GREMLIN Database
ROB - Right origin-binding protein
UniProt: P0ACI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11366
Length: 289 (269)
Sequences: 2906 (2203)
Seq/√Len: 134.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_H20_Q6.4101.00
62_S88_F4.5401.00
65_A80_Y3.6821.00
65_A79_Q3.6291.00
13_W17_H3.3281.00
25_D35_K3.3141.00
135_D218_M3.2781.00
72_P75_D2.8781.00
137_P216_P2.8741.00
71_R79_Q2.7231.00
10_L38_L2.7211.00
66_L73_I2.6991.00
71_R76_I2.6301.00
132_T223_E2.6241.00
84_S87_T2.6211.00
230_E280_R2.5371.00
228_T282_E2.4191.00
14_L54_I2.3601.00
74_L78_L2.3451.00
153_S156_R2.3441.00
152_I156_R2.3221.00
227_F243_V2.3151.00
76_I104_R2.3141.00
23_S26_N2.3011.00
137_P218_M2.2591.00
229_Y239_F2.2541.00
151_Q154_D2.2521.00
135_D221_G2.1471.00
69_T104_R2.1351.00
26_N29_A2.1151.00
122_E126_P2.0831.00
15_E57_R2.0461.00
42_F53_Y2.0221.00
142_T197_F2.0081.00
155_F159_M1.9901.00
156_R160_R1.9821.00
89_T99_T1.9661.00
59_L95_Q1.9611.00
74_L85_Q1.9571.00
65_A71_R1.9411.00
222_G256_R1.8201.00
223_E253_L1.8171.00
242_T246_T1.7721.00
225_V247_C1.7571.00
85_Q89_T1.7421.00
10_L30_K1.7351.00
211_V214_G1.7161.00
247_C251_L1.6971.00
48_H56_A1.6771.00
152_I160_R1.6751.00
10_L27_V1.6641.00
248_M251_L1.6611.00
53_Y57_R1.6041.00
18_L57_R1.5871.00
15_E53_Y1.5741.00
27_V30_K1.5731.00
228_T280_R1.5401.00
153_S157_H1.5321.00
19_D61_K1.5251.00
152_I155_F1.5141.00
24_L39_Q1.4931.00
180_G198_Y1.4751.00
6_I32_G1.4421.00
13_W30_K1.4371.00
136_T219_L1.4321.00
19_D79_Q1.4201.00
129_K226_M1.3961.00
240_I283_L1.3661.00
18_L61_K1.3511.00
142_T215_H1.3511.00
14_L22_L1.3461.00
78_L85_Q1.3191.00
263_R282_E1.3161.00
156_R159_M1.3161.00
177_V263_R1.3021.00
226_M284_L1.3021.00
244_Y255_R1.2831.00
69_T76_I1.2791.00
83_D87_T1.2751.00
128_H227_F1.2641.00
131_V226_M1.2611.00
267_A279_L1.2581.00
128_H225_V1.2541.00
157_H160_R1.2511.00
71_R75_D1.2321.00
132_T221_G1.2291.00
261_I284_L1.2261.00
123_F126_P1.2161.00
180_G264_Y1.2081.00
163_F166_D1.2031.00
140_G199_T1.1880.99
50_I54_I1.1830.99
52_A56_A1.1730.99
85_Q101_A1.1660.99
127_E228_T1.1580.99
138_L199_T1.1580.99
6_I9_D1.1490.99
102_L105_R1.1480.99
102_L106_S1.1440.99
59_L96_F1.1330.99
87_T91_A1.1270.99
86_Q89_T1.1010.99
134_E221_G1.0830.99
248_M255_R1.0760.99
133_L136_T1.0710.99
190_K193_E1.0610.99
13_W22_L1.0500.99
52_A55_R1.0450.99
9_D30_K1.0450.99
74_L86_Q1.0450.99
43_K49_A1.0420.99
235_G238_E1.0370.99
4_A8_R1.0300.99
73_I101_A1.0250.98
253_L287_I1.0240.98
243_V285_I1.0220.98
163_F167_F1.0190.98
147_C150_E1.0150.98
153_S160_R1.0130.98
154_D157_H1.0100.98
143_Q158_E1.0100.98
26_N30_K1.0100.98
23_S82_F1.0050.98
266_P279_L0.9950.98
222_G258_G0.9900.98
103_Y110_S0.9880.98
140_G217_V0.9840.98
75_D78_L0.9830.98
93_K102_L0.9780.98
51_G54_I0.9780.98
239_F283_L0.9780.98
9_D12_I0.9690.98
37_H40_R0.9670.98
12_I16_G0.9670.98
63_A103_Y0.9550.98
14_L17_H0.9550.98
7_I46_T0.9520.98
