GREMLIN Database
GLMU - Bifunctional protein GlmU
UniProt: P0ACC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11198
Length: 456 (378)
Sequences: 4338 (2824)
Seq/√Len: 145.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
298_I301_S3.9511.00
143_T165_I3.5171.00
300_N317_D3.3641.00
155_H163_R3.3561.00
151_G162_Q3.1121.00
340_E357_K2.9011.00
186_K208_E2.8221.00
132_K166_Q2.7551.00
121_K127_G2.6181.00
228_N249_L2.5931.00
289_R306_D2.5801.00
350_M353_A2.5591.00
22_D289_R2.5091.00
336_A350_M2.4651.00
355_L361_A2.3661.00
33_K41_D2.3251.00
145_E148_K2.3111.00
361_A367_L2.2911.00
23_L29_T2.2881.00
99_I177_G2.2591.00
357_K374_D2.2361.00
301_S315_V2.2231.00
132_K216_H2.1931.00
50_H72_N2.1511.00
267_T285_T2.1491.00
137_T155_H2.1171.00
306_D323_A2.1091.00
182_R208_E2.0711.00
269_G288_H2.0411.00
294_T311_P1.9971.00
247_L268_H1.9951.00
315_V318_A1.9931.00
119_D123_Q1.9881.00
288_H305_D1.9791.00
245_E249_L1.9511.00
303_I309_I1.9501.00
339_L357_K1.9431.00
247_L250_A1.9121.00
8_V48_A1.9111.00
149_V214_A1.9101.00
295_G312_Y1.9041.00
90_A185_A1.9041.00
287_G305_D1.8881.00
159_T162_Q1.8841.00
160_D163_R1.8811.00
272_V290_V1.8601.00
277_N295_G1.8591.00
226_V235_L1.8461.00
83_G187_L1.8181.00
337_E354_R1.8111.00
230_L249_L1.8081.00
113_T222_E1.8041.00
322_A340_E1.7911.00
335_G352_K1.7821.00
110_S222_E1.7811.00
305_D322_A1.7641.00
270_R288_H1.7571.00
145_E150_T1.7481.00
319_N337_E1.7441.00
338_L342_A1.7411.00
359_S376_V1.7341.00
307_C324_C1.7181.00
299_K316_E1.7151.00
304_G322_A1.7081.00
52_H74_V1.7041.00
353_A367_L1.6991.00
307_C340_E1.6831.00
8_V43_A1.6771.00
59_G75_L1.6611.00
98_D122_P1.6611.00
323_A341_G1.6461.00
315_V320_L1.6291.00
280_I284_V1.6201.00
272_V305_D1.6001.00
281_E299_K1.5981.00
320_L324_C1.5881.00
96_D178_A1.5701.00
321_A340_E1.5651.00
273_E291_K1.5651.00
37_Q65_A1.5551.00
90_A181_K1.5511.00
266_L280_I1.5391.00
44_N70_N1.5321.00
179_D210_R1.5071.00
40_I51_V1.4951.00
183_W204_L1.4931.00
101_M175_A1.4841.00
143_T151_G1.4831.00
138_G155_H1.4751.00
98_D174_I1.4721.00
80_L84_H1.4641.00
302_V319_N1.4621.00
285_T302_V1.4541.00
182_R186_K1.4331.00
36_V66_L1.4301.00
265_T283_N1.4161.00
246_K250_A1.4011.00
126_I205_A1.4001.00
344_V350_M1.3951.00
134_D166_Q1.3901.00
117_L127_G1.3891.00
355_L359_S1.3811.00
290_V307_C1.3691.00
269_G305_D1.3631.00
135_D155_H1.3591.00
318_A336_A1.3591.00
244_A254_L1.3531.00
321_A337_E1.3511.00
