GREMLIN Database
GLPR - Glycerol-3-phosphate regulon repressor
UniProt: P0ACL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10400
Length: 252 (246)
Sequences: 7678 (5622)
Seq/√Len: 358.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_S167_F3.1781.00
106_V205_V3.0741.00
84_K87_E3.0461.00
136_R143_E2.6481.00
168_G199_S2.5351.00
13_L28_H2.3641.00
108_H128_T2.2231.00
196_I220_G2.1971.00
208_H231_D2.1661.00
98_D192_K2.1521.00
13_L17_Q2.1051.00
161_S194_A2.1041.00
167_F203_M2.0601.00
90_P93_S2.0401.00
9_G12_E2.0351.00
203_M227_A2.0331.00
196_I202_V2.0051.00
83_R109_A1.9871.00
79_E105_A1.9791.00
96_F165_L1.9721.00
218_N221_S1.9321.00
91_N114_S1.9051.00
158_D161_S1.8841.00
167_F201_H1.8711.00
234_P239_M1.8701.00
97_I103_P1.8261.00
96_F195_I1.8111.00
201_H227_A1.7771.00
239_M243_T1.7671.00
105_A108_H1.7431.00
119_V165_L1.7201.00
221_S224_M1.6711.00
165_L195_I1.6551.00
85_V205_V1.6261.00
139_L151_I1.6131.00
157_L190_R1.6001.00
158_D162_Q1.5971.00
126_A139_L1.5911.00
85_V169_I1.5771.00
194_A197_E1.5711.00
106_V169_I1.5581.00
166_D200_R1.5541.00
74_Q209_S1.5321.00
19_Y57_A1.5271.00
161_S197_E1.5141.00
181_L225_V1.5041.00
74_Q77_E1.4951.00
118_I129_L1.4921.00
140_A159_F1.4891.00
181_L204_L1.4821.00
86_A109_A1.4821.00
140_A151_I1.4761.00
25_L36_I1.4541.00
31_V36_I1.4541.00
17_Q24_E1.4531.00
15_K58_L1.4361.00
40_L56_A1.4361.00
82_A109_A1.4291.00
118_I135_F1.4131.00
7_H46_Q1.4111.00
156_T191_T1.4091.00
79_E109_A1.4071.00
9_G13_L1.4041.00
194_A198_N1.3991.00
240_Q244_D1.3931.00
88_Q229_Y1.3901.00
204_L225_V1.3821.00
8_N12_E1.3811.00
13_L20_V1.3801.00
50_L59_P1.3781.00
89_I110_L1.3751.00
99_I150_G1.3691.00
140_A156_T1.3601.00
10_I25_L1.3601.00
88_Q203_M1.3521.00
93_S166_D1.3431.00
208_H233_P1.3371.00
11_I48_L1.3341.00
144_L151_I1.3291.00
21_S24_E1.3241.00
201_H226_D1.3151.00
75_T105_A1.3131.00
220_G224_M1.3111.00
7_H42_E1.3101.00
92_G115_N1.3081.00
77_E231_D1.3081.00
175_I211_F1.2991.00
143_E187_H1.2951.00
235_P238_V1.2881.00
14_V49_I1.2781.00
91_N113_H1.2761.00
14_V58_L1.2671.00
91_N115_N1.2661.00
23_E33_P1.2591.00
9_G29_F1.2551.00
169_I203_M1.2441.00
96_F198_N1.2351.00
117_R138_I1.2321.00
84_K88_Q1.2131.00
107_A129_L1.2111.00
236_V240_Q1.2041.00
52_H55_G1.1981.00
78_K101_T1.1961.00
174_G182_L1.1921.00
3_Q7_H1.1861.00
9_G28_H1.1861.00
79_E108_H1.1851.00
75_T79_E1.1791.00
240_Q243_T1.1661.00
41_N45_E1.1601.00
227_A248_Q1.1541.00
211_F234_P1.1501.00
172_I206_V1.1441.00
49_I56_A1.1391.00
11_I14_V1.1371.00
202_V225_V1.1371.00
197_E224_M1.1351.00
155_A159_F1.1331.00
117_R136_R1.1321.00
77_E208_H1.1261.00
176_D179_G1.1191.00
172_I219_M1.1141.00
88_Q227_A1.1131.00
82_A86_A1.1071.00
