GREMLIN Database
SSPA - Stringent starvation protein A
UniProt: P0ACA3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10977
Length: 212 (188)
Sequences: 23281 (15536)
Seq/√Len: 1133.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_T39_E3.1671.00
77_E100_R3.0191.00
81_E96_R2.9611.00
31_E193_R2.9511.00
147_P189_R2.8831.00
30_A198_A2.7671.00
67_L94_V2.7421.00
185_G189_R2.6661.00
15_S22_S2.6131.00
29_L36_F2.5471.00
12_T37_E2.4031.00
137_L180_A2.3501.00
51_I57_Q2.3481.00
140_A182_E2.2571.00
63_V68_T2.2061.00
144_G182_E2.1711.00
30_A36_F1.9731.00
15_S38_I1.9641.00
28_V76_M1.9071.00
154_F159_C1.8811.00
12_T63_V1.8711.00
184_K188_T1.8411.00
92_Y95_A1.8251.00
48_Q52_D1.7781.00
147_P152_D1.7551.00
14_F63_V1.6991.00
98_E101_L1.6471.00
31_E195_S1.6031.00
27_I196_F1.6001.00
81_E100_R1.5531.00
63_V66_E1.5391.00
49_D52_D1.5231.00
53_L63_V1.5111.00
102_Y142_V1.5091.00
32_K80_D1.4821.00
162_A190_V1.4781.00
53_L61_T1.4351.00
126_D130_K1.4331.00
122_A126_D1.4321.00
50_L61_T1.4101.00
182_E185_G1.4041.00
34_V83_F1.3761.00
137_L141_P1.3751.00
150_L155_S1.3731.00
64_D78_Y1.3651.00
187_M191_F1.3571.00
154_F193_R1.3471.00
28_V88_L1.3261.00
44_D47_P1.3171.00
121_S124_E1.3041.00
188_T192_E1.3011.00
28_V32_K1.2941.00
194_D198_A1.2811.00
50_L53_L1.2781.00
104_H107_E1.2751.00
94_V98_E1.2661.00
104_H108_K1.2611.00
142_V146_K1.2311.00
64_D67_L1.2271.00
138_A142_V1.2221.00
89_M99_S1.2111.00
90_P99_S1.2001.00
149_F161_L1.1981.00
129_R133_R1.1931.00
140_A144_G1.1911.00
14_F41_V1.1881.00
70_W101_L1.1881.00
174_E177_G1.1761.00
46_P57_Q1.1671.00
148_Y190_V1.1551.00
47_P51_I1.1511.00
77_E104_H1.1461.00
105_R138_A1.1441.00
130_K134_E1.1331.00
162_A191_F1.1301.00
141_P144_G1.1201.00
98_E142_V1.1171.00
15_S26_R1.1171.00
82_R93_P1.1101.00
103_M160_Y1.1051.00
154_F190_V1.0991.00
69_L97_G1.0961.00
133_R180_A1.0891.00
192_E197_L1.0851.00
11_M62_L1.0741.00
31_E154_F1.0411.00
131_Q134_E1.0391.00
105_R135_E1.0381.00
126_D129_R1.0271.00
76_M160_Y1.0231.00
169_P187_M1.0171.00
64_D82_R1.0171.00
88_L159_C1.0161.00
31_E159_C1.0151.00
25_V76_M1.0121.00
133_R137_L1.0031.00
130_K133_R1.0011.00
24_Q72_S1.0011.00
147_P185_G0.9991.00
127_A131_Q0.9931.00
95_A98_E0.9881.00
11_M34_V0.9831.00
13_L29_L0.9831.00
95_A153_E0.9661.00
99_S155_S0.9631.00
140_A181_K0.9621.00
25_V75_I0.9551.00
24_Q160_Y0.9551.00
122_A125_A0.9541.00
103_M156_L0.9431.00
184_K187_M0.9431.00
99_S150_L0.9391.00
141_P145_Q0.9381.00
48_Q51_I0.9381.00
26_R38_I0.9351.00
76_M156_L0.9241.00
106_I161_L0.9241.00
46_P51_I0.9201.00
89_M100_R0.9191.00
28_V159_C0.9141.00
188_T191_F0.9121.00
138_A141_P0.9091.00
42_E45_N0.9091.00
189_R192_E0.9081.00
166_W191_F0.9081.00
134_E137_L0.9061.00
142_V145_Q0.9061.00
58_S71_E0.9051.00
24_Q76_M0.8911.00
165_L186_Y0.8881.00
93_P97_G0.8861.00
96_R100_R0.8851.00
32_K79_L0.8831.00
186_Y190_V0.8821.00
64_D83_F0.8791.00
53_L68_T0.8781.00
11_M83_F0.8761.00
26_R30_A0.8751.00
73_R104_H0.8701.00
27_I159_C0.8611.00
22_S59_V0.8571.00
73_R160_Y0.8561.00
80_D87_P0.8501.00
140_A183_L0.8441.00
56_N105_R0.8441.00
61_T68_T0.8421.00
89_M96_R0.8421.00
162_A196_F0.8411.00