233_S257_P1.3451.00
286_L290_V1.3361.00
307_C321_A1.3361.00
330_A346_N1.3281.00
339_L354_R1.3241.00
230_L245_E1.3211.00
175_A201_I1.3161.00
130_T214_A1.3061.00
237_R258_A1.3061.00
291_K308_E1.3021.00
229_R253_M1.2891.00
37_Q41_D1.2811.00
298_I303_I1.2751.00
303_I307_C1.2741.00
42_A111_V1.2731.00
79_Q84_H1.2701.00
331_R346_N1.2681.00
84_H88_Q1.2621.00
372_I378_I1.2581.00
115_Q119_D1.2581.00
56_G79_Q1.2511.00
320_L326_I1.2501.00
84_H87_Q1.2451.00
343_H362_G1.2441.00
35_M226_V1.2421.00
45_E111_V1.2411.00
55_Y59_G1.2411.00
350_M367_L1.2401.00
286_L292_I1.2361.00
43_A102_L1.2341.00
156_K192_A1.2331.00
144_R167_E1.1981.00
312_Y329_F1.1971.00
203_A207_Q1.1961.00
289_R305_D1.1931.00
310_S325_T1.1901.00
354_R371_E1.1841.00
307_C322_A1.1831.00
117_L174_I1.1751.00
311_P328_P1.1711.00
243_Q247_L1.1671.00
59_G63_K1.1651.00
86_M101_M1.1641.00
255_R273_E1.1450.99
97_E177_G1.1440.99
31_A239_Y1.1430.99
356_G359_S1.1420.99
187_L204_L1.1300.99
148_K211_E1.1290.99
268_H286_L1.1280.99
29_T34_A1.1250.99
241_S258_A1.1230.99
341_G358_G1.1140.99
100_L114_L1.1090.99
341_G357_K1.1080.99
350_M355_L1.1050.99
189_N196_Y1.1050.99
269_G287_G1.1030.99
34_A65_A1.0990.99
26_V104_G1.0980.99
176_N179_D1.0950.99
353_A370_A1.0930.99
263_R266_L1.0830.99
161_E164_Q1.0820.99
80_L196_Y1.0770.99
303_I320_L1.0730.99
116_R119_D1.0720.99
134_D220_L1.0720.99
275_D291_K1.0700.99
103_Y106_V1.0660.99
55_Y73_W1.0640.99
224_E238_V1.0620.99
117_L129_L1.0590.99
241_S245_E1.0590.99
269_G272_V1.0580.99
95_D181_K1.0550.99
24_P61_L1.0530.99
262_L266_L1.0490.99
177_G181_K1.0480.99
36_V53_L1.0460.99
355_L367_L1.0460.99
293_G311_P1.0460.99
120_A215_V1.0440.99
361_A365_T1.0420.99
272_V287_G1.0420.99
205_A210_R1.0410.99
324_C342_A1.0400.99
94_A181_K1.0310.99
296_C313_T1.0230.99
63_K75_L1.0220.99
9_V99_I1.0210.99
27_L65_A1.0190.99
131_V168_I1.0100.99
278_V294_T1.0080.99
314_V329_F1.0060.99
338_L350_M1.0050.99
183_W208_E1.0040.99
186_K204_L0.9990.99
24_P58_G0.9970.99
324_C357_K0.9970.99
320_L332_L0.9940.99
179_D182_R0.9850.98
120_A124_G0.9830.98
67_K73_W0.9790.98
148_K206_Y0.9780.98
9_V86_M0.9760.98
330_A344_V0.9710.98
169_N173_L0.9690.98
98_D176_N0.9680.98
350_M361_A0.9680.98
367_L384_T0.9640.98
269_G290_V0.9620.98
308_E325_T0.9610.98
143_T153_V0.9580.98
187_L199_T0.9570.98
187_L201_I0.9560.98
372_I376_V0.9560.98
78_E84_H0.9550.98
61_L64_Q0.9540.98
323_A340_E0.9540.98
243_Q246_K0.9520.98
