GREMLIN Database
HSLR - Heat shock protein 15
UniProt: P0ACG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12929
Length: 133 (121)
Sequences: 1617 (937)
Seq/√Len: 85.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_I86_E3.2991.00
69_K86_E3.1491.00
76_R80_E2.7781.00
39_N53_A2.7301.00
20_F66_V2.5591.00
80_E83_L2.4051.00
54_T65_T2.3751.00
67_I88_T2.3361.00
51_L71_I2.2481.00
54_T67_I2.0741.00
72_T84_L1.9561.00
72_T76_R1.9401.00
59_Q64_R1.9141.00
117_D120_E1.9111.00
123_D126_R1.8271.00
77_P80_E1.8171.00
37_H42_R1.7451.00
114_R117_D1.7251.00
21_Y57_L1.6191.00
82_A85_Y1.5991.00
121_R125_L1.5921.00
58_R63_E1.5651.00
21_Y30_M1.4670.99
119_K123_D1.4630.99
70_A83_L1.4550.99
70_A84_L1.4440.99
109_M112_P1.4400.99
79_S82_A1.4390.99
86_E89_A1.4310.99
32_E45_P1.4250.99
11_L43_S1.4090.99
38_Y53_A1.3780.99
14_W18_A1.3520.99
8_E48_I1.3480.99
89_A93_E1.3190.99
100_L104_L1.3160.99
38_Y43_S1.3070.99
94_K98_M1.2970.98
55_L68_V1.2860.98
13_K73_E1.2640.98
50_E53_A1.2600.98
54_T88_T1.2580.98
18_A84_L1.2470.98
81_A85_Y1.2400.98
9_V71_I1.2360.98
98_M101_A1.2280.98
120_E123_D1.2240.98
97_K101_A1.2040.98
15_L21_Y1.2020.98
65_T90_E1.1880.97
14_W85_Y1.1710.97
38_Y55_L1.1670.97
93_E97_K1.1460.97
40_G56_T1.1110.96
18_A85_Y1.1090.96
9_V17_A1.1090.96
101_A105_N1.0790.95
43_S47_K1.0760.95
56_T63_E1.0720.95
96_E100_L1.0710.95
87_E90_E1.0590.95
97_K100_L1.0580.95
25_A29_E1.0410.94
112_P117_D1.0370.94
114_R120_E1.0330.94
120_E124_L1.0180.94
11_L31_I1.0170.94
17_A72_T1.0130.93
11_L38_Y1.0120.93
36_V57_L1.0120.93
104_L108_T1.0060.93
109_M120_E0.9980.93
49_V53_A0.9800.92
49_V68_V0.9590.91
117_D125_L0.9530.91
57_L66_V0.9480.91
16_W44_K0.9460.91
28_R31_I0.9400.91
124_L127_F0.9190.90
110_P113_D0.9150.89
8_E71_I0.9060.89
74_Q77_P0.9020.89
64_R82_A0.8890.88
21_Y59_Q0.8880.88
28_R32_E0.8850.88
51_L70_A0.8840.88
39_N43_S0.8790.87
49_V55_L0.8750.87
28_R45_P0.8740.87
90_E115_R0.8720.87
20_F57_L0.8650.87
109_M117_D0.8610.86
59_Q62_D0.8490.85
79_S83_L0.8300.84
76_R84_L0.8200.83
88_T91_S0.8140.83
118_K122_R0.8130.83
14_W55_L0.8090.83
109_M113_D0.8080.83
92_V96_E0.8070.82
72_T77_P0.7960.82
123_D127_F0.7860.81
109_M114_R0.7750.80
8_E50_E0.7720.80
38_Y49_V0.7600.79
16_W23_T0.7490.78
49_V71_I0.7440.77
81_A84_L0.7400.77
18_A55_L0.7380.76
89_A92_V0.7350.76
38_Y47_K0.7220.75
45_P106_A0.6950.72
115_R118_K0.6940.72
33_G37_H0.6930.72
9_V73_E0.6920.72
72_T80_E0.6910.72
101_A107_L0.6890.71
15_L20_F0.6880.71
60_G64_R0.6810.71
12_D15_L0.6680.69
9_V48_I0.6680.69
20_F84_L0.6610.68
125_L129_H0.6530.67
74_Q80_E0.6520.67
51_L69_K0.6510.67
91_S96_E0.6510.67
9_V74_Q0.6470.67
87_E91_S0.6440.66
85_Y88_T0.6420.66
7_V83_L0.6420.66
16_W19_R0.6410.66
9_V72_T0.6330.65
94_K97_K0.6290.64
91_S95_R0.6180.63
37_H56_T0.6020.61
13_K22_K0.5980.61
104_L107_L0.5970.60
55_L100_L0.5950.60
43_S46_S0.5940.60
33_G58_R0.5860.59
17_A74_Q0.5850.59
17_A21_Y0.5800.58
107_L113_D0.5800.58
52_N67_I0.5790.58
42_R95_R0.5650.56
9_V49_V0.5640.56
25_A28_R0.5600.56
16_W78_A0.5590.56
40_G54_T0.5580.55
11_L21_Y0.5520.55
32_E46_S0.5520.55
53_A125_L0.5510.54
115_R122_R0.5510.54
56_T65_T0.5490.54
47_K95_R0.5400.53
116_P121_R0.5370.53
17_A30_M0.5370.53
34_G42_R0.5360.52
23_T44_K0.5350.52
107_L110_P0.5350.52
21_Y31_I0.5330.52
13_K26_L0.5330.52
8_E51_L0.5320.52
29_E45_P0.5310.52
25_A49_V0.5300.52
117_D122_R0.5290.52
39_N74_Q0.5290.52
15_L66_V0.5250.51
26_L78_A0.5250.51
32_E120_E0.5170.50
36_V126_R0.5160.50
87_E95_R0.5160.50
44_K78_A0.5150.50
101_A106_A0.5150.50
93_E96_E0.5110.49
25_A43_S0.5100.49
44_K71_I0.5070.49
21_Y60_G0.5070.49
19_R75_R0.5030.48
44_K66_V0.5030.48
111_H120_E0.5010.48
65_T88_T0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dm9A 1 0.8045 100 0.377 Contact Map
2k6pA 1 0.6316 99.5 0.69 Contact Map
4bpeD 2 0.609 98.9 0.769 Contact Map
3j80J 1 0.6241 98.9 0.772 Contact Map
3j7aE 1 0.6466 98.9 0.774 Contact Map
3j38J 1 0.6165 98.9 0.774 Contact Map
3bbnD 1 0.8195 98.7 0.787 Contact Map
4ujpK 1 0.6165 98.7 0.789 Contact Map
3zey6 1 0.6391 98.7 0.79 Contact Map
4tp8D 1 0.8195 98.6 0.794 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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