GREMLIN Database
XYLR - Xylose operon regulatory protein
UniProt: P0ACI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20253
Length: 392 (370)
Sequences: 486 (405)
Seq/√Len: 21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_D217_G4.9061.00
107_V111_F4.6961.00
342_A368_F4.5101.00
297_H300_K4.5071.00
104_Y145_Q4.4811.00
114_L186_G4.1251.00
328_E333_M3.9621.00
245_Q248_K3.8731.00
139_R192_D3.7801.00
8_I254_L3.7191.00
284_D321_R3.6711.00
110_A216_I3.2741.00
59_G250_L3.2181.00
114_L216_I3.1331.00
110_A188_I3.0931.00
139_R217_G3.0490.99
220_N236_A2.9700.99
349_T384_R2.9490.99
333_M336_A2.9190.99
216_I235_V2.7670.99
351_L359_M2.7260.99
252_R257_E2.6560.98
192_D234_S2.5970.98
304_V315_R2.4720.98
353_I368_F2.4250.97
202_C213_L2.4240.97
220_N274_R2.3860.97
111_F142_A2.3600.97
139_R219_D2.3130.96
183_P213_L2.3110.96
294_I334_I2.2780.96
328_E336_A2.2690.96
106_L218_I2.2180.95
199_L215_V2.2110.95
349_T356_I2.1270.94
339_L376_Y2.1180.94
111_F115_K2.0840.93
25_G243_G2.0460.93
119_V186_G2.0340.93
36_E39_I2.0120.92
315_R319_E1.9920.92
107_V142_A1.9900.92
122_F143_F1.9540.91
139_R195_A1.9380.91
105_A108_E1.9240.90
178_L207_I1.8960.90
216_I271_V1.8910.90
67_K71_Q1.8810.89
331_H335_H1.8490.88
211_E255_D1.8470.88
143_F147_V1.8400.88
323_K328_E1.8380.88
216_I233_S1.8350.88
29_Y251_H1.8240.88
373_K386_V1.7810.86
28_E240_R1.7540.86
217_G234_S1.7530.86
81_V378_T1.7150.84
330_I362_Y1.6810.83
117_K277_T1.6790.83
347_I383_Y1.6490.82
269_V383_Y1.6110.80
183_P362_Y1.6100.80
32_A244_Y1.5810.79
108_E112_L1.5600.78
246_A372_F1.5350.77
177_W221_E1.5320.77
232_L266_V1.5210.76
216_I277_T1.5140.76
367_Y370_S1.5110.76
103_N237_Q1.5100.76
233_S277_T1.4660.73
8_I357_S1.4640.73
225_R230_V1.4600.73
192_D218_I1.4540.73
78_V198_I1.4540.73
10_L26_V1.4290.71
345_L351_L1.4210.71
103_N138_E1.4040.70
16_K84_G1.4040.70
290_A302_I1.4030.70
293_Y307_V1.3900.69
225_R234_S1.3810.69
102_D198_I1.3800.69
186_G216_I1.3790.69
9_T57_G1.3770.68
220_N234_S1.3730.68
139_R234_S1.3730.68
184_Q213_L1.3690.68
140_E144_R1.3420.66
163_A191_T1.3350.66
206_H313_I1.3240.65
260_P383_Y1.3110.65
112_L146_L1.3090.64
21_Q26_V1.3080.64
283_T339_L1.3070.64
18_Y219_D1.3070.64
233_S322_F1.3010.64
236_A272_I1.3000.64
79_P362_Y1.2990.64
210_P276_S1.2880.63
248_K330_I1.2760.62
304_V334_I1.2650.62
201_V205_L1.2610.61
121_R182_P1.2570.61
148_A349_T1.2550.61
177_W181_L1.2540.61
84_G191_T1.2480.61
216_I291_M1.2460.61
172_N179_Q1.2440.60
60_V155_V1.2250.59
274_R349_T1.2210.59
346_L380_P1.2190.59
343_R379_T1.2150.59
330_I335_H1.2140.58
266_V353_I1.2120.58
65_D82_G1.2050.58
103_N367_Y1.2020.58
188_I218_I1.2000.58
163_A194_R1.1780.56
243_G315_R1.1690.56
80_I266_V1.1660.55
221_E368_F1.1600.55
382_E385_D1.1600.55
341_K344_S1.1570.55
344_S348_S1.1520.54
111_F146_L1.1460.54
35_S42_E1.1440.54
342_A376_Y1.1430.54
18_Y217_G1.1390.54
293_Y302_I1.1380.53
164_P209_V1.1310.53
336_A362_Y1.1310.53
114_L220_N1.1280.53
58_D71_Q1.1280.53
326_V330_I1.1220.52
