GREMLIN Database
ASNC - Regulatory protein AsnC
UniProt: P0ACI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10093
Length: 152 (138)
Sequences: 13596 (8773)
Seq/√Len: 746.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A31_Q2.9431.00
47_K55_A2.8911.00
75_I135_S2.5711.00
104_H137_E2.5201.00
97_E110_K2.4791.00
25_Y43_V2.2581.00
114_R118_A2.2541.00
62_K117_D2.0821.00
10_D42_R2.0711.00
16_A23_T2.0441.00
45_K49_A2.0191.00
53_T60_S1.9891.00
77_K134_Q1.8851.00
92_L126_K1.8661.00
69_G110_K1.8511.00
53_T58_D1.8171.00
71_F99_Y1.7881.00
96_T112_M1.7651.00
92_L122_V1.7111.00
9_L34_V1.7081.00
16_A19_G1.6701.00
44_E48_Q1.6671.00
34_V38_T1.6481.00
26_A30_K1.6331.00
73_G139_L1.5871.00
23_T31_Q1.5541.00
88_K130_I1.5471.00
115_S118_A1.5421.00
118_A121_H1.5421.00
27_E30_K1.5061.00
26_A36_P1.4741.00
88_K91_S1.4701.00
34_V39_I1.4641.00
94_E118_A1.4361.00
35_S38_T1.4351.00
85_A89_L1.4261.00
25_Y40_H1.4151.00
13_I28_L1.4131.00
86_L90_E1.3911.00
73_G105_Y1.3831.00
74_I109_I1.3641.00
22_R55_A1.3531.00
32_F39_I1.3381.00
75_I104_H1.3351.00
23_T28_L1.2941.00
83_P87_A1.2921.00
121_H125_N1.2891.00
75_I134_Q1.2861.00
8_N12_G1.2851.00
66_Y114_R1.2851.00
72_I111_V1.2731.00
86_L143_Q1.2371.00
27_E31_Q1.2361.00
120_Q143_Q1.2251.00
17_L43_V1.2141.00
9_L12_G1.2131.00
44_E47_K1.1871.00
19_G31_Q1.1761.00
76_L85_A1.1721.00
20_N31_Q1.1591.00
68_V116_I1.1521.00
24_A27_E1.1441.00
94_E126_K1.1381.00
7_D42_R1.1381.00
16_A28_L1.1091.00
73_G137_E1.0941.00
9_L32_F1.0881.00
54_G58_D1.0741.00
81_D84_S1.0541.00
86_L107_I1.0411.00
12_G16_A1.0341.00
113_C118_A1.0281.00
95_V111_V1.0211.00
25_Y29_A1.0191.00
12_G15_E1.0141.00
15_E19_G1.0091.00
98_A109_I1.0001.00
60_S63_Q0.9821.00
23_T27_E0.9821.00
29_A39_I0.9811.00
84_S88_K0.9711.00
21_A55_A0.9711.00
71_F108_F0.9641.00
69_G112_M0.9601.00
87_A90_E0.9571.00
40_H44_E0.9441.00
113_C119_L0.9421.00
12_G32_F0.9421.00
101_T108_F0.9291.00
99_Y110_K0.9261.00
22_R47_K0.9141.00
36_P40_H0.9131.00
67_D115_S0.9091.00
61_P112_M0.9061.00
29_A34_V0.9001.00
25_Y36_P0.8991.00
71_F110_K0.8971.00
113_C122_V0.8911.00
111_V122_V0.8891.00
6_I11_R0.8791.00
71_F141_V0.8601.00
87_A91_S0.8581.00
99_Y141_V0.8551.00
95_V98_A0.8511.00
26_A40_H0.8441.00
46_M51_I0.8351.00
21_A27_E0.8221.00
95_V109_I0.8211.00
10_D45_K0.8141.00
104_H135_S0.7991.00
11_R15_E0.7911.00
88_K92_L0.7871.00
89_L98_A0.7751.00
99_Y144_N0.7671.00
83_P86_L0.7631.00
21_A57_I0.7611.00
28_L39_I0.7561.00
123_L138_T0.7511.00
13_I42_R0.7501.00
28_L43_V0.7481.00
37_G41_V0.7451.00
82_Y107_I0.7431.00
73_G108_F0.7381.00
6_I51_I0.7381.00
121_H126_K0.7311.00
74_I85_A0.7301.00
73_G104_H0.7271.00
84_S87_A0.7271.00
13_I39_I0.7241.00
66_Y94_E0.7141.00
7_D10_D0.7141.00
16_A20_N0.7091.00
105_Y137_E0.7071.00
20_N23_T0.7061.00
51_I63_Q0.6971.00
86_L145_P0.6961.00
128_Q136_T0.6931.00
100_Y107_I0.6871.00
75_I105_Y0.6821.00
94_E122_V0.6791.00
85_A107_I0.6791.00
117_D120_Q0.6771.00
77_K132_E0.6691.00
13_I23_T0.6631.00
70_C119_L0.6621.00
81_D129_T0.6591.00
66_Y112_M0.6581.00
70_C140_I0.6561.00
116_I140_I0.6521.00
102_T140_I0.6501.00
117_D121_H0.6491.00
41_V45_K0.6481.00
8_N11_R0.6451.00
84_S132_E0.6411.00
69_G99_Y0.6361.00
13_I16_A0.6351.00
72_I136_T0.6301.00
89_L109_I0.6301.00
21_A54_G0.6251.00
41_V44_E0.6231.00
10_D46_M0.6191.00
29_A36_P0.6141.00
14_L46_M0.6141.00
13_I43_V0.6111.00
94_E114_R0.6071.00
69_G144_N0.6011.00
69_G141_V0.6001.00
50_G53_T0.5981.00
123_L136_T0.5951.00
72_I109_I0.5941.00
74_I133_I0.5931.00
92_L130_I0.5921.00
42_R46_M0.5911.00
60_S64_L0.5881.00
25_Y39_I0.5831.00
75_I137_E0.5781.00
73_G101_T0.5701.00
59_V64_L0.5681.00
52_I55_A0.5681.00
37_G40_H0.5671.00
83_P129_T0.5661.00
70_C138_T0.5651.00
118_A122_V0.5631.00
13_I46_M0.5621.00
126_K130_I0.5611.00
116_I142_L0.5601.00
58_D61_P0.5461.00
122_V127_I0.5441.00
81_D131_D0.5441.00
101_T105_Y0.5431.00
122_V126_K0.5351.00
101_T141_V0.5351.00
119_L140_I0.5311.00
100_Y106_S0.5271.00
26_A29_A0.5251.00
100_Y128_Q0.5241.00
76_L106_S0.5241.00
9_L38_T0.5231.00
18_M56_R0.5211.00
45_K48_Q0.5131.00
117_D143_Q0.5071.00
78_S134_Q0.5061.00
15_E18_M0.5051.00
24_A29_A0.5041.00
74_I136_T0.5021.00
104_H139_L0.5011.00
96_T110_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9408 100 0.153 Contact Map
4un1B 1 0.9737 100 0.187 Contact Map
4pcqA 2 0.9803 100 0.208 Contact Map
2cg4A 6 0.9803 100 0.208 Contact Map
2p5vA 5 1 100 0.21 Contact Map
4un1A 1 0.9342 100 0.217 Contact Map
2e1cA 1 0.9605 100 0.224 Contact Map
2ia0A 2 0.9408 100 0.228 Contact Map
3i4pA 5 0.9605 100 0.249 Contact Map
2dbbA 4 0.9539 100 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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