GREMLIN Database
PRMC - Release factor glutamine methyltransferase
UniProt: P0ACC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12424
Length: 277 (263)
Sequences: 5829 (4465)
Seq/√Len: 275.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_R66_E4.8311.00
83_F151_R3.8881.00
74_V81_P3.6311.00
124_A138_A2.9461.00
262_R268_E2.5871.00
87_A144_D2.5511.00
143_P165_Q2.5111.00
166_S171_A2.4661.00
141_R205_T2.4571.00
178_A229_V2.2791.00
48_T51_Q2.2741.00
153_A163_I2.1731.00
114_L177_F2.1721.00
80_L129_S2.1081.00
124_A136_I2.0791.00
78_W130_E2.0531.00
76_E81_P2.0431.00
137_I177_F2.0351.00
137_I164_L2.0351.00
82_L126_A2.0181.00
210_A215_A2.0101.00
236_L250_F1.9931.00
221_I250_F1.9931.00
212_S218_V1.9791.00
58_L71_L1.9731.00
25_E36_R1.9651.00
35_G38_F1.9301.00
127_L181_V1.9171.00
85_S148_L1.9121.00
118_T149_A1.9101.00
189_E208_V1.8831.00
70_H202_E1.8291.00
125_L158_I1.7861.00
28_L55_L1.7781.00
101_Q261_C1.7741.00
102_A235_L1.7671.00
224_S234_L1.7641.00
83_F155_H1.7541.00
228_L232_G1.7381.00
31_V58_L1.7191.00
65_G197_G1.7181.00
112_R135_E1.7111.00
73_G83_F1.7071.00
243_G260_T1.6961.00
42_F45_T1.6841.00
80_L130_E1.6781.00
128_A160_N1.6601.00
80_L126_A1.6601.00
88_T120_T1.6521.00
94_D97_C1.6321.00
103_L131_R1.5861.00
192_P208_V1.5681.00
243_G268_E1.5401.00
10_A59_L1.5221.00
250_F273_G1.5151.00
168_W216_D1.5141.00
105_R233_F1.5111.00
34_R38_F1.4851.00
30_H72_T1.4791.00
128_A136_I1.4791.00
69_A75_R1.4721.00
95_T123_I1.4571.00
204_L208_V1.4391.00
169_F227_A1.4141.00
167_D219_H1.4121.00
146_V163_I1.3971.00
98_L235_L1.3881.00
78_W100_E1.3771.00
38_F42_F1.3771.00
138_A161_I1.3721.00
102_A179_M1.3711.00
76_E79_S1.3641.00
217_I236_L1.3541.00
66_E86_P1.3511.00
240_W267_N1.3441.00
188_D241_Q1.3421.00
13_Q63_R1.3251.00
247_R260_T1.3211.00
105_R235_L1.3191.00
167_D170_S1.3141.00
101_Q104_A1.3111.00
125_L153_A1.3021.00
219_H223_Q1.2991.00
21_R25_E1.2891.00
211_D218_V1.2681.00
10_A55_L1.2621.00
131_R134_C1.2581.00
30_H58_L1.2581.00
102_A181_V1.2531.00
82_L122_A1.2471.00
188_D191_D1.2201.00
248_Q252_L1.2201.00
30_H74_V1.2171.00
118_T124_A1.2161.00
247_R251_I1.2121.00
66_E71_L1.2091.00
235_L272_L1.2061.00
78_W126_A1.2011.00
47_L51_Q1.2011.00
116_L220_I1.1951.00
19_S23_D1.1941.00
221_I249_A1.1861.00
238_H271_T1.1781.00
142_M205_T1.1771.00
82_L125_L1.1731.00
176_Q229_V1.1641.00
261_C272_L1.1611.00
112_R175_Q1.1611.00
87_A148_L1.1561.00
146_V165_Q1.1461.00
81_P155_H1.1441.00
142_M145_A1.1371.00
52_C56_D1.1321.00
223_Q226_N1.1301.00
84_V148_L1.1271.00
69_A90_I1.1271.00
209_A217_I1.1261.00
113_I134_C1.1171.00
135_E162_H1.1151.00
182_S236_L1.1101.00
214_M249_A1.1081.00
239_G242_Q1.1021.00
138_A163_I1.0981.00
99_V126_A1.0951.00
106_L179_M1.0941.00
97_C264_Y1.0931.00
191_D241_Q1.0841.00
97_C270_V1.0701.00
149_A163_I1.0681.00
238_H243_G1.0681.00
214_M245_A1.0641.00
222_E253_A1.0611.00