124_F135_W1.1170.52
15_N23_V1.1090.52
79_P217_G1.1060.51
274_R384_R1.0990.51
78_V96_V1.0950.51
182_P260_P1.0950.51
107_V218_I1.0940.51
356_I360_C1.0910.50
127_L194_R1.0910.50
290_A307_V1.0910.50
289_Q379_T1.0830.50
127_L217_G1.0820.50
326_V371_V1.0780.49
213_L257_E1.0760.49
125_Y198_I1.0740.49
136_A230_V1.0690.49
138_E287_V1.0640.49
62_A99_I1.0590.48
287_V325_E1.0510.48
81_V108_E1.0460.47
30_L37_W1.0390.47
121_R155_V1.0380.47
191_T219_D1.0330.46
103_N106_L1.0300.46
52_I57_G1.0150.45
303_K313_I1.0110.45
22_V41_I1.0090.45
104_Y141_Y1.0080.45
366_Q370_S0.9990.44
34_Q178_L0.9970.44
316_S319_E0.9940.44
326_V343_R0.9940.44
113_H349_T0.9930.44
114_L235_V0.9900.44
230_V276_S0.9870.43
234_S274_R0.9840.43
236_A270_R0.9820.43
179_Q205_L0.9710.42
202_C277_T0.9680.42
114_L195_A0.9650.42
83_V246_A0.9640.42
114_L238_G0.9630.42
101_T107_V0.9630.42
298_A360_C0.9620.42
266_V358_Q0.9610.42
83_V190_V0.9600.42
10_L13_N0.9600.42
368_F376_Y0.9560.41
69_I72_A0.9560.41
313_I360_C0.9460.41
127_L323_K0.9460.41
329_T332_A0.9460.41
185_T362_Y0.9460.41
120_N147_V0.9450.41
185_T213_L0.9420.41
108_E307_V0.9370.40
110_A277_T0.9360.40
323_K382_E0.9350.40
192_D195_A0.9270.40
336_A375_A0.9200.39
334_I337_E0.9180.39
125_Y170_A0.9180.39
118_G246_A0.9110.39
211_E344_S0.9090.38
117_K279_Y0.9080.38
34_Q37_W0.9060.38
187_I198_I0.9050.38
191_T367_Y0.9030.38
25_G234_S0.9000.38
26_V41_I0.8950.38
100_A191_T0.8900.37
246_A361_G0.8870.37
125_Y227_L0.8870.37
337_E357_S0.8860.37
343_R376_Y0.8860.37
80_I364_S0.8850.37
308_L373_K0.8830.37
61_I142_A0.8830.37
122_F235_V0.8810.37
206_H260_P0.8800.37
57_G368_F0.8800.37
18_Y234_S0.8800.37
124_F188_I0.8790.37
195_A217_G0.8790.37
343_R383_Y0.8780.37
339_L364_S0.8750.36
58_D219_D0.8740.36
184_Q214_C0.8730.36
294_I337_E0.8720.36
361_G368_F0.8690.36
284_D291_M0.8650.36
59_G113_H0.8650.36
115_K244_Y0.8620.36
199_L232_L0.8580.35
44_D203_E0.8580.35
136_A190_V0.8560.35
18_Y192_D0.8510.35
287_V313_I0.8480.35
322_F333_M0.8470.35
192_D220_N0.8440.34
215_V276_S0.8390.34
241_Q245_Q0.8330.34
125_Y191_T0.8290.34
252_R382_E0.8270.33
151_K176_D0.8270.33
247_A278_D0.8230.33
293_Y306_Q0.8210.33
273_E276_S0.8190.33
189_A195_A0.8160.33
30_L108_E0.8130.33
26_V247_A0.8080.32
367_Y371_V0.8060.32
317_N321_R0.8050.32
135_W221_E0.8040.32
52_I99_I0.8030.32
52_I192_D0.8010.32
60_V187_I0.7980.32
375_A379_T0.7950.32
105_A328_E0.7940.32
84_G107_V0.7940.32
302_I322_F0.7920.31
302_I307_V0.7920.31
336_A383_Y0.7910.31
117_K273_E0.7890.31
105_A145_Q0.7880.31
84_G100_A0.7870.31
221_E231_A0.7860.31
61_I176_D0.7850.31
302_I305_D0.7820.31
367_Y380_P0.7810.31
111_F122_F0.7800.31
274_R277_T0.7720.30
212_K365_L0.7720.30
317_N368_F0.7700.30
25_G29_Y0.7700.30
59_G79_P0.7690.30
43_E254_L0.7680.30
213_L290_A0.7660.30
61_I246_A0.7640.30
122_F220_N0.7630.30
327_G348_S0.7630.30
111_F188_I0.7630.30
70_E209_V0.7560.29
333_M337_E0.7530.29
16_K19_D0.7530.29
187_I211_E0.7510.29
26_V148_A0.7510.29
297_H310_A0.7510.29
