GREMLIN Database
WCAF - Putative colanic acid biosynthesis acetyltransferase WcaF
UniProt: P0ACD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13574
Length: 182 (158)
Sequences: 5055 (3763)
Seq/√Len: 299.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_L92_I3.3841.00
106_L125_I2.9371.00
77_Y97_H2.8871.00
128_G147_D2.8461.00
148_G164_N2.8341.00
161_L167_C2.7281.00
73_T93_T2.4341.00
152_G168_R2.4011.00
168_R175_I2.2911.00
147_D163_A2.2911.00
83_D103_K2.2291.00
53_K73_T2.1861.00
55_G76_D2.1631.00
76_D96_A2.1581.00
129_E147_D2.0591.00
140_A153_A2.0321.00
130_K148_G2.0161.00
107_C135_T1.8471.00
93_T126_V1.8371.00
149_T163_A1.8011.00
97_H130_K1.7591.00
96_A129_E1.7321.00
30_T34_W1.7261.00
133_L139_V1.7241.00
165_V177_E1.7121.00
39_L42_W1.6851.00
165_V174_V1.6521.00
74_L78_A1.6141.00
149_T165_V1.6101.00
95_G129_E1.6021.00
128_G144_T1.5571.00
151_V161_L1.5561.00
103_K136_D1.5481.00
167_C174_V1.5421.00
106_L127_I1.5301.00
149_T161_L1.5221.00
113_H150_V1.4781.00
30_T37_Q1.4691.00
78_A96_A1.4581.00
75_G96_A1.4421.00
90_G122_A1.4361.00
126_V144_T1.4201.00
54_I58_V1.4111.00
174_V177_E1.3961.00
57_N77_Y1.3921.00
89_L122_A1.3871.00
25_W28_Q1.3681.00
73_T91_E1.3581.00
144_T160_S1.3501.00
44_A48_R1.3481.00
133_L137_V1.3431.00
162_P174_V1.3231.00
105_Y136_D1.2981.00
100_I106_L1.2681.00
167_C172_A1.2611.00
104_S137_V1.2521.00
155_S172_A1.2491.00
98_S129_E1.2301.00
151_V167_C1.2271.00
80_V84_V1.2181.00
22_Q25_W1.2141.00
78_A129_E1.1921.00
98_S147_D1.1331.00
140_A158_F1.1301.00
162_P167_C1.1221.00
78_A98_S1.1121.00
52_A73_T1.0951.00
85_N103_K1.0841.00
31_I36_P1.0821.00
146_G163_A1.0781.00
94_I100_I1.0611.00
42_W45_F1.0421.00
30_T36_P1.0391.00
123_T142_G1.0341.00
143_V159_K1.0201.00
106_L139_V1.0161.00
110_S141_P1.0121.00
128_G163_A1.0121.00
155_S170_N1.0101.00
137_V155_S0.9991.00
131_C149_T0.9981.00
56_K76_D0.9901.00
105_Y135_T0.9781.00
23_L70_W0.9701.00
113_H166_V0.9651.00
110_S123_T0.9621.00
105_Y138_F0.9511.00
110_S121_N0.9481.00
61_R79_W0.9471.00
111_H132_W0.9411.00
27_V38_V0.9391.00
151_V157_V0.9381.00
48_R54_I0.9381.00
74_L94_I0.9351.00
94_I106_L0.9231.00
143_V160_S0.9211.00
72_L88_T0.9161.00
98_S131_C0.9131.00
156_S170_N0.9091.00
166_V178_R0.9081.00
24_W28_Q0.9071.00
21_V70_W0.9031.00
95_G128_G0.9001.00
127_I133_L0.8991.00
100_I133_L0.8981.00
162_P165_V0.8941.00
147_D164_N0.8931.00
80_V100_I0.8901.00
95_G126_V0.8781.00
80_V86_L0.8751.00
25_W29_A0.8741.00
138_F154_R0.8721.00
21_V24_W0.8551.00
58_V74_L0.8551.00
58_V78_A0.8551.00
66_I72_L0.8541.00
130_K147_D0.8351.00
94_I127_I0.8301.00
21_V25_W0.8231.00
57_N76_D0.8231.00
74_L80_V0.8211.00
24_W27_V0.8151.00
160_S167_C0.8111.00
32_F35_S0.8101.00
