GREMLIN Database
AGAR - Putative aga operon transcriptional repressor
UniProt: P0ACK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12762
Length: 269 (250)
Sequences: 7668 (5661)
Seq/√Len: 358.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_H182_M3.3481.00
99_A102_E3.0841.00
121_I220_V2.9781.00
151_E158_H2.7261.00
183_L214_A2.6391.00
113_D207_N2.4511.00
25_R40_L2.3321.00
223_S246_D2.3031.00
123_R143_A2.2411.00
211_C235_I2.2141.00
242_M265_I2.1391.00
218_I242_M2.1021.00
105_Q108_H2.0731.00
182_M218_I2.0661.00
176_Q209_R2.0561.00
21_Q24_Q2.0301.00
111_I180_F2.0291.00
25_R29_Q2.0231.00
94_R120_E1.9941.00
211_C217_I1.9731.00
98_K124_L1.9721.00
233_K236_D1.9601.00
112_L118_T1.9241.00
173_Q176_Q1.9021.00
249_I254_L1.8951.00
182_M216_R1.8651.00
111_I210_M1.8421.00
216_R242_M1.7981.00
134_M180_F1.7961.00
106_P129_T1.7641.00
254_L258_R1.7541.00
120_E123_R1.7501.00
100_A184_F1.7261.00
99_A265_I1.7011.00
236_D239_R1.6951.00
180_F210_M1.6881.00
173_Q177_N1.6521.00
100_A220_V1.6201.00
155_T174_S1.5971.00
154_M166_F1.5881.00
172_E205_R1.5681.00
209_R212_E1.5651.00
181_D215_E1.5641.00
89_N224_S1.5511.00
141_A154_M1.5331.00
121_I184_F1.5261.00
196_V240_I1.5231.00
196_V219_V1.5201.00
43_V48_I1.5171.00
176_Q212_E1.5121.00
255_E259_K1.5091.00
101_V124_L1.4971.00
19_R58_Q1.4771.00
37_L48_I1.4741.00
97_A124_L1.4631.00
155_T166_F1.4451.00
31_S69_L1.4401.00
22_I37_L1.4381.00
94_R124_L1.4221.00
25_R32_V1.4141.00
106_P128_H1.4131.00
250_P253_S1.4131.00
89_N92_M1.4041.00
171_A206_L1.4031.00
52_L68_A1.4001.00
133_A144_L1.3951.00
29_Q36_D1.3841.00
21_Q25_R1.3821.00
209_R213_V1.3811.00
20_E24_Q1.3811.00
219_V240_I1.3741.00
27_R70_I1.3711.00
62_V71_C1.3681.00
103_L218_I1.3681.00
15_T19_R1.3671.00
114_S165_S1.3641.00
223_S248_G1.3631.00
159_L166_F1.3611.00
103_L244_I1.3521.00
108_H181_D1.3511.00
158_H202_D1.3381.00
92_M246_D1.3361.00
106_P130_D1.3151.00
35_N45_T1.3121.00
23_I60_I1.2931.00
90_T120_E1.2871.00
19_R54_F1.2831.00
133_A150_V1.2771.00
104_I125_M1.2771.00
64_A67_G1.2751.00
155_T171_A1.2681.00
107_G130_D1.2641.00
190_I226_F1.2531.00
93_K116_T1.2491.00
251_A255_E1.2421.00
33_Q36_D1.2331.00
94_R123_R1.2311.00
99_A103_L1.2311.00
235_I239_R1.2271.00
216_R241_D1.2131.00
103_L265_I1.2091.00
46_V50_N1.1971.00
21_Q40_L1.1971.00
132_I153_L1.1891.00
212_E239_R1.1861.00
111_I213_V1.1721.00
187_V221_T1.1651.00
255_E258_R1.1601.00
122_A144_L1.1571.00
91_A94_R1.1531.00
21_Q41_Y1.1531.00
26_L61_A1.1461.00
24_Q28_Q1.1231.00
172_E206_L1.1181.00
184_F218_I1.1141.00
191_D194_R1.1141.00
29_Q40_L1.1121.00
90_T94_R1.1101.00
53_A57_K1.1091.00
92_M223_S1.1081.00
105_Q182_M1.1011.00
132_I151_E1.1001.00
26_L70_I1.0931.00
189_A197_S1.0871.00
217_I240_I1.0811.00
