GREMLIN Database
DEOR - Deoxyribose operon repressor
UniProt: P0ACK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10223
Length: 252 (242)
Sequences: 7673 (5622)
Seq/√Len: 361.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_Q168_I3.3721.00
85_L88_T3.1341.00
107_I206_V2.9811.00
137_R144_E2.7541.00
169_A200_A2.6421.00
99_D193_K2.4671.00
15_E30_L2.3491.00
209_H232_D2.2721.00
197_M221_G2.2561.00
109_E129_A2.2521.00
204_V228_I2.1441.00
91_E94_Q2.1141.00
162_N195_W2.0781.00
168_I204_V2.0731.00
15_E19_S2.0421.00
11_Q14_Q2.0411.00
97_F166_P2.0191.00
197_M203_H2.0111.00
84_K110_A1.9841.00
80_R106_W1.9691.00
219_R222_D1.9481.00
235_P240_V1.9411.00
159_Q162_N1.9381.00
98_F104_T1.9251.00
168_I202_K1.9031.00
97_F196_A1.8591.00
120_V166_P1.8131.00
92_P114_E1.8081.00
240_V244_Q1.7801.00
106_W109_E1.7701.00
202_K228_I1.7581.00
222_D225_R1.7051.00
86_A170_F1.7001.00
166_P196_A1.6891.00
159_Q163_N1.6691.00
86_A206_V1.6481.00
140_L152_F1.5991.00
158_Q191_P1.5841.00
107_I170_F1.5801.00
195_W198_S1.5801.00
167_D201_Q1.5781.00
141_C160_T1.5601.00
75_L210_S1.5581.00
127_F140_L1.5581.00
182_A226_F1.5451.00
27_A38_I1.5081.00
87_A110_A1.5051.00
241_K245_T1.4991.00
33_V38_I1.4981.00
162_N198_S1.4911.00
182_A205_L1.4891.00
9_I48_P1.4891.00
21_K57_V1.4641.00
141_C152_F1.4531.00
12_L27_A1.4471.00
157_F192_V1.4401.00
83_A110_A1.4351.00
80_R110_A1.4341.00
89_L230_V1.4221.00
75_L78_E1.4171.00
119_A130_L1.4081.00
15_E22_L1.4041.00
42_L56_I1.4021.00
19_S26_D1.3991.00
195_W199_M1.3891.00
89_L204_V1.3881.00
10_G14_Q1.3871.00
100_C151_I1.3851.00
11_Q15_E1.3841.00
205_L226_F1.3821.00
52_L55_Y1.3771.00
209_H234_C1.3621.00
145_F152_F1.3571.00
17_K58_L1.3531.00
25_K35_E1.3431.00
94_Q167_D1.3311.00
92_P115_I1.3291.00
78_E232_D1.3271.00
9_I44_N1.3191.00
13_L50_V1.3161.00
144_E188_E1.3081.00
76_V106_W1.3001.00
92_P116_P1.2991.00
79_K102_T1.2961.00
141_C157_F1.2931.00
236_E239_Y1.2801.00
112_D133_K1.2791.00
90_V111_I1.2781.00
93_D116_P1.2761.00
119_A136_C1.2731.00
237_D241_K1.2651.00
23_H26_D1.2561.00
176_V212_F1.2541.00
36_M40_R1.2461.00
221_G225_R1.2301.00
80_R109_E1.2261.00
11_Q30_L1.2201.00
85_L89_L1.2191.00
202_K227_D1.2171.00
241_K244_Q1.1931.00
118_T139_F1.1901.00
11_Q31_L1.1881.00
198_S225_R1.1831.00
97_F199_M1.1681.00
108_I130_L1.1681.00
173_A207_V1.1591.00
16_L51_L1.1571.00
14_Q18_R1.1561.00
43_N47_A1.1451.00
170_F204_V1.1211.00
77_E80_R1.1181.00
212_F235_P1.1181.00
177_H180_K1.1141.00
76_V80_R1.1091.00
19_S30_L1.1091.00
78_E209_H1.1091.00
158_Q192_V1.1071.00
156_D160_T1.0991.00
91_E168_I1.0951.00
203_H226_F1.0911.00
118_T137_R1.0861.00
13_L16_L1.0831.00