209_V246_A0.7460.29
186_G214_C0.7460.29
7_R47_A0.7460.29
240_R379_T0.7450.29
270_R343_R0.7450.29
220_N235_V0.7420.29
318_L330_I0.7420.29
206_H210_P0.7420.29
332_A377_D0.7400.28
100_A103_N0.7360.28
212_K282_L0.7360.28
222_E271_V0.7350.28
213_L341_K0.7340.28
190_V218_I0.7340.28
106_L242_M0.7320.28
329_T381_K0.7310.28
13_N16_K0.7290.28
200_Q218_I0.7270.28
339_L348_S0.7270.28
190_V238_G0.7240.28
115_K150_E0.7240.28
84_G127_L0.7220.28
120_N257_E0.7220.28
203_E271_V0.7200.27
292_H296_N0.7190.27
233_S276_S0.7190.27
112_L245_Q0.7190.27
113_H199_L0.7190.27
69_I168_Q0.7160.27
118_G154_G0.7150.27
20_R110_A0.7150.27
109_S357_S0.7150.27
141_Y312_G0.7140.27
9_T60_V0.7120.27
127_L191_T0.7110.27
108_E245_Q0.7100.27
290_A293_Y0.7100.27
151_K206_H0.7080.27
126_G308_L0.7060.27
106_L237_Q0.7050.27
126_G284_D0.7030.27
76_V297_H0.7030.27
13_N23_V0.7010.26
115_K310_A0.7010.26
315_R321_R0.7000.26
10_L37_W0.7000.26
174_L177_W0.6970.26
329_T374_K0.6960.26
332_A336_A0.6950.26
345_L376_Y0.6940.26
192_D219_D0.6920.26
178_L353_I0.6920.26
308_L312_G0.6920.26
148_A213_L0.6910.26
304_V321_R0.6900.26
148_A236_A0.6890.26
81_V191_T0.6890.26
99_I292_H0.6880.26
260_P263_R0.6840.26
10_L44_D0.6840.26
187_I327_G0.6830.26
214_C232_L0.6830.26
81_V329_T0.6830.26
142_A146_L0.6780.25
378_T386_V0.6770.25
180_T297_H0.6770.25
189_A297_H0.6750.25
282_L292_H0.6730.25
337_E355_E0.6700.25
29_Y247_A0.6690.25
278_D293_Y0.6680.25
8_I14_A0.6670.25
103_N139_R0.6660.25
298_A302_I0.6630.25
201_V285_P0.6620.24
198_I360_C0.6610.24
118_G232_L0.6600.24
211_E328_E0.6580.24
181_L329_T0.6560.24
30_L35_S0.6560.24
71_Q176_D0.6550.24
279_Y341_K0.6530.24
24_E28_E0.6530.24
202_C207_I0.6520.24
313_I376_Y0.6520.24
226_Y294_I0.6510.24
345_L359_M0.6490.24
210_P346_L0.6480.24
222_E362_Y0.6450.24
233_S273_E0.6410.23
13_N83_V0.6400.23
119_V213_L0.6400.23
284_D304_V0.6390.23
86_S138_E0.6370.23
52_I199_L0.6360.23
10_L27_G0.6320.23
56_L382_E0.6310.23
167_W200_Q0.6300.23
47_A336_A0.6300.23
10_L22_V0.6300.23
21_Q272_I0.6290.23
328_E349_T0.6270.23
372_F383_Y0.6250.23
139_R218_I0.6250.23
326_V333_M0.6240.23
229_R379_T0.6240.23
107_V188_I0.6230.23
121_R173_R0.6220.23
123_A181_L0.6220.23
209_V232_L0.6220.23
113_H186_G0.6210.22
185_T253_L0.6210.22
11_L16_K0.6200.22
112_L116_E0.6200.22
135_W217_G0.6190.22
350_T357_S0.6190.22
187_I256_K0.6160.22
164_P175_A0.6160.22
379_T383_Y0.6130.22
62_A80_I0.6130.22
102_D362_Y0.6110.22
353_I381_K0.6090.22
344_S385_D0.6080.22
58_D294_I0.6050.22
104_Y138_E0.6050.22
299_C338_K0.6050.22
82_G219_D0.6040.22
102_D243_G0.6040.22
335_H371_V0.6030.22
342_A361_G0.6020.22
258_E343_R0.6010.22
211_E285_P0.6010.22
114_L140_E0.6000.22
122_F316_S0.5990.21
180_T353_I0.5990.21
61_I322_F0.5980.21
235_V246_A0.5950.21
373_K382_E0.5950.21
154_G257_E0.5910.21
340_E375_A0.5910.21
143_F334_I0.5900.21
101_T113_H0.5890.21
183_P212_K0.5890.21
293_Y303_K0.5880.21
301_G370_S0.5870.21
103_N192_D0.5860.21
14_A41_I0.5860.21
218_I238_G0.5860.21