187_V234_I1.0801.00
23_I26_L1.0801.00
170_Q174_S1.0781.00
226_F249_I1.0751.00
218_I244_I1.0721.00
242_M263_E1.0681.00
62_V69_L1.0681.00
34_V52_L1.0361.00
61_A68_A1.0351.00
104_I184_F1.0211.00
101_V104_I1.0181.00
153_L158_H1.0061.00
101_V121_I1.0041.00
134_M178_Y0.9981.00
54_F58_Q0.9961.00
100_A121_I0.9941.00
15_T54_F0.9871.00
92_M96_V0.9811.00
38_S45_T0.9761.00
112_L121_I0.9761.00
155_T175_L0.9711.00
122_A143_A0.9691.00
82_V116_T0.9641.00
226_F243_I0.9631.00
117_T222_D0.9611.00
170_Q178_Y0.9581.00
253_S256_G0.9521.00
17_E21_Q0.9521.00
183_L210_M0.9461.00
188_D198_T0.9431.00
53_A56_E0.9411.00
190_I221_T0.9411.00
254_L264_V0.9411.00
121_I124_L0.9341.00
97_A101_V0.9331.00
25_R28_Q0.9321.00
205_R208_R0.9271.00
187_V219_V0.9251.00
115_G118_T0.9251.00
118_T140_V0.9241.00
204_A232_H0.9151.00
172_E209_R0.9111.00
103_L242_M0.9091.00
93_K225_K0.9081.00
93_K117_T0.9081.00
94_R98_K0.9051.00
38_S48_I0.9011.00
36_D40_L0.8951.00
118_T121_I0.8941.00
54_F57_K0.8931.00
177_N208_R0.8911.00
191_D229_S0.8911.00
238_Q260_A0.8871.00
179_H194_R0.8851.00
179_H215_E0.8831.00
96_V117_T0.8831.00
139_N164_Q0.8791.00
89_N222_D0.8771.00
117_T225_K0.8731.00
126_R147_A0.8711.00
97_A121_I0.8641.00
32_V68_A0.8601.00
32_V37_L0.8551.00
97_A120_E0.8531.00
152_L159_L0.8421.00
55_L60_I0.8421.00
145_L164_Q0.8391.00
126_R143_A0.8301.00
198_T204_A0.8271.00
137_G140_V0.8261.00
178_Y201_E0.8251.00
175_L210_M0.8221.00
163_S188_D0.8161.00
23_I27_R0.8151.00
122_A140_V0.8151.00
184_F220_V0.8131.00
17_E20_E0.8101.00
215_E229_S0.8101.00
100_A244_I0.8081.00
170_Q177_N0.8081.00
217_I241_D0.8071.00
256_G259_K0.8051.00
179_H233_K0.8031.00
24_Q27_R0.8001.00
111_I175_L0.7901.00
95_S98_K0.7881.00
143_A146_E0.7881.00
179_H229_S0.7871.00
85_K188_D0.7851.00
160_R203_E0.7831.00
36_D39_A0.7821.00
14_G31_S0.7781.00
53_A63_R0.7751.00
175_L209_R0.7701.00
89_N223_S0.7691.00
118_T220_V0.7591.00
249_I253_S0.7581.00
130_D149_G0.7561.00
190_I196_V0.7561.00
201_E232_H0.7531.00
112_L122_A0.7511.00
126_R129_T0.7361.00
197_S229_S0.7351.00
119_F143_A0.7341.00
194_R229_S0.7331.00
142_N164_Q0.7321.00
177_N233_K0.7311.00
179_H213_V0.7291.00
112_L133_A0.7281.00
156_G171_A0.7281.00
249_I264_V0.7251.00
141_A166_F0.7220.99
17_E31_S0.7210.99
91_A95_S0.7210.99
116_T225_K0.7200.99
81_S84_D0.7200.99
30_G70_I0.7190.99
187_V196_V0.7180.99
120_E124_L0.7090.99
198_T203_E0.7060.99
19_R23_I0.7040.99
14_G17_E0.7030.99
196_V234_I0.6970.99
211_C234_I0.6960.99
180_F214_A0.6950.99
198_T234_I0.6900.99
43_V46_V0.6890.99
141_A159_L0.6840.99
52_L63_R0.6830.99
190_I237_T0.6830.99
114_S163_S0.6830.99
79_E85_K0.6810.99
183_L217_I0.6800.99
136_N210_M0.6780.99
221_T243_I0.6780.99
160_R167_Y0.6750.99
222_D225_K0.6710.99
98_K102_E0.6650.99
