GREMLIN Database
MELR - Melibiose operon regulatory protein
UniProt: P0ACH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11230
Length: 302 (249)
Sequences: 31565 (27284)
Seq/√Len: 1729.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_R282_V3.3561.00
234_L242_A3.3291.00
257_K265_T3.1251.00
201_A243_M3.0511.00
245_I282_V3.0411.00
247_H250_A2.9391.00
211_N221_A2.8911.00
199_F203_N2.7991.00
203_N206_Q2.7801.00
242_A281_Y2.6841.00
278_F289_Y2.4241.00
248_V274_F2.3981.00
251_L265_T2.3461.00
196_M224_A2.3091.00
228_F239_Y2.2231.00
209_T212_D2.1191.00
284_M292_L2.0941.00
251_L266_A2.0551.00
257_K261_D2.0341.00
200_I240_I1.9381.00
204_Y243_M1.9191.00
58_E65_K1.9191.00
199_F216_H1.8991.00
237_K241_T1.8971.00
58_E67_N1.8681.00
251_L257_K1.8521.00
245_I281_Y1.8521.00
196_M217_V1.8441.00
193_V232_M1.8151.00
197_L232_M1.8001.00
198_G202_E1.7531.00
213_V236_M1.7391.00
271_S275_Y1.7191.00
258_S261_D1.7141.00
210_I225_M1.7031.00
277_T280_K1.6951.00
60_L65_K1.6911.00
56_D67_N1.6741.00
250_A254_D1.6651.00
243_M247_H1.6551.00
223_Y227_I1.6531.00
252_L259_I1.6481.00
249_R289_Y1.6371.00
234_L238_Q1.6311.00
224_A236_M1.6151.00
247_H251_L1.6071.00
199_F208_L1.6011.00
236_M240_I1.5791.00
223_Y226_G1.5691.00
53_F94_A1.5551.00
260_L271_S1.5521.00
201_A239_Y1.5151.00
56_D69_N1.5091.00
273_R277_T1.5071.00
268_F277_T1.5051.00
284_M288_Q1.4931.00
219_L223_Y1.4821.00
204_Y247_H1.4761.00
261_D265_T1.4681.00
69_N72_H1.4581.00
54_D92_S1.4521.00
261_D264_L1.4511.00
260_L264_L1.4361.00
287_Q291_K1.4321.00
132_P136_R1.4301.00
190_Q231_V1.4221.00
212_D216_H1.4191.00
222_N226_G1.4151.00
163_R167_S1.4061.00
262_I266_A1.4051.00
205_D265_T1.4011.00
221_A225_M1.4011.00
58_E85_T1.4001.00
60_L83_Q1.4001.00
272_S275_Y1.4001.00
47_V78_A1.4001.00
225_M236_M1.3971.00
248_V266_A1.3961.00
159_L163_R1.3941.00
255_T290_R1.3791.00
197_L201_A1.3631.00
200_I243_M1.3521.00
247_H266_A1.3371.00
211_N215_E1.3351.00
62_N80_T1.3321.00
241_T277_T1.3091.00
235_T238_Q1.3081.00
206_Q212_D1.3061.00
242_A246_N1.2961.00
192_Y219_L1.2831.00
219_L224_A1.2581.00
275_Y285_S1.2481.00
220_N223_Y1.2241.00
196_M213_V1.2171.00
156_E159_L1.2051.00
243_M246_N1.1981.00
275_Y287_Q1.1791.00
249_R253_S1.1781.00
155_D158_G1.1651.00
208_L213_V1.1631.00
54_D70_Q1.1571.00
160_M163_R1.1451.00
77_W80_T1.1401.00
207_A269_R1.1361.00
246_N249_R1.1271.00
257_K262_I1.1091.00
276_S280_K1.1061.00
44_H82_H1.0861.00
210_I236_M1.0851.00
288_Q291_K1.0841.00
48_E82_H1.0781.00
155_D159_L1.0681.00
136_R140_Q1.0651.00
191_F195_Q1.0631.00
227_I230_R1.0561.00
285_S288_Q1.0471.00
205_D247_H1.0451.00
125_L128_Q1.0401.00
156_E160_M1.0401.00
42_H82_H1.0391.00
192_Y217_V1.0371.00
199_F217_V1.0371.00
41_S81_P1.0251.00
53_F92_S1.0251.00
154_I158_G1.0201.00
