23_Q1.5361.00
211_K215_W1.5211.00
106_S211_K1.5071.00
209_A213_A1.5071.00
7_R15_A1.5061.00
107_N110_E1.4901.00
147_H195_H1.4451.00
200_K204_R1.4281.00
148_I164_E1.4251.00
14_A59_E1.4181.00
197_Q213_A1.4141.00
65_R68_S1.4061.00
161_A165_K1.3921.00
151_A163_V1.3821.00
158_A169_Q1.3791.00
109_A210_A1.3741.00
127_I142_W1.3651.00
120_D153_A1.3611.00
102_Q215_W1.3431.00
130_Q142_W1.3271.00
125_M199_L1.3261.00
132_R192_C1.3201.00
204_R209_A1.3181.00
125_M129_E1.3141.00
102_Q222_K1.3111.00
207_P211_K1.2871.00
116_V121_I1.2871.00
96_E158_A1.2851.00
196_D200_K1.2831.00
36_R40_D1.2741.00
130_Q145_Q1.2621.00
37_F41_E1.2601.00
126_A130_Q1.2311.00
175_Y178_K1.2251.00
212_L216_Q1.1921.00
65_R71_H1.1851.00
38_I49_V1.1841.00
127_I149_Q1.1831.00
194_D217_H1.1791.00
12_Q16_D1.1701.00
31_K71_H1.1691.00
16_D19_E1.1641.00
128_Q196_D1.1531.00
95_F226_F1.1531.00
102_Q106_S1.1451.00
116_V205_K1.1371.00
148_I152_L1.1341.00
57_E64_V1.1251.00
110_E208_H1.1241.00
16_D42_K1.1161.00
150_V202_L1.1161.00
138_R141_E1.1141.00
95_F222_K1.1131.00
101_R105_E1.1061.00
209_A212_L1.1001.00
116_V120_D1.0981.00
200_K203_I1.0951.00
20_R42_K1.0931.00
116_V153_A1.0891.00
215_W219_E1.0881.00
106_S110_E1.0841.00
143_D147_H1.0831.00
26_Y72_V1.0781.00
109_A214_M1.0761.00
121_I205_K1.0711.00
145_Q149_Q1.0691.00
121_I199_L1.0621.00
108_I151_A1.0601.00
96_E156_N1.0581.00
128_Q132_R1.0531.00
109_A113_A1.0501.00
57_E62_V1.0491.00
128_Q131_A1.0431.00
127_I145_Q1.0351.00
99_Q156_N1.0341.00
199_L203_I1.0301.00
222_K226_F1.0261.00
142_W145_Q1.0251.00
147_H217_H1.0211.00
149_Q153_A1.0161.00
195_H217_H1.0161.00
123_K152_L1.0151.00
162_I165_K1.0011.00
63_E71_H0.9921.00
125_M196_D0.9821.00
129_E132_R0.9811.00
113_A207_P0.9781.00
197_Q216_Q0.9761.00
123_K126_A0.9731.00
111_F115_Q0.9711.00
35_E50_R0.9701.00
34_A37_F0.9691.00
146_F199_L0.9661.00
154_T160_A0.9651.00
201_A206_D0.9611.00
107_N211_K0.9611.00
51_E54_I0.9601.00
122_M126_A0.9481.00
197_Q209_A0.9471.00
141_E145_Q0.9351.00
198_I214_M0.9341.00
7_R12_Q0.9331.00
105_E147_H0.9311.00
193_D197_Q0.9301.00
123_K127_I0.9271.00
53_I70_I0.9181.00
65_R69_G0.9171.00
20_R26_Y0.9141.00
21_I72_V0.9131.00
176_W179_L0.9081.00
10_Y55_M0.9001.00
55_M58_V0.8941.00
113_A202_L0.8911.00
62_V70_I0.8871.00
68_S71_H0.8871.00
208_H212_L0.8861.00
31_K69_G0.8721.00
107_N111_F0.8721.00
208_H211_K0.8711.00
101_R218_L0.8661.00
129_E133_G0.8661.00
121_I125_M0.8661.00
14_A18_K0.8651.00
130_Q133_G0.8641.00
197_Q200_K0.8581.00
39_A49_V0.8581.00
127_I130_Q0.8581.00
118_K122_M0.8561.00
100_A158_A0.8511.00
160_A164_E0.8421.00
45_S48_V0.8401.00
92_Y155_Q0.8361.00
18_K61_Y0.8361.00
53_I62_V0.8321.00
92_Y96_E0.8301.00
93_G158_A0.8281.00
115_Q155_Q0.8251.00
112_A153_A0.8221.00
18_K22_E0.8171.00
192_C196_D0.8161.00
54_I57_E0.8121.00
37_F40_D0.8111.00
118_K205_K0.8041.00
113_A205_K0.7991.00
125_M200_K0.7991.00
11_Q55_M0.7981.00
116_V202_L0.7971.00
198_I213_A0.7931.00