156_G174_S0.6640.99
138_M166_F0.6620.99
109_R134_M0.6590.99
35_N39_A0.6590.99
168_G171_A0.6580.99
127_K147_A0.6570.99
37_L52_L0.6570.99
146_E164_Q0.6540.99
208_R212_E0.6540.99
23_I55_L0.6530.99
64_A69_L0.6520.99
223_S249_I0.6510.99
173_Q205_R0.6460.99
86_S119_F0.6460.99
34_V48_I0.6450.99
110_V182_M0.6430.99
129_T149_G0.6420.99
185_L214_A0.6410.99
95_S99_A0.6410.99
218_I241_D0.6380.99
56_E63_R0.6370.99
16_S19_R0.6350.99
26_L32_V0.6340.99
235_I240_I0.6330.99
110_V133_A0.6320.99
46_V137_G0.6320.99
147_A150_V0.6290.99
256_G260_A0.6270.99
216_R263_E0.6270.99
178_Y232_H0.6230.98
96_V220_V0.6210.98
176_Q213_V0.6190.98
169_D173_Q0.6180.98
252_D256_G0.6170.98
119_F139_N0.6160.98
56_E61_A0.6140.98
135_T141_A0.6140.98
188_D230_S0.6120.98
41_Y48_I0.6090.98
169_D205_R0.6080.98
214_A217_I0.6080.98
204_A234_I0.6060.98
251_A254_L0.6030.98
134_M231_L0.6000.98
18_R51_D0.5940.98
199_H230_S0.5940.98
138_M154_M0.5920.98
160_R200_N0.5880.98
93_K222_D0.5870.98
226_F253_S0.5850.98
188_D203_E0.5800.98
253_S257_L0.5760.98
113_D118_T0.5760.98
115_G186_G0.5740.97
95_S247_E0.5740.97
104_I121_I0.5730.97
110_V184_F0.5730.97
130_D151_E0.5730.97
165_S203_E0.5710.97
14_G64_A0.5710.97
138_M142_N0.5710.97
86_S120_E0.5700.97
137_G203_E0.5690.97
171_A174_S0.5680.97
39_A42_G0.5650.97
192_L253_S0.5650.97
139_N142_N0.5640.97
92_M248_G0.5620.97
109_R231_L0.5620.97
226_F245_V0.5590.97
202_D205_R0.5580.97
79_E160_R0.5550.97
134_M153_L0.5550.97
172_E176_Q0.5540.97
188_D199_H0.5530.97
85_K203_E0.5520.97
185_L234_I0.5480.97
206_L209_R0.5450.97
46_V188_D0.5450.97
169_D172_E0.5440.96
186_G198_T0.5410.96
198_T207_N0.5370.96
185_L217_I0.5370.96
110_V121_I0.5360.96
111_I183_L0.5360.96
217_I239_R0.5350.96
207_N234_I0.5340.96
115_G188_D0.5330.96
191_D197_S0.5310.96
83_E86_S0.5310.96
188_D207_N0.5300.96
169_D202_D0.5220.96
196_V235_I0.5220.96
111_I134_M0.5210.96
85_K113_D0.5190.95
185_L211_C0.5180.95
227_N253_S0.5180.95
50_N190_I0.5180.95
173_Q208_R0.5170.95
115_G137_G0.5140.95
192_L256_G0.5130.95
251_A258_R0.5110.95
114_S203_E0.5110.95
34_V38_S0.5080.95
96_V245_V0.5070.95
144_L150_V0.5070.95
189_A228_R0.5070.95
112_L140_V0.5030.95
166_F174_S0.5020.95
127_K149_G0.5020.95
153_L170_Q0.5010.94
170_Q173_Q0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9071 100 0.519 Contact Map
3rrlB 1 0.6357 100 0.543 Contact Map
2w48A 3 0.8773 100 0.592 Contact Map
3l7oA 2 0.5688 100 0.624 Contact Map
1o8bA 2 0.5576 100 0.631 Contact Map
1m0sA 2 0.5799 100 0.637 Contact Map
1lk5A 4 0.5762 100 0.639 Contact Map
1uj6A 2 0.5762 100 0.639 Contact Map
4l5jA 4 0.881 100 0.642 Contact Map
4io1A 2 0.5799 100 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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