30_A35_S0.8411.00
50_L54_N0.8391.00
67_L98_E0.8371.00
148_Y189_R0.8351.00
17_P40_H0.8261.00
99_S156_L0.8251.00
149_F157_V0.8231.00
185_G188_T0.8221.00
176_S184_K0.8151.00
49_D53_L0.8101.00
56_N70_W0.8031.00
102_Y150_L0.8001.00
146_K152_D0.7981.00
87_P153_E0.7941.00
73_R107_E0.7901.00
123_S126_D0.7831.00
15_S40_H0.7831.00
54_N61_T0.7791.00
78_Y82_R0.7771.00
113_L116_T0.7701.00
11_M64_D0.7631.00
128_A131_Q0.7621.00
87_P91_V0.7541.00
32_K83_F0.7521.00
169_P191_F0.7481.00
98_E146_K0.7471.00
28_V80_D0.7431.00
69_L78_Y0.7431.00
135_E138_A0.7421.00
173_I176_S0.7381.00
90_P95_A0.7351.00
23_H199_S0.7331.00
79_L83_F0.7291.00
121_S125_A0.7281.00
61_T70_W0.7201.00
127_A130_K0.7171.00
140_A180_A0.7171.00
27_I163_P0.7151.00
125_A129_R0.7071.00
165_L187_M0.7061.00
150_L157_V0.7021.00
84_P87_P0.6981.00
95_A150_L0.6931.00
194_D197_L0.6901.00
67_L97_G0.6881.00
19_D22_S0.6871.00
98_E102_Y0.6871.00
124_E128_A0.6851.00
27_I195_S0.6781.00
77_E81_E0.6761.00
133_R177_G0.6721.00
149_F186_Y0.6711.00
124_E127_A0.6691.00
32_K84_P0.6671.00
195_S198_A0.6621.00
123_S127_A0.6591.00
166_W196_F0.6561.00
112_T116_T0.6551.00
116_T131_Q0.6541.00
46_P50_L0.6511.00
145_Q182_E0.6461.00
148_Y154_F0.6441.00
74_I101_L0.6431.00
139_I161_L0.6421.00
139_I183_L0.6301.00
41_V44_D0.6291.00
137_L140_A0.6281.00
14_F39_E0.6271.00
28_V156_L0.6271.00
113_L135_E0.6261.00
139_I149_F0.6251.00
180_A183_L0.6251.00
97_G100_R0.6251.00
115_N118_I0.6251.00
102_Y149_F0.6221.00
134_E138_A0.6211.00
136_L183_L0.6181.00
132_L136_L0.6161.00
177_G184_K0.6141.00
189_R193_R0.6111.00
116_T119_N0.6101.00
114_M132_L0.6071.00
99_S157_V0.6021.00
74_I97_G0.6001.00
190_V196_F0.5991.00
32_K87_P0.5961.00
80_D156_L0.5931.00
80_D84_P0.5931.00
29_L79_L0.5901.00
23_H166_W0.5861.00
23_H163_P0.5831.00
177_G180_A0.5821.00
21_Y24_Q0.5791.00
30_A33_G0.5771.00
136_L180_A0.5761.00
27_I162_A0.5741.00
96_R99_S0.5721.00
81_E93_P0.5711.00
77_E156_L0.5711.00
81_E89_M0.5681.00
80_D89_M0.5641.00
69_L75_I0.5631.00
176_S180_A0.5611.00
13_L26_R0.5581.00
32_K86_P0.5581.00
169_P184_K0.5551.00
111_Y164_L0.5521.00
82_R94_V0.5511.00
98_E150_L0.5501.00
115_N119_N0.5491.00
147_P150_L0.5481.00
107_E111_Y0.5471.00
30_A199_S0.5461.00
181_K184_K0.5451.00
89_M156_L0.5361.00
26_R199_S0.5341.00
172_G175_F0.5331.00
73_R103_M0.5301.00
166_W200_L0.5281.00
13_L62_L0.5261.00
146_K189_R0.5251.00
146_K150_L0.5231.00
24_Q73_R0.5231.00
142_V149_F0.5221.00
117_I129_R0.5181.00
131_Q135_E0.5171.00
16_G43_K0.5161.00
102_Y105_R0.5131.00
97_G101_L0.5111.00
148_Y151_S0.5111.00
161_L186_Y0.5101.00
29_L34_V0.5041.00
84_P91_V0.5031.00
101_L105_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yy7A 2 0.9858 100 0.204 Contact Map
3lykA 2 0.9245 100 0.216 Contact Map
1oyjA 3 0.9717 100 0.224 Contact Map
4chsA 2 0.9623 100 0.226 Contact Map
1gwcA 1 0.967 100 0.227 Contact Map
1pn9A 2 0.9434 100 0.238 Contact Map
4dejA 2 0.9575 100 0.239 Contact Map
3lypA 2 0.9292 100 0.242 Contact Map
3vlnA 2 0.9953 100 0.244 Contact Map
4hojA 2 0.9198 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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