GREMLIN Database
WCAB - Putative colanic acid biosynthesis acetyltransferase WcaB
UniProt: P0ACC9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13570
Length: 162 (137)
Sequences: 8163 (5242)
Seq/√Len: 447.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G132_N3.2951.00
132_N148_N3.1781.00
112_G131_N3.1161.00
69_R89_D3.0781.00
78_V84_V2.8231.00
113_N131_N2.7111.00
68_R88_D2.6521.00
65_T85_V2.5961.00
131_N147_D2.4531.00
112_G128_T2.3841.00
145_V151_V2.3721.00
98_I109_P2.2981.00
152_V159_K2.2921.00
151_V156_A2.2651.00
136_G152_V2.2461.00
124_L137_A2.1861.00
110_H128_T1.9841.00
89_D114_G1.9601.00
75_G95_G1.9011.00
133_V149_A1.8231.00
66_I70_F1.7821.00
111_I117_L1.6971.00
67_G88_D1.6301.00
149_A158_V1.6271.00
133_V147_D1.6191.00
133_V145_V1.5951.00
37_N41_A1.5931.00
151_V158_V1.5441.00
87_G113_N1.5341.00
127_I144_S1.5111.00
38_N42_A1.5021.00
117_L121_V1.4701.00
99_G119_A1.4651.00
70_F88_D1.3891.00
128_T144_S1.3831.00
88_D113_N1.3481.00
117_L123_I1.3451.00
131_N148_N1.3291.00
45_L65_T1.3261.00
139_S156_A1.3121.00
146_P149_A1.2861.00
122_I138_G1.2451.00
92_I96_V1.2381.00
98_I111_I1.2371.00
85_V110_H1.2301.00
46_V50_I1.2061.00
146_P158_V1.1731.00
35_V38_N1.1551.00
72_I76_Y1.1421.00
47_L68_R1.1371.00
81_N106_M1.1271.00
92_I98_I1.1121.00
135_V145_V1.1021.00
95_G120_N1.0991.00
115_V133_V1.0961.00
97_T120_N1.0881.00
112_G147_D1.0641.00
22_R29_V1.0461.00
24_A28_S1.0441.00
129_L133_V1.0311.00
140_V154_E1.0291.00
130_G147_D1.0261.00
87_G112_G1.0231.00
77_A95_G1.0221.00
111_I115_V1.0161.00
70_F113_N0.9981.00
134_T150_L0.9951.00
20_A23_V0.9891.00
115_V131_N0.9871.00
70_F86_A0.9661.00
92_I117_L0.9441.00
80_I84_V0.9381.00
65_T83_N0.9281.00
59_E79_V0.9271.00
82_K100_N0.9251.00
40_W44_L0.9221.00
22_R26_F0.9211.00
122_I137_A0.9181.00
122_I140_V0.8971.00
90_F131_N0.8901.00
39_L42_A0.8891.00
109_P125_G0.8851.00
123_I127_I0.8831.00
25_H29_V0.8791.00
66_I86_A0.8701.00
82_K106_M0.8631.00
22_R28_S0.8611.00
86_A92_I0.8581.00
24_A27_C0.8541.00
72_I78_V0.8521.00
53_E71_T0.8511.00
47_L50_I0.8511.00
121_V139_S0.8441.00
114_G131_N0.8421.00
70_F90_F0.8281.00
129_L135_V0.8271.00
60_I64_A0.8261.00
58_Y75_G0.8261.00
25_H28_S0.8181.00
21_Y25_H0.8151.00
49_R69_R0.8131.00
90_F111_I0.8051.00
102_G107_A0.8021.00
103_A116_E0.8011.00
72_I92_I0.7971.00
90_F113_N0.7941.00
135_V151_V0.7931.00
66_I72_I0.7901.00
20_A24_A0.7881.00
112_G133_V0.7811.00
86_A98_I0.7791.00
61_Q64_A0.7781.00
97_T119_A0.7721.00
120_N138_G0.7681.00
57_G77_A0.7591.00
139_S154_E0.7561.00
146_P151_V0.7501.00
96_V121_V0.7361.00
36_L40_W0.7311.00
43_P47_L0.7281.00
57_G74_H0.7221.00
74_H77_A0.7191.00
86_A111_I0.7171.00
135_V141_V0.7161.00
152_V156_A0.7071.00
106_M110_H0.7061.00
23_V26_F0.7011.00
94_H99_G0.6961.00
94_H100_N0.6961.00
115_V147_D0.6911.00
109_P127_I0.6891.00
112_G130_G0.6881.00
73_H93_R0.6851.00
97_T122_I0.6821.00
129_L145_V0.6781.00
138_G154_E0.6761.00
108_C126_D0.6741.00
79_V97_T0.6671.00
89_D113_N0.6641.00
23_V27_C0.6581.00
55_F58_Y0.6561.00
64_A84_V0.6521.00
86_A90_F0.6511.00
48_Y51_I0.6511.00
44_L48_Y0.6511.00
45_L48_Y0.6481.00
69_R88_D0.6390.99
124_L142_L0.6360.99
41_A44_L0.6350.99
149_A152_V0.6350.99
94_H119_A0.6340.99
102_G125_G0.6250.99
129_L151_V0.6250.99
81_N100_N0.6220.99
74_H81_N0.6190.99
58_Y64_A0.6180.99
21_Y41_A0.6170.99
22_R27_C0.6080.99
21_Y27_C0.6070.99
111_I123_I0.6030.99
21_Y24_A0.6020.99
83_N108_C0.6010.99
46_V49_R0.6010.99
119_A122_I0.6010.99
141_V153_G0.5980.99
59_E81_N0.5970.99
153_G156_A0.5960.99
77_A97_T0.5850.99
130_G146_P0.5840.99
141_V156_A0.5810.99
38_N41_A0.5810.99
59_E77_A0.5750.99
98_I123_I0.5690.99
36_L43_P0.5680.99
107_A126_D0.5670.99
116_E134_T0.5650.99
127_I143_D0.5640.99
136_G150_L0.5600.99
152_V157_R0.5580.99
81_N99_G0.5570.99
28_S50_I0.5550.98
23_V28_S0.5550.98
43_P46_V0.5480.98
145_V149_A0.5470.98
90_F115_V0.5410.98
20_A46_V0.5410.98
87_G90_F0.5330.98
145_V156_A0.5320.98
122_I154_E0.5310.98
106_M119_A0.5300.98
139_S153_G0.5290.98
24_A29_V0.5280.98
96_V106_M0.5230.98
61_Q81_N0.5230.98
73_H91_T0.5220.98
64_A80_I0.5210.98
35_V39_L0.5200.98
23_V29_V0.5180.98
33_K36_L0.5170.98
67_G85_V0.5150.98
94_H97_T0.5110.97
43_P48_Y0.5040.97
36_L51_I0.5040.97
35_V40_W0.5010.97
20_A29_V0.5010.97
26_F34_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n6aA 3 0.963 100 0.295 Contact Map
3q1xA 3 0.9198 100 0.317 Contact Map
4h7oA 6 0.9815 100 0.32 Contact Map
3f1xA 6 0.9259 100 0.321 Contact Map
1ssqA 6 0.9815 100 0.333 Contact Map
3fttA 3 0.9938 100 0.337 Contact Map
3srtA 3 0.9815 100 0.343 Contact Map
3hjjA 3 0.9938 100 0.35 Contact Map
2p2oA 3 0.9815 100 0.351 Contact Map
1krrA 3 0.9815 100 0.353 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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