GREMLIN Database
DNAB - Replicative DNA helicase
UniProt: P0ACB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10236
Length: 471 (434)
Sequences: 3939 (2641)
Seq/√Len: 126.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
388_S391_Q4.1611.00
59_D130_A3.5091.00
327_A340_I3.4141.00
212_D462_N3.3961.00
223_P376_N3.3541.00
141_E164_R3.1901.00
209_T221_L3.1831.00
283_K293_D3.1501.00
57_A70_T2.9541.00
254_K338_G2.8541.00
255_P338_G2.8501.00
225_D267_Q2.7711.00
399_N415_I2.7231.00
240_F244_L2.6361.00
248_A339_L2.5951.00
452_T463_Y2.5311.00
396_R435_E2.4871.00
430_L450_R2.4581.00
422_E432_G2.3971.00
257_L330_I2.3631.00
418_I436_I2.3051.00
180_K265_S2.3001.00
217_K447_G2.2921.00
245_V341_M2.2501.00
340_I377_V2.2361.00
188_A266_E2.2301.00
208_N215_N2.2141.00
90_S93_R2.2111.00
365_S411_D2.2021.00
78_S90_S2.1491.00
433_I450_R2.1101.00
231_A418_I2.0851.00
392_R401_D2.0341.00
228_I412_A2.0021.00
72_M82_I1.9991.00
234_S443_N1.9961.00
417_F439_G1.9681.00
313_D326_R1.9611.00
255_P309_N1.9561.00
320_P367_S1.9511.00
214_L416_M1.9391.00
182_I269_M1.9341.00
311_Y334_H1.9131.00
130_A134_E1.9101.00
218_T414_L1.9041.00
229_V380_V1.8831.00
454_N461_D1.8811.00
74_R94_Q1.8771.00
327_A375_L1.8731.00
42_M87_L1.8621.00
421_D425_H1.8451.00
357_R360_E1.8371.00
357_R404_E1.8171.00
280_D283_K1.8101.00
226_L368_L1.7831.00
235_M423_V1.7781.00
331_A336_G1.7671.00
211_Y451_L1.7521.00
74_R90_S1.7511.00
323_V348_M1.7491.00
54_R123_A1.7411.00
210_G215_N1.7291.00
235_M424_Y1.7281.00
181_N184_D1.7131.00
48_W73_A1.7081.00
90_S94_Q1.6891.00
250_M308_R1.6881.00
246_E276_L1.6751.00
228_I408_I1.6671.00
191_A195_Q1.6601.00
41_L48_W1.6601.00
231_A235_M1.6481.00
194_E198_Q1.6181.00
292_E296_R1.6111.00
71_E90_S1.6051.00
145_A160_L1.5901.00
433_I463_Y1.5831.00
249_A310_I1.5741.00
441_Q445_P1.5681.00
207_V248_A1.5551.00
414_L441_Q1.5531.00
341_M380_V1.5491.00
97_L101_G1.5481.00
38_L65_H1.5371.00
365_S381_A1.5311.00
129_R132_V1.5271.00
277_S457_W1.5231.00
241_A341_M1.5221.00
136_I146_G1.5211.00
217_K438_I1.5171.00
89_E93_R1.5141.00
273_L297_I1.5121.00
362_A407_S1.5081.00
192_R266_E1.5071.00
68_I105_Y1.5051.00
192_R196_L1.4991.00
163_S167_K1.4941.00
88_A106_L1.4881.00
139_A142_I1.4871.00
37_V126_V1.4861.00
223_P338_G1.4851.00
278_R457_W1.4741.00
26_V29_H1.4721.00
179_P257_L1.4661.00
57_A73_A1.4571.00
58_D66_R1.4551.00
153_T156_D1.4541.00
435_E448_T1.4531.00
35_Q105_Y1.4521.00
41_L72_M1.4501.00
59_D127_R1.4331.00
134_E137_S1.4321.00
37_V55_V1.4181.00
276_L303_I1.4171.00
185_V265_S1.4151.00
71_E87_L1.4111.00
224_S264_P1.4101.00
239_T271_R1.4071.00
63_R66_R1.4041.00
69_F73_A1.3861.00
28_P136_I1.3761.00
205_T222_Q1.3751.00
120_S124_D1.3711.00
67_H96_Q1.3691.00
142_I161_A1.3611.00
239_T458_S1.3601.00
