GREMLIN Database
HEMY - Protein HemY
UniProt: P0ACB7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10434
Length: 398 (305)
Sequences: 8617 (7428)
Seq/√Len: 425.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
376_K379_E4.2111.00
202_A205_S4.1101.00
133_D136_R3.9281.00
278_D281_T3.8791.00
343_E346_E3.8601.00
244_G247_G3.7261.00
309_N312_Q3.6871.00
168_E171_A3.6771.00
99_D102_Q3.5171.00
270_A286_I2.8631.00
335_G351_F2.7511.00
331_W350_A2.5771.00
364_Y383_M2.5581.00
368_A384_R2.5351.00
91_A107_M2.4901.00
236_M252_W2.4211.00
194_E210_I2.3541.00
107_M123_L2.2731.00
125_A141_L2.2451.00
160_V176_V2.2171.00
266_Q285_I2.0991.00
121_Y140_H2.0341.00
141_L158_T2.0211.00
108_A124_A1.9741.00
177_D193_A1.9511.00
269_M285_I1.9001.00
142_E159_R1.8771.00
176_V192_L1.8481.00
253_K269_M1.8151.00
124_A140_H1.8061.00
156_E175_G1.8031.00
190_L209_I1.7901.00
193_A209_I1.7831.00
334_L350_A1.7591.00
348_S370_A1.7581.00
318_R334_L1.7421.00
283_Q287_I1.7381.00
317_L333_T1.7241.00
348_S352_R1.6871.00
128_A136_R1.6641.00
348_S367_L1.6631.00
252_W268_A1.6521.00
351_F366_W1.6391.00
303_P317_L1.6351.00
159_R175_G1.6341.00
314_E337_S1.6081.00
124_A128_A1.6041.00
163_Q175_G1.5841.00
311_E341_H1.5641.00
232_W251_W1.5361.00
352_R367_L1.5201.00
104_E127_A1.5191.00
87_Q106_L1.5151.00
371_L379_E1.5141.00
367_L383_M1.5111.00
386_D389_M1.4891.00
273_L281_T1.4871.00
143_R146_E1.4731.00
314_E318_R1.4691.00
254_N257_R1.4671.00
269_M273_L1.4391.00
372_D384_R1.4251.00
314_E334_L1.4231.00
353_A356_K1.4171.00
94_K99_D1.4071.00
211_P235_L1.4071.00
299_L316_V1.4051.00
193_A197_Y1.3861.00
371_L383_M1.3821.00
197_Y205_S1.3791.00
90_Q106_L1.3771.00
334_L338_L1.3771.00
173_R196_A1.3691.00
91_A110_N1.3661.00
163_Q171_A1.3661.00
163_Q168_E1.3651.00
332_S366_W1.3531.00
338_L346_E1.3491.00
197_Y209_I1.3471.00
94_K106_L1.3371.00
138_N159_R1.3341.00
235_L251_W1.3341.00
159_R163_Q1.3121.00
287_I302_I1.3101.00
239_A247_G1.2961.00
111_A120_N1.2901.00
354_A363_D1.2901.00
104_E124_A1.2891.00
90_Q94_K1.2891.00
173_R177_D1.2811.00
371_L376_K1.2771.00
249_R253_K1.2741.00
249_R273_L1.2661.00
236_M255_Q1.2651.00
94_K102_Q1.2611.00
339_M351_F1.2611.00
321_I330_L1.2541.00
128_A140_H1.2491.00
84_A110_N1.2481.00
101_Q131_R1.2331.00
249_R269_M1.2071.00
288_D291_K1.2051.00
319_Q322_K1.1981.00
138_N142_E1.1841.00
345_Q374_L1.1811.00
173_R200_T1.1761.00
104_E128_A1.1731.00
186_H189_V1.1661.00
381_A385_R1.1601.00
173_R193_A1.1521.00
314_E341_H1.1521.00
162_L166_R1.1481.00
368_A387_G1.1441.00
