GREMLIN Database
HEM2 - Delta-aminolevulinic acid dehydratase
UniProt: P0ACB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10428
Length: 324 (315)
Sequences: 2875 (1499)
Seq/√Len: 84.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_S259_L3.5621.00
226_R258_E3.5371.00
257_R261_E3.4331.00
91_D94_R3.4241.00
87_E126_S3.1001.00
30_D302_K3.0321.00
64_E315_L3.0291.00
117_S154_A2.8151.00
291_E320_K2.6631.00
249_A301_I2.6511.00
166_A171_Q2.6481.00
237_E265_L2.5701.00
100_A153_V2.5201.00
103_S115_V2.5071.00
298_L317_L2.4861.00
233_S244_L2.4651.00
156_A184_F2.3241.00
152_V178_A2.2651.00
107_K160_D2.2591.00
280_K290_E2.2111.00
22_E222_N2.2021.00
139_D142_A2.1481.00
226_R255_I2.1281.00
44_Y54_M2.1181.00
256_V269_A2.0651.00
46_A54_M2.0241.00
260_R307_D2.0231.00
93_W146_N2.0201.00
194_T233_S2.0191.00
66_E70_N1.9931.00
67_R319_E1.9731.00
289_D292_K1.9691.00
281_F287_A1.9671.00
8_P235_L1.9591.00
268_G308_L1.9061.00
95_E156_A1.9011.00
45_K55_R1.8871.00
243_C268_G1.8781.00
15_P19_A1.8711.00
294_V320_K1.8471.00
86_D90_S1.8341.00
103_S117_S1.8241.00
148_G178_A1.7941.00
62_A110_V1.7941.00
69_A110_V1.7521.00
32_V308_L1.7501.00
134_C137_G1.7411.00
227_R260_R1.7191.00
234_L238_A1.7141.00
60_H63_R1.7001.00
295_L317_L1.6921.00
44_Y60_H1.6641.00
93_W149_K1.6641.00
258_E261_E1.6561.00
62_A109_T1.6301.00
47_V53_V1.6231.00
48_E206_E1.6231.00
19_A74_R1.6191.00
6_Q231_R1.6011.00
58_E105_I1.5931.00
250_G271_Q1.5731.00
75_S116_M1.5671.00
132_V146_N1.5531.00
200_F297_S1.5491.00
61_L106_C1.5341.00
66_E110_V1.5331.00
63_R66_E1.5311.00
44_Y56_I1.5261.00
251_A300_S1.5000.99
227_R258_E1.4940.99
294_V313_F1.4740.99
234_L263_T1.4720.99
19_A29_N1.4710.99
43_D57_P1.4520.99
161_F243_C1.4460.99
76_V113_M1.4340.99
25_T29_N1.4330.99
76_V115_V1.4310.99
156_A182_A1.4170.99
253_L301_I1.4160.99
39_E101_R1.4150.99
249_A269_A1.4120.99
121_F150_Q1.4090.99
290_E294_V1.3980.99
137_G186_D1.3980.99
33_L68_I1.3960.99
49_A206_E1.3890.99
67_R315_L1.3840.99
77_M310_F1.3800.99
271_Q313_F1.3710.99
316_D319_E1.3700.99
42_D60_H1.3680.99
134_C139_D1.3630.99
190_M243_C1.3600.99
77_M163_A1.3540.99
259_L267_I1.3520.99
31_L317_L1.3370.99
65_I110_V1.3270.99
38_E45_K1.3270.99
290_E316_D1.3240.99
117_S159_A1.3180.99
279_I297_S1.3170.99
11_L21_F1.3140.99
237_E244_L1.3140.99
119_T162_I1.3030.98
62_A105_I1.3010.98
152_V182_A1.3000.98
65_I106_C1.2690.98
24_T301_I1.2590.98
271_Q297_S1.2490.98
161_F188_A1.2470.98
200_F251_A1.2320.98
65_I113_M1.2310.98
193_S233_S1.2310.98
97_G100_A1.2280.98