295_R333_M0.5850.21
113_H116_E0.5850.21
355_E373_K0.5840.21
74_A80_I0.5840.21
136_A376_Y0.5830.21
114_L233_S0.5810.21
296_N362_Y0.5800.21
67_K303_K0.5800.21
78_V329_T0.5800.21
255_D262_Q0.5790.21
302_I311_V0.5790.21
92_S191_T0.5790.21
87_Y92_S0.5780.21
213_L304_V0.5760.20
84_G99_I0.5730.20
219_D364_S0.5730.20
332_A335_H0.5730.20
161_E385_D0.5720.20
145_Q369_Y0.5720.20
338_K381_K0.5700.20
71_Q269_V0.5700.20
272_I302_I0.5700.20
78_V253_L0.5680.20
209_V374_K0.5680.20
12_F19_D0.5680.20
184_Q276_S0.5670.20
124_F302_I0.5660.20
104_Y112_L0.5650.20
16_K191_T0.5650.20
275_R330_I0.5630.20
12_F15_N0.5620.20
82_G194_R0.5620.20
142_A195_A0.5620.20
220_N319_E0.5620.20
144_R156_V0.5620.20
144_R148_A0.5610.20
62_A202_C0.5610.20
122_F147_V0.5590.20
41_I370_S0.5590.20
127_L192_D0.5580.20
289_Q309_D0.5580.20
298_A373_K0.5550.20
244_Y277_T0.5550.20
320_K331_H0.5550.20
301_G307_V0.5540.20
195_A219_D0.5530.19
117_K202_C0.5530.19
318_L347_I0.5500.19
284_D325_E0.5490.19
356_I384_R0.5480.19
112_L206_H0.5460.19
14_A337_E0.5440.19
270_R349_T0.5420.19
24_E27_G0.5410.19
101_T191_T0.5410.19
78_V252_R0.5410.19
317_N320_K0.5410.19
123_A319_E0.5400.19
59_G97_H0.5400.19
145_Q260_P0.5400.19
136_A192_D0.5400.19
8_I264_I0.5390.19
30_L186_G0.5390.19
320_K326_V0.5380.19
343_R375_A0.5360.19
141_Y145_Q0.5360.19
126_G304_V0.5350.19
31_Q329_T0.5340.19
273_E279_Y0.5340.19
81_V99_I0.5320.19
26_V37_W0.5320.19
321_R325_E0.5320.19
249_L271_V0.5310.19
274_R281_S0.5310.19
287_V290_A0.5310.19
48_R329_T0.5300.19
60_V253_L0.5300.19
28_E40_F0.5290.19
52_I217_G0.5290.19
107_V233_S0.5270.18
117_K125_Y0.5260.18
83_V273_E0.5240.18
27_G379_T0.5230.18
177_W316_S0.5230.18
46_R287_V0.5210.18
8_I21_Q0.5210.18
106_L191_T0.5210.18
257_E336_A0.5210.18
315_R364_S0.5210.18
122_F276_S0.5200.18
275_R296_N0.5200.18
177_W307_V0.5200.18
7_R36_E0.5200.18
178_L188_I0.5190.18
74_A104_Y0.5180.18
111_F150_E0.5180.18
307_V310_A0.5160.18
208_P212_K0.5150.18
48_R235_V0.5150.18
334_I380_P0.5140.18
184_Q384_R0.5120.18
195_A298_A0.5110.18
284_D308_L0.5110.18
209_V371_V0.5100.18
252_R353_I0.5090.18
210_P233_S0.5090.18
117_K218_I0.5080.18
136_A252_R0.5070.18
371_V374_K0.5070.18
101_T242_M0.5070.18
290_A311_V0.5040.18
138_E334_I0.5030.17
178_L231_A0.5030.17
179_Q347_I0.5030.17
76_V147_V0.5030.17
112_L378_T0.5030.17
353_I370_S0.5020.17
143_F217_G0.5020.17
336_A350_T0.5020.17
99_I163_A0.5010.17
212_K216_I0.5010.17
271_V294_I0.5000.17
233_S284_D0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fe7A 2 0.9668 100 0.378 Contact Map
3huuA 2 0.6607 100 0.599 Contact Map
2iksA 2 0.6837 100 0.6 Contact Map
3dbiA 2 0.6862 100 0.6 Contact Map
2hsgA 1 0.6811 100 0.6 Contact Map
3brqA 2 0.6811 100 0.602 Contact Map
4o5aA 2 0.6684 100 0.603 Contact Map
2o20A 2 0.6811 100 0.603 Contact Map
3jvdA 2 0.6556 100 0.607 Contact Map
3k4hA 2 0.6913 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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