ROB - ECOLI - GREMLIN Contacts

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ROB - Right origin-binding protein

UniProt:	P0ACI0	Sequences: MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKSAVALRLTARPILDIALQYRFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPLRLGEFTMPEHKFVTLEDTPLIGVTQSYSCSLEQISDFRHEMRYQFWHDFLGNAPTIPPVLYGLNETRPSQDKDDEQEVFYTTALAQDQADGYVLTGHPVMLQGGEYVMFTYEGLGTGVQEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCELLIPIRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11366
Length:	289 (269)
Sequences:	2906 (2203)
Seq/√Len:	134.3

ECOLI - ROB YKGA
BACSU - YDEE YBFP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_H	20_Q	6.410	1.00
62_S	88_F	4.540	1.00
65_A	80_Y	3.682	1.00
65_A	79_Q	3.629	1.00
13_W	17_H	3.328	1.00
25_D	35_K	3.314	1.00
135_D	218_M	3.278	1.00
72_P	75_D	2.878	1.00
137_P	216_P	2.874	1.00
71_R	79_Q	2.723	1.00
10_L	38_L	2.721	1.00
66_L	73_I	2.699	1.00
71_R	76_I	2.630	1.00
132_T	223_E	2.624	1.00
84_S	87_T	2.621	1.00
230_E	280_R	2.537	1.00
228_T	282_E	2.419	1.00
14_L	54_I	2.360	1.00
74_L	78_L	2.345	1.00
153_S	156_R	2.344	1.00
152_I	156_R	2.322	1.00
227_F	243_V	2.315	1.00
76_I	104_R	2.314	1.00
23_S	26_N	2.301	1.00
137_P	218_M	2.259	1.00
229_Y	239_F	2.254	1.00
151_Q	154_D	2.252	1.00
135_D	221_G	2.147	1.00
69_T	104_R	2.135	1.00
26_N	29_A	2.115	1.00
122_E	126_P	2.083	1.00
15_E	57_R	2.046	1.00
42_F	53_Y	2.022	1.00
142_T	197_F	2.008	1.00
155_F	159_M	1.990	1.00
156_R	160_R	1.982	1.00
89_T	99_T	1.966	1.00
59_L	95_Q	1.961	1.00
74_L	85_Q	1.957	1.00
65_A	71_R	1.941	1.00
222_G	256_R	1.820	1.00
223_E	253_L	1.817	1.00
242_T	246_T	1.772	1.00
225_V	247_C	1.757	1.00
85_Q	89_T	1.742	1.00
10_L	30_K	1.735	1.00
211_V	214_G	1.716	1.00
247_C	251_L	1.697	1.00
48_H	56_A	1.677	1.00
152_I	160_R	1.675	1.00
10_L	27_V	1.664	1.00
248_M	251_L	1.661	1.00
53_Y	57_R	1.604	1.00
18_L	57_R	1.587	1.00
15_E	53_Y	1.574	1.00
27_V	30_K	1.573	1.00
228_T	280_R	1.540	1.00
153_S	157_H	1.532	1.00
19_D	61_K	1.525	1.00
152_I	155_F	1.514	1.00
24_L	39_Q	1.493	1.00
180_G	198_Y	1.475	1.00
6_I	32_G	1.442	1.00
13_W	30_K	1.437	1.00
136_T	219_L	1.432	1.00
19_D	79_Q	1.420	1.00
129_K	226_M	1.396	1.00
240_I	283_L	1.366	1.00
18_L	61_K	1.351	1.00
142_T	215_H	1.351	1.00
14_L	22_L	1.346	1.00
78_L	85_Q	1.319	1.00
263_R	282_E	1.316	1.00
156_R	159_M	1.316	1.00
177_V	263_R	1.302	1.00
226_M	284_L	1.302	1.00
244_Y	255_R	1.283	1.00
69_T	76_I	1.279	1.00
83_D	87_T	1.275	1.00
128_H	227_F	1.264	1.00
131_V	226_M	1.261	1.00
267_A	279_L	1.258	1.00
128_H	225_V	1.254	1.00
157_H	160_R	1.251	1.00
71_R	75_D	1.232	1.00