263_V289_G1.1441.00
321_I331_W1.1311.00
249_R276_C1.1311.00
170_H200_T1.1281.00
95_L107_M1.1251.00
293_Q296_D1.1211.00
104_E131_R1.1121.00
336_Q366_W1.1091.00
324_V327_R1.1061.00
235_L239_A1.1001.00
256_S265_L1.0941.00
128_A133_D1.0941.00
273_L285_I1.0911.00
153_I179_L1.0901.00
246_E276_C1.0881.00
339_M370_A1.0851.00
338_L350_A1.0841.00
207_L211_P1.0681.00
152_T155_V1.0651.00
104_E108_A1.0571.00
273_L278_D1.0531.00
338_L343_E1.0501.00
233_I268_A1.0471.00
122_L126_E1.0421.00
138_N166_R1.0411.00
287_I312_Q1.0371.00
365_A369_D1.0281.00
348_S371_L1.0271.00
196_A200_T1.0271.00
364_Y386_D1.0271.00
369_D384_R1.0251.00
249_R272_H1.0221.00
300_L333_T1.0201.00
368_A383_M1.0191.00
314_E338_L1.0181.00
367_L371_L1.0181.00
180_L189_V1.0161.00
348_S374_L1.0131.00
270_A289_G1.0131.00
300_L304_R1.0111.00
118_V144_A1.0071.00
210_I234_G1.0051.00
327_R330_L1.0041.00
197_Y202_A1.0041.00
179_L189_V1.0011.00
160_V179_L0.9971.00
138_N162_L0.9931.00
255_Q265_L0.9921.00
110_N120_N0.9921.00
346_E349_L0.9911.00
271_E286_I0.9881.00
136_R139_Q0.9871.00
335_G354_A0.9811.00
194_E206_L0.9791.00
302_I316_V0.9641.00
190_L212_S0.9641.00
127_A131_R0.9601.00
92_L107_M0.9601.00
205_S208_D0.9581.00
204_S242_D0.9561.00
194_E213_M0.9531.00
331_W353_A0.9501.00
212_S215_K0.9501.00
283_Q302_I0.9481.00
332_S336_Q0.9451.00
379_E382_A0.9451.00
274_I286_I0.9441.00
164_L192_L0.9431.00
217_H220_D0.9401.00
121_Y143_R0.9391.00
125_A144_A0.9361.00
366_W369_D0.9291.00
117_P120_N0.9291.00
145_A155_V0.9241.00
339_M344_W0.9221.00
318_R346_E0.9191.00
138_N163_Q0.9171.00
135_A166_R0.9171.00
179_L182_V0.9121.00
298_L301_P0.9081.00
288_D292_R0.9031.00
351_F370_A0.8991.00
332_S363_D0.8991.00
289_G292_R0.8991.00
87_Q110_N0.8981.00
187_P213_M0.8971.00
145_A156_E0.8951.00
253_K281_T0.8941.00
129_Q141_L0.8901.00
88_T92_L0.8901.00
109_K112_D0.8891.00
239_A244_G0.8861.00
91_A103_V0.8811.00
355_L364_Y0.8781.00
92_L123_L0.8781.00
352_R356_K0.8741.00
355_L363_D0.8661.00
259_T262_Q0.8651.00
180_L190_L0.8631.00
336_Q351_F0.8601.00
156_E179_L0.8591.00
251_W255_Q0.8571.00
164_L196_A0.8531.00
106_L110_N0.8531.00
137_A141_L0.8501.00
95_L123_L0.8491.00
114_A117_P0.8441.00
148_A152_T0.8441.00
212_S216_A0.8411.00
87_Q113_H0.8391.00
160_V172_A0.8391.00
173_R197_Y0.8341.00
178_K181_E0.8341.00
256_S266_Q0.8311.00
129_Q158_T0.8301.00
353_A357_Q0.8301.00
344_W370_A0.8231.00
232_W255_Q0.8191.00
312_Q315_K0.8171.00
122_L158_T0.8171.00
207_L238_Q0.8131.00
239_A251_W0.8111.00
190_L213_M0.8111.00