193_I297_I1.3551.00
229_V240_F1.3521.00
339_L380_V1.3481.00
35_Q112_N1.3481.00
213_D216_K1.3451.00
437_I448_T1.3441.00
114_P122_Y1.3431.00
358_T362_A1.3361.00
213_D462_N1.3351.00
346_Q383_S1.3291.00
164_R167_K1.3271.00
54_R124_D1.3251.00
221_L339_L1.3231.00
139_A143_A1.3181.00
47_R119_I1.3171.00
274_A284_I1.3171.00
257_L340_I1.3171.00
285_R441_Q1.3161.00
31_I62_T1.3161.00
246_E275_S1.3011.00
234_S446_I1.3011.00
454_N457_W1.2981.00
280_D456_Q1.2961.00
41_L51_V1.2931.00
127_R131_V1.2891.00
257_L327_A1.2871.00
245_V258_I1.2851.00
419_Y424_Y1.2781.00
139_A146_G1.2631.00
434_A460_F1.2621.00
323_V342_I1.2541.00
208_N252_Q1.2491.00
62_T65_H1.2451.00
324_R374_E1.2421.00
249_A256_V1.2361.00
416_M436_I1.2351.00
255_P336_G1.2331.00
140_N143_A1.2280.99
441_Q444_G1.2260.99
221_L244_L1.2250.99
355_D359_L1.2210.99
244_L248_A1.2200.99
242_M272_S1.2170.99
396_R448_T1.2140.99
70_T74_R1.2090.99
189_T193_I1.2080.99
222_Q225_D1.1980.99
33_A126_V1.1980.99
240_F436_I1.1880.99
88_A92_E1.1820.99
331_A337_I1.1820.99
331_A376_N1.1810.99
452_T461_D1.1750.99
278_R459_R1.1740.99
403_R410_Q1.1740.99
371_L375_L1.1670.99
234_S440_K1.1670.99
201_H288_Q1.1650.99
40_G119_I1.1570.99
96_Q99_S1.1550.99
241_A382_L1.1550.99
25_K147_F1.1500.99
160_L163_S1.1420.99
258_I310_I1.1380.99
189_T270_M1.1380.99
60_F69_F1.1360.99
160_L164_R1.1350.99
356_N359_L1.1300.99
180_K185_V1.1270.99
224_S376_N1.1170.99
386_N389_L1.1150.99
253_D307_K1.1050.99
225_D443_N1.1040.99
279_V297_I1.1020.99
212_D216_K1.1010.99
33_A125_I1.0980.99
283_K290_D1.0970.99
136_I147_F1.0950.99
247_N252_Q1.0930.99
454_N459_R1.0920.99
290_D293_D1.0900.99
30_S89_E1.0900.99
35_Q65_H1.0840.99
245_V256_V1.0770.99
137_S141_E1.0740.99
119_I123_A1.0600.98
311_Y330_I1.0550.98
51_V123_A1.0540.98
318_L323_V1.0520.98
293_D296_R1.0390.98
396_R437_I1.0340.98
327_A379_V1.0320.98
180_K188_A1.0320.98
389_L423_V1.0290.98
97_L102_G1.0200.98
289_L297_I1.0160.98
195_Q198_Q1.0060.98
195_Q199_Q1.0050.98
39_G113_T1.0020.98
428_S431_K1.0010.98
138_V164_R0.9990.98
132_V157_L0.9970.98
345_L408_I0.9960.98
302_G307_K0.9880.98
403_R406_G0.9870.98
124_D128_E0.9870.98
65_H105_Y0.9840.98
192_R195_Q0.9830.98
103_F107_A0.9820.98
371_L379_V0.9800.97
392_R398_V0.9780.97
277_S300_T0.9750.97
51_V119_I0.9750.97
50_D120_S0.9700.97
387_R409_E0.9700.97
292_E295_A0.9630.97
127_R130_A0.9610.97
342_I368_L0.9600.97
211_Y243_N0.9600.97
257_L377_V0.9580.97
232_R390_E0.9580.97
89_E125_I0.9570.97
254_K336_G0.9560.97
89_E92_E0.9550.97
390_E395_K0.9550.97
189_T273_L0.9510.97
238_T268_I0.9510.97
141_E145_A0.9490.97
249_A308_R0.9480.97
125_I129_R0.9480.97
219_A286_T0.9460.97
234_S399_N0.9440.97
35_Q108_E0.9420.97
180_K184_D0.9380.97
248_A254_K0.9360.97
386_N415_I0.9330.97
420_R424_Y0.9320.97