64_E68_I1.2240.98
114_I161_F1.2230.98
40_E59_K1.2220.98
288_I293_V1.2210.98
280_K316_D1.2210.98
32_V116_M1.2140.98
148_G174_A1.2070.97
237_E263_T1.1960.97
199_S292_K1.1930.97
22_E224_M1.1890.97
69_A113_M1.1870.97
227_R307_D1.1860.97
56_I60_H1.1820.97
234_L262_R1.1730.97
66_E109_T1.1670.97
65_I76_V1.1650.97
269_A301_I1.1500.97
178_A182_A1.1420.96
251_A297_S1.1310.96
33_L53_V1.1250.96
250_G297_S1.1240.96
283_A288_I1.1180.96
244_L265_L1.1120.96
250_G300_S1.1020.96
200_F279_I1.1000.96
298_L301_I1.0960.96
199_S293_V1.0870.95
89_G125_T1.0830.95
105_I108_Q1.0830.95
134_C142_A1.0760.95
291_E294_V1.0700.95
68_I315_L1.0690.95
120_C130_C1.0670.95
283_A294_V1.0630.95
196_F221_M1.0620.95
244_L259_L1.0570.95
311_S314_A1.0560.95
226_R257_R1.0560.95
85_T211_A1.0550.95
16_A114_I1.0500.94
96_D101_R1.0430.94
13_K186_D1.0390.94
127_H133_L1.0210.94
38_E43_D1.0150.93
62_A66_E1.0090.93
73_I318_A1.0090.93
14_S188_A1.0040.93
116_M163_A0.9990.93
17_L114_I0.9920.93
55_R209_G0.9890.92
37_V61_L0.9880.92
31_L311_S0.9830.92
302_K309_I0.9680.92
224_M299_G0.9680.92
106_C110_V0.9630.91
50_M277_A0.9600.91
107_K115_V0.9600.91
151_A162_I0.9540.91
33_L315_L0.9520.91
38_E57_P0.9450.91
244_L267_I0.9440.91
119_T154_A0.9430.91
297_S300_S0.9430.91
147_L166_A0.9420.90
260_R264_E0.9390.90
279_I313_F0.9360.90
38_E55_R0.9340.90
230_I233_S0.9330.90
297_S313_F0.9330.90
49_A287_A0.9320.90
71_A315_L0.9310.90
13_K17_L0.9280.90
41_I57_P0.9260.90
120_C216_R0.9260.90
86_D89_G0.9260.90
130_C216_R0.9240.90
99_V124_Y0.9210.89
28_L318_A0.9190.89
280_K284_L0.9190.89
17_L188_A0.9180.89
253_L256_V0.9150.89
291_E295_L0.9140.89
58_E102_M0.9080.89
279_I288_I0.9070.89
116_M161_F0.9010.88
69_A112_E0.8980.88
68_I76_V0.8970.88
103_S159_A0.8940.88
93_W153_V0.8930.88
256_V301_I0.8920.88
64_E67_R0.8900.88
229_A255_I0.8880.88
243_C308_L0.8860.88
295_L320_K0.8840.87
173_Q177_Q0.8820.87
123_E209_G0.8810.87
71_A319_E0.8770.87
234_L264_E0.8770.87
279_I293_V0.8760.87
106_C113_M0.8720.87
172_V189_I0.8670.86
317_L320_K0.8660.86
105_I109_T0.8630.86
194_T244_L0.8610.86
200_F293_V0.8610.86
164_P175_I0.8570.86
121_F146_N0.8560.86
35_I61_L0.8540.86
146_N150_Q0.8470.85
253_L300_S0.8380.84
26_L317_L0.8380.84
6_Q238_A0.8370.84
190_M308_L0.8320.84
146_N149_K0.8310.84
40_E43_D0.8310.84
88_T93_W0.8310.84
256_V306_A0.8300.84
154_A162_I0.8270.84
32_V310_F0.8220.83
290_E320_K0.8210.83
39_E83_H0.8200.83
42_D59_K0.8200.83
28_L31_L0.8190.83
103_S154_A0.8180.83
230_I259_L0.8140.83
283_A290_E0.8070.82
208_A212_L0.8070.82