113_A210_A0.7911.00
131_A139_D0.7911.00
120_D123_K0.7901.00
174_P177_K0.7891.00
129_E196_D0.7861.00
9_L12_Q0.7831.00
9_L48_V0.7831.00
158_A162_I0.7741.00
177_K180_H0.7741.00
8_R11_Q0.7721.00
99_Q222_K0.7711.00
111_F114_T0.7701.00
54_I64_V0.7691.00
189_D193_D0.7641.00
219_E223_I0.7621.00
124_L149_Q0.7611.00
38_I53_I0.7591.00
197_Q201_A0.7501.00
148_I167_W0.7471.00
143_D195_H0.7461.00
110_E114_T0.7401.00
158_A161_A0.7351.00
122_M203_I0.7301.00
98_L221_T0.7291.00
99_Q115_Q0.7281.00
124_L199_L0.7251.00
100_A159_L0.7241.00
123_K145_Q0.7231.00
10_Y14_A0.7221.00
44_V49_V0.7211.00
138_R142_W0.7181.00
216_Q220_N0.7081.00
213_A216_Q0.7081.00
174_P178_K0.7051.00
111_F156_N0.7041.00
201_A213_A0.6971.00
130_Q138_R0.6941.00
198_I210_A0.6911.00
100_A108_I0.6841.00
122_M125_M0.6781.00
55_M59_E0.6781.00
128_Q192_C0.6741.00
25_V41_E0.6721.00
126_A129_E0.6721.00
93_G157_S0.6691.00
212_L215_W0.6681.00
7_R11_Q0.6681.00
112_A116_V0.6651.00
121_I202_L0.6611.00
145_Q148_I0.6591.00
148_I160_A0.6591.00
144_L167_W0.6581.00
219_E222_K0.6581.00
198_I217_H0.6571.00
120_D152_L0.6561.00
220_N224_M0.6471.00
48_V52_A0.6411.00
194_D197_Q0.6391.00
76_Q93_G0.6381.00
120_D149_Q0.6351.00
108_I154_T0.6281.00
176_W180_H0.6241.00
103_L159_L0.6201.00
112_A154_T0.6171.00
105_E195_H0.6111.00
26_Y30_D0.6111.00
102_Q218_L0.6091.00
139_D191_W0.6061.00
99_Q107_N0.6051.00
109_A207_P0.6041.00
20_R24_G0.6021.00
28_V74_S0.6001.00
67_G70_I0.5981.00
124_L153_A0.5941.00
103_L106_S0.5911.00
106_S207_P0.5901.00
71_H74_S0.5881.00
29_G74_S0.5881.00
100_A104_I0.5871.00
108_I159_L0.5851.00
106_S214_M0.5811.00
104_I163_V0.5741.00
161_A169_Q0.5701.00
118_K203_I0.5701.00
36_R39_A0.5691.00
151_A167_W0.5671.00
107_N159_L0.5661.00
223_I227_N0.5621.00
17_L38_I0.5591.00
223_I226_F0.5561.00
131_A192_C0.5551.00
105_E218_L0.5541.00
32_L62_V0.5541.00
42_K49_V0.5501.00
198_I201_A0.5481.00
54_I58_V0.5481.00
113_A214_M0.5461.00
10_Y51_E0.5461.00
201_A207_P0.5451.00
175_Y179_L0.5451.00
112_A150_V0.5441.00
110_E215_W0.5431.00
92_Y157_S0.5371.00
92_Y95_F0.5351.00
22_E61_Y0.5341.00
216_Q219_E0.5341.00
93_G96_E0.5321.00
119_Q123_K0.5301.00
26_Y32_L0.5301.00
40_D43_N0.5291.00
109_A150_V0.5241.00
124_L127_I0.5161.00
106_S109_A0.5161.00
187_T190_N0.5141.00
193_D196_D0.5141.00
20_R23_Q0.5141.00
210_A214_M0.5121.00
95_F99_Q0.5091.00
108_I150_V0.5071.00
194_D216_Q0.5041.00
26_Y41_E0.5011.00
132_R193_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sxyA 2 0.7674 100 0.249 Contact Map
3c7jA 4 0.845 100 0.264 Contact Map
4p96A 2 0.9109 100 0.267 Contact Map
2hs5A 1 0.7868 100 0.267 Contact Map
3ihuA 1 0.7752 100 0.272 Contact Map
4p9fA 1 0.8023 100 0.275 Contact Map
2di3A 2 0.8566 100 0.285 Contact Map
1hw1A 2 0.8566 100 0.294 Contact Map
3ic7A 2 0.4302 99.9 0.568 Contact Map
3by6A 2 0.469 99.9 0.568 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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