GREMLIN Database
GSTB - Glutathione S-transferase GstB
UniProt: P0ACA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13481
Length: 208 (192)
Sequences: 21624 (14714)
Seq/√Len: 1061.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E196_R3.5501.00
73_R96_E3.2411.00
3_T30_I3.1691.00
77_A92_R2.9921.00
188_R192_Q2.9871.00
6_G13_V2.9491.00
20_L27_Y2.9161.00
21_E201_K2.7231.00
142_A183_R2.5991.00
63_L90_A2.5511.00
3_T28_E2.4381.00
21_E27_Y2.3471.00
45_L51_G2.2921.00
152_K192_Q2.2631.00
3_T57_R2.1361.00
149_A185_N2.1311.00
145_D185_N2.1091.00
57_R64_I2.0981.00
23_L76_A1.9811.00
88_S91_R1.9111.00
22_E198_A1.9041.00
6_G29_Q1.8921.00
138_D182_P1.8721.00
19_T72_V1.8661.00
58_D74_Y1.8461.00
5_W57_R1.8381.00
42_A46_A1.8241.00
58_D63_L1.7821.00
159_F164_I1.7731.00
47_M57_R1.7511.00
131_D135_K1.7191.00
77_A96_E1.7081.00
58_D61_S1.6911.00
152_K157_D1.6801.00
94_E97_K1.6741.00
187_Q191_Q1.6541.00
127_Q131_D1.6531.00
57_R62_D1.6381.00
47_M55_L1.5591.00
18_L199_V1.5491.00
58_D78_Q1.5441.00
167_A193_L1.5041.00
185_N188_R1.5021.00
38_I41_D1.4881.00
44_F55_L1.4801.00
43_D46_A1.4731.00
98_W147_E1.4601.00
142_A146_A1.4391.00
5_W32_A1.4371.00
147_E151_V1.4331.00
159_F196_R1.4321.00
25_L79_Y1.4091.00
155_S160_G1.3731.00
191_Q195_E1.3471.00
85_W95_A1.3241.00
44_F47_M1.3171.00
86_I95_A1.3101.00
154_F166_I1.2991.00
100_D103_N1.2761.00
40_H51_G1.2541.00
19_T23_L1.2531.00
15_K68_S1.2451.00
66_W97_K1.2071.00
159_F193_L1.2041.00
134_C138_D1.2011.00
195_E200_R1.2001.00
4_L20_L1.1961.00
58_D79_Y1.1881.00
16_V72_V1.1871.00
190_Y194_T1.1861.00
19_T84_L1.1851.00
181_T187_Q1.1761.00
126_D129_A1.1571.00
73_R100_D1.1501.00
40_H45_L1.1241.00
136_E139_A1.1151.00
153_W193_L1.1141.00
142_A182_P1.1101.00
90_A94_E1.1101.00
138_D183_R1.1051.00
22_E159_F1.1031.00
197_P201_K1.0761.00
65_L93_A1.0711.00
78_Q89_P1.0701.00
23_L75_L1.0681.00
102_A166_I1.0571.00
72_V161_V1.0401.00
84_L164_I1.0221.00
13_V53_V1.0211.00
99_M165_A1.0071.00
152_K188_R0.9941.00
191_Q194_T0.9921.00
6_G17_L0.9881.00
145_D149_A0.9831.00
145_D184_P0.9811.00
15_K165_A0.9801.00
50_N101_W0.9771.00
146_A149_A0.9721.00
135_K139_A0.9701.00
52_L67_E0.9691.00
33_G39_N0.9611.00
10_S13_V0.9551.00
48_N55_L0.9511.00
153_W192_Q0.9501.00
72_V165_A0.9461.00
167_A194_T0.9361.00
138_D142_A0.9341.00
135_K138_D0.9281.00
131_D134_C0.9211.00
89_P93_A0.9161.00
44_F48_N0.9021.00
22_E164_I0.9001.00
85_W96_E0.8921.00
139_A142_A0.8891.00
100_D104_Q0.8861.00
192_Q195_E0.8861.00
147_E150_K0.8801.00
18_L164_I0.8781.00
91_R94_E0.8771.00
167_A199_V0.8751.00
94_E151_V0.8751.00
197_P200_R0.8741.00
128_A131_D0.8721.00
23_L82_K0.8701.00
95_A155_S0.8681.00
94_E147_E0.8651.00
189_W193_L0.8641.00
47_M64_I0.8641.00
95_A161_V0.8641.00
91_R158_E0.8611.00
174_F190_Y0.8601.00
23_L80_G0.8601.00
143_L147_E0.8581.00
99_M161_V0.8571.00
16_V71_I0.8451.00
132_A135_K0.8431.00
125_R130_I0.8401.00
146_A150_K0.8331.00
177_G180_W0.8321.00
86_I91_R0.8261.00
95_A160_G0.8251.00
8_N31_L0.8201.00
41_D45_L0.8161.00
95_A162_G0.8111.00
170_I189_W0.8061.00
188_R191_Q0.8031.00
75_L79_Y0.7991.00
69_N100_D0.7961.00
17_L29_Q0.7891.00
17_L21_E0.7891.00
42_A45_L0.7871.00