355_D358_T0.9320.97
63_R67_H0.9320.97
315_S318_L0.9310.97
49_D76_Q0.9290.97
88_A97_L0.9290.97
235_M434_A0.9210.96
421_D428_S0.9190.96
386_N423_V0.9160.96
84_L88_A0.9160.96
48_W52_A0.9140.96
389_L395_K0.9120.96
227_I414_L0.9120.96
222_Q285_R0.9120.96
274_A280_D0.9040.96
185_V269_M0.9020.96
242_M258_I0.9020.96
32_E35_Q0.8970.96
48_W76_Q0.8930.96
418_I434_A0.8930.96
218_T438_I0.8890.96
395_K424_Y0.8890.96
55_V60_F0.8880.96
179_P330_I0.8860.95
186_L301_M0.8860.95
197_F294_W0.8850.95
162_E166_F0.8840.95
232_R409_E0.8810.95
278_R461_D0.8800.95
261_L318_L0.8780.95
74_R78_S0.8760.95
131_V158_L0.8740.95
214_L436_I0.8730.95
28_P61_Y0.8680.95
369_K413_D0.8640.95
246_E272_S0.8600.95
282_T286_T0.8590.95
58_D134_E0.8550.95
59_D134_E0.8550.95
29_H61_Y0.8540.94
226_L365_S0.8530.94
108_E111_K0.8490.94
347_L411_D0.8480.94
30_S129_R0.8480.94
276_L300_T0.8440.94
387_R406_G0.8440.94
233_P409_E0.8430.94
28_P147_F0.8410.94
104_A108_E0.8400.94
191_A194_E0.8380.94
428_S433_I0.8370.94
242_M268_I0.8330.94
45_N82_I0.8330.94
104_A107_A0.8330.94
422_E455_G0.8290.94
365_S407_S0.8270.93
358_T404_E0.8260.93
82_I86_T0.8240.93
240_F418_I0.8220.93
84_L107_A0.8210.93
145_A164_R0.8210.93
140_N144_E0.8190.93
406_G409_E0.8140.93
138_V165_V0.8090.93
188_A191_A0.8090.93
362_A366_R0.8080.93
370_A373_K0.8080.93
68_I106_L0.8030.92
138_V168_I0.8020.92
41_L45_N0.7970.92
422_E431_K0.7930.92
432_G452_T0.7910.92
40_G116_A0.7900.92
229_V241_A0.7900.92
399_N439_G0.7890.92
196_L270_M0.7870.92
159_D163_S0.7870.92
256_V339_L0.7860.92
299_G303_I0.7840.92
38_L109_L0.7840.92
239_T242_M0.7820.91
118_N121_A0.7810.91
56_V59_D0.7760.91
209_T215_N0.7760.91
73_A77_E0.7750.91
339_L378_P0.7730.91
45_N87_L0.7720.91
338_G377_V0.7710.91
407_S411_D0.7700.91
245_V249_A0.7690.91
257_L337_I0.7690.91
226_L381_A0.7680.91
70_T96_Q0.7670.91
234_S414_L0.7660.91
450_R463_Y0.7640.90
435_E450_R0.7620.90
156_D159_D0.7600.90
422_E428_S0.7590.90
246_E250_M0.7550.90
259_F340_I0.7540.90
118_N122_Y0.7530.90
185_V189_T0.7510.90
214_L438_I0.7510.90
230_A385_L0.7490.90
267_Q443_N0.7480.90
178_G326_R0.7480.90
52_A76_Q0.7460.89
156_D160_L0.7440.89
67_H70_T0.7400.89
248_A256_V0.7380.89
309_N338_G0.7370.89
430_L433_I0.7360.89
199_Q202_D0.7360.89
390_E400_S0.7350.89
368_L381_A0.7350.89
83_D122_Y0.7340.89
31_I35_Q0.7310.88
425_H428_S0.7300.88
318_L326_R0.7300.88
132_V146_G0.7290.88
261_L347_L0.7280.88
192_R270_M0.7270.88
67_H100_V0.7270.88
44_D116_A0.7260.88
282_T445_P0.7260.88
47_R50_D0.7220.88
351_P363_E0.7210.88
166_F170_E0.7210.88
224_S267_Q0.7200.88
232_R387_R0.7190.88
342_I379_V0.7160.87
214_L221_L0.7160.87
245_V310_I0.7130.87
399_N417_F0.7110.87
412_A415_I0.7110.87
314_D373_K0.7090.87
318_L322_E0.7080.87
75_L80_S0.7080.87
217_K441_Q0.7070.87
76_Q82_I0.7060.87