12_E16_Q1.1021.00
76_E79_E1.0941.00
34_Q38_R1.0911.00
211_F228_V1.0871.00
50_L57_A1.0851.00
86_A89_I1.0851.00
175_I206_V1.0741.00
85_V106_V1.0631.00
89_I169_I1.0631.00
90_P167_F1.0621.00
157_L191_T1.0571.00
138_I143_E1.0511.00
67_W101_T1.0511.00
42_E46_Q1.0261.00
140_A160_I1.0241.00
119_V163_F1.0221.00
203_M229_Y1.0151.00
238_V241_V1.0141.00
17_Q28_H1.0061.00
5_Q9_G1.0001.00
100_G103_P0.9981.00
97_I106_V0.9971.00
13_L16_Q0.9971.00
106_V109_A0.9811.00
77_E81_I0.9761.00
86_A106_V0.9691.00
22_T40_L0.9681.00
168_G195_I0.9641.00
157_L194_A0.9611.00
137_I144_L0.9611.00
26_V33_P0.9591.00
173_S183_E0.9501.00
3_Q42_E0.9421.00
124_N149_G0.9321.00
24_E28_H0.9291.00
20_V25_L0.9281.00
190_R193_R0.9251.00
172_I204_L0.9231.00
223_S245_H0.9191.00
74_Q207_D0.9111.00
20_V56_A0.9111.00
155_A162_Q0.9061.00
42_E45_E0.9021.00
176_D214_N0.9021.00
162_Q193_R0.9021.00
107_A128_T0.8971.00
155_A163_F0.8931.00
79_E83_R0.8861.00
26_V36_I0.8861.00
169_I205_V0.8861.00
85_V229_Y0.8811.00
103_P125_V0.8811.00
11_I15_K0.8771.00
41_N44_A0.8741.00
164_R179_G0.8681.00
148_D173_S0.8661.00
103_P106_V0.8591.00
130_M149_G0.8571.00
81_I102_T0.8571.00
97_I107_A0.8531.00
163_F186_Y0.8531.00
111_L132_K0.8471.00
160_I194_A0.8411.00
200_R214_N0.8391.00
189_V217_V0.8381.00
5_Q8_N0.8371.00
111_L128_T0.8371.00
82_A106_V0.8351.00
102_T207_D0.8341.00
80_R83_R0.8271.00
107_A125_V0.8241.00
82_A105_A0.8191.00
122_N125_V0.8171.00
160_I195_I0.8141.00
241_V244_D0.8141.00
43_L48_L0.8101.00
78_K102_T0.8071.00
164_R218_N0.8071.00
202_V226_D0.8041.00
186_Y217_V0.8021.00
164_R200_R0.7991.00
96_F160_I0.7961.00
179_G214_N0.7901.00
165_L199_S0.7901.00
183_E189_V0.7891.00
164_R214_N0.7871.00
78_K210_K0.7841.00
12_E15_K0.7821.00
104_E128_T0.7811.00
145_R188_E0.7791.00
172_I181_L0.7721.00
5_Q19_Y0.7671.00
182_L214_N0.7661.00
177_S180_S0.7641.00
177_S241_V0.7641.00
103_P205_V0.7611.00
241_V245_H0.7581.00
164_R198_N0.7561.00
127_N149_G0.7511.00
102_T210_K0.7491.00
115_N134_D0.7461.00
97_I118_I0.7451.00
41_N51_R0.7411.00
81_I205_V0.7391.00
18_G58_L0.7391.00
181_L219_M0.7371.00
76_E80_R0.7371.00
196_I219_M0.7321.00
145_R152_I0.7311.00
24_E27_E0.7311.00
111_L114_S0.7301.00
74_Q208_H0.7291.00
193_R197_E0.7271.00
7_H11_I0.7271.00
126_A151_I0.7180.99
44_A51_R0.7150.99
162_Q218_N0.7140.99
70_R173_S0.7110.99
203_M226_D0.7030.99
237_S241_V0.6980.99
95_L118_I0.6980.99
206_V228_V0.6960.99
236_V239_M0.6960.99
154_E190_R0.6960.99
234_P238_V0.6880.99
175_I181_L0.6860.99
175_I222_I0.6850.99
14_V20_V0.6850.99
121_N195_I0.6840.99
168_G202_V0.6820.99
52_H57_A0.6820.99
11_I43_L0.6810.99
123_L151_I0.6790.99
183_E188_E0.6770.99
94_T119_V0.6760.99
80_R84_K0.6740.99