298_L302_I0.8041.00
213_M216_A0.8041.00
175_G179_L0.8031.00
157_I192_L0.7961.00
283_Q307_T0.7941.00
352_R371_L0.7941.00
207_L239_A0.7941.00
247_G250_N0.7941.00
95_L100_Y0.7921.00
134_E162_L0.7921.00
286_I301_P0.7891.00
144_A147_L0.7891.00
266_Q288_D0.7891.00
161_R192_L0.7861.00
248_L272_H0.7861.00
107_M111_A0.7801.00
281_T284_Q0.7801.00
109_K113_H0.7801.00
207_L235_L0.7791.00
121_Y144_A0.7771.00
121_Y147_L0.7761.00
255_Q258_K0.7761.00
352_R379_E0.7731.00
310_P337_S0.7731.00
93_L97_E0.7711.00
238_Q242_D0.7701.00
95_L127_A0.7681.00
90_Q93_L0.7681.00
183_T186_H0.7671.00
267_V301_P0.7651.00
280_D307_T0.7601.00
262_Q265_L0.7561.00
100_Y127_A0.7561.00
339_M366_W0.7511.00
344_W374_L0.7501.00
335_G350_A0.7491.00
164_L176_V0.7471.00
87_Q109_K0.7461.00
142_E146_E0.7461.00
140_H144_A0.7441.00
206_L210_I0.7421.00
337_S341_H0.7411.00
318_R322_K0.7391.00
283_Q309_N0.7391.00
320_Q330_L0.7381.00
123_L126_E0.7351.00
111_A121_Y0.7351.00
237_D268_A0.7271.00
209_I213_M0.7251.00
144_A155_V0.7231.00
304_R317_L0.7231.00
313_L317_L0.7211.00
344_W373_R0.7161.00
156_E178_K0.7131.00
143_R147_L0.7121.00
240_R252_W0.7071.00
279_H283_Q0.7061.00
339_M373_R0.7051.00
333_T366_W0.7041.00
214_A232_W0.7031.00
86_K93_L0.7021.00
110_N113_H0.7021.00
363_D366_W0.7001.00
272_H276_C0.6981.00
88_T117_P0.6961.00
318_R338_L0.6951.00
266_Q289_G0.6951.00
348_S376_K0.6941.00
245_S272_H0.6931.00
301_P304_R0.6931.00
331_W357_Q0.6901.00
207_L242_D0.6901.00
169_N196_A0.6871.00
270_A285_I0.6861.00
160_V175_G0.6861.00
236_M248_L0.6841.00
332_S354_A0.6831.00
232_W254_N0.6821.00
129_Q162_L0.6821.00
385_R389_M0.6791.00
86_K90_Q0.6781.00
191_R195_Q0.6741.00
338_L341_H0.6731.00
319_Q323_N0.6731.00
171_A174_H0.6691.00
331_W354_A0.6681.00
290_L299_L0.6671.00
248_L252_W0.6651.00
382_A386_D0.6651.00
157_I189_V0.6651.00
122_L155_V0.6641.00
192_L195_Q0.6620.99
364_Y387_G0.6550.99
271_E301_P0.6510.99
267_V271_E0.6500.99
289_G298_L0.6490.99
361_A387_G0.6480.99
177_D181_E0.6460.99
328_P354_A0.6440.99
314_E343_E0.6420.99
139_Q143_R0.6410.99
178_K182_V0.6410.99
88_T120_N0.6400.99
354_A357_Q0.6380.99
125_A140_H0.6370.99
297_R300_L0.6370.99
310_P340_K0.6360.99
157_I160_V0.6360.99
191_R234_G0.6350.99
314_E317_L0.6350.99
233_I237_D0.6340.99
92_L96_A0.6310.99
331_W364_Y0.6310.99
134_E166_R0.6300.99
125_A137_A0.6290.99
126_E141_L0.6280.99
91_A123_L0.6270.99
303_P320_Q0.6260.99
254_N258_K0.6240.99
87_Q90_Q0.6220.99
122_L144_A0.6150.99
204_S208_D0.6130.99
126_E158_T0.6110.99
170_H174_H0.6100.99