93_T124_P0.7880.99
35_S43_R0.7850.99
104_S133_L0.7850.99
94_I98_S0.7840.99
100_I104_S0.7800.99
46_L50_F0.7760.99
84_V104_S0.7750.99
91_E124_P0.7710.99
67_T89_L0.7690.99
22_Q28_Q0.7620.99
131_C147_D0.7590.99
47_L51_G0.7590.99
32_F47_L0.7580.99
102_Q135_T0.7470.99
27_V30_T0.7450.99
154_R170_N0.7420.99
139_V145_I0.7360.99
166_V176_R0.7330.99
45_F49_L0.7280.99
27_V36_P0.7250.99
29_A33_A0.7190.99
69_P88_T0.7180.99
65_K82_D0.7160.99
136_D154_R0.7030.99
31_I42_W0.7010.99
51_G54_I0.6990.99
79_W99_V0.6980.99
78_A94_I0.6980.99
128_G149_T0.6940.99
127_I131_C0.6900.99
55_G58_V0.6880.99
23_L27_V0.6840.99
145_I151_V0.6800.98
145_I161_L0.6700.98
72_L86_L0.6660.98
23_L26_A0.6640.98
91_E126_V0.6640.98
128_G146_G0.6540.98
86_L106_L0.6500.98
89_L109_G0.6490.98
35_S42_W0.6460.98
71_K91_E0.6410.98
30_T33_A0.6410.98
125_I141_P0.6360.98
81_G132_W0.6350.98
28_Q49_L0.6330.98
131_C163_A0.6320.98
146_G160_S0.6310.97
87_Y109_G0.6290.97
150_V166_V0.6220.97
138_F156_S0.6170.97
64_V72_L0.6170.97
165_V168_R0.6130.97
107_C138_F0.6130.97
65_K83_D0.6110.97
161_L172_A0.6090.97
31_I35_S0.6050.97
168_R173_V0.6050.97
110_S113_H0.6040.97
109_G122_A0.5990.97
22_Q27_V0.5980.97
36_P39_L0.5980.97
28_Q31_I0.5940.96
78_A100_I0.5940.96
54_I76_D0.5880.96
127_I139_V0.5880.96
31_I34_W0.5850.96
145_I149_T0.5800.96
168_R172_A0.5780.96
108_T141_P0.5780.96
22_Q26_A0.5750.96
85_N105_Y0.5720.96
100_I127_I0.5720.96
36_P40_Y0.5650.95
148_G163_A0.5610.95
35_S39_L0.5550.95
34_W37_Q0.5540.95
109_G120_I0.5540.95
60_I64_V0.5530.95
98_S127_I0.5510.95
151_V172_A0.5510.95
90_G108_T0.5510.95
21_V28_Q0.5460.94
75_G98_S0.5450.94
101_S110_S0.5430.94
156_S168_R0.5400.94
27_V31_I0.5400.94
165_V178_R0.5380.94
68_Y120_I0.5350.94
60_I80_V0.5340.94
81_G99_V0.5280.93
32_F62_P0.5280.93
77_Y96_A0.5270.93
47_L54_I0.5270.93
29_A66_I0.5260.93
99_V111_H0.5240.93
63_S83_D0.5230.93
157_V161_L0.5220.93
74_L98_S0.5200.93
41_R45_F0.5190.93
58_V76_D0.5180.93
64_V84_V0.5160.92
58_V96_A0.5140.92
161_L174_V0.5140.92
30_T35_S0.5130.92
161_L165_V0.5120.92
162_P177_E0.5110.92
67_T87_Y0.5080.92
81_G111_H0.5080.92
154_R158_F0.5050.92
108_T122_A0.5030.92
92_I108_T0.5020.91
145_I167_C0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3srtA 3 0.989 100 0.193 Contact Map
3fttA 3 1 100 0.201 Contact Map
1krrA 3 1 100 0.207 Contact Map
3nz2A 4 0.978 100 0.219 Contact Map
2p2oA 3 0.9835 100 0.219 Contact Map
3hjjA 3 0.989 100 0.227 Contact Map
1ocxA 3 0.9725 100 0.252 Contact Map
3vbiA 3 0.7912 100 0.435 Contact Map
4mzuA 5 0.8077 99.9 0.442 Contact Map
1mr7A 3 0.8242 99.9 0.45 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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