GREMLIN Database
CRP - cAMP-activated global transcriptional regulator CRP
UniProt: P0ACJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10164
Length: 210 (200)
Sequences: 6702 (5250)
Seq/√Len: 371.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T97_E3.0861.00
23_K94_E2.7981.00
51_L88_R2.7971.00
198_S207_Y2.7351.00
25_P28_S2.5591.00
50_V87_V2.4371.00
89_A93_C2.4131.00
198_S205_V2.2991.00
140_V179_C2.2961.00
45_K94_E2.2841.00
8_T11_T2.1571.00
145_A191_L2.1441.00
48_V87_V2.0841.00
31_I87_V2.0821.00
47_S91_T2.0801.00
24_Y30_L2.0531.00
140_V183_T1.9801.00
33_Q52_I1.9751.00
33_Q86_W1.9671.00
144_I187_I1.9321.00
44_V96_A1.9231.00
190_M194_Q1.9011.00
99_S102_K1.8961.00
125_L128_T1.8861.00
170_R185_G1.8301.00
49_A88_R1.8021.00
21_I94_E1.8021.00
48_V93_C1.7391.00
28_S89_A1.7051.00
26_S91_T1.7031.00
24_Y95_V1.6881.00
189_K193_D1.6691.00
25_P92_A1.6621.00
49_A61_I1.6491.00
141_T190_M1.6271.00
108_Q115_M1.6091.00
105_Q109_V1.6071.00
141_T194_Q1.6061.00
51_L86_W1.6011.00
32_H35_E1.5981.00
37_A83_R1.5691.00
139_D142_G1.5631.00
192_E198_S1.5271.00
191_L196_L1.5101.00
23_K92_A1.4991.00
29_T88_R1.4981.00
29_T86_W1.4931.00
29_T32_H1.4741.00
165_Q203_T1.4731.00
78_E126_Q1.4551.00
22_H97_E1.4521.00
14_W109_V1.4381.00
145_A149_L1.4371.00
49_A59_E1.4311.00
49_A90_K1.4201.00
26_S92_A1.4101.00
192_E199_A1.4051.00
152_A206_V1.4021.00
182_E186_R1.3991.00
171_Q175_Q1.3911.00
43_I65_L1.3711.00
43_I93_C1.3671.00
44_V94_E1.3421.00
163_G203_T1.3401.00
163_G205_V1.3381.00
100_Y104_R1.3371.00
59_E175_Q1.3221.00
189_K192_E1.3161.00
128_T132_V1.3161.00
65_L69_D1.3131.00
118_S121_M1.2931.00
179_C184_V1.2621.00
102_K105_Q1.2361.00
11_T110_N1.2351.00
73_E124_R1.2311.00
147_T173_I1.2191.00
134_N146_Q1.2191.00
30_L48_V1.2181.00
31_I83_R1.1861.00
64_Y90_K1.1631.00
14_W17_S1.1621.00
52_I133_G1.1451.00
45_K67_Q1.1441.00
6_P116_R1.1391.00
30_L71_I1.1221.00
170_R181_R1.1131.00
171_Q181_R1.1041.00
43_I48_V1.1011.00
108_Q112_D1.1011.00
49_A64_Y1.0941.00
18_H102_K1.0931.00
9_D13_E1.0881.00
50_V85_A1.0851.00
47_S66_N1.0811.00
187_I190_M1.0761.00
54_D58_K1.0721.00
72_G83_R1.0711.00
24_Y28_S1.0681.00
59_E88_R1.0661.00
141_T187_I1.0651.00
47_S90_K1.0541.00
43_I67_Q1.0501.00
107_I114_L1.0441.00
65_L71_I1.0401.00
41_Y95_V1.0331.00
24_Y48_V1.0271.00
200_H203_T1.0211.00
114_L118_S1.0191.00
147_T177_V1.0191.00
144_I177_V1.0181.00
50_V65_L1.0171.00
47_S93_C1.0151.00
181_R185_G1.0051.00
11_T112_D1.0051.00
7_Q11_T0.9961.00
187_I191_L0.9891.00
47_S64_Y0.9711.00
27_K88_R0.9601.00
21_I96_A0.9591.00
104_R108_Q0.9531.00
21_I44_V0.9521.00
142_G145_A0.9371.00
31_I85_A0.9311.00
11_T14_W0.9221.00
13_E17_S0.9181.00
75_G85_A0.9161.00
30_L95_V0.9151.00
147_T176_I0.8991.00
106_L113_I0.8941.00
40_L103_F0.8931.00
43_I95_V0.8891.00
177_V184_V0.8891.00
101_K105_Q0.8861.00
66_N69_D0.8811.00
22_H95_V0.8671.00
20_H97_E0.8641.00
181_R184_V0.8631.00
19_C96_A0.8621.00
134_N150_N0.8571.00
145_A196_L0.8571.00
33_Q133_G0.8551.00
41_Y97_E0.8531.00
41_Y71_I0.8521.00
195_N207_Y0.8511.00
53_K59_E0.8501.00
40_L98_I0.8491.00
156_D161_P0.8471.00
104_R115_M0.8351.00
107_I110_N0.8341.00
130_E150_N0.8321.00
105_Q108_Q0.8251.00
24_Y93_C0.8211.00
116_R120_Q0.8181.00
141_T191_L0.8081.00
36_K82_E0.8071.00
14_W18_H0.8061.00
200_H205_V0.8021.00
76_L100_Y0.7931.00