130_T167_E0.9470.98
22_D288_H0.9470.98
325_T343_H0.9460.98
30_L236_E0.9450.98
327_G346_N0.9440.98
23_L61_L0.9440.98
290_V305_D0.9430.98
153_V162_Q0.9340.98
263_R281_E0.9290.98
356_G371_E0.9240.98
281_E297_V0.9210.98
38_H239_Y0.9130.97
128_L149_V0.9110.97
224_E235_L0.9080.97
40_I71_L0.9040.97
133_L168_I0.8990.97
22_D270_R0.8970.97
116_R218_Q0.8960.97
342_A356_G0.8880.97
7_S50_H0.8880.97
283_N300_N0.8870.97
268_H272_V0.8860.97
44_N51_V0.8860.97
152_I199_T0.8850.97
53_L71_L0.8820.97
221_S238_V0.8820.97
365_T382_T0.8810.97
262_L274_I0.8790.97
58_G61_L0.8790.97
43_A48_A0.8760.97
307_C326_I0.8740.97
297_V314_V0.8740.97
306_D322_A0.8710.97
150_T206_Y0.8710.97
142_I149_V0.8690.97
359_S374_D0.8680.97
275_D293_G0.8670.97
56_G84_H0.8600.96
303_I315_V0.8570.96
238_V241_S0.8520.96
52_H92_F0.8510.96
244_A248_L0.8510.96
87_Q90_A0.8440.96
206_Y212_I0.8390.96
100_L118_R0.8360.96
121_K176_N0.8350.96
324_C340_E0.8350.96
10_I43_A0.8330.96
167_E214_A0.8290.96
15_K79_Q0.8290.96
182_R185_A0.8270.95
46_L114_L0.8270.95
131_V223_V0.8260.95
98_D121_K0.8200.95
156_K193_Q0.8190.95
267_T283_N0.8170.95
111_V115_Q0.8160.95
11_L54_V0.8150.95
31_A243_Q0.8110.95
16_G25_K0.8070.95
128_L142_I0.8060.95
126_I175_A0.8030.95
254_L260_F0.7990.95
352_K371_E0.7990.95
11_L103_Y0.7970.94
298_I309_I0.7950.94
158_A163_R0.7940.94
228_N231_Q0.7910.94
275_D281_E0.7890.94
83_G188_T0.7840.94
359_S375_N0.7820.94
157_D193_Q0.7820.94
304_G307_C0.7780.94
287_G290_V0.7780.94
55_Y63_K0.7760.94
324_C339_L0.7750.94
140_G154_E0.7740.94
138_G231_Q0.7740.94
290_V322_A0.7720.94
274_I278_V0.7720.94
80_L189_N0.7700.93
183_W201_I0.7700.93
316_E331_R0.7680.93
367_L378_I0.7670.93
93_F97_E0.7660.93
87_Q185_A0.7660.93
370_A384_T0.7650.93
224_E234_R0.7640.93
63_K73_W0.7630.93
60_D64_Q0.7620.93
87_Q196_Y0.7620.93
7_S93_F0.7610.93
60_D63_K0.7580.93
272_V288_H0.7570.93
274_I280_I0.7560.93
31_A38_H0.7540.93
365_T381_G0.7530.93
307_C320_L0.7500.93
90_A94_A0.7490.92
247_L252_V0.7490.92
128_L170_T0.7490.92
120_A123_Q0.7480.92
124_G213_V0.7480.92
238_V242_E0.7460.92
298_I315_V0.7450.92
324_C338_L0.7440.92
287_G322_A0.7420.92
38_H264_G0.7380.92
103_Y170_T0.7380.92
234_R245_E0.7360.92
219_R242_E0.7360.92
170_T223_V0.7340.92
275_D294_T0.7340.92
133_L166_Q0.7330.92
304_G340_E0.7320.92
290_V304_G0.7320.92
110_S113_T0.7290.91
356_G374_D0.7270.91
239_Y243_Q0.7260.91
121_K174_I0.7260.91
342_A355_L0.7240.91