132_T	221_G	1.229	1.00
261_I	284_L	1.226	1.00
123_F	126_P	1.216	1.00
180_G	264_Y	1.208	1.00
163_F	166_D	1.203	1.00
140_G	199_T	1.188	0.99
50_I	54_I	1.183	0.99
52_A	56_A	1.173	0.99
85_Q	101_A	1.166	0.99
127_E	228_T	1.158	0.99
138_L	199_T	1.158	0.99
6_I	9_D	1.149	0.99
102_L	105_R	1.148	0.99
102_L	106_S	1.144	0.99
59_L	96_F	1.133	0.99
87_T	91_A	1.127	0.99
86_Q	89_T	1.101	0.99
134_E	221_G	1.083	0.99
248_M	255_R	1.076	0.99
133_L	136_T	1.071	0.99
190_K	193_E	1.061	0.99
13_W	22_L	1.050	0.99
52_A	55_R	1.045	0.99
9_D	30_K	1.045	0.99
74_L	86_Q	1.045	0.99
43_K	49_A	1.042	0.99
235_G	238_E	1.037	0.99
4_A	8_R	1.030	0.99
73_I	101_A	1.025	0.98
253_L	287_I	1.024	0.98
243_V	285_I	1.022	0.98
163_F	167_F	1.019	0.98
147_C	150_E	1.015	0.98
153_S	160_R	1.013	0.98
154_D	157_H	1.010	0.98
143_Q	158_E	1.010	0.98
26_N	30_K	1.010	0.98
23_S	82_F	1.005	0.98
266_P	279_L	0.995	0.98
222_G	258_G	0.990	0.98
103_Y	110_S	0.988	0.98
140_G	217_V	0.984	0.98
75_D	78_L	0.983	0.98
93_K	102_L	0.978	0.98
51_G	54_I	0.978	0.98
239_F	283_L	0.978	0.98
9_D	12_I	0.969	0.98
37_H	40_R	0.967	0.98
12_I	16_G	0.967	0.98
63_A	103_Y	0.955	0.98
14_L	17_H	0.955	0.98
7_I	46_T	0.952	0.98
89_T	100_P	0.948	0.97
39_Q	51_G	0.942	0.97
151_Q	159_M	0.940	0.97
241_L	245_G	0.937	0.97
230_E	278_N	0.936	0.97
144_S	195_E	0.936	0.97
11_L	53_Y	0.933	0.97
150_E	182_N	0.931	0.97
166_D	169_G	0.930	0.97
31_A	38_L	0.930	0.97
194_Q	198_Y	0.926	0.97
88_F	92_F	0.920	0.97
165_H	168_L	0.918	0.97
117_P	121_G	0.918	0.97
238_E	242_T	0.906	0.97
93_K	99_T	0.904	0.97
182_N	196_V	0.904	0.97
61_K	80_Y	0.904	0.97
36_W	125_M	0.894	0.96
20_Q	26_N	0.888	0.96
246_T	287_I	0.885	0.96
56_A	95_Q	0.881	0.96
265_Y	280_R	0.879	0.96
24_L	35_K	0.874	0.96
36_W	40_R	0.874	0.96
152_I	157_H	0.872	0.96
198_Y	201_A	0.863	0.96
32_G	121_G	0.851	0.95
220_Q	258_G	0.849	0.95
25_D	29_A	0.835	0.95
131_V	284_L	0.834	0.95
236_V	247_C	0.832	0.95
5_G	9_D	0.830	0.95
155_F	158_E	0.830	0.95
165_H	169_G	0.829	0.94
22_L	28_A	0.827	0.94
56_A	60_S	0.822	0.94
164_W	168_L	0.821	0.94
137_P	205_D	0.817	0.94
180_G	262_E	0.817	0.94
14_L	50_I	0.813	0.94
240_I	281_C	0.811	0.94
151_Q	155_F	0.808	0.94
141_V	155_F	0.808	0.94
240_I	286_P	0.807	0.94
246_T	250_M	0.805	0.94
14_L	18_L	0.805	0.94
240_I	285_I	0.804	0.94
172_P	205_D	0.804	0.94
73_I	76_I	0.801	0.93
33_Y	38_L	0.799	0.93
152_I	159_M	0.797	0.93
133_L	284_L	0.794	0.93
11_L	15_E	0.793	0.93
236_V	240_I	0.791	0.93
233_G	236_V	0.784	0.93
139_I	214_G	0.782	0.93
164_W	167_F	0.778	0.92
37_H	41_M	0.777	0.92
163_F	168_L	0.775	0.92
98_Q	103_Y	0.770	0.92
10_L	31_A	0.769	0.92