89_T100_P0.9480.97
39_Q51_G0.9420.97
151_Q159_M0.9400.97
241_L245_G0.9370.97
230_E278_N0.9360.97
144_S195_E0.9360.97
11_L53_Y0.9330.97
150_E182_N0.9310.97
166_D169_G0.9300.97
31_A38_L0.9300.97
194_Q198_Y0.9260.97
88_F92_F0.9200.97
165_H168_L0.9180.97
117_P121_G0.9180.97
238_E242_T0.9060.97
93_K99_T0.9040.97
182_N196_V0.9040.97
61_K80_Y0.9040.97
36_W125_M0.8940.96
20_Q26_N0.8880.96
246_T287_I0.8850.96
56_A95_Q0.8810.96
265_Y280_R0.8790.96
24_L35_K0.8740.96
36_W40_R0.8740.96
152_I157_H0.8720.96
198_Y201_A0.8630.96
32_G121_G0.8510.95
220_Q258_G0.8490.95
25_D29_A0.8350.95
131_V284_L0.8340.95
236_V247_C0.8320.95
5_G9_D0.8300.95
155_F158_E0.8300.95
165_H169_G0.8290.94
22_L28_A0.8270.94
56_A60_S0.8220.94
164_W168_L0.8210.94
137_P205_D0.8170.94
180_G262_E0.8170.94
14_L50_I0.8130.94
240_I281_C0.8110.94
151_Q155_F0.8080.94
141_V155_F0.8080.94
240_I286_P0.8070.94
246_T250_M0.8050.94
14_L18_L0.8050.94
240_I285_I0.8040.94
172_P205_D0.8040.94
73_I76_I0.8010.93
33_Y38_L0.7990.93
152_I159_M0.7970.93
133_L284_L0.7940.93
11_L15_E0.7930.93
236_V240_I0.7910.93
233_G236_V0.7840.93
139_I214_G0.7820.93
164_W167_F0.7780.92
37_H41_M0.7770.92
163_F168_L0.7750.92
98_Q103_Y0.7700.92
10_L31_A0.7690.92
130_F223_E0.7690.92
128_H131_V0.7680.92
232_L235_G0.7680.92
151_Q160_R0.7660.92
39_Q49_A0.7600.91
14_L27_V0.7600.91
247_C253_L0.7560.91
152_I158_E0.7540.91
92_F100_P0.7500.91
53_Y60_S0.7470.91
136_T177_V0.7420.90
67_R107_P0.7380.90
199_T215_H0.7360.90
142_T199_T0.7360.90
243_V283_L0.7340.90
239_F243_V0.7340.90
60_S188_Q0.7320.90
154_D158_E0.7300.90
115_R118_L0.7290.90
140_G197_F0.7260.90
74_L84_S0.7230.89
17_H22_L0.7220.89
179_Y263_R0.7170.89
265_Y282_E0.7160.89
38_L101_A0.7160.89
11_L46_T0.7150.89
140_G215_H0.7120.89
198_Y264_Y0.7090.88
57_R140_G0.7090.88
116_P120_L0.7080.88
53_Y82_F0.7030.88
8_R12_I0.7010.88
265_Y281_C0.6960.87
26_N54_I0.6930.87
9_D31_A0.6930.87
112_F116_P0.6930.87
145_Y248_M0.6920.87
9_D16_G0.6900.87
180_G196_V0.6830.86
6_I33_Y0.6820.86
60_S96_F0.6810.86
140_G201_A0.6800.86
130_F287_I0.6770.86
226_M282_E0.6750.86
244_Y260_D0.6740.86
153_S262_E0.6720.86
156_R164_W0.6710.86
73_I104_R0.6700.85
199_T204_Q0.6690.85
64_V68_L0.6680.85
229_Y281_C0.6670.85
59_L91_A0.6650.85
61_K65_A0.6640.85
231_G281_C0.6640.85
263_R284_L0.6600.85
51_G55_R0.6600.85
35_K39_Q0.6570.84
130_F225_V0.6570.84
265_Y269_D0.6560.84
155_F160_R0.6520.84
227_F242_T0.6510.84
268_E279_L0.6500.84
18_L54_I0.6500.84
234_T238_E0.6500.84
47_G241_L0.6470.83
194_Q201_A0.6440.83
57_R60_S0.6440.83
86_Q90_R0.6430.83
222_G225_V0.6410.83
51_G86_Q0.6380.83
196_V199_T0.6380.83
189_D194_Q0.6350.82
141_V158_E0.6340.82
25_D78_L0.6340.82
139_I211_V0.6340.82
255_R260_D0.6320.82
112_F115_R0.6310.82
24_L27_V0.6300.82
36_W39_Q0.6270.81
31_A37_H0.6260.81
24_L50_I0.6250.81
194_Q199_T0.6250.81
233_G281_C0.6240.81
27_V105_R0.6230.81
229_Y236_V0.6210.81