68_D73_W0.7240.91
296_C311_P0.7240.91
179_D205_A0.7230.91
109_I172_I0.7170.91
304_G319_N0.7160.91
183_W205_A0.7130.91
175_A180_M0.7100.90
34_A37_Q0.7070.90
74_V89_A0.7060.90
101_M198_I0.7060.90
66_L69_D0.7040.90
52_H89_A0.7030.90
84_H196_Y0.7030.90
310_S328_P0.7030.90
178_A182_R0.7020.90
296_C328_P0.7010.90
362_G380_A0.7000.90
151_G203_A0.7000.90
304_G321_A0.7000.90
87_Q188_T0.6960.89
7_S99_I0.6940.89
173_L223_V0.6940.89
124_G211_E0.6930.89
31_A264_G0.6910.89
280_I286_L0.6900.89
167_E216_H0.6890.89
358_G375_N0.6880.89
103_Y173_L0.6860.89
8_V46_L0.6840.89
37_Q69_D0.6810.88
102_L114_L0.6810.88
42_A45_E0.6810.88
307_C323_A0.6800.88
254_L262_L0.6750.88
25_K105_D0.6750.88
186_K207_Q0.6740.88
313_T326_I0.6730.88
100_L174_I0.6710.88
293_G296_C0.6700.88
30_L35_M0.6690.88
243_Q262_L0.6690.88
64_Q68_D0.6670.87
36_V62_L0.6650.87
130_T133_L0.6640.87
10_I40_I0.6620.87
221_S224_E0.6560.87
28_H229_R0.6560.87
301_S318_A0.6560.87
293_G308_E0.6550.86
86_M180_M0.6540.86
31_A236_E0.6530.86
18_R25_K0.6510.86
237_R240_Q0.6510.86
55_Y62_L0.6500.86
128_L202_I0.6500.86
313_T328_P0.6490.86
332_L336_A0.6490.86
313_T330_A0.6480.86
130_T142_I0.6430.85
220_L223_V0.6390.85
338_L344_V0.6360.85
275_D278_V0.6360.85
269_G289_R0.6350.85
66_L73_W0.6310.84
355_L362_G0.6300.84
130_T149_V0.6290.84
361_A378_I0.6270.84
74_V88_Q0.6250.84
29_T273_E0.6240.84
199_T202_I0.6240.84
148_K213_V0.6240.84
234_R237_R0.6230.84
231_Q234_R0.6230.84
282_G300_N0.6220.83
155_H158_A0.6200.83
195_E200_D0.6190.83
50_H70_N0.6180.83
143_T162_Q0.6170.83
355_L372_I0.6170.83
332_L338_L0.6170.83
14_G25_K0.6160.83
64_Q67_K0.6160.83
72_N92_F0.6130.83
133_L220_L0.6120.83
314_V331_R0.6100.82
278_V293_G0.6080.82
127_G174_I0.6040.82
99_I180_M0.6040.82
103_Y171_G0.6030.82
42_A46_L0.6020.81
91_P94_A0.6020.81
127_G215_V0.5980.81
309_I326_I0.5940.81
110_S242_E0.5940.81
42_A114_L0.5920.80
283_N302_V0.5900.80
255_R275_D0.5900.80
362_G375_N0.5900.80
125_G213_V0.5890.80
76_Q85_A0.5880.80
230_L248_L0.5870.80
365_T383_I0.5870.80
7_S52_H0.5780.79
136_P168_I0.5780.79
108_L239_Y0.5770.79
33_K38_H0.5760.79
106_V172_I0.5740.78
296_C312_Y0.5710.78
348_V353_A0.5710.78
126_I212_I0.5700.78
358_G374_D0.5700.78
58_G79_Q0.5700.78
329_F347_F0.5690.78
217_P223_V0.5680.78
131_V170_T0.5670.77
40_I66_L0.5650.77
17_T20_Y0.5640.77
52_H72_N0.5610.77
83_G199_T0.5600.77
152_I202_I0.5600.77
103_Y172_I0.5590.76
