GREMLIN Database
FUCR - L-fucose operon activator
UniProt: P0ACK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10353
Length: 243 (233)
Sequences: 7485 (5459)
Seq/√Len: 357.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_M168_L3.3761.00
86_E89_A3.0851.00
108_L206_L2.9371.00
137_Q144_T2.7401.00
169_F200_A2.6371.00
100_D193_K2.4711.00
12_L27_Q2.3321.00
197_L221_G2.2171.00
110_R129_E2.2141.00
209_K232_D2.2081.00
204_L228_H2.1311.00
92_E95_M2.1201.00
162_K195_M2.0951.00
168_L204_L2.0881.00
98_A166_I2.0591.00
8_A11_D2.0511.00
12_L16_H2.0341.00
197_L203_S1.9881.00
85_R111_Q1.9721.00
81_A107_Y1.9691.00
219_R222_H1.9671.00
159_S162_K1.9451.00
99_L105_C1.9361.00
93_E115_I1.9311.00
168_L202_Q1.9091.00
98_A196_L1.8541.00
120_F166_I1.8111.00
107_Y110_R1.7661.00
87_A170_I1.7181.00
202_Q228_H1.7041.00
166_I196_L1.7001.00
222_H225_E1.6731.00
159_S163_S1.6721.00
87_A206_L1.6281.00
158_I191_D1.6021.00
195_M198_K1.6011.00
140_S152_Y1.5921.00
141_S160_Q1.5701.00
182_L226_V1.5651.00
167_D201_A1.5621.00
127_C140_S1.5581.00
108_L170_I1.5471.00
18_S56_K1.5431.00
88_L111_Q1.5221.00
162_K198_K1.5201.00
182_L205_L1.5071.00
76_H210_S1.5051.00
6_Q45_Q1.4891.00
24_L35_I1.4851.00
30_V35_I1.4851.00
81_A111_Q1.4281.00
12_L19_L1.4271.00
84_A111_Q1.4261.00
157_L192_Y1.4191.00
9_I24_L1.4101.00
141_S152_Y1.4091.00
7_Q11_D1.4061.00
39_L55_A1.4051.00
119_V130_L1.4021.00
8_A12_L1.3961.00
195_M199_R1.3931.00
49_L58_I1.3891.00
90_W230_I1.3881.00
76_H79_H1.3851.00
16_H23_A1.3831.00
209_K234_R1.3821.00
90_W204_L1.3711.00
145_L152_Y1.3631.00
14_L57_Y1.3621.00
205_L226_V1.3591.00
95_M167_D1.3481.00
22_E32_K1.3391.00
101_A151_C1.3311.00
51_N54_R1.3271.00
6_Q41_E1.3241.00
93_E116_N1.3151.00
79_H232_D1.3131.00
10_V47_K1.3071.00
80_K103_S1.3061.00
144_T188_I1.3061.00
77_Y107_Y1.2981.00
33_E37_R1.2771.00
202_Q227_T1.2761.00
212_F235_Q1.2611.00
119_V136_I1.2611.00
176_I212_F1.2551.00
20_T23_A1.2551.00
221_G225_E1.2471.00
141_S157_L1.2471.00
91_I112_L1.2371.00
86_E90_W1.2241.00
94_G116_N1.2241.00
81_A110_R1.2201.00
118_Q139_I1.2021.00
198_K225_E1.1921.00
8_A27_Q1.1921.00
8_A28_L1.1861.00
109_A130_L1.1831.00
98_A199_R1.1791.00
40_N44_T1.1591.00
78_A81_A1.1551.00
170_I204_L1.1441.00
173_C207_I1.1281.00
203_S226_V1.1141.00
79_H209_K1.1141.00
13_L57_Y1.1081.00
13_L48_I1.1051.00
11_D15_N1.1041.00
92_E168_L1.0991.00
118_Q137_Q1.0971.00
173_C220_I1.0921.00
77_Y81_A1.0921.00
204_L230_I1.0891.00
156_S160_Q1.0871.00
49_L56_K1.0871.00
158_I192_Y1.0861.00
16_H27_Q1.0831.00