133_F137_R1.0191.00
241_T280_K1.0071.00
197_L239_Y1.0061.00
192_Y227_I1.0021.00
212_D215_E0.9991.00
194_S198_G0.9961.00
259_I262_I0.9951.00
287_Q290_R0.9921.00
227_I231_V0.9871.00
214_A221_A0.9781.00
251_L262_I0.9741.00
44_H48_E0.9731.00
195_Q216_H0.9721.00
244_R266_A0.9531.00
145_P149_I0.9521.00
270_S276_S0.9491.00
237_K273_R0.9461.00
52_P57_V0.9411.00
133_F136_R0.9401.00
200_I236_M0.9341.00
213_V216_H0.9311.00
238_Q242_A0.9221.00
275_Y279_G0.9171.00
249_R278_F0.9101.00
60_L63_N0.9091.00
277_T281_Y0.9071.00
162_K166_L0.9061.00
245_I277_T0.9051.00
282_V289_Y0.8961.00
255_T262_I0.8951.00
207_A212_D0.8941.00
217_V224_A0.8921.00
210_I221_A0.8911.00
219_L227_I0.8901.00
199_F213_V0.8891.00
127_T131_S0.8861.00
150_R154_I0.8831.00
222_N225_M0.8781.00
195_Q198_G0.8781.00
288_Q292_L0.8781.00
252_L290_R0.8721.00
241_T281_Y0.8691.00
155_D162_K0.8671.00
238_Q241_T0.8631.00
273_R276_S0.8581.00
252_L262_I0.8511.00
60_L85_T0.8481.00
204_Y240_I0.8451.00
47_V75_L0.8441.00
228_F236_M0.8431.00
195_Q217_V0.8421.00
193_V227_I0.8391.00
57_V68_I0.8371.00
123_K127_T0.8351.00
193_V196_M0.8351.00
129_Q133_F0.8341.00
279_G285_S0.8331.00
228_F232_M0.8321.00
159_L166_L0.8301.00
203_N216_H0.8241.00
160_M166_L0.8191.00
158_G162_K0.8171.00
58_E87_T0.8151.00
263_A271_S0.8141.00
193_V231_V0.8061.00
56_D87_T0.8041.00
130_L133_F0.8031.00
124_S128_Q0.7971.00
204_Y266_A0.7961.00
196_M228_F0.7911.00
200_I239_Y0.7841.00
238_Q281_Y0.7771.00
100_M104_L0.7761.00
203_N212_D0.7731.00
163_R166_L0.7731.00
57_V67_N0.7701.00
41_S83_Q0.7701.00
237_K240_I0.7701.00
59_Y74_T0.7691.00
112_L116_V0.7681.00
248_V251_L0.7681.00
48_E97_N0.7671.00
50_N95_I0.7671.00
160_M164_F0.7621.00
226_G230_R0.7601.00
253_S289_Y0.7591.00
152_L159_L0.7551.00
51_V73_I0.7541.00
204_Y208_L0.7531.00
245_I274_F0.7521.00
279_G288_Q0.7471.00
61_I64_E0.7471.00
152_L156_E0.7431.00
160_M165_S0.7421.00
194_S197_L0.7361.00
272_S285_S0.7311.00
270_S273_R0.7301.00
196_M199_F0.7291.00
264_L269_R0.7291.00
112_L115_H0.7281.00
197_L228_F0.7251.00
189_A230_R0.7251.00
137_R141_E0.7251.00
121_V124_S0.7231.00
68_I74_T0.7231.00
225_M229_Q0.7221.00
128_Q132_P0.7181.00
196_M236_M0.7171.00
149_I153_A0.7161.00
239_Y243_M0.7151.00
190_Q227_I0.7121.00
156_E163_R0.7101.00
213_V224_A0.7101.00
129_Q132_P0.7101.00
284_M289_Y0.7041.00
159_L162_K0.7021.00
225_M235_T0.7001.00
201_A247_H0.6971.00
124_S127_T0.6971.00
153_A156_E0.6971.00
256_D262_I0.6921.00
151_Q154_I0.6851.00
57_V84_L0.6831.00
225_M237_K0.6831.00
208_L212_D0.6811.00
109_D113_I0.6771.00
204_Y244_R0.6761.00
141_E145_P0.6761.00
262_I290_R0.6751.00
192_Y195_Q0.6751.00
76_F82_H0.6731.00
46_Q97_N0.6701.00
130_L134_E0.6701.00
208_L244_R0.6641.00
52_P93_M0.6621.00
269_R273_R0.6611.00
117_T120_M0.6601.00