153_G156_T0.6730.99
44_A49_I0.6720.99
126_A144_L0.6710.99
23_E27_E0.6690.99
154_E158_D0.6670.99
40_L51_R0.6650.99
101_T210_K0.6590.99
119_V216_M0.6590.99
89_I106_V0.6580.99
141_G159_F0.6540.99
161_S198_N0.6510.99
105_A109_A0.6490.99
66_P69_D0.6480.99
158_D190_R0.6420.99
156_T159_F0.6410.99
183_E219_M0.6400.99
83_R87_E0.6400.99
141_G156_T0.6370.99
113_H116_L0.6370.99
64_N70_R0.6340.99
99_I148_D0.6300.99
173_S215_A0.6290.99
71_K104_E0.6270.99
128_T131_V0.6260.99
95_L167_F0.6220.98
132_K135_F0.6210.98
201_H248_Q0.6150.98
119_V138_I0.6130.98
124_N127_N0.6130.98
64_N145_R0.6120.98
114_S134_D0.6100.98
22_T36_I0.6090.98
238_V242_L0.6080.98
31_V34_Q0.6030.98
181_L220_G0.6020.98
123_L139_L0.6000.98
6_R39_D0.6000.98
104_E124_N0.5990.98
187_H190_R0.5950.98
163_F217_V0.5950.98
25_L40_L0.5940.98
154_E157_L0.5920.98
145_R185_D0.5910.98
115_N136_R0.5880.98
95_L169_I0.5870.98
189_V219_M0.5860.98
155_A158_D0.5850.98
34_Q173_S0.5830.98
97_I125_V0.5810.98
220_G225_V0.5810.98
100_G171_G0.5810.98
207_D210_K0.5800.98
94_T216_M0.5790.98
123_L127_N0.5770.98
4_T7_H0.5750.97
157_L161_S0.5750.97
199_S202_V0.5710.97
170_L196_I0.5690.97
29_F36_I0.5680.97
170_L199_S0.5640.97
191_T194_A0.5620.97
77_E233_P0.5620.97
150_G188_E0.5600.97
174_G215_A0.5590.97
77_E80_R0.5590.97
40_L44_A0.5580.97
68_H71_K0.5550.97
98_D103_P0.5550.97
34_Q122_N0.5550.97
80_R232_A0.5530.97
173_S184_F0.5520.97
96_F168_G0.5470.97
171_G183_E0.5440.97
184_F215_A0.5440.97
173_S188_E0.5430.96
97_I110_L0.5420.96
208_H232_A0.5420.96
95_L106_V0.5420.96
233_P239_M0.5410.96
158_D193_R0.5400.96
151_I159_F0.5390.96
211_F230_T0.5380.96
96_F119_V0.5330.96
176_D182_L0.5320.96
7_H29_F0.5320.96
208_H234_P0.5310.96
154_E187_H0.5300.96
170_L202_V0.5290.96
170_L219_M0.5280.96
22_T26_V0.5260.96
243_T248_Q0.5250.96
236_V243_T0.5240.96
202_V224_M0.5240.96
228_V242_L0.5230.96
241_V246_H0.5220.96
192_K219_M0.5200.96
71_K105_A0.5200.96
155_A186_Y0.5190.95
173_S192_K0.5160.95
120_T126_A0.5130.95
174_G213_R0.5120.95
130_M144_L0.5120.95
126_A137_I0.5110.95
127_N130_M0.5090.95
22_T53_H0.5070.95
26_V32_S0.5050.95
93_S203_M0.5040.95
72_A75_T0.5020.95
193_R224_M0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9405 100 0.51 Contact Map
3rrlB 1 0.6706 100 0.526 Contact Map
2w48A 3 0.9325 100 0.566 Contact Map
3l7oA 2 0.5992 100 0.606 Contact Map
1o8bA 2 0.5873 100 0.612 Contact Map
2o0mA 1 0.7024 100 0.615 Contact Map
1m0sA 2 0.6111 100 0.618 Contact Map
1uj6A 2 0.6071 100 0.62 Contact Map
1lk5A 4 0.6071 100 0.621 Contact Map
4io1A 2 0.6111 100 0.626 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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