130_F	223_E	0.769	0.92
128_H	131_V	0.768	0.92
232_L	235_G	0.768	0.92
151_Q	160_R	0.766	0.92
39_Q	49_A	0.760	0.91
14_L	27_V	0.760	0.91
247_C	253_L	0.756	0.91
152_I	158_E	0.754	0.91
92_F	100_P	0.750	0.91
53_Y	60_S	0.747	0.91
136_T	177_V	0.742	0.90
67_R	107_P	0.738	0.90
199_T	215_H	0.736	0.90
142_T	199_T	0.736	0.90
243_V	283_L	0.734	0.90
239_F	243_V	0.734	0.90
60_S	188_Q	0.732	0.90
154_D	158_E	0.730	0.90
115_R	118_L	0.729	0.90
140_G	197_F	0.726	0.90
74_L	84_S	0.723	0.89
17_H	22_L	0.722	0.89
179_Y	263_R	0.717	0.89
265_Y	282_E	0.716	0.89
38_L	101_A	0.716	0.89
11_L	46_T	0.715	0.89
140_G	215_H	0.712	0.89
198_Y	264_Y	0.709	0.88
57_R	140_G	0.709	0.88
116_P	120_L	0.708	0.88
53_Y	82_F	0.703	0.88
8_R	12_I	0.701	0.88
265_Y	281_C	0.696	0.87
26_N	54_I	0.693	0.87
9_D	31_A	0.693	0.87
112_F	116_P	0.693	0.87
145_Y	248_M	0.692	0.87
9_D	16_G	0.690	0.87
180_G	196_V	0.683	0.86
6_I	33_Y	0.682	0.86
60_S	96_F	0.681	0.86
140_G	201_A	0.680	0.86
130_F	287_I	0.677	0.86
226_M	282_E	0.675	0.86
244_Y	260_D	0.674	0.86
153_S	262_E	0.672	0.86
156_R	164_W	0.671	0.86
73_I	104_R	0.670	0.85
199_T	204_Q	0.669	0.85
64_V	68_L	0.668	0.85
229_Y	281_C	0.667	0.85
59_L	91_A	0.665	0.85
61_K	65_A	0.664	0.85
231_G	281_C	0.664	0.85
263_R	284_L	0.660	0.85
51_G	55_R	0.660	0.85
35_K	39_Q	0.657	0.84
130_F	225_V	0.657	0.84
265_Y	269_D	0.656	0.84
155_F	160_R	0.652	0.84
227_F	242_T	0.651	0.84
268_E	279_L	0.650	0.84
18_L	54_I	0.650	0.84
234_T	238_E	0.650	0.84
47_G	241_L	0.647	0.83
194_Q	201_A	0.644	0.83
57_R	60_S	0.644	0.83
86_Q	90_R	0.643	0.83
222_G	225_V	0.641	0.83
51_G	86_Q	0.638	0.83
196_V	199_T	0.638	0.83
189_D	194_Q	0.635	0.82
141_V	158_E	0.634	0.82
25_D	78_L	0.634	0.82
139_I	211_V	0.634	0.82
255_R	260_D	0.632	0.82
112_F	115_R	0.631	0.82
24_L	27_V	0.630	0.82
36_W	39_Q	0.627	0.81
31_A	37_H	0.626	0.81
24_L	50_I	0.625	0.81
194_Q	199_T	0.625	0.81
233_G	281_C	0.624	0.81
27_V	105_R	0.623	0.81
229_Y	236_V	0.621	0.81
82_F	93_K	0.620	0.81
84_S	90_R	0.619	0.81
269_D	279_L	0.618	0.81
57_R	80_Y	0.615	0.80
82_F	96_F	0.613	0.80
235_G	239_F	0.613	0.80
101_A	105_R	0.612	0.80
167_F	170_N	0.609	0.80
11_L	42_F	0.606	0.79
28_A	63_A	0.605	0.79
82_F	259_Q	0.605	0.79
17_H	223_E	0.603	0.79
189_D	195_E	0.603	0.79
196_V	201_A	0.602	0.79
63_A	92_F	0.601	0.79
179_Y	203_A	0.600	0.79
98_Q	106_S	0.600	0.79
27_V	54_I	0.599	0.78
82_F	103_Y	0.595	0.78
203_A	206_Q	0.595	0.78
182_N	235_G	0.594	0.78
143_Q	155_F	0.594	0.78
142_T	183_E	0.593	0.78
202_L	206_Q	0.593	0.78
65_A	69_T	0.592	0.78
179_Y	182_N	0.592	0.78
121_G	127_E	0.590	0.77
233_G	279_L	0.589	0.77
13_W	27_V	0.587	0.77
