GREMLIN Database
LRP - Leucine-responsive regulatory protein
UniProt: P0ACJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10547
Length: 164 (141)
Sequences: 13551 (8650)
Seq/√Len: 728.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_E61_Y2.9921.00
22_E37_R2.9251.00
105_E118_K2.6591.00
112_D145_R2.6081.00
81_T143_D2.5511.00
31_N49_V2.3441.00
122_P126_A2.2871.00
68_H125_S2.2381.00
16_D48_R2.1771.00
59_Q66_N2.0981.00
22_E29_I2.0661.00
51_R55_Q2.0111.00
83_N142_N1.9451.00
89_V92_Q1.9351.00
77_F107_H1.8741.00
59_Q64_L1.8391.00
100_L130_L1.7691.00
50_R54_R1.7481.00
40_L44_P1.7281.00
22_E25_K1.7191.00
75_L118_K1.7121.00
15_I40_L1.7101.00
100_L134_T1.6891.00
33_E36_K1.6621.00
104_Q120_R1.6531.00
126_A129_K1.5801.00
123_D126_A1.5791.00
19_I34_L1.5731.00
29_I37_R1.5581.00
32_V36_K1.5511.00
79_E147_Y1.5311.00
40_L45_C1.4921.00
96_A99_K1.4911.00
102_E126_A1.4891.00
93_F97_V1.4791.00
41_S44_P1.4461.00
31_N46_L1.4421.00
38_V45_C1.4291.00
28_R61_Y1.4181.00
94_N98_Q1.4021.00
96_A138_L1.3991.00
32_V42_P1.3731.00
129_K133_E1.3711.00
152_E155_Q1.3581.00
78_V119_T1.3441.00
80_I117_L1.3441.00
91_E95_T1.3141.00
81_T112_D1.2941.00
128_R151_E1.2891.00
33_E37_R1.2741.00
14_R18_N1.2711.00
23_L49_V1.2561.00
25_K37_R1.2561.00
29_I34_L1.2531.00
79_E113_F1.2491.00
102_E134_T1.2361.00
94_N151_E1.2321.00
74_L124_M1.2271.00
30_S33_E1.2251.00
13_D48_R1.2241.00
82_L93_F1.2021.00
72_A122_P1.1991.00
15_I18_N1.1891.00
50_R53_E1.1731.00
81_T142_N1.1651.00
15_I38_V1.1481.00
26_D37_R1.1451.00
22_E34_L1.1231.00
79_E145_R1.1221.00
18_N21_N1.0431.00
75_L120_R1.0331.00
31_N35_S1.0171.00
106_C117_L1.0131.00
73_S123_D1.0081.00
66_N69_Y0.9971.00
18_N22_E0.9961.00
109_V116_L0.9941.00
92_Q96_A0.9871.00
28_R53_E0.9801.00
21_N25_K0.9791.00
77_F116_L0.9701.00
27_G61_Y0.9701.00
94_N115_Y0.9681.00
29_I33_E0.9671.00
60_G64_L0.9661.00
31_N42_P0.9591.00
95_T99_K0.9551.00
35_S45_C0.9421.00
103_I119_T0.9291.00
121_V126_A0.9291.00
42_P46_L0.9281.00
119_T130_L0.9231.00
121_V127_Y0.9211.00
95_T98_Q0.9161.00
107_H118_K0.8981.00
77_F118_K0.8971.00
121_V130_L0.8941.00
35_S40_L0.8811.00
34_L49_V0.8661.00
46_L50_R0.8511.00
97_V106_C0.8411.00
32_V46_L0.8301.00
67_P120_R0.8271.00
27_G63_A0.8251.00
52_L57_F0.8241.00
77_F149_V0.8241.00
107_H152_E0.8231.00
103_I106_C0.8151.00
112_D143_D0.8101.00
18_N38_V0.8071.00
107_H149_V0.8041.00
103_I117_L0.8031.00