50_N76_F0.6591.00
272_S276_S0.6581.00
50_N93_M0.6561.00
240_I244_R0.6531.00
151_Q155_D0.6531.00
134_E137_R0.6511.00
246_N281_Y0.6501.00
199_F212_D0.6481.00
158_G168_G0.6471.00
258_S262_I0.6451.00
193_V197_L0.6441.00
104_L108_L0.6391.00
50_N59_Y0.6351.00
229_Q235_T0.6341.00
111_D114_N0.6311.00
213_V217_V0.6301.00
52_P55_G0.6291.00
245_I268_F0.6291.00
196_M200_I0.6291.00
190_Q194_S0.6221.00
278_F284_M0.6201.00
153_A160_M0.6191.00
196_M216_H0.6181.00
270_S280_K0.6161.00
193_V224_A0.6161.00
140_Q144_S0.6151.00
52_P68_I0.6151.00
139_Q143_N0.6141.00
189_A231_V0.6121.00
111_D115_H0.6111.00
119_G123_K0.6101.00
210_I237_K0.6071.00
109_D115_H0.6071.00
112_L117_T0.6061.00
187_R190_Q0.6031.00
50_N74_T0.6031.00
189_A192_Y0.6021.00
153_A166_L0.6011.00
134_E138_W0.5991.00
248_V262_I0.5981.00
232_M239_Y0.5971.00
166_L170_E0.5971.00
137_R140_Q0.5961.00
43_W81_P0.5931.00
130_L137_R0.5911.00
170_E177_T0.5891.00
127_T130_L0.5881.00
215_E218_K0.5821.00
49_V75_L0.5781.00
62_N81_P0.5781.00
214_A217_V0.5761.00
198_G201_A0.5751.00
157_I160_M0.5741.00
110_K114_N0.5741.00
234_L239_Y0.5731.00
274_F286_P0.5731.00
101_H104_L0.5701.00
125_L129_Q0.5691.00
240_I243_M0.5681.00
141_E144_S0.5681.00
210_I222_N0.5671.00
152_L155_D0.5661.00
49_V73_I0.5651.00
207_A244_R0.5571.00
259_I287_Q0.5551.00
133_F140_Q0.5541.00
271_S274_F0.5501.00
59_Y84_L0.5491.00
241_T245_I0.5461.00
191_F231_V0.5461.00
251_L254_D0.5461.00
146_N149_I0.5451.00
200_I208_L0.5441.00
160_M167_S0.5431.00
100_M103_F0.5431.00
250_A253_S0.5421.00
246_N282_V0.5421.00
224_A232_M0.5391.00
121_V125_L0.5381.00
162_K168_G0.5371.00
277_T282_V0.5341.00
59_Y76_F0.5331.00
157_I164_F0.5271.00
148_Q152_L0.5271.00
274_F278_F0.5261.00
151_Q162_K0.5251.00
148_Q151_Q0.5251.00
56_D90_C0.5241.00
268_F273_R0.5241.00
263_A268_F0.5231.00
213_V244_R0.5221.00
254_D257_K0.5211.00
259_I271_S0.5201.00
208_L240_I0.5191.00
161_L165_S0.5181.00
101_H105_S0.5181.00
217_V221_A0.5171.00
229_Q232_M0.5171.00
45_G99_P0.5151.00
150_R153_A0.5131.00
113_I117_T0.5121.00
135_V139_Q0.5121.00
264_L271_S0.5121.00
114_N118_H0.5101.00
191_F194_S0.5101.00
61_I76_F0.5091.00
252_L289_Y0.5071.00
114_N117_T0.5071.00
131_S139_Q0.5061.00
45_G79_C0.5021.00
203_N208_L0.5021.00
241_T273_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8278 100 0.265 Contact Map
1bl0A 1 0.3775 100 0.481 Contact Map
3oouA 1 0.3477 100 0.485 Contact Map
3oioA 1 0.3709 100 0.488 Contact Map
3mn2A 1 0.351 100 0.493 Contact Map
3w6vA 1 0.3675 100 0.494 Contact Map
3mklA 1 0.3675 100 0.496 Contact Map
2k9sA 1 0.351 100 0.501 Contact Map
3lsgA 2 0.3377 100 0.507 Contact Map
1d5yA 1 0.3775 99.9 0.515 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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