359_S362_G0.5590.76
244_A260_F0.5580.76
352_K369_D0.5580.76
119_D122_P0.5540.76
342_A350_M0.5540.76
250_A372_I0.5540.76
339_L342_A0.5540.76
142_I167_E0.5530.76
344_V355_L0.5520.76
309_I313_T0.5520.76
15_K58_G0.5510.75
292_I296_C0.5500.75
230_L233_S0.5500.75
324_C343_H0.5460.75
54_V76_Q0.5440.75
116_R120_A0.5430.74
204_L207_Q0.5430.74
18_R225_G0.5420.74
30_L239_Y0.5420.74
280_I301_S0.5420.74
26_V62_L0.5410.74
362_G367_L0.5410.74
129_L217_P0.5400.74
328_P346_N0.5390.74
321_A339_L0.5390.74
266_L284_V0.5390.74
254_L274_I0.5370.74
244_A259_R0.5370.74
365_T380_A0.5370.74
263_R284_V0.5340.73
316_E346_N0.5340.73
136_P155_H0.5340.73
34_A41_D0.5330.73
34_A38_H0.5330.73
135_D138_G0.5320.73
37_Q40_I0.5320.73
16_G82_T0.5320.73
113_T129_L0.5310.73
204_L208_E0.5310.73
57_H79_Q0.5300.73
378_I383_I0.5290.73
66_L71_L0.5290.73
13_A16_G0.5280.72
293_G310_S0.5280.72
54_V88_Q0.5270.72
116_R215_V0.5270.72
14_G18_R0.5270.72
27_L59_G0.5270.72
110_S220_L0.5250.72
87_Q184_L0.5250.72
44_N69_D0.5250.72
37_Q70_N0.5240.72
263_R279_I0.5240.72
316_E362_G0.5240.72
56_G80_L0.5230.72
310_S330_A0.5230.72
260_F280_I0.5220.72
77_A84_H0.5220.72
344_V348_V0.5220.72
50_H94_A0.5210.71
120_A127_G0.5210.71
240_Q244_A0.5210.71
175_A179_D0.5210.71
184_L201_I0.5200.71
6_M122_P0.5190.71
63_K66_L0.5190.71
345_G360_K0.5180.71
301_S316_E0.5170.71
149_V212_I0.5160.71
326_I338_L0.5160.71
290_V303_I0.5150.71
268_H274_I0.5150.71
261_D277_N0.5150.71
259_R277_N0.5140.70
110_S246_K0.5140.70
345_G363_H0.5140.70
325_T362_G0.5140.70
41_D69_D0.5140.70
247_L262_L0.5130.70
159_T163_R0.5130.70
345_G351_K0.5130.70
27_L66_L0.5110.70
367_L370_A0.5070.69
331_R349_E0.5070.69
290_V309_I0.5060.69
75_L79_Q0.5060.69
313_T346_N0.5060.69
144_R214_A0.5060.69
24_P39_V0.5040.69
97_E176_N0.5030.69
38_H41_D0.5020.69
255_R276_T0.5020.69
285_T288_H0.5010.68
168_I223_V0.5010.68
262_L268_H0.5000.68
48_A51_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v0hA 3 0.9868 100 0.38 Contact Map
4g3qA 3 0.989 100 0.381 Contact Map
4fceA 3 0.9649 100 0.384 Contact Map
1hm9A 3 0.9868 100 0.385 Contact Map
2ggoA 3 0.8618 100 0.526 Contact Map
1yp2A 4 0.8377 100 0.575 Contact Map
3brkX 2 0.7763 100 0.593 Contact Map
2i5kA 5 0.6842 100 0.629 Contact Map
2icyA 1 0.6776 100 0.632 Contact Map
4r7pA 4 0.6579 100 0.635 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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