71_E74_R0.7060.87
80_S124_D0.7060.87
358_T407_S0.7050.87
358_T386_N0.7030.86
238_T242_M0.7020.86
233_P406_G0.6980.86
247_N251_L0.6960.86
327_A337_I0.6930.86
128_E153_T0.6930.86
92_E97_L0.6920.86
361_I405_S0.6900.85
342_I381_A0.6890.85
152_R156_D0.6880.85
83_D118_N0.6870.85
298_S302_G0.6860.85
167_K170_E0.6850.85
189_T269_M0.6820.85
233_P390_E0.6820.85
221_L248_A0.6810.85
436_I451_L0.6810.85
30_S33_A0.6800.85
57_A66_R0.6790.84
420_R434_A0.6780.84
253_D309_N0.6780.84
243_N275_S0.6770.84
394_D419_Y0.6760.84
356_N360_E0.6750.84
88_A103_F0.6720.84
295_A299_G0.6710.84
161_A165_V0.6700.84
300_T303_I0.6690.84
47_R51_V0.6670.83
186_L189_T0.6620.83
250_M303_I0.6610.83
71_E94_Q0.6610.83
316_S374_E0.6610.83
74_R77_E0.6610.83
243_N246_E0.6610.83
97_L100_V0.6590.83
140_N147_F0.6590.83
256_V341_M0.6550.82
39_G115_S0.6550.82
281_Q458_S0.6530.82
423_V446_I0.6520.82
121_A124_D0.6500.82
371_L374_E0.6470.82
406_G410_Q0.6460.81
43_L114_P0.6450.81
422_E434_A0.6450.81
219_A222_Q0.6440.81
89_E129_R0.6430.81
261_L403_R0.6420.81
225_D441_Q0.6410.81
320_P350_V0.6400.81
331_A338_G0.6390.81
214_L218_T0.6380.81
244_L339_L0.6380.81
420_R423_V0.6370.81
191_A298_S0.6360.80
159_D321_T0.6350.80
320_P348_M0.6350.80
98_D101_G0.6350.80
136_I140_N0.6340.80
372_A379_V0.6330.80
262_E384_Q0.6330.80
43_L116_A0.6330.80
349_R363_E0.6310.80
427_N431_K0.6310.80
75_L86_T0.6270.80
327_A371_L0.6260.79
237_K343_D0.6250.79
346_Q404_E0.6240.79
120_S123_A0.6230.79
36_S83_D0.6220.79
283_K288_Q0.6210.79
44_D47_R0.6210.79
331_A375_L0.6210.79
213_D449_V0.6200.79
135_M165_V0.6200.79
108_E112_N0.6190.79
141_E144_E0.6190.79
250_M276_L0.6170.78
213_D463_Y0.6160.78
280_D293_D0.6150.78
206_G287_G0.6150.78
337_I375_L0.6140.78
139_A165_V0.6140.78
233_P410_Q0.6130.78
135_M139_A0.6130.78
221_L380_V0.6110.78
79_G349_R0.6100.78
235_M402_L0.6100.78
33_A85_I0.6080.77
84_L106_L0.6080.77
366_R370_A0.6050.77
204_V208_N0.6040.77
114_P126_V0.6010.77
244_L380_V0.6010.77
263_M442_R0.6000.76
51_V54_R0.5990.76
127_R171_S0.5980.76
383_S407_S0.5980.76
56_V73_A0.5960.76
295_A298_S0.5950.76
272_S310_I0.5950.76
48_W82_I0.5940.76
141_E160_L0.5930.76
68_I109_L0.5930.76
131_V154_S0.5910.75
232_R410_Q0.5910.75
327_A331_A0.5900.75
145_A157_L0.5900.75
70_T94_Q0.5890.75
421_D430_L0.5890.75
42_M72_M0.5890.75
436_I449_V0.5880.75
347_L366_R0.5880.75
419_Y437_I0.5880.75
391_Q398_V0.5850.75
91_L97_L0.5850.75
55_V69_F0.5850.75
61_Y133_R0.5850.75
222_Q441_Q0.5830.74
421_D424_Y0.5830.74
422_E425_H0.5830.74
389_L419_Y0.5820.74
317_G349_R0.5820.74
37_V60_F0.5820.74
419_Y423_V0.5810.74
40_G122_Y0.5800.74
138_V161_A0.5800.74
349_R370_A0.5800.74
182_I186_L0.5790.74
434_A455_G0.5780.74
68_I71_E0.5780.74
239_T453_F0.5770.74
260_S314_D0.5770.74
233_P412_A0.5760.74