82_F93_K0.6200.81
84_S90_R0.6190.81
269_D279_L0.6180.81
57_R80_Y0.6150.80
82_F96_F0.6130.80
235_G239_F0.6130.80
101_A105_R0.6120.80
167_F170_N0.6090.80
11_L42_F0.6060.79
28_A63_A0.6050.79
82_F259_Q0.6050.79
17_H223_E0.6030.79
189_D195_E0.6030.79
196_V201_A0.6020.79
63_A92_F0.6010.79
179_Y203_A0.6000.79
98_Q106_S0.6000.79
27_V54_I0.5990.78
82_F103_Y0.5950.78
203_A206_Q0.5950.78
182_N235_G0.5940.78
143_Q155_F0.5940.78
142_T183_E0.5930.78
202_L206_Q0.5930.78
65_A69_T0.5920.78
179_Y182_N0.5920.78
121_G127_E0.5900.77
233_G279_L0.5890.77
13_W27_V0.5870.77
91_A220_Q0.5860.77
266_P281_C0.5860.77
112_F120_L0.5830.77
165_H170_N0.5820.76
92_F103_Y0.5790.76
168_L236_V0.5780.76
169_G172_P0.5770.76
159_M178_L0.5770.76
13_W68_L0.5760.76
17_H117_P0.5760.76
164_W214_G0.5730.75
163_F171_A0.5730.75
5_G123_F0.5730.75
11_L57_R0.5710.75
99_T102_L0.5710.75
133_L224_Y0.5700.75
37_H243_V0.5690.75
22_L54_I0.5680.75
183_E217_V0.5680.75
225_V251_L0.5660.74
156_R196_V0.5650.74
83_D86_Q0.5640.74
147_C194_Q0.5630.74
144_S197_F0.5630.74
229_Y283_L0.5620.74
15_E42_F0.5610.74
210_Y213_T0.5600.74
33_Y41_M0.5600.74
240_I260_D0.5580.73
249_P252_N0.5570.73
166_D170_N0.5530.73
177_V201_A0.5520.73
227_F231_G0.5520.73
45_V245_G0.5520.73
33_Y260_D0.5510.73
43_K103_Y0.5510.73
27_V31_A0.5500.72
163_F170_N0.5500.72
19_D45_V0.5500.72
87_T229_Y0.5500.72
148_S261_I0.5490.72
256_R286_P0.5460.72
180_G236_V0.5460.72
168_L171_A0.5460.72
170_N173_T0.5420.71
270_A277_I0.5410.71
82_F87_T0.5410.71
192_D195_E0.5410.71
22_L26_N0.5400.71
147_C196_V0.5390.71
156_R180_G0.5390.71
144_S148_S0.5380.71
72_P89_T0.5360.70
38_L50_I0.5350.70
38_L100_P0.5350.70
156_R182_N0.5340.70
159_M164_W0.5330.70
117_P122_E0.5320.70
210_Y216_P0.5300.70
130_F253_L0.5290.69
243_V248_M0.5250.69
157_H163_F0.5240.69
179_Y201_A0.5220.68
124_T127_E0.5220.68
240_I262_E0.5210.68
76_I89_T0.5190.68
229_Y240_I0.5180.68
139_I178_L0.5170.68
164_W170_N0.5170.68
24_L216_P0.5170.68
42_F46_T0.5150.67
24_L67_R0.5150.67
57_R74_L0.5150.67
58_R80_Y0.5150.67
37_H244_Y0.5110.67
108_E118_L0.5110.67
60_S64_V0.5100.67
65_A96_F0.5080.66
101_A126_P0.5080.66
254_T283_L0.5070.66
36_W91_A0.5060.66
270_A278_N0.5050.66
9_D287_I0.5050.66
43_K102_L0.5040.66
139_I204_Q0.5020.65
123_F127_E0.5020.65
212_L234_T0.5020.65
190_K195_E0.5010.65
115_R119_R0.5010.65
39_Q244_Y0.5000.65
121_G125_M0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d5yA 1 0.9689 100 0.278 Contact Map
3gbgA 1 0.3772 100 0.566 Contact Map
1bl0A 1 0.4014 100 0.584 Contact Map
4fe7A 2 0.3772 100 0.584 Contact Map
3w6vA 1 0.3841 100 0.588 Contact Map
3oioA 1 0.3841 100 0.589 Contact Map
3mn2A 1 0.3668 100 0.59 Contact Map
2k9sA 1 0.3668 100 0.591 Contact Map
3oouA 1 0.3633 100 0.595 Contact Map
3lsgA 2 0.3529 99.9 0.599 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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