GREMLIN Database
DBHB - DNA-binding protein HU-beta
UniProt: P0ACF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10467
Length: 90 (89)
Sequences: 4703 (2618)
Seq/√Len: 277.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_K78_S3.3591.00
59_T68_E2.7541.00
35_S40_D2.5631.00
22_G26_D2.5601.00
54_E75_K2.4481.00
57_A70_T2.3691.00
61_R66_G2.3181.00
59_T70_T2.1651.00
52_V75_K2.1321.00
8_D18_K2.0851.00
60_G71_I2.0641.00
20_A23_R2.0031.00
83_K87_D1.9891.00
10_I25_L1.8861.00
19_A23_R1.8301.00
61_R68_E1.8221.00
54_E73_A1.6461.00
51_A80_R1.6251.00
28_I32_V1.6031.00
36_L85_L1.5871.00
36_L52_V1.5151.00
41_D49_T1.4841.00
41_D51_A1.4331.00
55_R76_V1.4281.00
33_T85_L1.4001.00
10_I28_I1.3751.00
17_S20_A1.3721.00
21_A24_A1.3511.00
45_V82_G1.3311.00
9_K13_G1.3291.00
6_L44_L1.2731.00
16_I24_A1.1671.00
9_K31_S1.1541.00
16_I21_A1.1431.00
13_G34_E1.1371.00
3_K26_D1.1301.00
57_A73_A1.1161.00
32_V42_V1.0851.00
30_A33_T1.0491.00
33_T88_A1.0471.00
9_K12_A1.0461.00
13_G31_S1.0391.00
34_E38_E1.0271.00
48_G79_F1.0251.00
37_K88_A1.0191.00
14_A21_A0.9961.00
43_A49_T0.9801.00
29_I47_F0.9531.00
39_G75_K0.9511.00
64_Q67_K0.9511.00
29_I44_L0.9481.00
31_S35_S0.9431.00
8_D12_A0.9121.00
27_A31_S0.9111.00
47_F50_F0.9061.00
25_L29_I0.8961.00
74_A86_K0.8931.00
16_I20_A0.8811.00
5_Q8_D0.8561.00
51_A78_S0.8541.00
28_I31_S0.8461.00
58_R76_V0.8381.00
1_M5_Q0.8341.00
62_N67_K0.8120.99
77_P89_V0.8080.99
47_F82_G0.8080.99
36_L77_P0.7780.99
84_A87_D0.7710.99
34_E37_K0.7690.99
13_G30_A0.7680.99
61_R64_Q0.7600.99
55_R74_A0.7520.99
2_N5_Q0.7420.99
49_T80_R0.7290.99
62_N66_G0.7190.99
60_G69_I0.7100.99
43_A58_R0.7090.98
77_P86_K0.7040.98
35_S42_V0.6980.98
77_P85_L0.6970.98
30_A34_E0.6950.98
10_I24_A0.6940.98
31_S34_E0.6920.98
15_D23_R0.6860.98
24_A31_S0.6800.98
13_G27_A0.6790.98
4_S8_D0.6760.98
55_R58_R0.6760.98
10_I14_A0.6700.98
33_T37_K0.6670.98
45_V84_A0.6640.98
22_G41_D0.6550.97
35_S38_E0.6540.97
50_F79_F0.6300.97
11_A14_A0.6290.97
38_E54_E0.6220.97
39_G54_E0.6190.96
34_E54_E0.6180.96
23_R27_A0.6180.96
60_G68_E0.6140.96
57_A72_A0.6080.96
29_I33_T0.6070.96
26_D30_A0.6040.96
7_I22_G0.6010.96
53_K76_V0.5900.95
17_S21_A0.5870.95
49_T82_G0.5800.95
43_A84_A0.5750.95
32_V47_F0.5710.94
19_A22_G0.5650.94
59_T69_I0.5620.94
62_N65_T0.5530.94
15_D21_A0.5490.93
3_K22_G0.5440.93
27_A30_A0.5420.93
18_K49_T0.5400.93
2_N6_L0.5360.92
9_K38_E0.5360.92
2_N45_V0.5350.92
46_G82_G0.5340.92
9_K35_S0.5300.92
56_A75_K0.5290.92
10_I21_A0.5230.92
14_A24_A0.5220.91
11_A18_K0.5210.91
52_V85_L0.5160.91
21_A31_S0.5080.90
14_A27_A0.5080.90
32_V50_F0.5060.90
15_D20_A0.5050.90
4_S58_R0.5050.90
61_R69_I0.5020.90
41_D84_A0.5020.90
38_E70_T0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjuA 2 1 100 0.146 Contact Map
4p3vA 2 0.8 100 0.154 Contact Map
2iieA 1 1 100 0.156 Contact Map
1mulA 2 0.8444 100 0.158 Contact Map
1b8zA 2 0.7444 100 0.159 Contact Map
1exeA 2 1 100 0.164 Contact Map
1p71A 2 1 100 0.164 Contact Map
4pt4A 2 1 100 0.166 Contact Map
1owfB 1 1 100 0.166 Contact Map
1owfA 1 1 100 0.17 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.