144_L174_A0.8030.82
280_K294_V0.7960.81
171_Q191_S0.7940.81
280_K313_F0.7930.81
279_I283_A0.7900.81
65_I105_I0.7890.81
151_A175_I0.7840.80
271_Q279_I0.7820.80
281_F285_A0.7800.80
106_C115_V0.7790.80
80_G130_C0.7780.80
66_E69_A0.7740.79
119_T166_A0.7720.79
313_F320_K0.7720.79
314_A318_A0.7710.79
14_S17_L0.7710.79
58_E98_L0.7700.79
26_L31_L0.7680.79
145_E149_K0.7670.79
133_L138_V0.7620.78
80_G120_C0.7610.78
43_D60_H0.7590.78
104_R156_A0.7580.78
200_F250_G0.7550.78
295_L299_G0.7540.78
264_E267_I0.7460.77
80_G216_R0.7430.77
244_L263_T0.7410.76
120_C123_E0.7400.76
122_C130_C0.7390.76
245_M310_F0.7380.76
194_T259_L0.7340.76
20_M74_R0.7320.76
26_L295_L0.7310.75
230_I234_L0.7300.75
35_I78_T0.7300.75
87_E127_H0.7290.75
53_V276_Y0.7290.75
104_R108_Q0.7280.75
35_I64_E0.7260.75
123_E130_C0.7240.75
81_I123_E0.7230.75
56_I64_E0.7210.74
125_T133_L0.7200.74
61_L65_I0.7170.74
14_S114_I0.7160.74
229_A233_S0.7160.74
200_F313_F0.7140.74
225_N228_E0.7030.73
38_E41_I0.7030.73
119_T171_Q0.7000.72
6_Q235_L0.6990.72
47_V206_E0.6940.72
76_V106_C0.6920.71
58_E62_A0.6920.71
251_A301_I0.6890.71
43_D59_K0.6880.71
26_L298_L0.6880.71
147_L171_Q0.6840.71
45_K209_G0.6810.70
133_L137_G0.6800.70
13_K137_G0.6780.70
278_M282_A0.6760.70
191_S194_T0.6750.70
8_P11_L0.6710.69
55_R123_E0.6710.69
81_I209_G0.6690.69
41_I59_K0.6680.69
290_E313_F0.6640.68
123_E216_R0.6610.68
230_I262_R0.6600.68
251_A271_Q0.6580.68
122_C208_A0.6580.68
152_V155_A0.6560.67
138_V168_M0.6550.67
245_M268_G0.6540.67
133_L136_H0.6490.67
283_A289_D0.6480.66
37_V102_M0.6470.66
78_T103_S0.6460.66
223_P299_G0.6430.66
268_G310_F0.6430.66
250_G301_I0.6420.66
65_I68_I0.6410.66
36_F204_F0.6400.65
293_V297_S0.6390.65
57_P60_H0.6350.65
21_F222_N0.6330.65
19_A224_M0.6320.64
271_Q298_L0.6270.64
122_C216_R0.6270.64
155_A187_T0.6250.64
51_P287_A0.6240.64
69_A111_P0.6210.63
44_Y64_E0.6200.63
62_A65_I0.6190.63
130_C208_A0.6180.63
58_E101_R0.6170.63
294_V316_D0.6170.63
143_T147_L0.6150.62
260_R265_L0.6140.62
107_K111_P0.6130.62
227_R257_R0.6130.62
100_A150_Q0.6110.62
77_M116_M0.6090.62
71_A318_A0.6070.61
280_K283_A0.6060.61
110_V113_M0.6050.61
100_A154_A0.6040.61
133_L139_D0.6040.61
155_A188_A0.6040.61
172_V175_I0.6030.61
263_T267_I0.6020.61
178_A181_A0.6020.61
77_M80_G0.6000.60
120_C208_A0.5980.60
73_I315_L0.5980.60
35_I76_V0.5980.60
227_R264_E0.5970.60
15_P22_E0.5970.60
11_L188_A0.5960.60
233_S237_E0.5950.60
121_F132_V0.5930.60
121_F171_Q0.5910.59
40_E57_P0.5910.59
61_L102_M0.5890.59
41_I101_R0.5880.59
197_A217_K0.5860.59