25_P89_A0.7901.00
111_P114_L0.7871.00
115_M119_A0.7851.00
156_D162_D0.7851.00
143_R148_L0.7801.00
157_A161_P0.7801.00
60_M131_K0.7791.00
140_V143_R0.7781.00
19_C98_I0.7741.00
199_A204_I0.7701.00
73_E83_R0.7691.00
51_L59_E0.7671.00
183_T186_R0.7661.00
29_T51_L0.7661.00
32_H86_W0.7621.00
60_M136_A0.7571.00
48_V95_V0.7561.00
38_E99_S0.7541.00
133_G137_F0.7521.00
53_K86_W0.7511.00
18_H105_Q0.7491.00
103_F107_I0.7491.00
40_L76_L0.7441.00
138_L146_Q0.7441.00
179_C183_T0.7391.00
78_E82_E0.7371.00
159_T163_G0.7351.00
78_E123_R0.7271.00
74_L85_A0.7241.00
201_G204_I0.7201.00
33_Q53_K0.7181.00
173_I184_V0.7161.00
45_K91_T0.7151.00
169_T172_E0.7121.00
13_E16_L0.7070.99
185_G189_K0.7060.99
123_R127_V0.7040.99
134_N138_L0.6930.99
42_Y70_F0.6910.99
132_V135_L0.6880.99
148_L206_V0.6860.99
24_Y89_A0.6830.99
104_R119_A0.6780.99
120_Q124_R0.6720.99
16_L19_C0.6720.99
145_A206_V0.6710.99
110_N114_L0.6690.99
190_M193_D0.6650.99
37_A75_G0.6650.99
60_M133_G0.6650.99
43_I66_N0.6640.99
49_A172_E0.6550.99
78_E81_Q0.6550.99
156_D164_M0.6540.99
51_L61_I0.6470.99
75_G84_S0.6460.99
121_M125_L0.6460.99
89_A92_A0.6430.99
74_L125_L0.6420.99
84_S126_Q0.6380.99
157_A165_Q0.6350.99
74_L78_E0.6340.99
116_R119_A0.6340.99
151_L164_M0.6340.99
83_R87_V0.6340.99
15_F106_L0.6330.99
144_I173_I0.6330.99
141_T145_A0.6310.99
78_E122_A0.6290.99
34_G82_E0.6210.99
37_A77_F0.6180.99
112_D116_R0.6180.99
12_L16_L0.6170.99
146_Q150_N0.6140.99
149_L196_L0.6120.99
71_I87_V0.6120.99
188_L197_I0.6080.98
48_V89_A0.6080.98
30_L89_A0.6050.98
138_L142_G0.6030.98
160_H163_G0.6020.98
75_G83_R0.6010.98
19_C44_V0.5950.98
168_I173_I0.5950.98
39_T99_S0.5940.98
147_T168_I0.5940.98
170_R199_A0.5920.98
43_I68_G0.5890.98
171_Q201_G0.5860.98
149_L153_K0.5860.98
148_L188_L0.5840.98
144_I184_V0.5810.98
52_I130_E0.5800.98
196_L206_V0.5780.98
157_A163_G0.5770.98
136_A170_R0.5770.98
174_G179_C0.5740.98
180_S183_T0.5740.98
28_S92_A0.5730.98
81_Q123_R0.5710.98
147_T151_L0.5650.97
144_I191_L0.5610.97
155_P164_M0.5600.97
118_S122_A0.5580.97
140_V177_V0.5580.97
61_I90_K0.5520.97
27_K89_A0.5510.97
45_K92_A0.5460.97
85_A129_S0.5460.97
199_A203_T0.5450.97
74_L84_S0.5440.97
113_I116_R0.5440.97
140_V144_I0.5430.97
107_I117_L0.5420.97
60_M137_F0.5410.97
174_G184_V0.5390.97
170_R182_E0.5380.97
159_T162_D0.5340.96
10_P14_W0.5320.96
11_T113_I0.5300.96
48_V71_I0.5290.96
149_L206_V0.5280.96
169_T181_R0.5270.96
103_F113_I0.5260.96
11_T116_R0.5240.96
177_V185_G0.5240.96
14_W106_L0.5230.96
188_L191_L0.5220.96
28_S32_H0.5220.96
166_I204_I0.5210.96
18_H107_I0.5170.96
40_L70_F0.5150.96
111_P115_M0.5130.96
170_R186_R0.5120.96
36_K101_K0.5110.96
37_A85_A0.5110.96
151_L154_Q0.5100.95
131_K147_T0.5100.95
112_D115_M0.5060.95
147_T184_V0.5030.95
72_G75_G0.5010.95
63_S69_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gauA 2 0.9714 100 0.192 Contact Map
3iwzA 2 0.9667 100 0.193 Contact Map
4cydA 2 0.9952 100 0.196 Contact Map
3e97A 2 0.9762 100 0.199 Contact Map
3i54A 2 0.9952 100 0.2 Contact Map
3dkwA 2 0.9857 100 0.201 Contact Map
4r8hA 2 0.9524 100 0.203 Contact Map
4ev0A 2 0.9667 100 0.21 Contact Map
3kccA 2 0.9476 100 0.213 Contact Map
3fx3A 2 0.9762 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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