GREMLIN Database
SFSB - Sugar fermentation stimulation protein B
UniProt: P0ACH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10656
Length: 92 (71)
Sequences: 372 (193)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_D67_S5.5921.00
41_A53_I3.5521.00
17_L56_A3.3311.00
14_I18_R2.3590.97
27_E31_N2.3540.97
28_S33_L2.3030.97
46_W49_G2.1730.96
12_D19_K1.9850.93
51_M55_K1.7870.89
25_A36_S1.6940.86
51_M60_D1.6640.85
72_P75_H1.6360.84
16_G57_L1.4940.78
12_D15_A1.4710.77
12_D16_G1.4080.74
25_A29_R1.3810.72
9_H19_K1.3080.68
9_H15_A1.2190.62
17_L22_T1.1690.59
33_L37_T1.1450.57
70_H75_H1.0900.54
14_I41_A1.0610.51
18_R27_E1.0550.51
36_S46_W1.0510.51
34_S70_H1.0400.50
63_V70_H1.0360.50
37_T46_W1.0320.49
34_S71_D1.0190.49
71_D75_H1.0080.48
27_E41_A0.9990.47
32_G69_Y0.9660.45
30_R56_A0.9650.45
72_P76_E0.9610.45
10_P43_S0.9510.44
6_I59_T0.9500.44
11_A14_I0.9370.43
45_P51_M0.9310.43
5_F63_V0.9260.42
33_L50_E0.9100.41
14_I36_S0.8950.40
23_S39_A0.8920.40
73_Q76_E0.8870.40
35_S44_R0.8830.39
10_P57_L0.8830.39
29_R33_L0.8770.39
43_S52_I0.8660.38
8_W16_G0.8540.37
29_R40_N0.8540.37
52_I56_A0.8490.37
22_T30_R0.8460.37
18_R22_T0.8420.37
6_I62_W0.8410.37
17_L21_G0.8410.37
24_M63_V0.8350.36
27_E62_W0.8330.36
5_F51_M0.8280.36
13_I56_A0.8080.34
28_S40_N0.8020.34
10_P27_E0.7910.33
40_N49_G0.7890.33
28_S38_L0.7810.33
37_T49_G0.7650.32
59_T73_Q0.7520.31
42_L49_G0.7510.31
34_S45_P0.7460.31
28_S44_R0.7440.31
33_L46_W0.7230.29
54_A60_D0.7190.29
13_I45_P0.7040.28
37_T50_E0.6990.28
28_S35_S0.6710.26
6_I63_V0.6670.26
25_A39_A0.6640.26
15_A66_P0.6480.25
44_R48_K0.6420.25
40_N44_R0.6330.24
31_N36_S0.6290.24
14_I24_M0.6260.24
20_K29_R0.6240.24
41_A63_V0.6200.24
12_D46_W0.6060.23
37_T48_K0.6040.23
40_N48_K0.6000.23
20_K43_S0.6000.23
26_A33_L0.5940.23
5_F20_K0.5830.22
62_W70_H0.5820.22
35_S39_A0.5810.22
42_L45_P0.5780.22
45_P56_A0.5750.22
11_A19_K0.5750.22
52_I73_Q0.5740.22
29_R39_A0.5510.21
8_W59_T0.5500.20
33_L49_G0.5480.20
20_K40_N0.5470.20
17_L30_R0.5430.20
6_I10_P0.5400.20
16_G20_K0.5360.20
8_W51_M0.5350.20
32_G40_N0.5300.20
22_T25_A0.5180.19
14_I38_L0.5180.19
32_G46_W0.5070.19
26_A43_S0.5060.19
70_H73_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1neqA 1 0.7935 99.3 0.652 Contact Map
2ewtA 2 0.7174 96.7 0.822 Contact Map
1y7yA 2 0.663 96.3 0.829 Contact Map
3tysA 2 0.7065 95.4 0.841 Contact Map
3g5gA 2 0.8152 95.3 0.842 Contact Map
4i6rA 2 0.8043 95.3 0.842 Contact Map
3b7hA 2 0.7826 95.2 0.842 Contact Map
2b5aA 2 0.7826 94.7 0.847 Contact Map
3qq6A 2 0.7174 94.7 0.847 Contact Map
3bs3A 2 0.6413 94.7 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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