21_T39_L1.0571.00
10_V13_L1.0561.00
41_E45_Q1.0501.00
175_G183_W1.0341.00
139_I144_T1.0171.00
88_L91_I1.0131.00
120_F164_L1.0061.00
90_W228_H1.0061.00
91_I170_I1.0051.00
48_I55_A1.0021.00
88_L108_L0.9971.00
79_H83_I0.9971.00
141_S161_L0.9871.00
87_A108_L0.9841.00
25_S32_K0.9801.00
156_S164_L0.9791.00
109_A129_E0.9771.00
99_L108_L0.9771.00
69_F103_S0.9761.00
176_I207_I0.9741.00
212_F229_I0.9681.00
4_A8_A0.9671.00
174_E184_D0.9611.00
12_L15_N0.9531.00
81_A85_R0.9431.00
169_F196_L0.9411.00
104_T208_D0.9391.00
41_E44_T0.9371.00
80_K104_T0.9371.00
158_I195_M0.9361.00
105_C126_I0.9311.00
40_N43_Q0.9301.00
80_K211_K0.9291.00
102_S105_C0.9221.00
173_C205_L0.9201.00
177_D180_G0.9201.00
191_D194_S0.9191.00
165_E201_A0.9161.00
108_L111_Q0.9101.00
105_C108_L0.9091.00
125_P150_G0.9081.00
190_A218_A0.9051.00
83_I104_T0.9041.00
84_A88_L0.8931.00
76_H208_D0.8921.00
163_S194_S0.8901.00
104_T211_K0.8831.00
25_S35_I0.8811.00
19_L24_L0.8801.00
177_D215_S0.8801.00
23_A27_Q0.8751.00
84_A107_Y0.8681.00
131_G150_G0.8681.00
113_P133_R0.8661.00
19_L55_A0.8651.00
164_L187_A0.8601.00
84_A108_L0.8561.00
123_S126_I0.8541.00
113_P129_E0.8531.00
10_V14_L0.8511.00
138_L145_L0.8501.00
42_L47_K0.8431.00
109_A126_I0.8411.00
161_L196_L0.8401.00
201_A215_S0.8401.00
203_S227_T0.8341.00
72_R174_E0.8321.00
165_E219_R0.8261.00
149_Y174_E0.8221.00
4_A7_Q0.8201.00
156_S163_S0.8201.00
184_D190_A0.8181.00
11_D14_L0.8111.00
173_C182_L0.8071.00
165_E215_S0.8031.00
178_S181_A0.8021.00
82_D85_R0.8021.00
40_N50_R0.8021.00
170_I206_L0.7961.00
4_A18_S0.7941.00
87_A230_I0.7921.00
76_H209_K0.7871.00
116_N135_R0.7861.00
23_A26_E0.7821.00
105_C206_L0.7821.00
165_E180_G0.7771.00
187_A218_A0.7691.00
98_A161_L0.7591.00
180_G215_S0.7501.00
183_W215_S0.7461.00
176_I182_L0.7451.00
129_E132_K0.7441.00
99_L119_V0.7441.00
106_W129_E0.7391.00
161_L195_M0.7381.00
127_C152_Y0.7361.00
163_S219_R0.7341.00
184_D220_I0.7331.00
146_E189_N0.7331.00
128_H150_G0.7291.00
99_L109_A0.7291.00
127_C145_L0.7271.00
165_E199_R0.7251.00
107_Y111_Q0.7251.00
78_A82_D0.7210.99
142_G157_L0.7210.99
17_T57_Y0.7210.99
184_D189_N0.7190.99
197_L220_I0.7190.99
103_S211_K0.7170.99
6_Q10_V0.7110.99
68_P71_I0.7110.99
66_G72_R0.7070.99
82_D86_E0.7040.99
22_E26_E0.7000.99
146_E153_V0.6970.99
85_R89_A0.6950.99
204_L227_T0.6930.99
166_I200_A0.6880.99
101_A149_Y0.6870.99
182_L220_I0.6860.99
171_F200_A0.6850.99
169_F203_S0.6820.99
208_D211_K0.6810.99
96_V120_F0.6810.99
10_V42_L0.6790.99
207_I229_I0.6780.99
142_G160_Q0.6730.99
30_V33_E0.6720.99