91_A	220_Q	0.586	0.77
266_P	281_C	0.586	0.77
112_F	120_L	0.583	0.77
165_H	170_N	0.582	0.76
92_F	103_Y	0.579	0.76
168_L	236_V	0.578	0.76
169_G	172_P	0.577	0.76
159_M	178_L	0.577	0.76
13_W	68_L	0.576	0.76
17_H	117_P	0.576	0.76
164_W	214_G	0.573	0.75
163_F	171_A	0.573	0.75
5_G	123_F	0.573	0.75
11_L	57_R	0.571	0.75
99_T	102_L	0.571	0.75
133_L	224_Y	0.570	0.75
37_H	243_V	0.569	0.75
22_L	54_I	0.568	0.75
183_E	217_V	0.568	0.75
225_V	251_L	0.566	0.74
156_R	196_V	0.565	0.74
83_D	86_Q	0.564	0.74
147_C	194_Q	0.563	0.74
144_S	197_F	0.563	0.74
229_Y	283_L	0.562	0.74
15_E	42_F	0.561	0.74
210_Y	213_T	0.560	0.74
33_Y	41_M	0.560	0.74
240_I	260_D	0.558	0.73
249_P	252_N	0.557	0.73
166_D	170_N	0.553	0.73
177_V	201_A	0.552	0.73
227_F	231_G	0.552	0.73
45_V	245_G	0.552	0.73
33_Y	260_D	0.551	0.73
43_K	103_Y	0.551	0.73
27_V	31_A	0.550	0.72
163_F	170_N	0.550	0.72
19_D	45_V	0.550	0.72
87_T	229_Y	0.550	0.72
148_S	261_I	0.549	0.72
256_R	286_P	0.546	0.72
180_G	236_V	0.546	0.72
168_L	171_A	0.546	0.72
170_N	173_T	0.542	0.71
270_A	277_I	0.541	0.71
82_F	87_T	0.541	0.71
192_D	195_E	0.541	0.71
22_L	26_N	0.540	0.71
147_C	196_V	0.539	0.71
156_R	180_G	0.539	0.71
144_S	148_S	0.538	0.71
72_P	89_T	0.536	0.70
38_L	50_I	0.535	0.70
38_L	100_P	0.535	0.70
156_R	182_N	0.534	0.70
159_M	164_W	0.533	0.70
117_P	122_E	0.532	0.70
210_Y	216_P	0.530	0.70
130_F	253_L	0.529	0.69
243_V	248_M	0.525	0.69
157_H	163_F	0.524	0.69
179_Y	201_A	0.522	0.68
124_T	127_E	0.522	0.68
240_I	262_E	0.521	0.68
76_I	89_T	0.519	0.68
229_Y	240_I	0.518	0.68
139_I	178_L	0.517	0.68
164_W	170_N	0.517	0.68
24_L	216_P	0.517	0.68
42_F	46_T	0.515	0.67
24_L	67_R	0.515	0.67
57_R	74_L	0.515	0.67
58_R	80_Y	0.515	0.67
37_H	244_Y	0.511	0.67
108_E	118_L	0.511	0.67
60_S	64_V	0.510	0.67
65_A	96_F	0.508	0.66
101_A	126_P	0.508	0.66
254_T	283_L	0.507	0.66
36_W	91_A	0.506	0.66
270_A	278_N	0.505	0.66
9_D	287_I	0.505	0.66
43_K	102_L	0.504	0.66
139_I	204_Q	0.502	0.65
123_F	127_E	0.502	0.65
212_L	234_T	0.502	0.65
190_K	195_E	0.501	0.65
115_R	119_R	0.501	0.65
39_Q	244_Y	0.500	0.65
121_G	125_M	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1d5yA	1	0.9689	100	0.278	Contact Map
3gbgA	1	0.3772	100	0.566	Contact Map
1bl0A	1	0.4014	100	0.584	Contact Map
4fe7A	2	0.3772	100	0.584	Contact Map
3w6vA	1	0.3841	100	0.588	Contact Map
3oioA	1	0.3841	100	0.589	Contact Map
3mn2A	1	0.3668	100	0.59	Contact Map
2k9sA	1	0.3668	100	0.591	Contact Map
3oouA	1	0.3633	100	0.595	Contact Map
3lsgA	2	0.3529	99.9	0.599	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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