132_V150_Q0.5860.59
8_P231_R0.5850.59
71_A74_R0.5830.58
294_V297_S0.5830.58
80_G123_E0.5820.58
17_L20_M0.5810.58
193_S259_L0.5810.58
121_F166_A0.5800.58
142_A145_E0.5790.58
84_H91_D0.5790.58
49_A277_A0.5780.58
81_I85_T0.5760.57
93_W150_Q0.5760.57
31_L116_M0.5750.57
23_E225_N0.5740.57
217_K292_K0.5740.57
223_P252_Y0.5730.57
208_A216_R0.5730.57
65_I109_T0.5730.57
16_A19_A0.5710.57
56_I65_I0.5710.57
249_A256_V0.5710.57
260_R263_T0.5690.56
162_I175_I0.5680.56
45_K123_E0.5670.56
258_E262_R0.5660.56
68_I113_M0.5650.56
17_L161_F0.5650.56
25_T30_D0.5650.56
180_D185_K0.5650.56
24_T299_G0.5630.56
52_G316_D0.5620.56
311_S317_L0.5610.55
7_R10_R0.5590.55
42_D57_P0.5590.55
196_F226_R0.5570.55
260_R267_I0.5560.55
36_F270_Y0.5560.55
24_T224_M0.5550.55
38_E59_K0.5540.55
161_F190_M0.5540.55
138_V219_Y0.5530.54
89_G121_F0.5470.54
162_I189_I0.5450.53
176_R180_D0.5440.53
32_V75_S0.5420.53
226_R261_E0.5410.53
30_D309_I0.5390.53
297_S301_I0.5380.52
78_T99_V0.5350.52
92_A150_Q0.5340.52
77_M122_C0.5340.52
50_M287_A0.5330.52
142_A146_N0.5330.52
91_D150_Q0.5310.51
81_I120_C0.5290.51
67_R71_A0.5290.51
66_E108_Q0.5290.51
301_I306_A0.5280.51
313_F316_D0.5280.51
193_S245_M0.5270.51
81_I216_R0.5240.51
232_E235_L0.5240.51
138_V218_S0.5220.50
192_Y210_S0.5220.50
81_I130_C0.5210.50
63_R67_R0.5210.50
143_T166_A0.5210.50
295_L298_L0.5200.50
91_D123_E0.5200.50
24_T226_R0.5180.50
63_R109_T0.5180.50
80_G122_C0.5180.50
174_A178_A0.5180.50
47_V55_R0.5170.50
96_D104_R0.5170.50
204_F270_Y0.5160.49
41_I44_Y0.5150.49
279_I290_E0.5140.49
227_R231_R0.5140.49
35_I65_I0.5130.49
38_E42_D0.5120.49
132_V142_A0.5120.49
277_A281_F0.5110.49
20_M308_L0.5110.49
34_P204_F0.5100.49
154_A159_A0.5090.49
33_L64_E0.5090.49
144_L148_G0.5080.48
257_R260_R0.5070.48
80_G98_L0.5060.48
46_A284_L0.5040.48
73_I113_M0.5040.48
77_M216_R0.5030.48
87_E132_V0.5030.48
234_L237_E0.5020.48
289_D294_V0.5020.48
282_A287_A0.5020.48
259_L262_R0.5010.47
231_R263_T0.5010.47
100_A212_L0.5000.47
66_E156_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l6sA 5 0.9969 100 -0.002 Contact Map
1w1zA 5 0.9815 100 0.006 Contact Map
3obkA 5 0.9969 100 0.012 Contact Map
1w5qA 5 0.9722 100 0.015 Contact Map
1h7nA 5 0.9969 100 0.045 Contact Map
1pv8A 5 0.8673 100 0.054 Contact Map
3vcrA 3 0.6019 96.5 0.953 Contact Map
1wbhA 3 0.5864 96.1 0.955 Contact Map
1vhcA 3 0.5833 94.9 0.959 Contact Map
3i4eA 4 0.8704 94.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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