37_T41_A1.0601.00
84_V88_T1.0351.00
125_L156_L1.0281.00
168_W219_H1.0221.00
112_R137_I1.0211.00
107_P131_R1.0201.00
115_D124_A1.0181.00
10_A14_L1.0161.00
260_T271_T1.0111.00
103_L130_E1.0081.00
27_L55_L1.0001.00
13_Q56_D0.9921.00
113_I127_L0.9921.00
65_G198_D0.9881.00
139_V166_S0.9801.00
169_F223_Q0.9771.00
177_F180_I0.9711.00
61_R64_D0.9641.00
137_I162_H0.9621.00
151_R155_H0.9611.00
116_L168_W0.9601.00
31_V51_Q0.9511.00
129_S158_I0.9511.00
113_I136_I0.9501.00
11_I15_Q0.9461.00
139_V172_L0.9451.00
124_A128_A0.9431.00
99_V123_I0.9361.00
11_I14_L0.9361.00
192_P204_L0.9351.00
101_Q272_L0.9321.00
224_S255_Y0.9311.00
140_D146_V0.9271.00
124_A161_I0.9211.00
126_A130_E0.9131.00
22_R26_I0.9121.00
112_R177_F0.9111.00
11_I21_R0.9101.00
23_D62_R0.9041.00
56_D60_T0.9001.00
118_T140_D0.8971.00
243_G247_R0.8931.00
100_E104_A0.8901.00
209_A216_D0.8861.00
260_T268_E0.8801.00
111_C134_C0.8791.00
153_A158_I0.8791.00
250_F271_T0.8761.00
129_S156_L0.8751.00
26_I68_I0.8691.00
209_A215_A0.8691.00
34_R42_F0.8661.00
62_R198_D0.8651.00
128_A161_I0.8581.00
162_H175_Q0.8571.00
54_Q57_A0.8551.00
101_Q270_V0.8491.00
85_S151_R0.8491.00
192_P195_Q0.8481.00
29_E32_T0.8371.00
27_L58_L0.8361.00
261_C270_V0.8351.00
244_E248_Q0.8331.00
23_D68_I0.8331.00
49_D52_C0.8250.99
262_R266_D0.8240.99
117_G168_W0.8230.99
79_S130_E0.8230.99
74_V155_H0.8200.99
14_L59_L0.8170.99
248_Q251_I0.8150.99
79_S129_S0.8140.99
151_R154_Q0.8130.99
189_E192_P0.8050.99
112_R229_V0.8040.99
60_T63_R0.8000.99
238_H246_V0.7970.99
99_V103_L0.7960.99
105_R259_E0.7910.99
259_E272_L0.7910.99
116_L169_F0.7880.99
212_S215_A0.7880.99
123_I181_V0.7860.99
187_I207_L0.7800.99
221_I273_G0.7770.99
88_T148_L0.7750.99
80_L156_L0.7700.99
45_T51_Q0.7700.99
214_M218_V0.7670.99
113_I131_R0.7660.99
55_L59_L0.7620.99
115_D118_T0.7580.99
70_H90_I0.7580.99
189_E210_A0.7580.99
217_I246_V0.7450.99
150_Q153_A0.7430.99
150_Q154_Q0.7430.99
173_A227_A0.7380.99
101_Q105_R0.7350.99
110_P135_E0.7350.99
247_R258_V0.7330.99
85_S144_D0.7320.99
94_D270_V0.7320.99
137_I175_Q0.7310.99
70_H87_A0.7310.99
243_G267_N0.7280.99
106_L131_R0.7280.99
255_Y273_G0.7270.99
142_M146_V0.7250.99
54_Q58_L0.7230.99
216_D219_H0.7130.99
144_D147_S0.7120.98
49_D53_Q0.7090.98
220_I234_L0.7080.98
238_H260_T0.7080.98
189_E211_D0.7040.98
90_I202_E0.7020.98
258_V273_G0.6970.98
99_V127_L0.6960.98
94_D265_G0.6950.98
221_I236_L0.6930.98
153_A161_I0.6910.98
244_E268_E0.6910.98
219_H222_E0.6900.98
192_P209_A0.6900.98
191_D240_W0.6890.98
102_A106_L0.6880.98
117_G216_D0.6870.98
113_I179_M0.6870.98
51_Q54_Q0.6830.98
125_L129_S0.6800.98
66_E201_F0.6790.98
57_A60_T0.6780.98
247_R268_E0.6750.98
153_A156_L0.6650.98
17_S20_P0.6650.98
136_I161_I0.6630.98
101_Q235_L0.6600.98
114_L169_F0.6570.97
29_E34_R0.6550.97
217_I238_H0.6520.97
118_T138_A0.6500.97
192_P200_R0.6470.97