204_V230_V1.0801.00
173_A220_M1.0651.00
175_G183_T1.0611.00
24_L42_L1.0561.00
16_L58_L1.0541.00
51_L56_I1.0441.00
139_F144_E1.0361.00
44_N48_P1.0291.00
87_A90_V1.0271.00
120_V164_F1.0091.00
90_V170_F1.0001.00
28_A35_E0.9971.00
7_E11_Q0.9971.00
89_L228_I0.9961.00
87_A107_I0.9901.00
98_F107_I0.9881.00
86_A107_I0.9871.00
156_D164_F0.9791.00
212_F229_V0.9781.00
78_E82_A0.9751.00
141_C161_L0.9701.00
174_A184_C0.9701.00
68_L102_T0.9651.00
43_N46_S0.9581.00
79_K211_K0.9501.00
239_Y242_Y0.9501.00
101_G104_T0.9451.00
79_K103_T0.9431.00
103_T208_D0.9401.00
108_I129_A0.9401.00
176_V207_V0.9391.00
169_A196_A0.9351.00
158_Q195_W0.9301.00
83_A87_A0.9291.00
80_R84_K0.9251.00
191_P194_H0.9231.00
15_E18_R0.9201.00
44_N47_A0.9181.00
224_K246_Q0.9171.00
107_I110_A0.9121.00
28_A38_I0.9061.00
104_T107_I0.9041.00
165_C201_Q0.9021.00
125_N150_A0.9021.00
104_T126_T0.9011.00
103_T211_K0.8991.00
163_N194_H0.8991.00
173_A205_L0.8941.00
190_L218_A0.8931.00
83_A107_I0.8911.00
83_A106_W0.8901.00
26_D30_L0.8881.00
82_A103_T0.8871.00
177_H215_V0.8781.00
75_L208_D0.8751.00
138_A145_F0.8731.00
165_C180_K0.8721.00
22_L56_I0.8701.00
22_L27_A0.8641.00
123_S126_T0.8321.00
45_H50_V0.8311.00
164_F187_L0.8291.00
156_D163_N0.8251.00
108_I126_T0.8251.00
149_N174_A0.8251.00
13_L17_K0.8211.00
131_K150_A0.8211.00
201_Q215_V0.8171.00
161_L196_A0.8151.00
165_C215_V0.8101.00
184_C190_L0.8081.00
203_H227_D0.8061.00
165_C219_R0.8061.00
86_A230_V0.8061.00
7_E10_G0.8041.00
112_D129_A0.8011.00
242_Y245_T0.8011.00
170_F206_V0.7961.00
26_D29_A0.7861.00
71_Q174_A0.7831.00
81_R84_K0.7801.00
14_Q17_K0.7781.00
75_L209_H0.7741.00
176_V182_A0.7671.00
187_L218_A0.7661.00
7_E21_K0.7611.00
129_A132_E0.7601.00
180_K215_V0.7561.00
98_F108_I0.7561.00
97_F161_L0.7541.00
173_A182_A0.7531.00
105_P129_A0.7511.00
183_T215_V0.7501.00
104_T206_V0.7481.00
161_L195_W0.7471.00
102_T211_K0.7461.00
178_V181_G0.7421.00
67_L70_D0.7411.00
98_F119_A0.7371.00
133_K136_C0.7371.00
116_P135_H0.7371.00
165_C199_M0.7271.00
77_E81_R0.7251.00
146_H189_E0.7231.00
9_I13_L0.7231.00
100_C149_N0.7190.99
235_P239_Y0.7160.99
163_N219_R0.7150.99
128_L150_A0.7130.99
142_G157_F0.7110.99
184_C220_M0.7110.99
197_M220_M0.7080.99
127_F145_F0.7070.99
127_F152_F0.7060.99
182_A220_M0.7040.99
166_P200_A0.7010.99
33_V36_M0.6980.99
46_S51_L0.6970.99
178_V242_Y0.6960.99
20_D58_L0.6950.99
146_H153_K0.6940.99
169_A203_H0.6930.99
208_D211_K0.6920.99
106_W110_A0.6830.99
142_G160_T0.6820.99
176_V223_L0.6800.99
154_P157_F0.6800.99
25_K29_A0.6790.99
52_L57_V0.6760.99
65_H71_Q0.6720.99
207_V229_V0.6720.99
204_V227_D0.6720.99
237_D240_V0.6680.99
84_K88_T0.6680.99