176_I223_L0.6700.99
51_N56_K0.6680.99
154_N157_L0.6680.99
221_G226_V0.6620.99
24_L39_L0.6590.99
132_K150_G0.6570.99
39_L50_R0.6570.99
122_N196_L0.6540.99
33_E123_S0.6520.99
133_R136_I0.6510.99
79_H234_R0.6480.99
124_H152_Y0.6460.99
162_K199_R0.6430.99
97_I168_L0.6420.99
21_T35_I0.6400.99
73_L106_W0.6400.99
159_S191_D0.6400.99
174_E216_G0.6390.99
155_P191_D0.6390.99
114_D133_R0.6390.99
190_A220_I0.6380.99
106_W125_P0.6330.99
43_Q48_I0.6320.99
155_P159_S0.6290.99
164_L218_A0.6290.99
97_I119_V0.6290.99
13_L19_L0.6270.99
121_T127_C0.6260.99
28_L35_I0.6250.99
43_Q50_R0.6230.98
123_S189_N0.6230.98
124_H140_S0.6230.98
114_D135_R0.6220.98
194_S198_K0.6210.98
83_I206_L0.6170.98
200_A203_S0.6170.98
102_S172_S0.6150.98
209_K235_Q0.6100.98
5_R38_D0.6080.98
120_F217_E0.6030.98
185_S216_G0.6000.98
231_S235_Q0.5970.98
3_A6_Q0.5970.98
82_D233_E0.5930.98
100_D105_C0.5910.98
33_E174_E0.5900.98
66_G146_E0.5890.98
91_I108_L0.5830.98
174_E189_N0.5820.98
158_I162_K0.5810.98
151_C189_N0.5800.98
80_K208_D0.5790.98
155_P158_I0.5780.98
146_E186_N0.5770.98
188_I191_D0.5740.97
184_D193_K0.5740.97
171_F220_I0.5730.97
125_P128_H0.5730.97
124_H128_H0.5720.97
72_R189_N0.5710.97
116_N137_Q0.5690.97
172_S184_D0.5690.97
73_L107_Y0.5680.97
97_I170_I0.5680.97
174_E185_S0.5680.97
98_A169_F0.5660.97
102_S174_E0.5640.97
102_S123_S0.5640.97
177_D183_W0.5620.97
157_L160_Q0.5600.97
120_F139_I0.5600.97
96_V217_E0.5580.97
171_F203_S0.5570.97
212_F231_S0.5560.97
37_R176_I0.5520.97
155_P188_I0.5490.97
193_K220_I0.5490.97
70_H73_L0.5450.97
175_G216_G0.5440.96
98_A120_F0.5420.96
232_D235_Q0.5400.96
25_S31_S0.5390.96
203_S225_E0.5380.96
97_I108_L0.5370.96
192_Y195_M0.5370.96
174_E193_K0.5360.96
171_F197_L0.5320.96
101_A189_N0.5290.96
9_I28_L0.5230.96
137_Q147_R0.5210.96
28_L34_T0.5200.95
130_L136_I0.5200.95
159_S194_S0.5200.95
182_L221_G0.5180.95
33_E184_D0.5150.95
156_S159_S0.5130.95
72_R100_D0.5120.95
152_Y160_Q0.5110.95
79_H82_D0.5100.95
26_E29_K0.5080.95
139_I156_S0.5070.95
66_G185_S0.5050.95
21_T25_S0.5050.95
69_F150_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rrlB 1 0.6749 100 0.508 Contact Map
1stzA 3 0.9342 100 0.511 Contact Map
2w48A 3 0.9671 100 0.564 Contact Map
2o0mA 1 0.7243 100 0.608 Contact Map
3l7oA 2 0.6008 100 0.613 Contact Map
4io1A 2 0.6132 100 0.617 Contact Map
1o8bA 2 0.5885 100 0.617 Contact Map
3ixqA 4 0.6049 99.9 0.619 Contact Map
1m0sA 2 0.6091 99.9 0.62 Contact Map
4l5jA 4 0.9588 99.9 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.