71_E75_L0.5750.73
260_S268_I0.5730.73
393_A427_N0.5710.73
245_V268_I0.5710.73
385_L403_R0.5710.73
216_K288_Q0.5710.73
278_R454_N0.5700.73
91_L101_G0.5680.73
227_I380_V0.5670.72
103_F108_E0.5660.72
320_P368_L0.5660.72
218_T222_Q0.5640.72
407_S410_Q0.5630.72
211_Y247_N0.5620.72
435_E462_N0.5610.72
367_S370_A0.5610.72
389_L392_R0.5610.72
188_A265_S0.5610.72
211_Y240_F0.5590.71
98_D102_G0.5540.71
340_I371_L0.5540.71
43_L113_T0.5530.71
241_A380_V0.5520.70
233_P385_L0.5520.70
363_E367_S0.5520.70
230_A402_L0.5500.70
320_P371_L0.5490.70
402_L415_I0.5490.70
349_R366_R0.5470.70
419_Y435_E0.5440.69
67_H71_E0.5430.69
193_I284_I0.5420.69
264_P267_Q0.5420.69
105_Y109_L0.5410.69
193_I196_L0.5400.69
51_V69_F0.5400.69
358_T373_K0.5380.68
49_D332_R0.5380.68
184_D188_A0.5380.68
289_L293_D0.5370.68
224_S373_K0.5360.68
233_P402_L0.5360.68
273_L301_M0.5360.68
438_I441_Q0.5350.68
344_Y361_I0.5340.68
143_A146_G0.5340.68
237_K262_E0.5330.68
142_I165_V0.5330.68
315_S326_R0.5320.68
185_V188_A0.5310.67
138_V142_I0.5280.67
317_G370_A0.5280.67
452_T464_A0.5270.67
402_L417_F0.5260.67
416_M438_I0.5260.67
36_S85_I0.5260.67
230_A389_L0.5250.67
325_S329_R0.5240.66
222_Q443_N0.5220.66
441_Q449_V0.5220.66
441_Q447_G0.5210.66
25_K140_N0.5200.66
423_V434_A0.5200.66
86_T125_I0.5190.66
423_V436_I0.5180.66
409_E412_A0.5180.66
142_I146_G0.5170.65
402_L406_G0.5170.65
366_R411_D0.5170.65
309_N334_H0.5170.65
451_L462_N0.5170.65
361_I365_S0.5160.65
81_P86_T0.5160.65
415_I439_G0.5150.65
65_H68_I0.5140.65
196_L287_G0.5140.65
232_R406_G0.5130.65
187_D306_E0.5130.65
44_D50_D0.5110.65
396_R419_Y0.5110.65
301_M306_E0.5100.64
229_V436_I0.5100.64
41_L69_F0.5100.64
225_D234_S0.5090.64
246_E308_R0.5090.64
71_E91_L0.5070.64
132_V154_S0.5070.64
222_Q234_S0.5070.64
353_L356_N0.5070.64
337_I377_V0.5070.64
72_M114_P0.5070.64
158_L164_R0.5060.64
259_F326_R0.5060.64
331_A334_H0.5050.64
430_L435_E0.5050.64
394_D424_Y0.5040.63
334_H337_I0.5030.63
79_G82_I0.5030.63
217_K445_P0.5020.63
72_M87_L0.5020.63
234_S423_V0.5020.63
340_I379_V0.5020.63
426_E431_K0.5020.63
262_E442_R0.5020.63
166_F169_A0.5020.63
247_N451_L0.5020.63
143_A147_F0.5010.63
79_G416_M0.5010.63
347_L385_L0.5010.63
209_T380_V0.5000.63
190_V301_M0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q6tA 1 0.8981 100 0.235 Contact Map
4nmnA 3 0.9066 100 0.236 Contact Map
3bgwA 3 0.8832 100 0.244 Contact Map
2r6aA 5 0.8917 100 0.273 Contact Map
4a1fA 2 0.6115 100 0.527 Contact Map
3bh0A 1 0.5945 100 0.536 Contact Map
1cr0A 3 0.4968 100 0.606 Contact Map
1q57A 3 0.9087 100 0.618 Contact Map
3io5A 2 0.4098 100 0.687 Contact Map
1nlfA 3 0.4947 100 0.709 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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