GREMLIN Database
ERPA - Iron-sulfur cluster insertion protein ErpA
UniProt: P0ACC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12332
Length: 114 (105)
Sequences: 3631 (1899)
Seq/√Len: 185.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_S98_T4.5121.00
18_K21_S3.5791.00
32_K70_V3.1091.00
16_A65_Q3.0671.00
72_D75_S3.0371.00
36_Y48_G2.8651.00
10_E83_S2.7171.00
102_A105_T2.6421.00
13_D65_Q2.5441.00
63_E68_G2.4981.00
9_L84_V2.3481.00
61_T68_G2.2551.00
34_R59_D2.2311.00
38_T48_G2.2011.00
55_V70_V2.1661.00
12_T85_D1.9841.00
82_G97_V1.8731.00
63_E66_G1.8411.00
88_E93_S1.7531.00
20_K66_G1.7081.00
20_K24_A1.6381.00
32_K68_G1.5161.00
13_D64_K1.4891.00
45_F78_Y1.4831.00
40_G90_L1.4021.00
55_V61_T1.3921.00
52_D56_N1.3791.00
14_A85_D1.2851.00
87_T96_I1.2461.00
11_F19_V1.2121.00
104_S113_S1.2121.00
19_V33_L1.1741.00
17_N20_K1.1681.00
52_D55_V1.1581.00
26_E31_L1.1541.00
35_V79_L1.1381.00
13_D17_N1.1201.00
60_M73_P1.1021.00
77_Q80_V1.0721.00
89_G96_I1.0651.00
18_K95_F1.0641.00
8_P80_V1.0451.00
16_A67_V1.0181.00
74_M77_Q1.0120.99
82_G110_S0.9990.99
39_G43_S0.9660.99
24_A27_D0.9610.99
18_K22_L0.9370.99
62_I76_L0.9320.99
87_T92_G0.9270.99
14_A17_N0.9170.99
73_P77_Q0.9060.99
89_G94_R0.8880.99
16_A64_K0.8860.99
43_S113_S0.8820.99
15_A107_G0.8790.99
24_A29_P0.8750.99
40_G46_Q0.8550.98
81_G100_P0.8460.98
31_L55_V0.8320.98
11_F69_L0.8310.98
18_K91_E0.8270.98
20_K67_V0.8250.98
103_K113_S0.8140.98
75_S84_V0.8020.97
18_K86_Y0.7880.97
79_L101_N0.7860.97
33_L95_F0.7820.97
23_I31_L0.7810.97
11_F64_K0.7810.97
17_N65_Q0.7720.97
23_I32_K0.7550.96
76_L80_V0.7520.96
8_P76_L0.7460.96
20_K65_Q0.7450.96
26_E53_D0.7440.96
27_D30_N0.7430.96
35_V84_V0.7390.96
23_I30_N0.7380.96
11_F95_F0.7370.96
11_F16_A0.7340.96
34_R52_D0.7300.96
40_G102_A0.7270.95
36_Y50_T0.7260.95
55_V68_G0.7250.95
87_T94_R0.7210.95
32_K55_V0.7130.95
45_F49_F0.7080.95
89_G92_G0.7070.95
15_A92_G0.7060.95
29_P53_D0.7040.95
81_G101_N0.7040.95
43_S112_F0.7010.94
108_C111_S0.6900.94
49_F78_Y0.6880.94
19_V67_V0.6840.94
22_L95_F0.6830.94
89_G93_S0.6810.94
60_M76_L0.6810.94
39_G45_F0.6790.93
37_I112_F0.6710.93
61_T70_V0.6670.93
102_A112_F0.6570.92
23_I51_F0.6550.92
16_A66_G0.6540.92
60_M80_V0.6410.91
31_L53_D0.6370.91
87_T91_E0.6320.91
19_V95_F0.6260.90
43_S104_S0.6250.90
52_D59_D0.6220.90
45_F112_F0.6200.90
43_S78_Y0.6170.90
11_F84_V0.6140.89
109_G112_F0.6120.89
19_V23_I0.6100.89
40_G43_S0.6090.89
37_I40_G0.6020.89
64_K69_L0.6020.89
17_N24_A0.6010.88
9_L81_G0.5960.88
56_N59_D0.5940.88
88_E107_G0.5900.88
13_D16_A0.5880.87
22_L51_F0.5830.87
108_C112_F0.5770.86
97_V110_S0.5760.86
49_F82_G0.5760.86
18_K88_E0.5720.86
15_A103_K0.5720.86
56_N73_P0.5720.86
99_N102_A0.5720.86
24_A56_N0.5620.85
32_K61_T0.5620.85
9_L82_G0.5590.85
32_K69_L0.5530.84
60_M77_Q0.5510.84
47_Y109_G0.5480.83
49_F92_G0.5460.83
86_Y93_S0.5450.83
74_M78_Y0.5440.83
8_P64_K0.5430.83
39_G49_F0.5420.83
30_N53_D0.5420.83
20_K23_I0.5410.83
39_G74_M0.5400.83
19_V25_D0.5380.82
67_V82_G0.5340.82
43_S93_S0.5330.82
58_G73_P0.5300.81
106_C111_S0.5270.81
57_E73_P0.5250.81
76_L96_I0.5190.80
9_L94_R0.5110.79
41_G111_S0.5100.79
81_G99_N0.5090.79
45_F107_G0.5020.78
21_S24_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d2aA 2 0.9912 100 0.132 Contact Map
1nwbA 1 0.8772 100 0.159 Contact Map
2apnA 1 1 100 0.167 Contact Map
1x0gA 4 0.9386 100 0.17 Contact Map
1r94A 3 0.8509 100 0.175 Contact Map
2k4zA 1 0.9298 100 0.338 Contact Map
2p2eA 1 0.9035 99.9 0.47 Contact Map
2qgoA 1 0.7719 99.8 0.489 Contact Map
3butA 2 0.3246 12.7 0.932 Contact Map
4dapA 1 0.7544 8.3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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