GREMLIN Database
HINT - HIT-like protein HinT
UniProt: P0ACE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12172
Length: 119 (107)
Sequences: 5262 (3306)
Seq/√Len: 319.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D30_R3.0171.00
5_T8_S2.9801.00
22_Q45_N2.7181.00
8_S47_L2.4561.00
25_L64_R2.4311.00
13_R19_I2.4191.00
81_D92_H2.3571.00
5_T47_L2.2691.00
46_I58_H2.2661.00
29_F43_I2.1991.00
30_R76_E2.0751.00
19_I27_T2.0671.00
20_V40_I2.0141.00
87_M102_M1.9501.00
9_K14_E1.9231.00
23_D64_R1.8241.00
55_S58_H1.6511.00
27_T45_N1.6351.00
17_S27_T1.6291.00
8_S12_R1.6041.00
42_I104_L1.5321.00
19_I22_Q1.5261.00
25_L61_A1.5201.00
26_V64_R1.4991.00
26_V65_M1.4731.00
28_A40_I1.4631.00
50_T53_D1.4411.00
37_P108_R1.4161.00
92_H109_P1.4001.00
52_N83_Y1.3941.00
10_I17_S1.3881.00
59_E67_T1.3821.00
84_R107_G1.3051.00
66_I102_M1.2951.00
78_I106_G1.2701.00
40_I104_L1.2431.00
50_T90_N1.2241.00
70_A74_E1.1811.00
54_V100_I1.1681.00
4_E8_S1.1641.00
65_M102_M1.1631.00
49_P53_D1.1551.00
35_Q105_L1.1321.00
50_T89_T1.1031.00
26_V68_V1.0941.00
48_I100_I1.0931.00
71_K75_Q1.0791.00
38_T106_G1.0611.00
11_I27_T1.0611.00
72_I76_E1.0581.00
91_R98_Y1.0571.00
21_Y68_V1.0561.00
48_I55_S1.0541.00
6_I32_I1.0461.00
50_T98_Y1.0331.00
64_R68_V1.0311.00
30_R40_I1.0291.00
56_A67_T1.0211.00
87_M100_I1.0101.00
68_V71_K0.9991.00
27_T43_I0.9981.00
86_I105_L0.9931.00
49_P90_N0.9781.00
48_I54_V0.9511.00
62_L66_I0.9471.00
20_V30_R0.9411.00
84_R88_N0.9251.00
82_G93_G0.9191.00
9_K15_I0.9151.00
35_Q96_E0.8801.00
4_E12_R0.8781.00
40_I72_I0.8741.00
46_I55_S0.8741.00
71_K74_E0.8661.00
63_G66_I0.8491.00
56_A70_A0.8371.00
48_I58_H0.8241.00
28_A42_I0.8031.00
36_A108_R0.7981.00
82_G92_H0.7901.00
54_V62_L0.7831.00
30_R38_T0.7831.00
67_T71_K0.7650.99
36_A105_L0.7650.99
4_E9_K0.7480.99
46_I61_A0.7440.99
83_Y104_L0.7440.99
51_V85_L0.7420.99
11_I43_I0.7390.99
60_Q64_R0.7360.99
63_G67_T0.7310.99
85_L89_T0.7250.99
68_V72_I0.7210.99
13_R22_Q0.7200.99
49_P98_Y0.7190.99
51_V66_I0.7160.99
40_I76_E0.7140.99
66_I69_A0.7090.99
52_N89_T0.7080.99
61_A64_R0.7000.99
72_I75_Q0.6990.99
4_E47_L0.6980.99
38_T78_I0.6950.99
107_G110_L0.6900.99
6_I15_I0.6900.99
23_D26_V0.6900.99
25_L60_Q0.6820.99
67_T70_A0.6790.99
77_G80_E0.6650.99
83_Y88_N0.6600.98
56_A60_Q0.6550.98
59_E63_G0.6540.98
51_V87_M0.6530.98
86_I108_R0.6390.98
40_I69_A0.6320.98
6_I9_K0.6320.98
93_G96_E0.6280.98
8_S11_I0.6270.98
25_L46_I0.6230.98
90_N93_G0.6170.98
59_E62_L0.6120.98
54_V59_E0.6110.98
6_I97_V0.6070.97
31_D105_L0.6060.97
23_D61_A0.6050.97
47_L99_H0.6030.97
23_D68_V0.5960.97
57_E60_Q0.5950.97
65_M69_A0.5900.97
58_H61_A0.5850.97
78_I81_D0.5810.97
23_D71_K0.5760.96
5_T99_H0.5740.96
91_R109_P0.5730.96
61_A65_M0.5700.96
73_A104_L0.5690.96
26_V61_A0.5650.96
19_I45_N0.5640.96
15_I32_I0.5580.96
83_Y89_T0.5550.96
82_G106_G0.5510.95
11_I17_S0.5450.95
52_N90_N0.5450.95
84_R93_G0.5370.95
8_S99_H0.5340.95
31_D88_N0.5290.94
73_A76_E0.5280.94
80_E108_R0.5250.94
64_R67_T0.5250.94
51_V67_T0.5240.94
3_E14_E0.5210.94
10_I16_P0.5170.94
18_D32_I0.5150.94
86_I107_G0.5130.93
33_S97_V0.5100.93
46_I57_E0.5090.93
95_Q98_Y0.5080.93
15_I33_S0.5030.93
60_Q63_G0.5020.93
65_M68_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ksvA 2 0.9748 100 0.223 Contact Map
3n1sA 6 1 100 0.231 Contact Map
3lb5A 2 0.9832 100 0.249 Contact Map
3o0mA 2 0.958 100 0.267 Contact Map
3l7xA 2 0.9748 100 0.269 Contact Map
3imiA 2 0.9832 100 0.272 Contact Map
2pofA 1 0.9664 100 0.272 Contact Map
4njyA 2 0.8319 100 0.283 Contact Map
1y23A 2 0.9664 100 0.285 Contact Map
2eo4A 2 0.958 100 0.286 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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