117_G182_S0.6460.97
147_S150_Q0.6460.97
31_V54_Q0.6430.97
246_V249_A0.6430.97
241_Q267_N0.6420.97
251_I258_V0.6410.97
118_T163_I0.6390.97
220_I224_S0.6370.97
164_L175_Q0.6360.97
215_A218_V0.6340.97
19_S22_R0.6290.97
139_V164_L0.6290.97
179_M233_F0.6290.97
26_I72_T0.6280.97
225_R255_Y0.6280.97
234_L273_G0.6250.97
188_D209_A0.6230.97
188_D192_P0.6230.97
128_A153_A0.6220.96
143_P147_S0.6220.96
110_P133_D0.6210.96
90_I206_A0.6200.96
12_S15_Q0.6200.96
189_E209_A0.6160.96
87_A203_P0.6160.96
97_C101_Q0.6130.96
209_A212_S0.6130.96
197_G200_R0.6130.96
222_E225_R0.6110.96
104_A261_C0.6100.96
233_F272_L0.6100.96
125_L161_I0.6080.96
74_V83_F0.6070.96
59_L63_R0.6060.96
221_I246_V0.6060.96
14_L17_S0.6040.96
166_S172_L0.6040.96
50_E54_Q0.6010.96
24_A55_L0.6000.96
106_L134_C0.5980.96
26_I30_H0.5940.95
25_E40_L0.5930.95
17_S65_G0.5920.95
141_R165_Q0.5910.95
73_G151_R0.5910.95
32_T51_Q0.5900.95
34_R45_T0.5890.95
190_Q211_D0.5880.95
105_R272_L0.5880.95
221_I253_A0.5880.95
218_V249_A0.5870.95
195_Q207_L0.5840.95
111_C131_R0.5830.95
126_A129_S0.5830.95
140_D149_A0.5820.95
116_L139_V0.5740.95
38_F45_T0.5740.95
234_L250_F0.5740.95
169_F172_L0.5730.94
247_R271_T0.5700.94
246_V271_T0.5690.94
245_A248_Q0.5680.94
150_Q163_I0.5670.94
114_L180_I0.5640.94
127_L134_C0.5630.94
122_A126_A0.5590.94
236_L246_V0.5570.94
17_S23_D0.5570.94
127_L131_R0.5560.94
124_A163_I0.5530.93
82_L156_L0.5500.93
15_Q20_P0.5470.93
96_E99_V0.5450.93
182_S220_I0.5430.93
65_G196_Q0.5420.93
191_D194_L0.5420.93
62_R71_L0.5400.93
188_D212_S0.5390.92
213_G242_Q0.5380.92
57_A61_R0.5370.92
25_E29_E0.5360.92
205_T216_D0.5350.92
195_Q208_V0.5340.92
164_L171_A0.5330.92
191_D239_G0.5320.92
187_I199_V0.5320.92
10_A24_A0.5310.92
70_H84_V0.5310.92
82_L158_I0.5300.92
29_E39_I0.5280.92
146_V150_Q0.5280.92
180_I224_S0.5220.91
111_C178_A0.5220.91
225_R253_A0.5220.91
78_W129_S0.5200.91
192_P196_Q0.5180.91
40_L43_G0.5180.91
98_L181_V0.5170.91
224_S228_L0.5170.91
235_L270_V0.5160.91
85_S88_T0.5140.91
27_L31_V0.5130.91
84_V120_T0.5130.91
158_I161_I0.5130.91
15_Q21_R0.5130.91
142_M148_L0.5120.90
114_L166_S0.5110.90
120_T148_L0.5110.90
180_I227_A0.5100.90
111_C133_D0.5090.90
238_H268_E0.5090.90
114_L172_L0.5080.90
38_F41_A0.5080.90
58_L62_R0.5050.90
166_S169_F0.5040.90
29_E36_R0.5030.90
168_W223_Q0.5020.90
200_R208_V0.5010.90
84_V202_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3tA 1 0.9964 100 0.327 Contact Map
1nv8A 1 0.9531 100 0.343 Contact Map
4dzrA 2 0.5487 100 0.623 Contact Map
3tm4A 1 0.9025 100 0.662 Contact Map
4dcmA 1 0.8448 100 0.665 Contact Map
3c6kA 2 0.8989 100 0.665 Contact Map
1uwvA 1 0.8881 100 0.667 Contact Map
3evzA 1 0.6895 100 0.668 Contact Map
4mtlA 4 0.7076 100 0.693 Contact Map
1uirA 4 0.7906 100 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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