349_L353_A0.6090.99
252_W256_S0.6080.99
175_G178_K0.6070.99
370_A374_L0.6060.99
137_A162_L0.6040.99
161_R176_V0.6030.99
298_L303_P0.6030.99
213_M231_A0.6020.99
120_N123_L0.6000.99
208_D212_S0.6000.99
335_G347_A0.5990.99
123_L158_T0.5990.99
177_D205_S0.5980.99
328_P358_R0.5980.99
157_I179_L0.5960.99
203_W238_Q0.5950.99
107_M127_A0.5950.99
195_Q210_I0.5940.99
88_T107_M0.5940.99
299_L319_Q0.5920.99
117_P121_Y0.5910.99
145_A159_R0.5890.99
214_A231_A0.5850.99
138_N168_E0.5840.99
304_R333_T0.5820.99
361_A368_A0.5800.99
122_L152_T0.5790.99
316_V320_Q0.5780.99
237_D252_W0.5780.99
194_E209_I0.5760.99
382_A385_R0.5760.99
191_R213_M0.5740.99
153_I183_T0.5730.99
270_A282_A0.5730.99
290_L298_L0.5720.99
209_I212_S0.5710.99
102_Q105_K0.5690.98
158_T161_R0.5690.98
195_Q234_G0.5670.98
240_R268_A0.5660.98
198_I210_I0.5660.98
111_A124_A0.5660.98
169_N199_R0.5650.98
344_W348_S0.5630.98
157_I186_H0.5620.98
240_R272_H0.5620.98
156_E182_V0.5620.98
287_I291_K0.5590.98
365_A384_R0.5590.98
274_I279_H0.5590.98
330_L333_T0.5520.98
279_H307_T0.5480.98
365_A387_G0.5480.98
139_Q142_E0.5460.98
108_A112_D0.5450.98
102_Q106_L0.5440.98
206_L238_Q0.5420.98
297_R301_P0.5420.98
250_N254_N0.5390.98
95_L130_Q0.5380.98
245_S275_E0.5350.98
240_R245_S0.5330.98
106_L109_K0.5330.98
329_L362_Y0.5320.98
100_Y131_R0.5310.98
80_K83_R0.5300.98
88_T123_L0.5300.98
126_E130_Q0.5300.98
190_L266_Q0.5290.98
89_E92_L0.5280.98
350_A354_A0.5280.98
349_L352_R0.5270.97
236_M251_W0.5260.97
333_T336_Q0.5260.97
285_I288_D0.5240.97
91_A106_L0.5220.97
180_L193_A0.5210.97
283_Q286_I0.5190.97
118_V125_A0.5180.97
203_W207_L0.5170.97
262_Q266_Q0.5170.97
195_Q199_R0.5160.97
88_T110_N0.5140.97
152_T156_E0.5140.97
220_D231_A0.5140.97
350_A353_A0.5110.97
161_R165_A0.5110.97
211_P215_K0.5110.97
313_L320_Q0.5100.97
157_I161_R0.5080.97
355_L367_L0.5080.97
129_Q134_E0.5060.97
336_Q339_M0.5050.97
299_L302_I0.5030.97
369_D373_R0.5020.97
103_V107_M0.5010.97
305_L312_Q0.5000.97
266_Q292_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w3bA 2 0.9271 100 0.319 Contact Map
2y4tA 1 0.7764 100 0.34 Contact Map
3iegA 1 0.7739 100 0.363 Contact Map
4ui9C 2 0.9372 100 0.368 Contact Map
5aioA 1 0.7613 100 0.375 Contact Map
4ui9J 2 0.9497 100 0.378 Contact Map
4ui9X 2 0.9548 100 0.381 Contact Map
4rg9A 2 0.8593 100 0.395 Contact Map
4kvmA 3 0.897 100 0.395 Contact Map
4jsnB 1 0.7563 100 0.402 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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