GREMLIN Database
MARA - Multiple antibiotic resistance protein MarA
UniProt: P0ACH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11434
Length: 127 (104)
Sequences: 42318 (32468)
Seq/√Len: 3183.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_A100_F2.9251.00
52_H60_S2.5101.00
75_E83_R2.3031.00
19_E61_R2.2501.00
96_F107_Y2.1921.00
66_I92_L2.1391.00
69_K83_R2.0981.00
29_E39_K2.0611.00
17_W21_N1.9781.00
69_K84_Y1.9531.00
60_S99_Y1.9521.00
14_I42_L1.9351.00
65_E68_Q1.8781.00
21_N24_S1.8091.00
15_L50_T1.7501.00
17_W34_R1.6861.00
102_V110_T1.5811.00
63_M100_F1.5661.00
27_S30_K1.5611.00
89_Q93_T1.5531.00
39_K43_Q1.5501.00
95_T98_N1.5191.00
46_F57_Y1.4941.00
41_H45_M1.4931.00
59_R95_T1.4381.00
69_K75_E1.4231.00
67_A107_Y1.4201.00
55_G59_R1.4181.00
75_E79_Y1.4071.00
22_L61_R1.3751.00
40_W44_R1.3651.00
78_L89_Q1.3431.00
61_R65_E1.3161.00
61_R64_T1.3131.00
76_P79_Y1.3051.00
15_L19_E1.2891.00
52_H56_Q1.2731.00
31_V54_L1.2271.00
68_Q72_E1.2271.00
18_I58_I1.2261.00
91_T95_T1.1911.00
37_Y41_H1.1861.00
17_W26_L1.1611.00
70_L77_I1.1561.00
78_L82_E1.1081.00
43_Q54_L1.0991.00
65_E69_K1.0951.00
79_Y82_E1.0831.00
45_M49_E1.0721.00
30_K34_R1.0631.00
8_A49_E1.0621.00
79_Y83_R1.0511.00
41_H44_R1.0411.00
14_I35_S1.0331.00
59_R98_N0.9961.00
102_V106_K0.9941.00
63_M99_Y0.9931.00
105_H109_M0.9871.00
60_S64_T0.9771.00
16_D20_D0.9761.00
11_I50_T0.9651.00
71_K111_N0.9471.00
90_Q93_T0.9451.00
15_L57_Y0.9381.00
22_L65_E0.9331.00
23_E83_R0.9291.00
28_L43_Q0.9281.00
10_T37_Y0.9131.00
53_S56_Q0.9131.00
66_I84_Y0.9001.00
67_A71_K0.8991.00
103_P106_K0.8891.00
15_L46_F0.8821.00
65_E84_Y0.8811.00
42_L54_L0.8771.00
40_W43_Q0.8701.00
73_S108_R0.8671.00
46_F54_L0.8591.00
75_E80_L0.8531.00
24_S30_K0.8461.00
10_T45_M0.8261.00
56_Q59_R0.8251.00
106_K110_T0.8231.00
95_T99_Y0.8211.00
38_S41_H0.8161.00
59_R99_Y0.7991.00
13_S35_S0.7771.00
56_Q60_S0.7751.00
97_K103_P0.7731.00
29_E33_E0.7711.00
26_L31_V0.7681.00
37_Y42_L0.7661.00
86_F95_T0.7481.00
80_L84_Y0.7451.00
18_I54_L0.7451.00
93_T97_K0.7441.00
54_L58_I0.7371.00
105_H108_R0.7341.00
10_T35_S0.7311.00
102_V107_Y0.7301.00
32_S39_K0.7221.00
28_L54_L0.7181.00
28_L39_K0.7171.00
91_T94_R0.7171.00
22_L58_I0.7131.00
45_M48_K0.7131.00
64_T67_A0.7081.00
81_A89_Q0.7061.00
93_T105_H0.6871.00
90_Q94_R0.6811.00
56_Q99_Y0.6771.00
13_S16_D0.6711.00
14_I31_V0.6671.00
17_W35_S0.6611.00
25_P87_E0.6471.00
12_H16_D0.6401.00
70_L108_R0.6401.00
23_E65_E0.6381.00
77_I80_L0.6361.00
57_Y61_R0.6301.00
70_L80_L0.6281.00
30_K33_E0.6221.00
94_R98_N0.6211.00
106_K109_M0.6181.00
18_I61_R0.6111.00
8_A12_H0.6091.00
52_H57_Y0.6091.00
21_N34_R0.6061.00
11_I49_E0.6011.00
19_E57_Y0.5981.00
14_I46_F0.5981.00
62_K84_Y0.5951.00
67_A96_F0.5941.00
9_I13_S0.5931.00
88_S91_T0.5851.00
82_E87_E0.5741.00
35_S42_L0.5661.00
31_V34_R0.5641.00
73_S80_L0.5641.00
11_I45_M0.5631.00
13_S34_R0.5631.00
43_Q47_K0.5631.00
92_L96_F0.5621.00
93_T103_P0.5611.00
22_L26_L0.5581.00
47_K53_S0.5451.00
46_F50_T0.5401.00
64_T100_F0.5371.00
22_L84_Y0.5331.00
12_H15_L0.5311.00
88_S94_R0.5301.00
55_G91_T0.5291.00
37_Y45_M0.5211.00
17_W30_K0.5081.00
86_F91_T0.5051.00
87_E91_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bl0A 1 0.9134 100 0.129 Contact Map
3gbgA 1 0.8898 100 0.133 Contact Map
3oouA 1 0.8268 100 0.175 Contact Map
3oioA 1 0.8819 100 0.177 Contact Map
3w6vA 1 0.874 100 0.178 Contact Map
3mklA 1 0.874 100 0.184 Contact Map
3mn2A 1 0.8346 100 0.185 Contact Map
4fe7A 2 0.8898 100 0.189 Contact Map
2k9sA 1 0.8346 100 0.197 Contact Map
3lsgA 2 0.8031 99.9 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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