132_E150_A0.6650.99
72_K105_P0.6600.99
96_L168_I0.6580.99
13_L45_H0.6580.99
36_M123_S0.6560.99
95_T120_V0.6550.99
124_L152_F0.6550.99
96_L119_A0.6530.99
27_A42_L0.6510.99
184_C189_E0.6490.99
122_Y196_A0.6460.99
171_Y200_A0.6460.99
238_E242_Y0.6430.99
81_R85_L0.6410.99
174_A216_R0.6410.99
24_L38_I0.6400.99
194_H198_S0.6380.99
105_P125_N0.6340.99
155_I159_Q0.6290.99
87_A114_E0.6290.99
164_F218_A0.6290.99
82_A206_V0.6290.99
162_N199_M0.6260.99
124_L140_L0.6220.99
113_N133_K0.6220.99
116_P137_R0.6210.99
6_E9_I0.6200.98
221_G226_F0.6180.98
242_Y246_Q0.6170.98
159_Q191_P0.6160.98
239_Y243_A0.6150.98
121_C127_F0.6150.98
155_I191_P0.6120.98
16_L22_L0.6110.98
31_L38_I0.6100.98
8_R41_D0.6060.98
101_G172_S0.6050.98
200_A203_H0.6030.98
120_V217_P0.6010.98
71_Q189_E0.5950.98
190_L220_M0.5940.98
78_E234_C0.5900.98
65_H146_H0.5880.98
185_F216_R0.5880.98
146_H186_N0.5870.98
99_D104_T0.5860.98
123_S189_E0.5800.98
124_L128_L0.5770.98
155_I158_Q0.5760.98
174_A189_E0.5740.98
172_S184_C0.5700.97
90_V107_I0.5700.97
79_K208_D0.5700.97
171_Y220_M0.5670.97
69_S72_K0.5650.97
125_N128_L0.5650.97
36_M174_A0.5640.97
96_L170_F0.5640.97
72_K106_W0.5620.97
95_T217_P0.5610.97
188_E191_P0.5590.97
158_Q162_N0.5580.97
155_I188_E0.5580.97
193_K220_M0.5570.97
97_F169_A0.5560.97
96_L107_I0.5550.97
114_E133_K0.5540.97
101_G174_A0.5520.97
234_C240_V0.5520.97
174_A185_F0.5510.97
12_L31_L0.5500.97
81_R233_C0.5490.97
174_A193_K0.5490.97
151_I189_E0.5470.97
184_C193_K0.5450.97
120_V139_F0.5430.97
171_Y197_M0.5430.97
42_L46_S0.5390.96
212_F231_S0.5390.96
31_L37_T0.5390.96
192_V195_W0.5370.96
212_F239_Y0.5360.96
175_G216_R0.5340.96
157_F160_T0.5340.96
171_Y203_H0.5320.96
152_F160_T0.5310.96
177_H183_T0.5310.96
40_R176_V0.5260.96
97_F120_V0.5230.96
209_H235_P0.5220.96
101_G123_S0.5220.96
22_L52_L0.5210.96
175_G214_K0.5200.96
130_L136_C0.5170.95
203_H225_R0.5170.95
182_A221_G0.5150.95
113_N135_H0.5140.95
178_V239_Y0.5130.95
24_L28_A0.5110.95
112_D115_I0.5090.95
29_A32_G0.5080.95
115_I135_H0.5070.95
36_M52_L0.5030.95
68_L150_A0.5010.95
159_Q194_H0.5010.95
237_D244_Q0.5000.95
71_Q99_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rrlB 1 0.6667 100 0.526 Contact Map
1stzA 3 0.9405 100 0.532 Contact Map
2w48A 3 0.9286 100 0.589 Contact Map
3l7oA 2 0.5952 100 0.604 Contact Map
1o8bA 2 0.5833 100 0.608 Contact Map
1m0sA 2 0.6071 100 0.614 Contact Map
1uj6A 2 0.6032 100 0.617 Contact Map
1lk5A 4 0.6032 100 0.617 Contact Map
3uw1A 2 0.6151 100 0.622 Contact Map
4io1A 2 0.6071 100 0.622 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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