92_Q95_T0.7991.00
12_L17_R0.7951.00
80_I93_F0.7901.00
129_K134_T0.7681.00
16_D51_R0.7621.00
17_R21_N0.7601.00
34_L45_C0.7431.00
79_E116_L0.7431.00
90_F115_Y0.7381.00
131_L146_T0.7321.00
19_I29_I0.7291.00
110_S148_V0.7221.00
96_A100_L0.7131.00
57_F69_Y0.7121.00
91_E94_N0.7111.00
83_N140_G0.7111.00
27_G33_E0.7091.00
113_F145_R0.7071.00
13_D16_D0.6961.00
93_F115_Y0.6951.00
76_V127_Y0.6941.00
125_S128_R0.6881.00
124_M148_V0.6861.00
83_N89_V0.6841.00
76_V146_T0.6781.00
22_E26_D0.6761.00
94_N153_V0.6751.00
26_D29_I0.6711.00
14_R17_R0.6701.00
78_V144_T0.6701.00
108_L115_Y0.6701.00
43_T47_E0.6691.00
81_T113_F0.6661.00
75_L149_V0.6621.00
47_E51_R0.6621.00
19_I22_E0.6611.00
136_L144_T0.6561.00
27_G60_G0.6541.00
97_V117_L0.6501.00
72_A120_R0.6481.00
19_I45_C0.6421.00
19_I48_R0.6391.00
47_E50_R0.6341.00
12_L57_F0.6341.00
65_L70_L0.6321.00
130_L135_L0.6311.00
31_N45_C0.6241.00
100_L138_L0.6171.00
66_N70_L0.6161.00
80_I141_V0.6161.00
19_I52_L0.6161.00
102_E130_L0.6091.00
78_V117_L0.6081.00
79_E112_D0.6021.00
56_G59_Q0.6001.00
48_R52_L0.5961.00
43_T46_L0.5951.00
35_S42_P0.5921.00
109_V113_F0.5911.00
79_E109_V0.5851.00
131_L144_T0.5841.00
130_L134_T0.5801.00
76_V148_V0.5791.00
125_S129_K0.5781.00
124_M150_M0.5761.00
58_I61_Y0.5721.00
16_D52_L0.5691.00
109_V149_V0.5691.00
126_A130_L0.5671.00
80_I144_T0.5661.00
20_L52_L0.5611.00
92_Q140_G0.5541.00
38_V44_P0.5511.00
26_D33_E0.5511.00
24_Q62_T0.5461.00
19_I49_V0.5451.00
127_Y148_V0.5451.00
112_D147_Y0.5441.00
72_A102_E0.5431.00
17_R24_Q0.5421.00
75_L107_H0.5421.00
134_T138_L0.5341.00
30_S35_S0.5301.00
15_I44_P0.5261.00
92_Q139_P0.5261.00
100_L103_I0.5231.00
96_A139_P0.5191.00
131_L150_M0.5191.00
108_L114_D0.5191.00
82_L114_D0.5161.00
104_Q118_K0.5111.00
75_L152_E0.5111.00
88_D92_Q0.5111.00
110_S150_M0.5081.00
91_E137_R0.5051.00
32_V35_S0.5040.99
105_E155_Q0.5020.99
90_F136_L0.5010.99
102_E122_P0.5010.99
136_L143_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8293 100 0.199 Contact Map
4un1A 1 0.8659 100 0.221 Contact Map
4un1B 1 0.9146 100 0.222 Contact Map
2e1cA 1 0.8963 100 0.227 Contact Map
4pcqA 2 0.9207 100 0.232 Contact Map
2p5vA 5 0.9573 100 0.237 Contact Map
3i4pA 5 0.9268 100 0.25 Contact Map
2ia0A 2 0.8963 100 0.261 Contact Map
2pn6A 5 0.8963 100 0.271 Contact Map
2cg4A 6 0.9085 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.