132_A136_E0.7841.00
50_N66_W0.7821.00
70_A97_K0.7811.00
63_L93_A0.7781.00
41_D44_F0.7761.00
67_E105_T0.7721.00
34_R39_N0.7721.00
171_Y194_T0.7721.00
145_D183_R0.7711.00
83_R158_E0.7671.00
15_K72_V0.7671.00
63_L94_E0.7661.00
92_R96_E0.7631.00
69_N165_A0.7621.00
55_L64_I0.7621.00
83_R87_D0.7601.00
55_L66_W0.7581.00
4_L17_L0.7561.00
179_T182_P0.7541.00
101_W140_L0.7531.00
154_F189_W0.7511.00
109_A112_G0.7501.00
32_A38_I0.7481.00
94_E98_W0.7451.00
19_T164_I0.7451.00
69_N103_N0.7421.00
18_L168_P0.7351.00
127_Q130_I0.7301.00
70_A93_A0.7241.00
98_W101_W0.7241.00
170_I190_Y0.7231.00
143_L146_A0.7211.00
74_Y78_Q0.7171.00
144_L166_I0.7121.00
154_F162_G0.7111.00
73_R77_A0.7101.00
171_Y199_V0.6931.00
12_N15_K0.6881.00
23_L83_R0.6861.00
109_A140_L0.6861.00
125_R128_A0.6851.00
58_D90_A0.6821.00
145_D186_L0.6801.00
133_S136_E0.6801.00
18_L167_A0.6751.00
18_L198_A0.6701.00
61_S90_A0.6621.00
151_V157_D0.6581.00
153_W159_F0.6551.00
76_A83_R0.6541.00
14_K202_V0.6541.00
183_R186_L0.6521.00
111_R115_M0.6491.00
19_T76_A0.6471.00
142_A145_D0.6471.00
126_D130_I0.6461.00
56_L75_L0.6441.00
182_P187_Q0.6381.00
115_M128_A0.6291.00
91_R155_S0.6261.00
112_G136_E0.6231.00
5_W47_M0.6221.00
150_K185_N0.6181.00
141_F183_R0.6121.00
85_W161_V0.6121.00
58_D65_L0.6111.00
77_A89_P0.6091.00
4_L56_L0.6091.00
30_I38_I0.6081.00
76_A85_W0.6081.00
23_L79_Y0.6061.00
110_H137_C0.6021.00
147_E154_F0.6021.00
174_F194_T0.5951.00
70_A100_D0.5931.00
124_E130_I0.5931.00
124_E127_Q0.5901.00
113_I134_C0.5891.00
144_L186_L0.5861.00
33_G38_I0.5861.00
145_D148_L0.5851.00
62_D90_A0.5831.00
15_K103_N0.5821.00
20_L25_L0.5791.00
128_A132_A0.5781.00
65_L71_I0.5741.00
17_L202_V0.5701.00
155_S162_G0.5701.00
77_A85_W0.5691.00
156_G163_D0.5691.00
184_P187_Q0.5661.00
92_R95_A0.5631.00
78_Q90_A0.5631.00
15_K69_N0.5621.00
40_H44_F0.5591.00
93_A96_E0.5571.00
5_W30_I0.5541.00
77_A93_A0.5541.00
12_N52_L0.5531.00
141_F186_L0.5461.00
129_A132_A0.5461.00
129_A133_S0.5441.00
7_R33_G0.5431.00
98_W155_S0.5431.00
69_N99_M0.5411.00
152_K155_S0.5401.00
130_I134_C0.5391.00
124_E128_A0.5361.00
19_T161_V0.5361.00
109_A133_S0.5341.00
94_E155_S0.5301.00
25_L75_L0.5281.00
21_E26_P0.5271.00
7_R53_V0.5261.00
58_D62_D0.5261.00
174_F187_Q0.5261.00
63_L74_Y0.5261.00
97_K147_E0.5251.00
7_R34_R0.5251.00
96_E100_D0.5231.00
153_W156_G0.5211.00
20_L75_L0.5181.00
164_I168_P0.5161.00
32_A41_D0.5161.00
70_A96_E0.5131.00
151_V185_N0.5121.00
32_A39_N0.5101.00
102_A106_L0.5101.00
124_E129_A0.5101.00
117_L134_C0.5091.00
76_A161_V0.5051.00
26_P29_Q0.5051.00
101_W143_L0.5041.00
4_L16_V0.5031.00
14_K172_N0.5021.00
21_E24_E0.5001.00
137_C141_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kdxA 1 0.9856 100 0.154 Contact Map
4kh7A 2 0.9904 100 0.171 Contact Map
2v6kA 2 0.9904 100 0.18 Contact Map
4ielA 2 0.9904 100 0.181 Contact Map
4o7hA 2 0.9808 100 0.19 Contact Map
1k0dA 2 0.9808 100 0.19 Contact Map
3einA 2 0.9567 100 0.193 Contact Map
3nivA 2 0.9183 100 0.193 Contact Map
4igjA 2 0.9519 100 0.196 Contact Map
2x64A 2 0.976 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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